Detailed information for compound 402092

Basic information

Technical information
  • TDR Targets ID: 402092
  • Name: (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2- [[(2S)-2-[[2-[2-[2-[bis(carboxymethyl)amino]e thyl-(carboxymethyl)amino]ethyl-(carboxymethy l)amino]acetyl]amino]-5-(diaminomethylideneam ino)pentanoyl]amino]-5-(diaminomethylideneami no)pentanoyl]pyrrolidine-2-carbonyl]amino]-3- (4-hydroxyphenyl)propanoyl]amino]-3-methylpen tanoyl]amino]-4-methylpentanoic acid
  • MW: 1192.32 | Formula: C52H85N15O17
  • H donors: 15 H acceptors: 17 LogP: -8.26 Rotable bonds: 47
    Rule of 5 violations (Lipinski): 4
  • SMILES: CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)O)CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC(=O)O)CCCN=C(N)N)CCCN=C(N)N)Cc1ccc(cc1)O)C
  • InChi: 1S/C52H85N15O17/c1-5-31(4)44(48(81)62-37(50(83)84)23-30(2)3)63-46(79)36(24-32-12-14-33(68)15-13-32)61-47(80)38-11-8-18-67(38)49(82)35(10-7-17-58-52(55)56)60-45(78)34(9-6-16-57-51(53)54)59-39(69)25-65(27-41(72)73)21-19-64(26-40(70)71)20-22-66(28-42(74)75)29-43(76)77/h12-15,30-31,34-38,44,68H,5-11,16-29H2,1-4H3,(H,59,69)(H,60,78)(H,61,80)(H,62,81)(H,63,79)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,83,84)(H4,53,54,57)(H4,55,56,58)/t31-,34-,35-,36-,37-,38-,44-/m0/s1
  • InChiKey: QQOAEOLGZFCDKU-BFCKNADUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetyl]amino]-5-guanidino-pentanoyl]amino]-5-guanidino-pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methyl-pentanoyl]amino]-4-methyl-pentanoic acid
  • (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]ethyl-(carboxymethyl)amino]-1-oxoethyl]amino]-5-guanidino-1-oxopentyl]amino]-5-guanidino-1-oxopentyl]-2-pyrrolidinyl]-oxomethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-3-methyl-1-oxopentyl]amino]-4-methylpentanoic acid
  • (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-5-[bis(azanyl)methylideneamino]-2-[[(2S)-5-[bis(azanyl)methylideneamino]-2-[2-[2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]ethyl-(carboxymethyl)amino]ethanoylamino]pentanoyl]amino]pentanoyl]pyrrolidin-2-yl]carbonylamino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methyl-pentanoyl]amino]-4-methyl-pentanoic acid
  • (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetyl]amino]-5-guanidino-pentanoyl]amino]-5-guanidino-pentanoyl]prolyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methyl-pentanoyl]amino]-4-methyl-valeric acid
  • (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[2-[2-(bis(carboxymethyl)amino)ethyl-(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid
  • (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[2-[2-(bis(carboxymethyl)amino)ethyl-(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetyl]amino]-5-guanidino-pentanoyl]amino]-5-guanidino-pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methyl-pentanoyl]amino]-4-methyl-pentanoic acid
  • (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[2-[2-(bis(carboxymethyl)amino)ethyl-(carboxymethyl)amino]ethyl-(carboxymethyl)amino]-1-oxoethyl]amino]-5-guanidino-1-oxopentyl]amino]-5-guanidino-1-oxopentyl]-2-pyrrolidinyl]-oxomethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-3-methyl-1-oxopentyl]amino]-4-methylpentanoic acid
  • (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[2-[2-(bis(carboxymethyl)amino)ethyl-(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetyl]amino]-5-guanidino-pentanoyl]amino]-5-guanidino-pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methyl-pentanoyl]amino]-4-methyl-valeric acid
  • (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[2-[2-[2-(bis(carboxymethyl)amino)ethyl-(carboxymethyl)amino]ethyl-(carboxymethyl)amino]ethanoylamino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidin-2-yl]carbonylamino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methyl-pentanoyl]amino]-4-methyl-pentanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neurotensin receptor 1 (high affinity) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0066 0.0072
Entamoeba histolytica peptidase, putative 0.0036 0.0331 1
Plasmodium vivax FACT complex subunit SPT16, putative 0.0036 0.0331 0.0901
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0066 0.000001172
Schistosoma mansoni topbp1 0.0011 0.0066 0.0072
Loa Loa (eye worm) transcription factor SMAD2 0.0137 0.1425 0.4737
Trypanosoma cruzi aminopeptidase P1, putative 0.0036 0.0331 0.0901
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0283 0.3008 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0036 0.0331 0.0901
Loa Loa (eye worm) methionine aminopeptidase type I 0.0283 0.3008 1
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0283 0.3008 1
Entamoeba histolytica methionine aminopeptidase, putative 0.0036 0.0331 1
Entamoeba histolytica hypothetical protein, conserved 0.0036 0.0331 1
Echinococcus multilocularis methionyl aminopeptidase 2 0.0036 0.0331 0.0287
Brugia malayi initiation factor 2-associated protein. 0.0036 0.0331 0.1101
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0036 0.0331 1
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.0036 0.0331 1
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.0036 0.0331 0.0901
Loa Loa (eye worm) hypothetical protein 0.0036 0.0331 0.1101
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0036 0.0331 1
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0036 0.0331 0.0901
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0036 0.0331 1
Plasmodium falciparum methionine aminopeptidase 2 0.0036 0.0331 0.0901
Onchocerca volvulus 0.0036 0.0331 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0066 0.022
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0036 0.0331 1
Brugia malayi metallopeptidase family M24 containing protein 0.0036 0.0331 0.1101
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0036 0.0331 0.0901
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0036 0.0331 0.0966
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0036 0.0331 0.0966
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0066 0.0072
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.0036 0.0331 0.0901
Echinococcus multilocularis xaa Pro dipeptidase 0.0036 0.0331 0.0287
Brugia malayi metallopeptidase family M24 containing protein 0.0036 0.0331 0.1101
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0036 0.0331 1
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0036 0.0331 0.0901
Schistosoma mansoni DNA ligase IV 0.0011 0.0066 0.0072
Echinococcus multilocularis nibrin 0.0011 0.0066 0.0021
Plasmodium falciparum FACT complex subunit SPT16, putative 0.0036 0.0331 0.0901
Schistosoma mansoni peptidase 0.0036 0.0331 0.0966
Loa Loa (eye worm) initiation factor 2-associated protein 0.0036 0.0331 0.1101
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0036 0.0331 0.0901
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0283 0.3008 1
Brugia malayi topoisomerase 0.0011 0.0066 0.022
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0283 0.3008 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0036 0.0331 0.0901
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0066 0.022
Treponema pallidum aminopeptidase P 0.0036 0.0331 0.0901
Loa Loa (eye worm) hypothetical protein 0.0011 0.0066 0.022
Echinococcus multilocularis methionine aminopeptidase, type I 0.0036 0.0331 0.0287
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0045 0.015
Echinococcus granulosus methionine aminopeptidase type I 0.0036 0.0331 0.0966
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0036 0.0331 0.0901
Loa Loa (eye worm) hypothetical protein 0.0011 0.0066 0.022
Mycobacterium ulcerans dipeptidase PepE 0.0036 0.0331 0.0901
Treponema pallidum methionine aminopeptidase (map) 0.0283 0.3008 1
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0283 0.3008 1
Mycobacterium ulcerans methionine aminopeptidase 0.0283 0.3008 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0036 0.0331 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0036 0.0331 1
Brugia malayi Methionine aminopeptidase protein type I 0.0283 0.3008 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0331 0.1101
Echinococcus granulosus xaa Pro dipeptidase 0.0036 0.0331 0.0966
Echinococcus multilocularis xaa Pro dipeptidase 0.0036 0.0331 0.0287
Brugia malayi MH1 domain containing protein 0.0009 0.0045 0.015
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0283 0.3008 1
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0066 0.022
Trypanosoma brucei Metallopeptidase family M24, putative 0.0036 0.0331 0.0901
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0283 0.3008 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0331 0.1101
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0036 0.0331 0.0966
Plasmodium vivax proliferation-associated protein 2g4, putative 0.0036 0.0331 0.0901
Echinococcus granulosus xaa Pro dipeptidase 0.0036 0.0331 0.0966
Loa Loa (eye worm) hypothetical protein 0.0011 0.0066 0.022
Giardia lamblia Xaa-Pro dipeptidase 0.0036 0.0331 1
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0283 0.3008 1
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0283 0.3008 1
Echinococcus multilocularis FACT complex subunit SPT16 0.0036 0.0331 0.0287
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0036 0.0331 1
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0036 0.0331 0.0287
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0066 0.0021
Brugia malayi DKFZp564C0469 protein 0.0011 0.0066 0.022
Toxoplasma gondii peptidase D, putative 0.0036 0.0331 0.0901
Toxoplasma gondii creatinase domain-containing protein 0.0036 0.0331 0.0901
Loa Loa (eye worm) hypothetical protein 0.0011 0.0066 0.022
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0036 0.0331 0.0901
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0036 0.0331 1
Echinococcus granulosus Proliferation associated protein 2G4 0.0036 0.0331 0.0966
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0283 0.3008 0.2976
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.0036 0.0331 0.0901
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0036 0.0331 0.1101
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0036 0.0331 0.0901
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0036 0.0331 1
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0283 0.3008 1
Toxoplasma gondii methionine aminopeptidase 0.0283 0.3008 1
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0036 0.0331 0.0966
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0036 0.0331 0.0966
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0036 0.0331 0.0901
Loa Loa (eye worm) hypothetical protein 0.0011 0.0066 0.022
Plasmodium vivax methionine aminopeptidase 1c, putative 0.0036 0.0331 0.0901
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.0036 0.0331 0.0901
Entamoeba histolytica aminopeptidase, putative 0.0036 0.0331 1
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0036 0.0331 0.0901
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0283 0.3008 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0137 0.1425 0.4737
Toxoplasma gondii transcriptional elongation factor FACT140 0.0036 0.0331 0.0901
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0045 0.015
Echinococcus granulosus FACT complex subunit SPT16 0.0036 0.0331 0.0966
Plasmodium vivax peptidase, putative 0.0036 0.0331 0.0901
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0036 0.0331 0.0901
Brugia malayi MH2 domain containing protein 0.0137 0.1425 0.4737
Brugia malayi hypothetical protein 0.0011 0.0066 0.022
Brugia malayi MH2 domain containing protein 0.0009 0.0045 0.015
Brugia malayi metallopeptidase family M24 containing protein 0.0036 0.0331 0.1101
Trypanosoma cruzi aminopeptidase P, putative 0.0036 0.0331 0.0901
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0036 0.0331 0.0901
Giardia lamblia Methionine aminopeptidase 0.0036 0.0331 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0036 0.0331 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0036 0.0331 1
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0283 0.3008 1
Echinococcus granulosus xaa pro aminopeptidase 0.0036 0.0331 0.0966
Echinococcus granulosus nibrin 0.0011 0.0066 0.0072
Brugia malayi hypothetical protein 0.0011 0.0066 0.022
Toxoplasma gondii methionine aminopeptidase 0.0283 0.3008 1
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0283 0.3008 1
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0283 0.3008 1
Brugia malayi MH2 domain containing protein 0.0009 0.0045 0.015
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0036 0.0331 0.0901
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0036 0.0331 1
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0283 0.3008 1
Brugia malayi Smad1 0.0009 0.0045 0.015
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0283 0.3008 1
Mycobacterium ulcerans aminopeptidase 0.0036 0.0331 0.0901
Chlamydia trachomatis methionine aminopeptidase 0.0283 0.3008 1
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.0036 0.0331 0.0901
Loa Loa (eye worm) Smad1 0.0009 0.0045 0.015
Onchocerca volvulus Dipeptidase C homolog 0.0036 0.0331 1
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0036 0.0331 0.1101
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0036 0.0331 0.0901
Mycobacterium ulcerans dipeptidase 0.0036 0.0331 0.0901
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0283 0.3008 1
Echinococcus granulosus methionyl aminopeptidase 2 0.0036 0.0331 0.0966
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0036 0.0331 0.0901
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0036 0.0331 0.0966
Plasmodium vivax methionine aminopeptidase 2, putative 0.0036 0.0331 0.0901
Schistosoma mansoni topbp1 0.0011 0.0066 0.0072
Trypanosoma brucei methionine aminopeptidase, putative 0.0283 0.3008 1
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.0036 0.0331 1
Echinococcus multilocularis Proliferation associated protein 2G4 0.0036 0.0331 0.0287
Loa Loa (eye worm) DNA-binding protein 0.0036 0.0331 0.1101
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0036 0.0331 0.0966
Echinococcus multilocularis xaa pro aminopeptidase 0.0036 0.0331 0.0287
Chlamydia trachomatis aminopeptidase P 0.0036 0.0331 0.0901
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0036 0.0331 0.0901
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0283 0.3008 0.2976
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0036 0.0331 1
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0283 0.3008 1
Plasmodium falciparum aminopeptidase P 0.0036 0.0331 0.0901
Giardia lamblia Xaa-Pro dipeptidase 0.0036 0.0331 1
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0036 0.0331 0.0966
Brugia malayi MH1 domain containing protein 0.0009 0.0045 0.015
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0283 0.3008 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.4 nM Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide ChEMBL. 12852770
IC50 (binding) = 0.4 nM Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide ChEMBL. 12852770

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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