TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 969.02 | Formula: C50H58N5O15+
H donors: 10 H acceptors: 11 LogP: 3.14 Rotable bonds: 22
Rule of 5 violations (Lipinski): 4
SMILES: [NH3+]CCCC[C@H](C(=O)Nc1ccc(cc1)COC(=O)NC1CC(OC(C1O)C)O[C@@H]1C[C@@](O)(Cc2c1c(O)c1c(c2O)C(=O)c2c(C1=O)c(OC)ccc2)C(=O)CO)NC(=O)[C@H](Cc1ccccc1)N
InChi: 1S/C50H57N5O15/c1-25-42(58)33(55-49(65)68-24-27-14-16-28(17-15-27)53-48(64)32(12-6-7-18-51)54-47(63)31(52)19-26-9-4-3-5-10-26)20-37(69-25)70-35-22-50(66,36(57)23-56)21-30-39(35)46(62)41-40(44(30)60)43(59)29-11-8-13-34(67-2)38(29)45(41)61/h3-5,8-11,13-17,25,31-33,35,37,42,56,58,60,62,66H,6-7,12,18-24,51-52H2,1-2H3,(H,53,64)(H,54,63)(H,55,65)/p+1/t25?,31-,32-,33?,35-,37?,42?,50-/m0/s1
InChiKey: AEKAJIWUQRBKSC-UKRWDWRVSA-O

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0033	0.0212	0.0194
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0103	0.2646	0.7927
Brugia malayi	Cathepsin L-like precursor	0.0103	0.2646	0.2633
Trypanosoma cruzi	cysteine peptidase, putative	0.0103	0.2646	0.255
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1556	0.1556
Entamoeba histolytica	cysteine proteinase, putative	0.0072	0.1556	0.5264
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0103	0.2646	0.7927
Loa Loa (eye worm)	hypothetical protein	0.0057	0.1035	0.1035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.2646	0.7927
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0103	0.2646	0.7927
Entamoeba histolytica	cysteine protease, putative	0.0057	0.1048	0.3054
Onchocerca volvulus	Cathepsin F homolog	0.0103	0.2646	1
Onchocerca volvulus	Cathepsin L homolog	0.0103	0.2646	1
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1338	0.1323
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0103	0.2646	0.7927
Schistosoma mansoni	hypothetical protein	0.0033	0.0212	0.0194
Entamoeba histolytica	cysteine proteinase, putative	0.0103	0.2646	1
Echinococcus granulosus	cathepsin l1	0.0072	0.1556	0.1541
Echinococcus granulosus	short transient receptor potential channel 6	0.0066	0.1369	0.1354
Loa Loa (eye worm)	cysteine protease	0.0103	0.2646	0.2646
Schistosoma mansoni	hypothetical protein	0.0037	0.0345	0.0328
Plasmodium vivax	vivapain-1	0.0057	0.1048	0.365
Echinococcus granulosus	a disintegrin and metalloproteinase with	0.0083	0.1948	0.1934
Trypanosoma cruzi	cysteine proteinase, putative	0.0057	0.1048	0.0931
Onchocerca volvulus	Cathepsin L homolog	0.0103	0.2646	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0103	0.2646	1
Loa Loa (eye worm)	ctsf protein	0.0103	0.2646	0.2646
Loa Loa (eye worm)	hypothetical protein	0.0062	0.1238	0.1238
Schistosoma mansoni	cathepsin F (C01 family)	0.0103	0.2646	0.2633
Entamoeba histolytica	cysteine protease, putative	0.0057	0.1048	0.3054
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0105	0.2746	0.2746
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1338	0.1323
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1338	0.1323
Echinococcus multilocularis	a disintegrin and metalloproteinase with	0.0083	0.1948	0.1934
Echinococcus multilocularis	cathepsin b	0.0312	1	1
Brugia malayi	Cathepsin L-like precursor	0.0103	0.2646	0.2633
Entamoeba histolytica	cysteine protease, putative	0.0057	0.1048	0.3054
Schistosoma mansoni	transient receptor potential channel	0.0066	0.1369	0.1354
Plasmodium vivax	unspecified product	0.0057	0.1048	0.365
Entamoeba histolytica	cysteine proteinase, putative	0.0103	0.2646	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0212	0.0212
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0103	0.2646	0.7927
Onchocerca volvulus		0.0103	0.2646	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0212	0.0194
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.2646	0.7927
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0103	0.2646	0.7927
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0103	0.2646	0.7927
Trypanosoma cruzi	cysteine peptidase, putative	0.0103	0.2646	0.255
Onchocerca volvulus		0.0103	0.2646	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0103	0.2646	0.255
Brugia malayi	cathepsin F-like cysteine proteinase	0.0031	0.0129	0.0111
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0312	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0103	0.2646	0.7927
Loa Loa (eye worm)	hypothetical protein	0.0312	1	1
Brugia malayi	hypothetical protein	0.0037	0.0345	0.0328
Loa Loa (eye worm)	RNA binding protein	0.0065	0.1338	0.1338
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.1573	0.1558
Entamoeba histolytica	cysteine protease, putative	0.0057	0.1048	0.3054
Loa Loa (eye worm)	MH2 domain-containing protein	0.0252	0.7916	0.7916
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0103	0.2646	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0103	0.2646	0.2633
Echinococcus multilocularis	transient receptor potential ion channel A	0.0097	0.2445	0.2431
Loa Loa (eye worm)	cathepsin B	0.0114	0.3064	0.3064
Echinococcus multilocularis	cathepsin b	0.0312	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.2646	0.7927
Echinococcus granulosus	cysteine protease	0.0057	0.1048	0.1032
Echinococcus granulosus	TRP transient receptor potential channel	0.0037	0.0349	0.0332
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0103	0.2646	0.7927
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.2646	0.7927
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0103	0.2646	0.7927
Giardia lamblia	Cathepsin B precursor	0.0114	0.3064	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0129	0.0129
Giardia lamblia	Cathepsin B precursor	0.0114	0.3064	0.5
Brugia malayi	ADAMTS-like protease	0.0061	0.1175	0.1159
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0345	0.0328
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0103	0.2646	0.7927
Loa Loa (eye worm)	hypothetical protein	0.01	0.2562	0.2562
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0037	0.0349	0.0332
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0212	0.0194
Echinococcus granulosus	GPCR family 2	0.0033	0.0212	0.0194
Echinococcus granulosus	cathepsin l1	0.0103	0.2646	0.2633
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1338	0.1323
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.1556	0.2522
Entamoeba histolytica	cysteine protease, putative	0.0057	0.1048	0.3054
Brugia malayi	MH2 domain containing protein	0.0252	0.7916	0.7912
Trypanosoma cruzi	cruzipain precursor, putative	0.0103	0.2646	0.255
Echinococcus granulosus	short transient receptor potential channel 6	0.0066	0.1369	0.1354
Entamoeba histolytica	cysteine protease, putative	0.0057	0.1048	0.3054
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0018	0.0018
Entamoeba histolytica	cysteine proteinase, putative	0.0057	0.1048	0.3054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.2646	0.7927
Echinococcus multilocularis	short transient receptor potential channel 6	0.0066	0.1369	0.1354
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.2646	0.7927
Echinococcus multilocularis	cysteine protease	0.0103	0.2646	0.2633
Trypanosoma cruzi	cysteine peptidase, putative	0.0103	0.2646	0.255
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0349	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0198	0.6003	0.6003
Trypanosoma cruzi	cysteine protease, putative	0.0057	0.1048	0.0931
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0129	0.0111
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0312	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0114	0.3064	0.3051
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0103	0.2646	0.7927
Onchocerca volvulus	Papilin homolog	0.0062	0.1238	0.4642
Echinococcus granulosus	tar DNA binding protein	0.0065	0.1338	0.1323
Echinococcus multilocularis	cathepsin L cysteine protease	0.0103	0.2646	0.2633
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.2646	0.7927
Entamoeba histolytica	cysteine protease, putative	0.0057	0.1048	0.3054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0057	0.1048	0.1032
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0312	1	1
Entamoeba histolytica	cysteine protease, putative	0.0103	0.2646	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0212	0.0194
Brugia malayi	Papain family cysteine protease containing protein	0.0103	0.2646	0.2633
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0072	0.1556	0.1446
Echinococcus granulosus	transient receptor potential gamma protein	0.01	0.2562	0.2549
Schistosoma mansoni	hypothetical protein	0.0072	0.1573	0.1558
Entamoeba histolytica	cysteine protease, putative	0.0057	0.1048	0.3054
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0129	0.0129
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0103	0.2646	0.2646
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.2646	0.7927
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0103	0.2646	0.7927
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0192	0.5778	0.577
Loa Loa (eye worm)	angiogenesis inhibito	0.0031	0.0122	0.0122
Echinococcus multilocularis	transient receptor potential gamma protein	0.01	0.2562	0.2549
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0312	1	1
Entamoeba histolytica	cysteine protease, putative	0.0057	0.1048	0.3054
Schistosoma mansoni	ADAMTS5 peptidase (M12 family)	0.0083	0.1948	0.1934
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0018	0.0018
Entamoeba histolytica	cysteine protease, putative	0.0057	0.1048	0.3054
Toxoplasma gondii	cathepsin B	0.0114	0.3064	1
Schistosoma mansoni	adam (A disintegrin and metalloprotease	0.0057	0.1035	0.1019
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.2646	0.7927
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0072	0.1556	0.1541
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1338	0.1323
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0105	0.2746	0.2733
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0103	0.2646	0.2646
Schistosoma mansoni	transient receptor potential channel	0.01	0.2562	0.2549
Schistosoma mansoni	hypothetical protein	0.0033	0.0212	0.0194
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0345	0.0328
Loa Loa (eye worm)	hypothetical protein	0.003	0.0092	0.0092
Schistosoma mansoni	transient receptor potential channel	0.0066	0.1369	0.1354
Schistosoma mansoni	transient receptor potential channel 4	0.01	0.2562	0.2549
Brugia malayi	Papain family cysteine protease containing protein	0.0057	0.1048	0.1032
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0057	0.1048	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0129	0.0129
Brugia malayi	Cathepsin L-like precursor	0.0103	0.2646	0.2633
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0103	0.2646	0.2633
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0103	0.2646	0.7927
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0103	0.2646	1
Brugia malayi	Transient-receptor-potential like protein	0.0037	0.0349	0.0332
Brugia malayi	Cathepsin L-like precursor	0.0072	0.1556	0.1541
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0018	0.0018
Brugia malayi	cathepsin L-like precursor	0.0072	0.1556	0.1541
Schistosoma mansoni	cathepsin F (C01 family)	0.0072	0.1556	0.1541
Entamoeba histolytica	cysteine protease, putative	0.0057	0.1048	0.3054
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0114	0.3064	0.2973
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0057	0.1048	0.1032
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0031	0.0129	0.0111
Brugia malayi	Cathepsin L-like precursor	0.0103	0.2646	0.2633
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0103	0.2646	0.2633
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0212	0.0194
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.2646	0.7927
Brugia malayi	hypothetical protein	0.0057	0.1035	0.1019
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0103	0.2646	0.7927
Onchocerca volvulus		0.0103	0.2646	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0057	0.1048	0.0931
Plasmodium vivax	vivapain-3	0.0057	0.1048	0.365
Brugia malayi	ADAM-TS Spacer 1 family protein	0.0198	0.6003	0.5996
Echinococcus multilocularis	cathepsin L	0.0057	0.1048	0.1032
Brugia malayi	angiogenesis inhibito	0.0061	0.1175	0.1159
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0103	0.2646	0.7927
Echinococcus granulosus	adam	0.0057	0.1035	0.1019
Brugia malayi	Papain family cysteine protease containing protein	0.0057	0.1048	0.1032
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0312	1	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1556	0.1556
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0103	0.2646	0.7927
Trypanosoma cruzi	cysteine proteinase, putative	0.0057	0.1048	0.0931
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.2646	0.7927
Echinococcus multilocularis	adam	0.0057	0.1035	0.1019
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.1338	0.1338
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0103	0.2646	0.7927
Brugia malayi	Cathepsin L-like precursor	0.0103	0.2646	0.2633
Loa Loa (eye worm)	hypothetical protein	0.0103	0.2646	0.2646
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0232	0.0232
Echinococcus multilocularis	cysteine protease	0.0103	0.2646	0.2633
Entamoeba histolytica	cysteine proteinase, putative	0.0057	0.1048	0.3054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0031	0.0129	0.0129
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0212	0.0194
Plasmodium vivax	vivapain-2	0.0103	0.2646	1
Entamoeba histolytica	cysteine proteinase 2	0.0057	0.1048	0.3054
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1556	0.1556
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0103	0.2646	0.7927
Schistosoma mansoni	cathepsin F (C01 family)	0.0103	0.2646	0.2633
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.1338	0.1323
Loa Loa (eye worm)	hypothetical protein	0.0264	0.8312	0.8312
Echinococcus granulosus	cathepsin b	0.0312	1	1
Onchocerca volvulus		0.0103	0.2646	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0192	0.5778	0.577
Echinococcus multilocularis	short transient receptor potential channel 6	0.0066	0.1369	0.1354
Onchocerca volvulus		0.0072	0.1556	0.5853
Echinococcus granulosus	transient receptor potential ion channel A	0.0097	0.2445	0.2431
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.1556	0.2522
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0114	0.3064	1
Brugia malayi	Cathepsin L-like precursor	0.0103	0.2646	0.2633
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0103	0.2646	0.2633
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0103	0.2646	0.7927
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.2646	0.7927
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1573	0.1573
Trypanosoma cruzi	cysteine peptidase, putative	0.0057	0.1048	0.0931
Onchocerca volvulus		0.0103	0.2646	1
Loa Loa (eye worm)	fibroinase	0.0103	0.2646	0.2646
Onchocerca volvulus		0.0103	0.2646	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0103	0.2646	0.7927
Entamoeba histolytica	cysteine proteinase, putative	0.0057	0.1048	0.3054
Entamoeba histolytica	cysteine protease, putative	0.0057	0.1048	0.3054
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1252	0.1252
Brugia malayi	TAR-binding protein	0.0065	0.1338	0.1323
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0264	0.8312	0.8309
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0114	0.3064	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0057	0.1048	0.1032
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0103	0.2646	0.2633
Plasmodium vivax	vivapain-2	0.0103	0.2646	1
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.1338	0.1323
Schistosoma mansoni	cathepsin s	0.0031	0.0129	0.0111
Entamoeba histolytica	cysteine proteinase, putative	0.0057	0.1048	0.3054
Giardia lamblia	Cathepsin B precursor	0.0114	0.3064	0.5
Brugia malayi	RNA binding protein	0.0065	0.1338	0.1323
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0114	0.3064	1
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0212	0.0194
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0103	0.2646	0.7927
Entamoeba histolytica	cysteine proteinase 1, putative	0.0057	0.1048	0.3054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.2646	0.7927
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0345	0.0328
Entamoeba histolytica	cysteine protease, putative	0.0057	0.1048	0.3054
Brugia malayi	Cathepsin L-like precursor	0.0072	0.1556	0.1541
Onchocerca volvulus		0.0103	0.2646	1
Echinococcus granulosus	cathepsin b	0.0312	1	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0212	0.0212
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.2646	0.7927
Echinococcus granulosus	cathepsin L	0.0057	0.1048	0.1032
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.1338	0.1338
Loa Loa (eye worm)	transcription factor SMAD2	0.0252	0.7916	0.7916

Activities

Activity type	Activity value	Assay description	Source	Reference
T1/2 (ADMET)	= 3.7 hr	Half-life of the compound was calculated by Cathepsin B assay at 37 degree centigrade	ChEMBL.	9873731

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 285282

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 402185