Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0688 | 0.3519 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0688 | 0.3519 | 0.3519 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0688 | 0.3519 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Leishmania major | cathepsin L-like protease | 0.0688 | 0.3519 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0688 | 0.3519 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0688 | 0.3519 | 0.3519 |
Echinococcus multilocularis | cysteine protease | 0.0688 | 0.3519 | 0.3519 |
Leishmania major | cathepsin L-like protease | 0.0688 | 0.3519 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1272 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Onchocerca volvulus | 0.0688 | 0.3519 | 1 | |
Loa Loa (eye worm) | cathepsin B | 0.05 | 0.1436 | 0.0356 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.05 | 0.1436 | 0.1436 |
Brugia malayi | Cathepsin L-like precursor | 0.0688 | 0.3519 | 0.3519 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0688 | 0.3519 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1272 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0688 | 0.3519 | 0.3519 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1272 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0688 | 0.3519 | 0.3519 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0688 | 0.3519 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0688 | 0.3519 | 0.3519 |
Leishmania major | cysteine peptidase A (CPA) | 0.0688 | 0.3519 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0688 | 0.3519 | 0.2702 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0688 | 0.3519 | 0.3519 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0688 | 0.3519 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.05 | 0.1436 | 0.4079 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0688 | 0.3519 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0688 | 0.3519 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0472 | 0.112 | 0.112 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0688 | 0.3519 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0688 | 0.3519 | 0.3519 |
Leishmania major | cathepsin L-like protease | 0.0688 | 0.3519 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.05 | 0.1436 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0688 | 0.3519 | 0.3519 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0688 | 0.3519 | 1 |
Onchocerca volvulus | 0.0688 | 0.3519 | 1 | |
Onchocerca volvulus | 0.0688 | 0.3519 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0688 | 0.3519 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0688 | 0.3519 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0688 | 0.3519 | 0.2702 |
Brugia malayi | Cathepsin L-like precursor | 0.0688 | 0.3519 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1272 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0472 | 0.112 | 0.112 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1272 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0688 | 0.3519 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0688 | 0.3519 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Onchocerca volvulus | 0.0688 | 0.3519 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1272 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0688 | 0.3519 | 1 |
Plasmodium vivax | vivapain-2 | 0.0688 | 0.3519 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0688 | 0.3519 | 1 |
Plasmodium vivax | vivapain-2 | 0.0688 | 0.3519 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0688 | 0.3519 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0688 | 0.3519 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0472 | 0.112 | 0.112 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0472 | 0.112 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0688 | 0.3519 | 0.3519 |
Onchocerca volvulus | Cathepsin L homolog | 0.0688 | 0.3519 | 1 |
Leishmania major | cathepsin L-like protease | 0.0688 | 0.3519 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0688 | 0.3519 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Onchocerca volvulus | 0.0688 | 0.3519 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0688 | 0.3519 | 0.3519 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0472 | 0.112 | 0.112 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0688 | 0.3519 | 0.3519 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0472 | 0.112 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Echinococcus granulosus | cathepsin b | 0.1272 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0688 | 0.3519 | 0.2702 |
Leishmania major | cathepsin L-like protease | 0.0688 | 0.3519 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0472 | 0.112 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.0688 | 0.3519 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0688 | 0.3519 | 0.3519 |
Echinococcus multilocularis | cathepsin b | 0.1272 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0688 | 0.3519 | 0.2702 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0688 | 0.3519 | 0.3519 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0688 | 0.3519 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0688 | 0.3519 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0688 | 0.3519 | 0.3519 |
Echinococcus granulosus | cathepsin l1 | 0.0472 | 0.112 | 0.112 |
Loa Loa (eye worm) | hypothetical protein | 0.0688 | 0.3519 | 0.2702 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0688 | 0.3519 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.05 | 0.1436 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.05 | 0.1436 | 0.4079 |
Loa Loa (eye worm) | cysteine protease | 0.0688 | 0.3519 | 0.2702 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0688 | 0.3519 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1272 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.1272 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0688 | 0.3519 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0688 | 0.3519 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0688 | 0.3519 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0472 | 0.112 | 0.112 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0688 | 0.3519 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.05 | 0.1436 | 0.1436 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.05 | 0.1436 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Leishmania major | cathepsin L-like protease | 0.0688 | 0.3519 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0688 | 0.3519 | 0.3519 |
Onchocerca volvulus | 0.0688 | 0.3519 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0472 | 0.112 | 0.112 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0688 | 0.3519 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | ~ 50 % | Cu(II) complex of the compound was tested for cleavage of phi X174 RF plasmid DNA from intact form I to nicked form II at 250 uM compound and 100 microM Cu(II) | ChEMBL. | No reference |
Activity (binding) | = 70 % | Cu(II) complex of the compound was tested for cleavage of phi X174 RF plasmid DNA from intact form I to nicked form II at 250 uM compound and 200 microM Cu(II) | ChEMBL. | No reference |
Activity (binding) | > 90 % | Cu(II) complex of the compound was tested for cleavage of phi X174 RF plasmid DNA from intact form I to nicked form II at 350 microM of Cu(II) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.