Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neuropeptide receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.007 | 0.0555 | 0.0555 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0234 | 0.2944 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | neuropeptides capa receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | neuropeptide receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.007 | 0.0555 | 0.0555 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0234 | 0.2944 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.0719 | 1 | 1 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | somatostatin receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | g protein coupled receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | 7tm_1 domain containing protein | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | dro:myosuppressin receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | fmrfamide receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | peptide allatostatin:somatostatin | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | orexin receptor type 2 | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | adenosine deaminase | 0.0719 | 1 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.007 | 0.0555 | 0.0555 |
Treponema pallidum | adenosine deaminase | 0.0719 | 1 | 0.5 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.007 | 0.0555 | 0.0555 |
Plasmodium falciparum | adenosine deaminase | 0.0719 | 1 | 1 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.007 | 0.0555 | 0.0555 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0234 | 0.2944 | 0.5 |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | AMP deaminase 2 | 0.0234 | 0.2944 | 0.2944 |
Echinococcus granulosus | g-protein coupled receptor | 0.007 | 0.0555 | 0.0555 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.0234 | 0.2944 | 0.2529 |
Echinococcus multilocularis | g protein coupled receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | sex peptide receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | serotonin receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | 7TM GPCR rhodopsin | 0.007 | 0.0555 | 0.0555 |
Mycobacterium ulcerans | adenosine deaminase | 0.0719 | 1 | 0.5 |
Echinococcus granulosus | orexin receptor type 2 | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | neuropeptide s receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.007 | 0.0555 | 0.0555 |
Trypanosoma brucei | AMP deaminase, putative | 0.0234 | 0.2944 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0234 | 0.2944 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.007 | 0.0555 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.0485 | 0.6591 | 0.6391 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.007 | 0.0555 | 0.0555 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0234 | 0.2944 | 0.5 |
Echinococcus multilocularis | fmrfamide receptor | 0.007 | 0.0555 | 0.0555 |
Onchocerca volvulus | 0.0234 | 0.2944 | 0.2529 | |
Echinococcus granulosus | tm gpcr rhodopsin | 0.007 | 0.0555 | 0.0555 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0719 | 1 | 1 |
Echinococcus granulosus | neuropeptides capa receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | G protein coupled receptor 139 | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | g-protein coupled receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | neuropeptide s receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.007 | 0.0555 | 0.0555 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0719 | 1 | 0.5 |
Echinococcus multilocularis | sex peptide receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | g protein coupled receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.007 | 0.0555 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.0485 | 0.6591 | 0.6391 |
Echinococcus granulosus | allatostatin A receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.007 | 0.0555 | 0.0555 |
Schistosoma mansoni | adenosine deaminase-related | 0.0719 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0719 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0719 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0719 | 1 | 1 |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.007 | 0.0555 | 0.0555 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0234 | 0.2944 | 0.5 |
Loa Loa (eye worm) | AMP deaminase | 0.0234 | 0.2944 | 0.2529 |
Echinococcus multilocularis | g protein coupled receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.007 | 0.0555 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.0485 | 0.6591 | 0.6391 |
Echinococcus granulosus | hypothetical protein | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.007 | 0.0555 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.0485 | 0.6591 | 0.6391 |
Trypanosoma brucei | AMP deaminase, putative | 0.0234 | 0.2944 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | neuropeptide Y receptor | 0.007 | 0.0555 | 0.0555 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0719 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0719 | 1 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | alpha 1A adrenergic receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | adenosine deaminase | 0.0719 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0719 | 1 | 1 |
Echinococcus multilocularis | allatostatin A receptor | 0.007 | 0.0555 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.2944 | 0.2529 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0719 | 1 | 0.5 |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.007 | 0.0555 | 0.0555 |
Trypanosoma brucei | AMP deaminase, putative | 0.0234 | 0.2944 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0719 | 1 | 1 |
Echinococcus multilocularis | fmrfamide receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.007 | 0.0555 | 0.0555 |
Brugia malayi | adenosine monophosphate deaminase | 0.0234 | 0.2944 | 0.2529 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0234 | 0.2944 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | neuropeptide receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.007 | 0.0555 | 0.0555 |
Echinococcus granulosus | serotonin receptor | 0.007 | 0.0555 | 0.0555 |
Schistosoma mansoni | AMP deaminase | 0.0234 | 0.2944 | 0.2529 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0719 | 1 | 0.5 |
Echinococcus multilocularis | somatostatin receptor | 0.007 | 0.0555 | 0.0555 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0234 | 0.2944 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.0719 | 1 | 1 |
Echinococcus granulosus | neuropeptide Y receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | neuropeptide receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.007 | 0.0555 | 0.0555 |
Echinococcus multilocularis | AMP deaminase 2 | 0.0234 | 0.2944 | 0.2944 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0234 | 0.2944 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.25 uM | Inhibitory activity of the compound evaluated by its ability to displace [3H]-CPP from rat cortical membrane N-methyl-D-aspartate glutamate receptor at 10E-5 concentration of the compound | ChEMBL. | 1533423 |
IC50 (functional) | = 36 uM | Compound was evaluated in vitro for antagonist activity by its ability to inhibit glutamate-induced accumulation of [45Ca2+]- in cultured rat cortical neurons. | ChEMBL. | 1533423 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.