Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0849 | 0.3969 | 0.625 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0716 | 0.3323 | 0.3323 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0051 | 0.0097 | 0.0823 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0249 | 0.106 | 0.106 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0226 | 0.5 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0226 | 0.5 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0292 | 0.1268 | 0.1268 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.0226 | 0.0324 |
Brugia malayi | Cathepsin L-like precursor | 0.1338 | 0.6337 | 0.6337 |
Echinococcus granulosus | cathepsin L | 0.0716 | 0.3323 | 0.3323 |
Entamoeba histolytica | hypothetical protein | 0.0292 | 0.1268 | 0.1957 |
Trypanosoma cruzi | cysteine protease, putative | 0.0716 | 0.3323 | 0.3309 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0226 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0716 | 0.3323 | 0.5218 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0085 | 0.0085 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0051 | 0.0097 | 0.0823 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0021 | 0.0021 |
Giardia lamblia | Cathepsin B precursor | 0.0849 | 0.3969 | 1 |
Onchocerca volvulus | 0.1338 | 0.6337 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1338 | 0.6337 | 0.6337 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.0292 | 0.1268 | 0.1974 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0021 | 0.0021 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0579 | 0.2658 | 0.2658 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.0226 | 0.0226 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1338 | 0.6337 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1338 | 0.6337 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0097 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0424 | 0.1906 | 0.1906 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.0173 | 0.0173 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0579 | 0.2658 | 0.2658 |
Giardia lamblia | Cathepsin B precursor | 0.0849 | 0.3969 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0292 | 0.1268 | 0.1268 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0424 | 0.1906 | 0.1906 |
Echinococcus multilocularis | cathepsin b | 0.2093 | 1 | 1 |
Plasmodium vivax | serine-repeat antigen 2 (SERA) | 0.0292 | 0.1268 | 0.1974 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0021 | 0.0021 |
Leishmania major | cathepsin L-like protease | 0.1338 | 0.6337 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1338 | 0.6337 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0914 | 0.4282 | 0.6739 |
Onchocerca volvulus | 0.1338 | 0.6337 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.1056 | 0.1056 |
Brugia malayi | Cathepsin L-like precursor | 0.1338 | 0.6337 | 0.6337 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1338 | 0.6337 | 0.6329 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0914 | 0.4282 | 0.6746 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1338 | 0.6337 | 0.6329 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or H-like cysteine peptidase | 0.0292 | 0.1268 | 0.1974 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.106 | 0.106 |
Entamoeba histolytica | cysteine protease, putative | 0.0716 | 0.3323 | 0.5218 |
Onchocerca volvulus | 0.1338 | 0.6337 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.0292 | 0.1268 | 0.1957 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0021 | 0.0021 |
Plasmodium vivax | serine-repeat antigen (SERA) | 0.0292 | 0.1268 | 0.1974 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1338 | 0.6337 | 0.6337 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0048 | 0.0082 | 0.0082 |
Entamoeba histolytica | cysteine protease, putative | 0.0292 | 0.1268 | 0.1957 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Plasmodium vivax | serine-repeat antigen 4 (SERA) | 0.0292 | 0.1268 | 0.1974 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0716 | 0.3323 | 0.3323 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.1338 | 0.6337 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0716 | 0.3323 | 0.5228 |
Entamoeba histolytica | cysteine protease, putative | 0.0292 | 0.1268 | 0.1957 |
Plasmodium falciparum | serine repeat antigen 6 | 0.0292 | 0.1268 | 0.1705 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Plasmodium vivax | serine-repeat antigen (SERA), putative | 0.0292 | 0.1268 | 0.1974 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0085 | 0.0085 |
Echinococcus granulosus | cysteine protease | 0.0716 | 0.3323 | 0.3323 |
Loa Loa (eye worm) | hypothetical protein | 0.0914 | 0.4282 | 0.4282 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0716 | 0.3323 | 0.3323 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0716 | 0.3323 | 0.5228 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0292 | 0.1268 | 0.1974 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.0097 | 0.0097 |
Schistosoma mansoni | subfamily C1A non-peptidase homologue (C01 family) | 0.0292 | 0.1268 | 0.1268 |
Echinococcus multilocularis | cathepsin b | 0.2093 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0849 | 0.3969 | 0.3956 |
Plasmodium vivax | dipeptidyl aminopeptidase 3, putative | 0.0292 | 0.1268 | 0.1974 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0716 | 0.3323 | 0.3323 |
Plasmodium vivax | serine-repeat antigen 5 (SERA) | 0.0292 | 0.1268 | 0.1974 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0292 | 0.1268 | 0.1974 |
Loa Loa (eye worm) | glutaminase 2 | 0.027 | 0.1158 | 0.1158 |
Toxoplasma gondii | cathepsin CPC1 | 0.0292 | 0.1268 | 0.1974 |
Entamoeba histolytica | cysteine protease, putative | 0.0716 | 0.3323 | 0.5218 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0226 | 0.1803 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0226 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0035 | 0.0035 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0021 | 0.0021 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0077 | 0.0226 | 0.0226 |
Brugia malayi | hypothetical protein | 0.0249 | 0.106 | 0.106 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.0292 | 0.1268 | 0.1974 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0716 | 0.3323 | 0.3309 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.1338 | 0.6337 | 0.6337 |
Entamoeba histolytica | cysteine protease, putative | 0.0716 | 0.3323 | 0.5218 |
Onchocerca volvulus | Cathepsin L homolog | 0.1338 | 0.6337 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Onchocerca volvulus | 0.0292 | 0.1268 | 0.1974 | |
Brugia malayi | cathepsin L-like cysteine proteinase | 0.0292 | 0.1268 | 0.1268 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.0292 | 0.1268 | 0.1268 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0097 | 0.0323 | 0.0323 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.0226 | 0.0226 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin F-like cysteine peptidase | 0.0292 | 0.1268 | 0.1974 |
Schistosoma mansoni | glutaminase | 0.027 | 0.1158 | 0.1158 |
Leishmania major | cathepsin L-like protease | 0.1338 | 0.6337 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.0097 | 0.0097 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1338 | 0.6337 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1268 | 0.1268 |
Loa Loa (eye worm) | hypothetical protein | 0.0914 | 0.4282 | 0.4282 |
Loa Loa (eye worm) | ctsf protein | 0.1338 | 0.6337 | 0.6337 |
Leishmania major | cathepsin L-like protease | 0.1338 | 0.6337 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1338 | 0.6337 | 0.6337 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.0292 | 0.1268 | 0.1705 |
Brugia malayi | Cathepsin L-like precursor | 0.1338 | 0.6337 | 0.6337 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1338 | 0.6337 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.1338 | 0.6337 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.2093 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.2093 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1338 | 0.6337 | 0.6337 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0292 | 0.1268 | 0.1268 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Leishmania major | cathepsin L-like protease | 0.1338 | 0.6337 | 1 |
Toxoplasma gondii | cathepsin B | 0.0849 | 0.3969 | 0.625 |
Mycobacterium ulcerans | glutaminase | 0.027 | 0.1158 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1338 | 0.6337 | 0.6337 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0248 | 0.1056 | 0.1056 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1268 | 0.1268 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0051 | 0.0097 | 0.0097 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0085 | 0.0085 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.2093 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1338 | 0.6337 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0048 | 0.0082 | 0.0082 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0849 | 0.3969 | 0.3969 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1338 | 0.6337 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0292 | 0.1268 | 0.1974 |
Entamoeba histolytica | cysteine protease, putative | 0.0716 | 0.3323 | 0.5218 |
Echinococcus granulosus | cathepsin L | 0.0292 | 0.1268 | 0.1268 |
Loa Loa (eye worm) | hypothetical protein | 0.0914 | 0.4282 | 0.4282 |
Leishmania major | cathepsin L-like protease | 0.1338 | 0.6337 | 1 |
Plasmodium falciparum | serine repeat antigen 7 | 0.0292 | 0.1268 | 0.1705 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0716 | 0.3323 | 0.3309 |
Plasmodium vivax | unspecified product | 0.0716 | 0.3323 | 0.5228 |
Loa Loa (eye worm) | fibroinase | 0.1338 | 0.6337 | 0.6337 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0292 | 0.1268 | 0.1268 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0173 | 0.0173 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0085 | 0.0085 |
Entamoeba histolytica | cysteine protease, putative | 0.1338 | 0.6337 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0292 | 0.1268 | 0.1974 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1268 | 0.1268 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0021 | 0.0021 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1338 | 0.6337 | 1 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.0292 | 0.1268 | 0.1974 |
Leishmania major | cathepsin L-like protease | 0.1338 | 0.6337 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0716 | 0.3323 | 0.5218 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0292 | 0.1268 | 0.1268 |
Onchocerca volvulus | 0.0228 | 0.0958 | 0.1483 | |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.1906 | 0.1906 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.1602 | 0.7622 | 0.7622 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1338 | 0.6337 | 0.6337 |
Schistosoma mansoni | cathepsin S (C01 family) | 0.0292 | 0.1268 | 0.1268 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1338 | 0.6337 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0085 | 0.0085 |
Echinococcus granulosus | cathepsin b | 0.2093 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.2093 | 1 | 1 |
Schistosoma mansoni | cathepsin C | 0.0292 | 0.1268 | 0.1268 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0292 | 0.1268 | 0.1974 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0035 | 0.0035 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0292 | 0.1268 | 0.1268 |
Onchocerca volvulus | 0.1338 | 0.6337 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1268 | 0.1268 |
Onchocerca volvulus | 0.0914 | 0.4282 | 0.6746 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0424 | 0.1906 | 0.1889 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0716 | 0.3323 | 0.5218 |
Onchocerca volvulus | 0.0051 | 0.0097 | 0.0121 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0085 | 0.0085 |
Plasmodium falciparum | serine repeat antigen 3 | 0.0292 | 0.1268 | 0.1705 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0077 | 0.0226 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1338 | 0.6337 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0323 | 0.0323 |
Entamoeba histolytica | cysteine protease, putative | 0.0716 | 0.3323 | 0.5218 |
Schistosoma mansoni | subfamily C1A unassigned peptidase (C01 family) | 0.0292 | 0.1268 | 0.1268 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Plasmodium vivax | vivapain-1 | 0.0716 | 0.3323 | 0.5228 |
Entamoeba histolytica | cysteine protease, putative | 0.0716 | 0.3323 | 0.5218 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0292 | 0.1268 | 0.1268 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0292 | 0.1268 | 0.1249 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0021 | 0.0021 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0292 | 0.1268 | 0.1974 |
Schistosoma mansoni | cathepsin B (C01 family) | 0.0292 | 0.1268 | 0.1268 |
Loa Loa (eye worm) | glutaminase | 0.027 | 0.1158 | 0.1158 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0292 | 0.1268 | 0.1268 |
Onchocerca volvulus | 0.1338 | 0.6337 | 1 | |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0728 | 0.3379 | 0.3379 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.1338 | 0.6337 | 0.6329 |
Brugia malayi | cahepsin L-like non-peptiedase homolog | 0.0292 | 0.1268 | 0.1268 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0914 | 0.4282 | 0.6746 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0716 | 0.3323 | 0.3323 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0085 | 0.0085 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.1338 | 0.6337 | 0.6337 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase | 0.0292 | 0.1268 | 0.1974 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1338 | 0.6337 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.1338 | 0.6337 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1268 | 0.1268 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1338 | 0.6337 | 0.6337 |
Onchocerca volvulus | Cathepsin F homolog | 0.1338 | 0.6337 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0248 | 0.1056 | 0.1056 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0085 | 0.0085 |
Plasmodium falciparum | serine repeat antigen 4 | 0.0292 | 0.1268 | 0.1705 |
Brugia malayi | Probable ClpP-like protease | 0.0077 | 0.0226 | 0.0226 |
Entamoeba histolytica | cysteine protease, putative | 0.0716 | 0.3323 | 0.5218 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.1338 | 0.6337 | 0.6337 |
Entamoeba histolytica | cysteine protease, putative | 0.0292 | 0.1268 | 0.1957 |
Trichomonas vaginalis | glutaminase, putative | 0.027 | 0.1158 | 0.18 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1268 | 0.1268 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0424 | 0.1906 | 0.1889 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0914 | 0.4282 | 0.4282 |
Onchocerca volvulus | 0.1338 | 0.6337 | 1 | |
Echinococcus multilocularis | cysteine protease | 0.1338 | 0.6337 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.1906 | 0.1906 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0021 | 0.0021 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0097 | 0.0097 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0077 | 0.0226 | 0.0324 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0292 | 0.1268 | 0.1974 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0292 | 0.1268 | 0.1974 |
Brugia malayi | Cathepsin L-like precursor | 0.0424 | 0.1906 | 0.1906 |
Plasmodium falciparum | serine repeat antigen 5 | 0.0292 | 0.1268 | 0.1705 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1338 | 0.6337 | 0.6329 |
Echinococcus granulosus | cathepsin l1 | 0.0914 | 0.4282 | 0.4282 |
Entamoeba histolytica | cysteine protease, putative | 0.0292 | 0.1268 | 0.1957 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0173 | 0.0173 |
Echinococcus multilocularis | cathepsin L | 0.0716 | 0.3323 | 0.3323 |
Plasmodium falciparum | serine repeat antigen 1 | 0.0292 | 0.1268 | 0.1705 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.1338 | 0.6337 | 0.6337 |
Echinococcus granulosus | cathepsin b | 0.2093 | 1 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0728 | 0.3379 | 0.3379 |
Onchocerca volvulus | 0.1338 | 0.6337 | 1 | |
Echinococcus granulosus | geminin | 0.0333 | 0.1464 | 0.1464 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0716 | 0.3323 | 0.5218 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Schistosoma mansoni | subfamily C1A unassigned peptidase (C01 family) | 0.0292 | 0.1268 | 0.1268 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0716 | 0.3323 | 0.5228 |
Leishmania major | cysteine peptidase A (CPA) | 0.1338 | 0.6337 | 1 |
Schistosoma mansoni | cathepsin s | 0.0424 | 0.1906 | 0.1906 |
Leishmania major | cathepsin L-like protease | 0.1338 | 0.6337 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0097 | 0.0323 | 0.0323 |
Echinococcus multilocularis | cysteine protease | 0.1338 | 0.6337 | 0.6337 |
Brugia malayi | cathepsin L precursor | 0.0292 | 0.1268 | 0.1268 |
Plasmodium vivax | serine-repeat antigen 3 (SERA) | 0.0292 | 0.1268 | 0.1974 |
Toxoplasma gondii | cathepsin CPL | 0.1338 | 0.6337 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.1056 | 0.1056 |
Brugia malayi | Cathepsin L-like precursor | 0.0914 | 0.4282 | 0.4282 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.1338 | 0.6337 | 1 |
Onchocerca volvulus | 0.0248 | 0.1056 | 0.1638 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.0292 | 0.1268 | 0.1705 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0226 | 0.0226 |
Brugia malayi | Trypsin family protein | 0.0248 | 0.1056 | 0.1056 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0914 | 0.4282 | 0.4282 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0716 | 0.3323 | 0.3309 |
Plasmodium falciparum | serine repeat antigen 2 | 0.0292 | 0.1268 | 0.1705 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0035 | 0.0035 |
Schistosoma mansoni | hypothetical protein | 0.0333 | 0.1464 | 0.1464 |
Brugia malayi | glutaminase DH11.1 | 0.027 | 0.1158 | 0.1158 |
Echinococcus multilocularis | geminin | 0.0333 | 0.1464 | 0.1464 |
Plasmodium vivax | vivapain-3 | 0.0716 | 0.3323 | 0.5228 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0292 | 0.1268 | 0.1974 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0292 | 0.1268 | 0.1268 |
Plasmodium vivax | unspecified product | 0.0292 | 0.1268 | 0.1974 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Toxoplasma gondii | cathepsin CPC2 | 0.0292 | 0.1268 | 0.1974 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0716 | 0.3323 | 0.3309 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.1338 | 0.6337 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0716 | 0.3323 | 0.5218 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0728 | 0.3379 | 0.3379 |
Loa Loa (eye worm) | cysteine proteinase cathepsin Z | 0.0292 | 0.1268 | 0.1268 |
Entamoeba histolytica | cysteine protease, putative | 0.0716 | 0.3323 | 0.5218 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0021 | 0.0021 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0716 | 0.3323 | 0.5068 |
Entamoeba histolytica | cysteine protease, putative | 0.0716 | 0.3323 | 0.5218 |
Brugia malayi | fibroinase precursor | 0.0292 | 0.1268 | 0.1268 |
Loa Loa (eye worm) | cysteine protease | 0.1338 | 0.6337 | 0.6337 |
Plasmodium vivax | vivapain-2 | 0.1338 | 0.6337 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1338 | 0.6337 | 1 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0424 | 0.1906 | 0.1906 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.1906 | 0.1906 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1338 | 0.6337 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0716 | 0.3323 | 0.5218 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1338 | 0.6337 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0292 | 0.1268 | 0.1957 |
Entamoeba histolytica | cysteine protease, putative | 0.0716 | 0.3323 | 0.5218 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0292 | 0.1268 | 0.1249 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0849 | 0.3969 | 0.625 |
Brugia malayi | cathepsin L-like precursor | 0.0914 | 0.4282 | 0.4282 |
Entamoeba histolytica | papain family cysteine protease domain containing protein | 0.0292 | 0.1268 | 0.1957 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0292 | 0.1268 | 0.1974 |
Plasmodium vivax | vivapain-2 | 0.1338 | 0.6337 | 1 |
Plasmodium vivax | serine-repeat antigen (SERA), putative | 0.0292 | 0.1268 | 0.1974 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0716 | 0.3323 | 0.5218 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1338 | 0.6337 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0226 | 0.1803 |
Plasmodium vivax | serine-repeat antigen 4 (SERA), putative | 0.0292 | 0.1268 | 0.1974 |
Schistosoma mansoni | hypothetical protein | 0.0333 | 0.1464 | 0.1464 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0292 | 0.1268 | 0.1974 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0021 | 0.0021 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0292 | 0.1268 | 0.1974 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0051 | 0.0097 | 0.0097 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0716 | 0.3323 | 0.3323 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0051 | 0.0097 | 0.369 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0292 | 0.1268 | 0.1974 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.094 | 1 |
Plasmodium falciparum | serine repeat antigen 9 | 0.0292 | 0.1268 | 0.1705 |
Entamoeba histolytica | papain family cysteine protease domain containing protein | 0.0292 | 0.1268 | 0.1957 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0021 | 0.0021 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0292 | 0.1268 | 0.1268 |
Loa Loa (eye worm) | cathepsin B | 0.0849 | 0.3969 | 0.3969 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0292 | 0.1268 | 0.1974 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0849 | 0.3969 | 0.625 |
Plasmodium falciparum | serine repeat antigen 8 | 0.0292 | 0.1268 | 0.1705 |
Brugia malayi | Cathepsin L-like precursor | 0.1338 | 0.6337 | 0.6337 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0085 | 0.0085 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0914 | 0.4282 | 0.427 |
Leishmania major | cathepsin L-like protease | 0.1338 | 0.6337 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0716 | 0.3323 | 0.5218 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0292 | 0.1268 | 0.1268 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0716 | 0.3323 | 0.5228 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1338 | 0.6337 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0249 | 0.106 | 0.106 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0292 | 0.1268 | 0.1268 |
Plasmodium falciparum | dipeptidyl aminopeptidase 3 | 0.0292 | 0.1268 | 0.1705 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.0226 | 0.0324 |
Onchocerca volvulus | Cathepsin L homolog | 0.1338 | 0.6337 | 1 |
Plasmodium vivax | serine-repeat antigen (SERA) | 0.0292 | 0.1268 | 0.1974 |
Onchocerca volvulus | Cathepsin L homolog | 0.0292 | 0.1268 | 0.1974 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0035 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0021 | 0.0021 |
Plasmodium vivax | unspecified product | 0.0424 | 0.1906 | 0.2984 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0716 | 0.3323 | 0.5218 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.2093 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.2093 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0021 | 0.0021 |
Echinococcus multilocularis | cathepsin L | 0.0292 | 0.1268 | 0.1268 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0035 | 0.0035 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0292 | 0.1268 | 0.1974 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0292 | 0.1268 | 0.1268 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1338 | 0.6337 | 0.6329 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin H-like cysteine peptidase | 0.0292 | 0.1268 | 0.1974 |
Brugia malayi | Cathepsin L-like precursor | 0.0914 | 0.4282 | 0.4282 |
Giardia lamblia | Cathepsin B precursor | 0.0849 | 0.3969 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
APTT (functional) | = 1.2 IU mg-1 | In vitro anticoagulant activity determined by clotting test of activated partial thromboplastintime (APTT) on a pool of human plasma | ChEMBL. | 8246223 |
EC50 (functional) | = 2.5 ug ml-1 | Effective concentration to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-2 | ChEMBL. | 8246223 |
EC50 (functional) | = 6.5 ug ml-1 | Effective concentration to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1 | ChEMBL. | 8246223 |
EC50 (functional) | = 20 ug ml-1 | Giant-cell formation between persistently HIV-1 infected HUT-78 cells and uninfected MOLT-4 cells | ChEMBL. | 8246223 |
EC50 (functional) | = 100 ug ml-1 | Giant-cell formation between persistently HIV-2 infected HUT-78 cells and uninfected MOLT-4 cells | ChEMBL. | 8246223 |
Selectivity index (functional) | > 77 | Selectivity index for CC50 (cytotoxic concentration based on the reduction of the viability of mock-infected MT-4 cells) to that of EC50 against HIV-1 | ChEMBL. | 8246223 |
Selectivity index (functional) | > 200 | Selectivity index for CC50 (cytotoxic concentration based on reduction of viability of mock-infected MT-4 cells) to that of EC50 against HIV-2 | ChEMBL. | 8246223 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.