Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | adenosine deaminase | 0.0276 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0276 | 1 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.0276 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0276 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0276 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0276 | 1 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.0276 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.0276 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.0276 | 1 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0276 | 1 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.0276 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0276 | 1 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.0276 | 1 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0276 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0276 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0276 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0276 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0276 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 3 % | Inhibition of rat adjuvant induced polyarthritis (AIP) at the dose of 100 mg/kg in the injected paw | ChEMBL. | 8421279 |
Inhibition (functional) | = 6 % | Inhibition of rat adjuvant induced polyarthritis (AIP) at the dose of 15 mg/kg in the injected paw | ChEMBL. | 8421279 |
Inhibition (functional) | = 16 % | Inhibition of antigen-induced arthritis (AIA) in mice at the dose of 100 mg/kg in the non-injected paw | ChEMBL. | 8421279 |
Inhibition (functional) | = 16 % | Inhibition of antigen-induced arthritis (AIA) in mice at the dose of 100 mg/kg in the non-injected paw | ChEMBL. | 8421279 |
Inhibition (functional) | = 41 % | Inhibition of delayed type hypersensitivity granuloma results at 100 mg/kg in dry weight | ChEMBL. | 8421279 |
Inhibition (functional) | = 41 % | Inhibition of delayed type hypersensitivity granuloma results at 100 mg/kg in wet weight | ChEMBL. | 8421279 |
Inhibition (functional) | = 41 % | Inhibition of delayed type hypersensitivity granuloma results at 100 mg/kg in dry weight | ChEMBL. | 8421279 |
Inhibition (functional) | = 41 % | Inhibition of delayed type hypersensitivity granuloma results at 100 mg/kg in wet weight | ChEMBL. | 8421279 |
Inhibition (functional) | = 50 % | Inhibition of rat adjuvant-induced arthritis (AIP) at the dose of 100 mg/kg in the non-injected paw | ChEMBL. | 8421279 |
Inhibition (functional) | = 54 % | Inhibition of rat adjuvant-induced arthritis (AIP) at the dose of 15 mg/kg in the non-injected paw | ChEMBL. | 8421279 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.