Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | adenosine deaminase | 0.0998 | 1 | 1 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.0325 | 0.2293 | 0.2293 |
Loa Loa (eye worm) | hypothetical protein | 0.0998 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0325 | 0.2293 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0673 | 0.6276 | 0.6276 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0325 | 0.2293 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0325 | 0.2293 | 1 |
Leishmania major | adenine aminohydrolase | 0.0998 | 1 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0325 | 0.2293 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0998 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0998 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0325 | 0.2293 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.0998 | 1 | 1 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.0325 | 0.2293 | 0.2293 |
Entamoeba histolytica | AMP deaminase, putative | 0.0325 | 0.2293 | 0.2293 |
Loa Loa (eye worm) | hypothetical protein | 0.0673 | 0.6276 | 0.6276 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0998 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0998 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0325 | 0.2293 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0998 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0325 | 0.2293 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.0325 | 0.2293 | 0.2293 |
Schistosoma mansoni | AMP deaminase | 0.0325 | 0.2293 | 0.2293 |
Trypanosoma brucei | AMP deaminase, putative | 0.0325 | 0.2293 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.0325 | 0.2293 | 0.2293 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0325 | 0.2293 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.0998 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0325 | 0.2293 | 1 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0325 | 0.2293 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0998 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0325 | 0.2293 | 0.2293 |
Leishmania major | hypothetical protein, conserved | 0.0325 | 0.2293 | 0.2293 |
Mycobacterium ulcerans | adenosine deaminase | 0.0998 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0673 | 0.6276 | 0.6276 |
Treponema pallidum | adenosine deaminase | 0.0998 | 1 | 0.5 |
Plasmodium vivax | adenosine/AMP deaminase, putative | 0.0325 | 0.2293 | 0.2293 |
Echinococcus granulosus | AMP deaminase 2 | 0.0325 | 0.2293 | 0.2293 |
Echinococcus granulosus | adenosine deaminase | 0.0998 | 1 | 1 |
Echinococcus multilocularis | AMP deaminase 2 | 0.0325 | 0.2293 | 0.2293 |
Loa Loa (eye worm) | hypothetical protein | 0.0673 | 0.6276 | 0.6276 |
Toxoplasma gondii | AMP deaminase | 0.0325 | 0.2293 | 0.2293 |
Entamoeba histolytica | AMP deaminase, putative | 0.0325 | 0.2293 | 0.2293 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0998 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0325 | 0.2293 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.0998 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0998 | 1 | 1 |
Brugia malayi | adenosine monophosphate deaminase | 0.0325 | 0.2293 | 0.2293 |
Leishmania major | AMP deaminase, putative | 0.0325 | 0.2293 | 0.2293 |
Plasmodium falciparum | AMP deaminase, putative | 0.0325 | 0.2293 | 0.2293 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0998 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0998 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Diet (functional) | ND 0 % | In vivo Sterol lowering activity at dose as 0.10 % of the diet;ND means no data. | ChEMBL. | 6604816 |
Diet (functional) | ND 0 % | In vivo Sterol lowering activity at dose as 0.03 % of the diet;ND means no data. | ChEMBL. | 6604816 |
Diet (functional) | ND 0 % | In vivo Sterol lowering activity at dose as 0.01 % of the diet;ND means no data. | ChEMBL. | 6604816 |
Diet (functional) | ND 0 % | In vivo Triglyceride lowering activity at dose as 0.10 % of the diet;ND means no data. | ChEMBL. | 6604816 |
Diet (functional) | ND 0 % | In vivo Triglyceride lowering activity at dose as 0.03 % of the diet;ND means no data. | ChEMBL. | 6604816 |
Diet (functional) | ND 0 % | In vivo Triglyceride lowering activity at dose as 0.01 % of the diet;ND means no data. | ChEMBL. | 6604816 |
Inhibition (binding) | = 63 % | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase (ACAT) | ChEMBL. | 6604816 |
Inhibition (binding) | = 63 % | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase (ACAT) | ChEMBL. | 6604816 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.