Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cathepsin l1 | 0.002 | 0.0234 | 0.0252 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.2499 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.5262 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.002 | 0.0234 | 0.0234 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.2499 | 0.2925 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0112 | 0.5262 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.103 | 0.1564 |
Schistosoma mansoni | chromobox protein | 0.0082 | 0.3658 | 0.3658 |
Schistosoma mansoni | cpg binding protein | 0.0099 | 0.4557 | 0.4557 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0023 | 0.0421 | 0.0473 |
Trichomonas vaginalis | chromobox protein, putative | 0.005 | 0.1869 | 0.3252 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.2384 | 0.3602 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.002 | 0.0234 | 0.0252 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0034 | 0.1037 | 0.0933 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0177 | 0.8841 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0021 | 0.0309 | 0.015 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1478 | 0.2245 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0025 | 0.051 | 0.0549 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0035 | 0.1047 | 0.1618 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0046 | 0.1677 | 0.2871 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0035 | 0.1047 | 0.1618 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0046 | 0.1677 | 0.2871 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0047 | 0.1725 | 0.2598 |
Onchocerca volvulus | Cathepsin F homolog | 0.002 | 0.0234 | 0.0355 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1478 | 0.2475 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1478 | 0.1478 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0059 | 0.0058 |
Echinococcus multilocularis | cpg binding protein | 0.0099 | 0.4557 | 0.5354 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.002 | 0.0234 | 0.0252 |
Onchocerca volvulus | Cathepsin L homolog | 0.002 | 0.0234 | 0.0355 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0309 | 0.015 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.002 | 0.0234 | 0.1618 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0016 | 0.0051 | 0.0036 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.002 | 0.0234 | 0.0325 |
Onchocerca volvulus | 0.002 | 0.0234 | 0.0355 | |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0075 | 0.3278 | 0.6054 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0034 | 0.1037 | 0.12 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0035 | 0.1047 | 0.1618 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.002 | 0.0234 | 0.0252 |
Onchocerca volvulus | Huntingtin homolog | 0.0136 | 0.6584 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0939 | 0.1404 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0042 | 0.1434 | 0.1668 |
Onchocerca volvulus | 0.002 | 0.0234 | 0.0355 | |
Trypanosoma brucei | polo-like protein kinase | 0.0112 | 0.5262 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0939 | 0.1404 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0047 | 0.1725 | 0.1725 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0035 | 0.1047 | 0.1618 |
Schistosoma mansoni | chromobox protein | 0.0082 | 0.3658 | 0.3658 |
Echinococcus multilocularis | chromobox protein 1 | 0.0082 | 0.3658 | 0.4293 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0029 | 0.0733 | 0.0841 |
Echinococcus granulosus | chromodomain helicase DNA binding protein 4 | 0.0019 | 0.018 | 0.0188 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0048 | 0.1775 | 0.2071 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1478 | 0.2475 |
Loa Loa (eye worm) | CHromoDomain protein family member | 0.0019 | 0.018 | 0.0243 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1677 | 0.2525 |
Brugia malayi | PHD-finger family protein | 0.0034 | 0.1037 | 0.1575 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.5262 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0075 | 0.3278 | 0.6054 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0112 | 0.5262 | 0.6186 |
Trichomonas vaginalis | chromobox protein, putative | 0.0082 | 0.3658 | 0.681 |
Plasmodium falciparum | phd finger protein, putative | 0.0034 | 0.1037 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0309 | 0.015 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0035 | 0.1047 | 0.1618 |
Onchocerca volvulus | Alhambra homolog | 0.0034 | 0.1037 | 0.1575 |
Loa Loa (eye worm) | ctsf protein | 0.002 | 0.0234 | 0.0325 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0047 | 0.1725 | 0.2012 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0075 | 0.3278 | 0.6054 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.103 | 0.1538 |
Loa Loa (eye worm) | fibroinase | 0.002 | 0.0234 | 0.0325 |
Brugia malayi | jmjC domain containing protein | 0.0113 | 0.5328 | 0.8093 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.002 | 0.002 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0112 | 0.5262 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0029 | 0.0733 | 0.1086 |
Plasmodium vivax | vivapain-2 | 0.002 | 0.0234 | 0.1618 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0112 | 0.5262 | 0.7992 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.051 | 0.0549 |
Onchocerca volvulus | Cathepsin L homolog | 0.002 | 0.0234 | 0.0355 |
Echinococcus multilocularis | chromobox protein 1 | 0.0082 | 0.3658 | 0.4293 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0023 | 0.0421 | 0.0473 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.5262 | 1 |
Echinococcus multilocularis | cysteine protease | 0.002 | 0.0234 | 0.0252 |
Plasmodium vivax | hypothetical protein, conserved | 0.0034 | 0.1037 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.002 | 0.002 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1478 | 0.1721 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.005 | 0.1869 | 0.2839 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.2499 | 0.2499 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.002 | 0.0234 | 0.0252 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0046 | 0.1677 | 0.2548 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.002 | 0.0234 | 0.0325 |
Echinococcus multilocularis | geminin | 0.0171 | 0.8494 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0082 | 0.3658 | 0.4293 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.002 | 0.002 |
Leishmania major | cathepsin L-like protease | 0.0075 | 0.3278 | 0.6054 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1478 | 0.1478 |
Echinococcus granulosus | peregrin | 0.0034 | 0.1037 | 0.12 |
Onchocerca volvulus | 0.002 | 0.0234 | 0.0355 | |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.002 | 0.0234 | 0.1618 |
Brugia malayi | Papain family cysteine protease containing protein | 0.002 | 0.0234 | 0.0355 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.5262 | 1 |
Schistosoma mansoni | kinase | 0.0057 | 0.2256 | 0.2256 |
Echinococcus multilocularis | peregrin | 0.0034 | 0.1037 | 0.12 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.1899 | 0.2885 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.002 | 0.0234 | 0.1618 |
Schistosoma mansoni | cpg binding protein | 0.0093 | 0.4265 | 0.4265 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1478 | 0.1721 |
Schistosoma mansoni | jumonji domain containing protein | 0.009 | 0.4058 | 0.4058 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1478 | 0.2475 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0029 | 0.0733 | 0.0841 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0309 | 0.015 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0069 | 0.292 | 0.5342 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0035 | 0.1047 | 0.1618 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.5262 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0034 | 0.1037 | 0.1575 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0112 | 0.5262 | 0.7986 |
Schistosoma mansoni | cpg binding protein | 0.0099 | 0.4557 | 0.4557 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1037 | 0.1549 |
Schistosoma mansoni | chromodomain helicase DNA binding protein | 0.0019 | 0.018 | 0.018 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0112 | 0.5262 | 0.6186 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.5262 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.002 | 0.0234 | 0.0234 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0034 | 0.1037 | 0.1037 |
Brugia malayi | PHD-finger family protein | 0.0017 | 0.0059 | 0.0089 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.002 | 0.0234 | 0.0252 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.2499 | 0.5 |
Echinococcus multilocularis | chromodomain helicase DNA binding protein 4 | 0.0019 | 0.018 | 0.0188 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.004 | 0.1329 | 0.2019 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0309 | 0.015 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.002 | 0.002 |
Loa Loa (eye worm) | cysteine protease | 0.002 | 0.0234 | 0.0325 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.1899 | 0.2885 |
Brugia malayi | CHD4 protein | 0.0019 | 0.018 | 0.0273 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0034 | 0.1038 | 0.1038 |
Echinococcus multilocularis | cysteine protease | 0.002 | 0.0234 | 0.0252 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0034 | 0.1037 | 0.0933 |
Giardia lamblia | Kinase, PLK | 0.0112 | 0.5262 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1131 | 0.1693 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.002 | 0.0234 | 0.0252 |
Brugia malayi | chromobox protein homolog 3 | 0.0046 | 0.1677 | 0.2548 |
Onchocerca volvulus | 0.0036 | 0.1131 | 0.1718 | |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.2499 | 0.4504 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0234 | 0.0355 |
Plasmodium vivax | vivapain-2 | 0.002 | 0.0234 | 0.1618 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.8494 | 0.8494 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.6584 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.6584 | 1 |
Brugia malayi | hypothetical protein | 0.0136 | 0.6584 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0309 | 0.015 |
Trichomonas vaginalis | chromobox protein, putative | 0.005 | 0.1869 | 0.3252 |
Onchocerca volvulus | 0.002 | 0.0234 | 0.0355 | |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0047 | 0.1725 | 0.1725 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0016 | 0.0051 | 0.0036 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.5617 | 0.8531 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0234 | 0.0355 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0071 | 0.3045 | 0.4609 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0023 | 0.0421 | 0.0473 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1478 | 0.2475 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.2499 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0055 | 0.2176 | 0.3862 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.2499 | 0.2499 |
Echinococcus granulosus | chromobox protein 1 | 0.0082 | 0.3658 | 0.4293 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.1899 | 0.2863 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0234 | 0.0325 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.2499 | 0.2631 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0112 | 0.5262 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0234 | 0.0355 |
Leishmania major | cathepsin L-like protease | 0.0075 | 0.3278 | 0.6054 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0055 | 0.2176 | 0.3862 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0112 | 0.5262 | 0.5262 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0035 | 0.1047 | 0.1618 |
Brugia malayi | CXXC zinc finger family protein | 0.0093 | 0.4265 | 0.6479 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.5262 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0234 | 0.0355 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.2499 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0309 | 0.015 |
Onchocerca volvulus | 0.002 | 0.0234 | 0.0355 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0309 | 0.015 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.002 | 0.0031 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.5617 | 0.8527 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0059 | 0.2394 | 0.4297 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0034 | 0.1037 | 0.1549 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0093 | 0.4265 | 0.6468 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0309 | 0.015 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0023 | 0.0425 | 0.0381 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0234 | 0.0355 |
Brugia malayi | jmjC domain containing protein | 0.0047 | 0.1725 | 0.262 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.002 | 0.0031 |
Onchocerca volvulus | 0.002 | 0.0234 | 0.0355 | |
Onchocerca volvulus | 0.002 | 0.0234 | 0.0355 | |
Trichomonas vaginalis | chromobox protein, putative | 0.0082 | 0.3658 | 0.681 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1037 | 0.1037 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0082 | 0.3658 | 0.5543 |
Onchocerca volvulus | 0.0093 | 0.4265 | 0.6479 | |
Echinococcus granulosus | geminin | 0.0171 | 0.8494 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0234 | 0.0355 |
Brugia malayi | Heterochromatin protein 1 | 0.0082 | 0.3658 | 0.5556 |
Echinococcus granulosus | cpg binding protein | 0.0099 | 0.4557 | 0.5354 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0075 | 0.3278 | 0.6054 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.5617 | 0.8527 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0113 | 0.5328 | 0.6264 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0035 | 0.1047 | 0.1618 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.103 | 0.103 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0034 | 0.1037 | 0.12 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.2499 | 0.2925 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0023 | 0.0421 | 0.0473 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0113 | 0.5328 | 0.6264 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1899 | 0.2863 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0112 | 0.5262 | 1 |
Leishmania major | cathepsin L-like protease | 0.0075 | 0.3278 | 0.6054 |
Onchocerca volvulus | Huntingtin homolog | 0.0136 | 0.6584 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0309 | 0.015 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.8494 | 0.8494 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0112 | 0.5262 | 0.7992 |
Echinococcus granulosus | jumonji domain containing protein | 0.0048 | 0.1775 | 0.2071 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0 | Evaluated for inhibitory growth of P. carinii cysts in lungs administered at the dose of 10 mg/kg expressed as number of lungs positive/number tested for 3 weeks; 0/5 | ChEMBL. | 11212120 |
Activity (functional) | = 0 | Evaluated for inhibitory growth of P. carinii cysts in lungs administered at the dose of 10 mg/kg expressed as number of lungs positive for trophozoites/number tested for 3 weeks; 0/5 | ChEMBL. | 11212120 |
Activity (functional) | = 0 | Evaluated for inhibitory growth of P. carinii cysts in lungs administered at the dose of 10 mg/kg expressed as number of lungs positive for lesions/number tested for 3 weeks; 0/5 | ChEMBL. | 11212120 |
Activity (functional) | = 0 | Evaluated for inhibitory growth of P. carinii cysts in lungs administered at the dose of 10 mg/kg expressed as number of lungs positive/number tested for 8 weeks; 2/5 | ChEMBL. | 11212120 |
Activity (functional) | = 0 | Evaluated for inhibitory growth of P. carinii cysts in lungs administered at the dose of 10 mg/kg expressed as number of lungs positive for trophozoites/number tested for 8 weeks; 0/5 | ChEMBL. | 11212120 |
Activity (functional) | = 0 | Evaluated for inhibitory growth of P. carinii cysts in lungs administered at the dose of 10 mg/kg expressed as number of lungs positive for lesions/number tested for 8 weeks; 0/5 | ChEMBL. | 11212120 |
Activity (functional) | < 1.8 | Evaluated for inhibitory growth of P. carinii cysts in lungs administered at the dose of 10 mg/kg expressed as number of cysts/lungs for 3 weeks | ChEMBL. | 11212120 |
Activity (functional) | = 2 | Evaluated for inhibitory growth of P. carinii cysts in lungs administered at the dose of 10 mg/kg expressed as number of cysts/lungs for 8 weeks | ChEMBL. | 11212120 |
ED50 (functional) | = 1.1 ug ml-1 | In vivo effective dose for antifungal activity on sc administration in female mice infected with 2.5*10e6 cells/mL of Candida albicans at day 10 | ChEMBL. | 11212120 |
ED50 (functional) | = 2.9 ug ml-1 | In vivo effective dose for antifungal activity on sc administration in female mice infected with 2.5*10e6 cells/mL of Candida albicans at day 14 | ChEMBL. | 11212120 |
IC50 (functional) | = 0.004 ug ml-1 | In vitro antifungal activity against Candida albicans FP582 at 37 degrees C for 22h | ChEMBL. | 11212120 |
IC50 (functional) | = 0.004 ug ml-1 | In vitro antifungal activity against Aspergillus niger ATCC9642 at 37 degrees C for 22h | ChEMBL. | 11212120 |
IC50 (functional) | = 0.018 ug ml-1 | In vitro antifungal activity against Candida albicans FP629 at 37 degrees C for 22h | ChEMBL. | 11212120 |
IC50 (functional) | = 0.018 ug ml-1 | In vitro antifungal activity against Candida albicans FP633 at 37 degrees C for 22h | ChEMBL. | 11212120 |
IC50 (functional) | = 0.025 ug ml-1 | In vitro antifungal activity against Candida albicans FP578 at 37 degrees C for 22h | ChEMBL. | 11212120 |
IC50 (functional) | = 0.03 ug ml-1 | In vitro antifungal activity against Candida utilis YC123 at 37 degrees C for 22h | ChEMBL. | 11212120 |
IC50 (functional) | = 0.09 ug ml-1 | In vitro antifungal activity against Candida tropicalis YC118 at 37 degrees C for 22h | ChEMBL. | 11212120 |
IC50 (functional) | = 0.14 ug ml-1 | In vitro antifungal activity against Candida krusei YC109 at 37 degrees C for 22h | ChEMBL. | 11212120 |
IC50 (functional) | = 0.7 ug ml-1 | Compound was tested for inhibitory activity against 1,3-beta-glucan synthase from Candida albicans 6406 | ChEMBL. | 11212120 |
IC50 (functional) | = 1.3 ug ml-1 | In vitro antifungal activity against Aspergillus fumitgatus FD050 at 37 degrees C for 22h | ChEMBL. | 11212120 |
IC50 (functional) | > 2.5 ug ml-1 | In vitro antifungal activity against Cryptococcus neoformans YC203 at 30 degrees C for 48 hr | ChEMBL. | 11212120 |
LC30 (functional) | = 160 | Lytic concentration for hemolytic activity in human by akaishi method | ChEMBL. | 11212120 |
MLC (functional) | = 31 | Minimum lytic concentration that lysed red blood cells in human | ChEMBL. | 11212120 |
MLC (functional) | = 31 | Minimum lytic concentration that lysed red blood cells in mouse | ChEMBL. | 11212120 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.