Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0318 | 0.2924 | 0.2924 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0258 | 0.1716 | 0.1716 |
Leishmania major | cathepsin L-like protease | 0.0318 | 0.2924 | 1 |
Onchocerca volvulus | 0.0318 | 0.2924 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0258 | 0.1716 | 0.0866 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.067 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.067 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.067 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.067 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0219 | 0.093 | 0.093 |
Echinococcus multilocularis | cathepsin b | 0.067 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0318 | 0.2924 | 0.2198 |
Giardia lamblia | Cathepsin B precursor | 0.0258 | 0.1716 | 0.5 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0318 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0219 | 0.093 | 0.3182 |
Toxoplasma gondii | cathepsin CPL | 0.0318 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 0.2924 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0318 | 0.2924 | 0.2924 |
Brugia malayi | Cathepsin L-like precursor | 0.0318 | 0.2924 | 0.2924 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 0.2924 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0318 | 0.2924 | 0.2924 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0318 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.0318 | 0.2924 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0318 | 0.2924 | 0.2198 |
Leishmania major | cathepsin L-like protease | 0.0318 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0318 | 0.2924 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0318 | 0.2924 | 0.2924 |
Leishmania major | cysteine peptidase A (CPA) | 0.0318 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0219 | 0.093 | 0.093 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.0318 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin b | 0.067 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.093 | 0.3182 |
Onchocerca volvulus | 0.0318 | 0.2924 | 1 | |
Echinococcus multilocularis | cysteine protease | 0.0318 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0318 | 0.2924 | 0.2924 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0258 | 0.1716 | 0.1716 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0318 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Plasmodium vivax | vivapain-2 | 0.0318 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0318 | 0.2924 | 0.2924 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0258 | 0.1716 | 0.5868 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0219 | 0.093 | 0.093 |
Echinococcus granulosus | cathepsin l1 | 0.0318 | 0.2924 | 0.2924 |
Brugia malayi | Cathepsin L-like precursor | 0.0318 | 0.2924 | 0.2924 |
Giardia lamblia | Cathepsin B precursor | 0.0258 | 0.1716 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0318 | 0.2924 | 0.2924 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.067 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0318 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 0.2924 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0219 | 0.093 | 0.093 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0318 | 0.2924 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0258 | 0.1716 | 0.5 |
Onchocerca volvulus | 0.0318 | 0.2924 | 1 | |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0318 | 0.2924 | 0.2198 |
Brugia malayi | Cathepsin L-like precursor | 0.0318 | 0.2924 | 0.2924 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.067 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0318 | 0.2924 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0318 | 0.2924 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0318 | 0.2924 | 0.2198 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0258 | 0.1716 | 0.5868 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.0318 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0318 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0219 | 0.093 | 0.093 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0318 | 0.2924 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.067 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0318 | 0.2924 | 0.2924 |
Loa Loa (eye worm) | hypothetical protein | 0.067 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 0.2924 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0318 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.0318 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Onchocerca volvulus | 0.0318 | 0.2924 | 1 | |
Onchocerca volvulus | 0.0318 | 0.2924 | 1 | |
Loa Loa (eye worm) | ctsf protein | 0.0318 | 0.2924 | 0.2198 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0318 | 0.2924 | 0.2198 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.093 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0318 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0318 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 0.2924 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0318 | 0.2924 | 0.2924 |
Brugia malayi | Cathepsin L-like precursor | 0.0219 | 0.093 | 0.093 |
Brugia malayi | Cathepsin L-like precursor | 0.0318 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.0318 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0219 | 0.093 | 0.093 |
Plasmodium vivax | vivapain-2 | 0.0318 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Onchocerca volvulus | 0.0318 | 0.2924 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0318 | 0.2924 | 0.2924 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0318 | 0.2924 | 1 |
Onchocerca volvulus | 0.0318 | 0.2924 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0318 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0318 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0318 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 0.2924 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Relative potency (functional) | < 0.000001 | Relative potency for induction of Colony-Stimulating activity(CSA) of C6 stromal line. | ChEMBL. | 8809169 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.