Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0325 | 0.2293 | 0.2293 |
Mycobacterium ulcerans | adenosine deaminase | 0.0998 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.0998 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0325 | 0.2293 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0998 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0325 | 0.2293 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0325 | 0.2293 | 0.2293 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0998 | 1 | 1 |
Brugia malayi | adenosine monophosphate deaminase | 0.0325 | 0.2293 | 0.2293 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0325 | 0.2293 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0998 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.0998 | 1 | 1 |
Plasmodium falciparum | AMP deaminase, putative | 0.0325 | 0.2293 | 0.2293 |
Leishmania major | AMP deaminase, putative | 0.0325 | 0.2293 | 0.2293 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0998 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0998 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.0998 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0673 | 0.6276 | 0.6276 |
Echinococcus multilocularis | AMP deaminase 2 | 0.0325 | 0.2293 | 0.2293 |
Echinococcus granulosus | adenosine deaminase | 0.0998 | 1 | 1 |
Echinococcus granulosus | AMP deaminase 2 | 0.0325 | 0.2293 | 0.2293 |
Plasmodium vivax | adenosine/AMP deaminase, putative | 0.0325 | 0.2293 | 0.2293 |
Loa Loa (eye worm) | hypothetical protein | 0.0673 | 0.6276 | 0.6276 |
Toxoplasma gondii | AMP deaminase | 0.0325 | 0.2293 | 0.2293 |
Entamoeba histolytica | AMP deaminase, putative | 0.0325 | 0.2293 | 0.2293 |
Leishmania major | adenine aminohydrolase | 0.0998 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0998 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0998 | 1 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0325 | 0.2293 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.0998 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0325 | 0.2293 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0998 | 1 | 1 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.0325 | 0.2293 | 0.2293 |
Loa Loa (eye worm) | hypothetical protein | 0.0998 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0325 | 0.2293 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0673 | 0.6276 | 0.6276 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0325 | 0.2293 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0325 | 0.2293 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0325 | 0.2293 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.0325 | 0.2293 | 0.2293 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.0325 | 0.2293 | 0.2293 |
Loa Loa (eye worm) | hypothetical protein | 0.0673 | 0.6276 | 0.6276 |
Entamoeba histolytica | AMP deaminase, putative | 0.0325 | 0.2293 | 0.2293 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0998 | 1 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.0325 | 0.2293 | 0.2293 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0325 | 0.2293 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0998 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0325 | 0.2293 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0998 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0325 | 0.2293 | 1 |
Schistosoma mansoni | AMP deaminase | 0.0325 | 0.2293 | 0.2293 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Diet (functional) | < 46 % | In vivo triglyceride lowering activity dosed at 0.10 % of the diet | ChEMBL. | 6604816 |
Diet (functional) | = 103 % | In vivo sterol lowering activity dosed at 0.10 % of the diet | ChEMBL. | 6604816 |
Inhibition (binding) | < 40 % | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase (ACAT) | ChEMBL. | 6604816 |
Inhibition (binding) | < 40 % | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase (ACAT) | ChEMBL. | 6604816 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.