Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.1608 | 0.9992 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 | 0.0221 | 0.1098 | 0.1099 |
Onchocerca volvulus | 0.0221 | 0.1098 | 1 | |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0221 | 0.1098 | 0.5 |
Leishmania major | fk506-binding protein 1-like protein | 0.1608 | 0.9992 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1609 | 1 | 1 |
Onchocerca volvulus | 0.0221 | 0.1098 | 1 | |
Schistosoma mansoni | immunophilin | 0.1609 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0221 | 0.1098 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 | 0.0221 | 0.1098 | 0.1099 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1608 | 0.9992 | 1 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0223 | 0.1106 | 0.1106 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1608 | 0.9992 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1608 | 0.9992 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0221 | 0.1098 | 0.0804 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0221 | 0.1098 | 0.5 |
Echinococcus multilocularis | 0.0221 | 0.1098 | 0.1098 | |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.0221 | 0.1098 | 0.1099 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1608 | 0.9992 | 1 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.032 | 0.032 |
Schistosoma mansoni | hypothetical protein | 0.0221 | 0.1098 | 0.1098 |
Echinococcus granulosus | FK506 binding protein 2 | 0.0221 | 0.1098 | 0.1098 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.0221 | 0.1098 | 0.1098 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1608 | 0.9992 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1608 | 0.9992 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.1608 | 0.9992 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.1609 | 1 | 1 |
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | 0.0221 | 0.1098 | 0.0804 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.1608 | 0.9992 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.1608 | 0.9992 | 1 |
Schistosoma mansoni | immunophilin | 0.1388 | 0.8581 | 0.8581 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.1098 | 0.1099 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.1388 | 0.8581 | 0.8581 |
Trypanosoma brucei | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0221 | 0.1098 | 0.0804 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0221 | 0.1098 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1388 | 0.8581 | 0.8581 |
Loa Loa (eye worm) | FKBP5 protein | 0.1608 | 0.9992 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.1608 | 0.9992 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 | 0.0221 | 0.1098 | 0.1099 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0221 | 0.1098 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.1608 | 0.9992 | 0.9992 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.1608 | 0.9992 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.1608 | 0.9992 | 0.9992 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.1608 | 0.9992 | 0.9992 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0221 | 0.1098 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.1609 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0221 | 0.1098 | 0.0804 |
Loa Loa (eye worm) | hypothetical protein | 0.1386 | 0.8572 | 0.858 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0221 | 0.1098 | 0.5 |
Schistosoma mansoni | fk506 binding protein | 0.0221 | 0.1098 | 0.1098 |
Trichomonas vaginalis | immunophilin, putative | 0.1608 | 0.9992 | 1 |
Schistosoma mansoni | immunophilin | 0.1609 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0221 | 0.1098 | 0.5 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.1608 | 0.9992 | 1 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.1608 | 0.9992 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.0221 | 0.1098 | 0.1099 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1608 | 0.9992 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.1608 | 0.9992 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.1608 | 0.9992 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.1608 | 0.9992 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.1608 | 0.9992 | 1 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0221 | 0.1098 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.0221 | 0.1098 | 0.1099 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.78 ug ml-1 | Antibacterial activity of the compound against methyllin resistant S. aureus M133 (MRSA) | ChEMBL. | 14643333 |
MIC (functional) | = 1.56 ug ml-1 | Antibacterial activity of the compound against S. aureus 209P JC-1 | ChEMBL. | 14643333 |
MIC (functional) | = 3.12 ug ml-1 | Antibacterial activity of the compound against methyllin resistant S. aureus M126 (MRSA) | ChEMBL. | 14643333 |
MIC (functional) | = 6.25 ug ml-1 | Antibacterial activity of the compound against S. epidermidis ATCC 14990 | ChEMBL. | 14643333 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity of the compound against E. hirae ATCC 8043 | ChEMBL. | 14643333 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity of the compound against E. faecalis W-73 | ChEMBL. | 14643333 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity of the compound against vancomycin resistant E. faecium vanA (VRE) | ChEMBL. | 14643333 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity of the compound against vancomycin resistant E. faecalis NCTC 12201 (VRE) | ChEMBL. | 14643333 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.