Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0563 | 0.2435 |
Leishmania major | carbonic anhydrase-like protein | 0.0255 | 0.2314 | 0.1514 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0563 | 0.2435 |
Echinococcus granulosus | farnesyl pyrophosphate synthase | 0.0224 | 0.1794 | 0.7031 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0255 | 0.2314 | 0.1514 |
Echinococcus multilocularis | hexokinase | 0.0174 | 0.0942 | 0.2164 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0255 | 0.2314 | 1 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.0224 | 0.1794 | 0.0941 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.0224 | 0.1794 | 0.0941 |
Toxoplasma gondii | V-type H(+)-translocating pyrophosphatase VP1 | 0.0706 | 1 | 1 |
Echinococcus multilocularis | farnesyl pyrophosphate synthase | 0.0224 | 0.1794 | 0.7031 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.0224 | 0.1794 | 0.5 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.0224 | 0.1794 | 0.0941 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0255 | 0.2314 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0174 | 0.0942 | 0.5 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 2, putative | 0.0706 | 1 | 1 |
Plasmodium falciparum | V-type K+-independent H+-translocating inorganic pyrophosphatase | 0.0706 | 1 | 1 |
Plasmodium vivax | V-type H(+)-translocating pyrophosphatase, putative | 0.0706 | 1 | 1 |
Plasmodium falciparum | V-type H(+)-translocating pyrophosphatase, putative | 0.0706 | 1 | 1 |
Trypanosoma cruzi | Vacuolar proton pyrophosphatase 1, putative | 0.0706 | 1 | 1 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0224 | 0.1794 | 0.1304 |
Echinococcus multilocularis | hexokinase | 0.0174 | 0.0942 | 0.2164 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0255 | 0.2314 | 1 |
Onchocerca volvulus | 0.0174 | 0.0942 | 0.5 | |
Echinococcus granulosus | hexokinase | 0.0174 | 0.0942 | 0.2164 |
Onchocerca volvulus | 0.0174 | 0.0942 | 0.5 | |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.0224 | 0.1794 | 0.5 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.0224 | 0.1794 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0174 | 0.0942 | 0.0401 |
Entamoeba histolytica | hexokinase 1 | 0.0174 | 0.0942 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0255 | 0.2314 | 1 |
Leishmania major | farnesyl pyrophosphate synthase | 0.0224 | 0.1794 | 0.0941 |
Loa Loa (eye worm) | hexokinase type II | 0.0174 | 0.0942 | 0.4072 |
Schistosoma mansoni | farnesyl pyrophosphate synthase | 0.0224 | 0.1794 | 0.7031 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.0224 | 0.1794 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0174 | 0.0942 | 0.2164 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0152 | 0.0563 | 0.2435 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0255 | 0.2314 | 1 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.0224 | 0.1794 | 0.5 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.0224 | 0.1794 | 0.0941 |
Echinococcus granulosus | carbonic anhydrase II | 0.0255 | 0.2314 | 1 |
Echinococcus granulosus | hexokinase | 0.0174 | 0.0942 | 0.2164 |
Loa Loa (eye worm) | hexokinase | 0.0174 | 0.0942 | 0.4072 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.0224 | 0.1794 | 0.5 |
Onchocerca volvulus | 0.0174 | 0.0942 | 0.5 | |
Echinococcus granulosus | hexokinase type 2 | 0.0174 | 0.0942 | 0.2164 |
Brugia malayi | hexokinase | 0.0174 | 0.0942 | 0.2164 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 1 | 0.0706 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0563 | 0.2435 |
Trypanosoma cruzi | vacuolar-type proton translocating pyrophosphatase 1 | 0.0706 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.0174 | 0.0942 | 0.0401 |
Loa Loa (eye worm) | hexokinase | 0.0174 | 0.0942 | 0.4072 |
Schistosoma mansoni | hexokinase | 0.0174 | 0.0942 | 0.2164 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.0224 | 0.1794 | 0.1304 |
Treponema pallidum | hexokinase (hxk) | 0.0174 | 0.0942 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0255 | 0.2314 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0255 | 0.2314 | 0.1514 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.0224 | 0.1794 | 0.7754 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0255 | 0.2314 | 0.1514 |
Echinococcus multilocularis | hexokinase type 2 | 0.0174 | 0.0942 | 0.2164 |
Brugia malayi | Polyprenyl synthetase family protein | 0.0224 | 0.1794 | 0.7031 |
Brugia malayi | Hexokinase family protein | 0.0174 | 0.0942 | 0.2164 |
Echinococcus multilocularis | hexokinase | 0.0174 | 0.0942 | 0.2164 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0255 | 0.2314 | 1 |
Plasmodium vivax | vacuolar-type H+ pumping pyrophosphatase, putative | 0.0706 | 1 | 1 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.0224 | 0.1794 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | < 0.25 ug ml-1 | Antibacterial activity against Staphylococcus aureus ATCC-13709 | ChEMBL. | 14711312 |
MIC (functional) | = 0.25 ug ml-1 | Antibacterial activity against Staphylococcus aureus PSCB-0538 | ChEMBL. | 14711312 |
MIC (functional) | = 0.5 ug ml-1 | Antibacterial activity against Staphylococcus aureus PSCB-0331 | ChEMBL. | 14711312 |
MIC (functional) | = 0.5 ug ml-1 | Antibacterial activity against Streptococcus pyogenes PSCB-0545 | ChEMBL. | 14711312 |
MIC (functional) | = 2 ug ml-1 | Antibacterial activity against Enterococcus faecalis ATCC-29212 | ChEMBL. | 14711312 |
MIC (functional) | = 2 ug ml-1 | Antibacterial activity against Streptococcus pyogenes PSCB-0543 | ChEMBL. | 14711312 |
MIC (functional) | = 4 ug ml-1 | Antibacterial activity against Streptococcus pneumoniae PSCB-0541 | ChEMBL. | 14711312 |
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against Haemophilus influenzae ATCC-49247 | ChEMBL. | 14711312 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Staphylococcus aureus PSCB-0330 | ChEMBL. | 14711312 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Escherichia coli ATCC-125922 | ChEMBL. | 14711312 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Escherichia coli ATCC-125922 | ChEMBL. | 14711312 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.