Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0122 | 0.117 | 0.9542 | |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.009 | 0.0714 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0736 | 1 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0081 | 0.0588 | 0.0588 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0065 | 0.0362 | 0.3155 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0081 | 0.0588 | 0.0588 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0085 | 0.0637 | 0.6337 |
Loa Loa (eye worm) | fatty acid synthase | 0.0054 | 0.0196 | 0.0425 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0044 | 0.005 | 0.005 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0096 | 0.0795 | 0.5 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0108 | 0.0977 | 1 |
Mycobacterium ulcerans | thioesterase TesA | 0.0046 | 0.0075 | 0.0075 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0108 | 0.0977 | 0.0977 |
Loa Loa (eye worm) | beta-ketoacyl synthase domain-containing protein | 0.009 | 0.0714 | 0.5778 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0085 | 0.0637 | 0.0637 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.008 | 0.0564 | 0.0517 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0736 | 1 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0081 | 0.0588 | 0.581 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0081 | 0.0588 | 0.0588 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0063 | 0.0322 | 0.2941 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0736 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0243 | 0.0912 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0081 | 0.0588 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0085 | 0.0637 | 0.059 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0081 | 0.0588 | 0.0588 |
Schistosoma mansoni | 3-oxoacyl-[ACP] synthase | 0.009 | 0.0714 | 0.5 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0046 | 0.0075 | 0.0026 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0081 | 0.0588 | 0.3814 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0085 | 0.0637 | 0.059 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.009 | 0.0714 | 0.4917 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0108 | 0.0977 | 0.0932 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0085 | 0.0637 | 0.0637 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0108 | 0.0977 | 0.0932 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0062 | 0.0312 | 0.2191 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0071 | 0.0445 | 0.0398 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.009 | 0.0714 | 0.0714 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0085 | 0.0637 | 0.6337 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0071 | 0.0435 | 0.0435 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.009 | 0.0714 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0045 | 0.0073 | 0.0023 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0085 | 0.0637 | 0.059 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0096 | 0.0795 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0081 | 0.0588 | 0.0541 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0071 | 0.0435 | 0.0435 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0081 | 0.0588 | 0.0541 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier protein] synthase 1 KasA (beta-ketoacyl-ACP synthase) (KAS I) | 0.005 | 0.0134 | 0.0085 |
Toxoplasma gondii | 3-oxoacyl-acyl-carrier protein synthase I/II, putative | 0.009 | 0.0714 | 1 |
Mycobacterium leprae | 3-oxoacyl-[acyl-carrier-protein] synthase 1 KasA (BETA-KETOACYL-ACP SYNTHASE) (KAS I) | 0.005 | 0.0134 | 0.0916 |
Mycobacterium ulcerans | thioesterase | 0.0046 | 0.0075 | 0.0075 |
Mycobacterium leprae | 3-oxoacyl-[acyl-carrier-protein] synthase 2 KasB (BETA-KETOACYL-ACP SYNTHASE) (KAS I) | 0.005 | 0.0134 | 0.0916 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.1122 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0081 | 0.0588 | 0.0588 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0063 | 0.0322 | 0.0322 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.008 | 0.0564 | 0.0517 |
Leishmania major | beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative | 0.009 | 0.0714 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0736 | 1 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.013 | 0.1291 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0736 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0736 | 1 | 1 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0125 | 0.1219 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0071 | 0.0435 | 0.4155 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0049 | 0.012 | 0.0071 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0096 | 0.0795 | 0.5 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0085 | 0.0637 | 0.6337 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0051 | 0.0155 | 0.0106 |
Trypanosoma brucei | beta-ketoacyl-ACP synthase | 0.009 | 0.0714 | 0.5 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.009 | 0.0714 | 0.5 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0046 | 0.0075 | 0.0277 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0736 | 1 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0081 | 0.0588 | 0.0541 |
Echinococcus multilocularis | 3 oxoacyl (acyl carrier protein) synthase | 0.009 | 0.0714 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0085 | 0.0637 | 0.8509 |
Mycobacterium ulcerans | polyketide synthase | 0.0085 | 0.0637 | 0.0637 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0058 | 0.0249 | 0.0201 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.009 | 0.0714 | 0.0714 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0096 | 0.0795 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier protein] synthase 2 KasB (beta-ketoacyl-ACP synthase) (KAS I) | 0.005 | 0.0134 | 0.0085 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0096 | 0.0795 | 0.5 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0063 | 0.0322 | 0.0322 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.00000074 M | inhibition of the association of [125I]-alpha-bungarotoxin [125I]-alpha-BTX] to nicotinic acetylcholine receptors from mouse muscle derived BC3H-1 cells at alpha/gamma binding site. | ChEMBL. | 11123987 |
NA (binding) | 0 | inhibition of the association of [125I]-alpha-bungarotoxin [125I]-alpha-BTX] to nicotinic acetylcholine receptors from mouse muscle derived BC3H-1 cells at alpha/delta binding site; Not applicable | ChEMBL. | 11123987 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.