Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Rattus norvegicus | Adrenergic receptor alpha-2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | serotonin receptor | Adrenergic receptor alpha-2 | 450 aa | 426 aa | 31.9 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Adrenergic receptor alpha-2 | 450 aa | 423 aa | 31.7 % |
Echinococcus granulosus | alpha 1A adrenergic receptor | Adrenergic receptor alpha-2 | 450 aa | 476 aa | 21.0 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Adrenergic receptor alpha-2 | 450 aa | 473 aa | 24.1 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Adrenergic receptor alpha-2 | 450 aa | 433 aa | 27.9 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Adrenergic receptor alpha-2 | 450 aa | 378 aa | 20.9 % |
Schistosoma mansoni | amine GPCR | Adrenergic receptor alpha-2 | 450 aa | 439 aa | 29.2 % |
Onchocerca volvulus | Adrenergic receptor alpha-2 | 450 aa | 467 aa | 25.1 % | |
Onchocerca volvulus | Adrenergic receptor alpha-2 | 450 aa | 420 aa | 19.8 % | |
Echinococcus multilocularis | alpha 1A adrenergic receptor | Adrenergic receptor alpha-2 | 450 aa | 478 aa | 20.7 % |
Echinococcus multilocularis | fmrfamide receptor | Adrenergic receptor alpha-2 | 450 aa | 366 aa | 19.9 % |
Loa Loa (eye worm) | TYRA-2 protein | Adrenergic receptor alpha-2 | 450 aa | 488 aa | 23.8 % |
Echinococcus multilocularis | neuropeptides capa receptor | Adrenergic receptor alpha-2 | 450 aa | 486 aa | 20.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.6107 | 0.5169 |
Echinococcus multilocularis | AMP deaminase 2 | 0.0177 | 0.1943 | 0.1943 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0101 | 0.0268 | 0.0268 |
Mycobacterium ulcerans | adenosine deaminase | 0.0544 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0544 | 1 | 1 |
Echinococcus granulosus | AMP deaminase 2 | 0.0177 | 0.1943 | 0.1722 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0544 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0177 | 0.1943 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.0544 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0544 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0544 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0177 | 0.1943 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0177 | 0.1937 | 0.1715 |
Loa Loa (eye worm) | hypothetical protein | 0.0544 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0177 | 0.1943 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.0544 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0544 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0177 | 0.1943 | 0.5 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0177 | 0.1943 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0177 | 0.1943 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.6107 | 0.5169 |
Trypanosoma brucei | AMP deaminase, putative | 0.0177 | 0.1943 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0177 | 0.1943 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0544 | 1 | 1 |
Schistosoma mansoni | AMP deaminase | 0.0177 | 0.1943 | 0.1229 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0544 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0544 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0177 | 0.1943 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.6107 | 0.5169 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0177 | 0.1943 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0544 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.6107 | 0.5169 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0544 | 1 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0177 | 0.1937 | 0.1937 |
Trypanosoma brucei | AMP deaminase, putative | 0.0177 | 0.1943 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0544 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.0544 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.0544 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.0544 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0544 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0177 | 0.1943 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1300 nm | Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]-rauwolscine as radioligand | ChEMBL. | 2864446 |
Ki (binding) | = 1300 nm | Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]-rauwolscine as radioligand | ChEMBL. | 2864446 |
Ki (binding) | = 8700 nm | Binding affinity against alpha-1 adrenergic receptor in rat using [3H]-prazosin as radioligand | ChEMBL. | 2864446 |
Ki (binding) | = 8700 nm | Binding affinity against alpha-1 adrenergic receptor in rat using [3H]-prazosin as radioligand | ChEMBL. | 2864446 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.