Detailed information for compound 405474

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1077.24 | Formula: C54H72N14O10
  • H donors: 12 H acceptors: 10 LogP: 1.35 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 3
  • SMILES: O=C1CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](NC(=O)[C@@H]2N(C(=O)CN1)CCC2)Cc1ccc2c(c1)cccc2)Cc1c[nH]c2c1cccc2)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N)C(C)C)C(C)C
  • InChi: 1S/C54H72N14O10/c1-29(2)45(52(77)61-27-42(55)69)67-53(78)46(30(3)4)66-48(73)38-19-20-43(70)60-28-44(71)68-22-10-16-41(68)51(76)65-39(24-31-17-18-32-11-5-6-12-33(32)23-31)49(74)62-37(15-9-21-58-54(56)57)47(72)64-40(50(75)63-38)25-34-26-59-36-14-8-7-13-35(34)36/h5-8,11-14,17-18,23,26,29-30,37-41,45-46,59H,9-10,15-16,19-22,24-25,27-28H2,1-4H3,(H2,55,69)(H,60,70)(H,61,77)(H,62,74)(H,63,75)(H,64,72)(H,65,76)(H,66,73)(H,67,78)(H4,56,57,58)/t37-,38+,39-,40+,41-,45+,46+/m1/s1
  • InChiKey: DOBARAYAGKVEBY-UAXGYZNNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase, putative 0.0034 0.008 0.008
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0013 0.0221
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.008 0.089
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0116 0.0116
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0041 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0013 0.0221
Echinococcus multilocularis solute carrier family 22 0.0015 0.0027 0.0027
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0092 0.0091
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0006 0.0001 0.0001
Brugia malayi Cytochrome P450 family protein 0.0048 0.012 0.2053
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0029 0.0029
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0116 0.1975
Onchocerca volvulus 0.002 0.0041 0.0423
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.009 0.009
Leishmania major hypothetical protein, conserved 0.0015 0.0027 0.0027
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0007 0.0005 0.0444
Leishmania major glucose transporter, lmgt3 0.0034 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0144
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0007 0.0005 0.0444
Trypanosoma cruzi hexose transporter, putative 0.0034 0.008 0.0078
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0044 0.0044
Trypanosoma brucei glucose transporter 1E 0.0034 0.008 0.008
Trypanosoma cruzi beta tubulin, putative 0.0027 0.0062 0.0061
Brugia malayi Cytochrome P450 family protein 0.0007 0.0005 0.0088
Schistosoma mansoni inositol monophosphatase 0.0037 0.009 0.009
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0027 0.2927
Plasmodium falciparum protein kinase 6 0.0461 0.1297 1
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0062 0.0062
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0013 0.0013
Trypanosoma cruzi hexose transporter 0.0034 0.008 0.0078
Onchocerca volvulus 0.0015 0.0027 0.0219
Schistosoma mansoni ap endonuclease 0.0019 0.0038 0.0038
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0053 0.0053
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0038 0.4133
Brugia malayi nuclear hormone receptor 0.001 0.0013 0.0221
Schistosoma mansoni tubulin subunit beta 0.0027 0.0062 0.0062
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0047 0.0047
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0007 0.0005 0.0507
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0007 0.0005 0.0444
Leishmania major beta tubulin 0.0027 0.0062 0.0062
Echinococcus multilocularis smad 0.0008 0.0007 0.0007
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.012 0.1338
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.0156 0.0156
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0041 0.0041
Brugia malayi hypothetical protein 0.002 0.0041 0.0694
Schistosoma mansoni glycyl-tRNA synthetase 0.0006 0.0001 0.0001
Leishmania major beta tubulin 0.0027 0.0062 0.0062
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.008 0.008
Brugia malayi Smad1 0.0008 0.0007 0.0124
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0079 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0053 0.0053
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.008 0.008
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.0293 0.0293
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0588
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0013 0.0013
Brugia malayi Pre-SET motif family protein 0.0211 0.0585 1
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0017 0.1725
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.008 0.008
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.008 0.1366
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0452
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0053 0.0053
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.0077 0.0075
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0007 0.0005 0.0507
Schistosoma mansoni hypothetical protein 0.0364 0.1021 0.1021
Onchocerca volvulus 0.0015 0.0027 0.0219
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0144
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0053 0.6624
Trichomonas vaginalis helicase, putative 0.0007 0.0003 0.0003
Schistosoma mansoni loxhd1 0.002 0.0041 0.0041
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0092 0.0092
Trypanosoma brucei beta tubulin 0.0027 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0003
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0092 0.0092
Trypanosoma brucei sugar transporter, putative 0.0015 0.0027 0.0027
Echinococcus multilocularis neuropeptide receptor A26 0.0485 0.1366 0.1366
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0047 0.0046
Echinococcus granulosus beta tubulin 0.0027 0.0062 0.0062
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.3514 1 1
Trypanosoma brucei glucose transporter, putative 0.0034 0.008 0.008
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Schistosoma mansoni cpg binding protein 0.0031 0.0071 0.0071
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0156 0.0156
Brugia malayi beta-tubulin, identical 0.0027 0.0062 0.1054
Loa Loa (eye worm) inositol-1 0.0037 0.009 0.1005
Onchocerca volvulus 0.0015 0.0027 0.0219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0013 0.0144
Onchocerca volvulus 0.002 0.0041 0.0423
Onchocerca volvulus 0.0015 0.0027 0.0219
Onchocerca volvulus 0.0015 0.0027 0.0219
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0027 0.0466
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0013 0.0013
Echinococcus granulosus mitogen activated protein kinase 0.006 0.0156 0.0156
Loa Loa (eye worm) Smad1 0.0008 0.0007 0.0081
Trypanosoma brucei glucose transporter, putative 0.0034 0.008 0.008
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.0077 0.0077
Toxoplasma gondii beta tubulin 0.0027 0.0062 0.0719
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0007 0.0005 0.0444
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0008 0.0008
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0321 0.0898 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0029 0.0029
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.0077 0.1307
Loa Loa (eye worm) BEN-1 protein 0.0027 0.0062 0.0687
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.008 0.008
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0029 0.0226
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0003 0.0003
Echinococcus granulosus cytochrome P450 2K1 0.0007 0.0005 0.0005
Schistosoma mansoni glucose transport protein 0.0108 0.0293 0.0293
Trypanosoma brucei beta tubulin 0.0027 0.0062 0.0062
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.0324 0.0324
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0053 0.0407
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.0293 0.0293
Echinococcus multilocularis transcription factor eb 0.0112 0.0304 0.0304
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.009 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.0077 0.0077
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0027 0.0027
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0007 0.0005 0.0444
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0303
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0013 0.0144
Schistosoma mansoni sugar transporter 0.0015 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0034 0.008 0.008
Giardia lamblia Beta tubulin 0.0027 0.0062 0.0061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0116 0.0116
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0007 0.0005 0.0444
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0038 0.0038
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0364 0.1021 0.1021
Plasmodium falciparum tubulin beta chain 0.0027 0.0062 0.0476
Echinococcus granulosus smad 0.0008 0.0007 0.0007
Schistosoma mansoni cpg binding protein 0.0029 0.0067 0.0067
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0008 0.0008
Schistosoma mansoni importin beta-1 0.003 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0107 0.0289 0.3217
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0022 0.0243
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.0156 0.0156
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0013
Entamoeba histolytica DNA repair and recombination protein, putative 0.3514 1 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0038 0.0038
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.008 0.0617
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0116 0.0116
Brugia malayi CXXC zinc finger family protein 0.0029 0.0067 0.1137
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0007 0.0005 0.0507
Leishmania major importin beta-1 subunit, putative 0.0024 0.0053 0.0053
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0027 0.0027
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0007 0.0005 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0116 0.0116
Leishmania major beta tubulin 0.0027 0.0062 0.0062
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0156 0.0154
Onchocerca volvulus 0.0015 0.0027 0.0219
Echinococcus granulosus FTZ F1 alpha 0.001 0.0013 0.0013
Plasmodium falciparum hexose transporter 0.0108 0.0293 0.2258
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0038 0.4725
Brugia malayi glycyl-tRNA synthetase 0.0006 0.0001 0.002
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0072 0.0072
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0053 0.0407
Echinococcus granulosus RUN 0.002 0.0041 0.0041
Brugia malayi Sugar transporter family protein 0.0015 0.0027 0.0466
Leishmania major beta tubulin 0.0027 0.0062 0.0062
Leishmania major beta tubulin 0.0027 0.0062 0.0062
Schistosoma mansoni ap endonuclease 0.0019 0.0038 0.0038
Echinococcus granulosus solute carrier family 22 0.0015 0.0027 0.0027
Toxoplasma gondii beta-tubulin, putative 0.0027 0.0062 0.0719
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0013 0.0013
Brugia malayi hypothetical protein 0.0015 0.0027 0.0466
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.008 0.1373
Plasmodium vivax SET domain protein, putative 0.0031 0.0072 0.0552
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.008 0.008
Entamoeba histolytica hypothetical protein 0.0024 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0303
Echinococcus multilocularis snurportin 1 0.0321 0.0898 0.0898
Echinococcus multilocularis General substrate transporter 0.0093 0.0249 0.0249
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.0293 0.0293
Leishmania major beta tubulin 0.0027 0.0062 0.0062
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.0077 0.0077
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.008 0.008
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0303
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0038 0.0038
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0041 0.0041
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.009 0.009
Echinococcus multilocularis 0.0007 0.0005 0.0005
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.0156 0.1731
Brugia malayi ecdysteroid receptor 0.001 0.0013 0.0221
Onchocerca volvulus 0.0031 0.0072 0.0896
Loa Loa (eye worm) beta-tubulin 0.0027 0.0062 0.0687
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0144
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0062 0.0062
Echinococcus multilocularis tubulin subunit beta 0.0027 0.0062 0.0062
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0003 0.0003
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0007 0.0005 0.0005
Plasmodium vivax sugar transporter, putative 0.0015 0.0027 0.021
Loa Loa (eye worm) histone methyltransferase 0.001 0.0013 0.014
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0092 0.0708
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0041 0.0313
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.009 0.0089
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0062 0.0062
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0007 0.0005 0.0507
Leishmania major beta tubulin 0.0027 0.0062 0.0062
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0013 0.0013
Leishmania major cytochrome p450-like protein 0.0007 0.0005 0.0005
Entamoeba histolytica tubulin family protein 0.0027 0.0062 0.0062
Echinococcus granulosus solute carrier family 22 0.0015 0.0027 0.0027
Echinococcus multilocularis beta tubulin 0.0027 0.0062 0.0062
Loa Loa (eye worm) sugar transporter 0.0015 0.0027 0.0303
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0069 0.0809
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0038 0.0037
Schistosoma mansoni smad1 5 8 and 0.0008 0.0007 0.0007
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0034 0.008 0.008
Brugia malayi major facilitator superfamily protein 0.0015 0.0027 0.0466
Echinococcus multilocularis GPCR, family 2 0.0034 0.008 0.008
Toxoplasma gondii cytochrome p450 superfamily protein 0.0007 0.0005 0.006
Schistosoma mansoni hypothetical protein 0.0034 0.008 0.008
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0192 0.3287
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0027 0.0027
Trypanosoma brucei protein kinase, putative 0.006 0.0156 0.0156
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0041 0.0041
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.0156 0.0156
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.009 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0003 0.0003
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0156 0.0156
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.0293 0.0293
Leishmania major glucose transporter, lmgt2 0.0034 0.008 0.008
Echinococcus multilocularis RUN 0.002 0.0041 0.0041
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0013 0.0221
Echinococcus multilocularis solute carrier family 22 0.0015 0.0027 0.0027
Schistosoma mansoni glucose transport protein 0.0108 0.0293 0.0293
Echinococcus granulosus neuropeptide receptor A26 0.0485 0.1366 0.1366
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0007 0.0005 0.0507
Loa Loa (eye worm) hypothetical protein 0.0034 0.008 0.089
Brugia malayi Doublecortin family protein 0.002 0.0041 0.0694
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0007 0.0005 0.0444
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0013 0.0144
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0027 0.2927
Loa Loa (eye worm) DEAH box polypeptide 35 0.0037 0.009 0.1002
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0062 0.0062
Loa Loa (eye worm) doublecortin family protein 0.002 0.0041 0.0452
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0328 0.365
Onchocerca volvulus 0.0015 0.0027 0.0219
Schistosoma mansoni sugar transporter 0.0015 0.0027 0.0027
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0027 0.2927
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Schistosoma mansoni sugar transporter 0.0015 0.0027 0.0027
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0053 0.0053
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0038 0.0038
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0029 0.3613
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0067 0.0741
Loa Loa (eye worm) hypothetical protein 0.0157 0.0433 0.4817
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Loa Loa (eye worm) tubulin beta-4 chain 0.0027 0.0062 0.0687
Onchocerca volvulus 0.0015 0.0027 0.0219
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.008 0.0617
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0007 0.0005 0.0507
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0013 0.0221
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0013 0.0013
Brugia malayi Probable ATP-dependent helicase DHX35 0.0037 0.009 0.1538
Echinococcus granulosus tubulin beta 1 chain 0.0027 0.0062 0.0062
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0069 0.0069
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0013 0.0221
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0007 0.0005 0.0507
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.0156 0.1811
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.3514 1 1
Loa Loa (eye worm) BEN-1 protein 0.0027 0.0062 0.0687
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0.0005 0.0004
Brugia malayi hypothetical protein 0.0015 0.0027 0.0466
Schistosoma mansoni hypothetical protein 0.0034 0.008 0.008
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0007 0.0005 0.0444
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.008 0.008
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0007 0.0005 0.0444
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0092 0.107
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0034 0.008 0.0932
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0092 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.008 0.008
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0038 0.0038
Brugia malayi hypothetical protein 0.002 0.0041 0.0694
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0073 0.0073
Trichomonas vaginalis tubulin gamma chain, putative 0.0027 0.0062 0.0062
Echinococcus granulosus beta tubulin 0.0027 0.0062 0.0062
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0029 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0072 0.0072
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0013 0.0013
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0013 0.0013
Trichomonas vaginalis set domain proteins, putative 0.024 0.0668 0.0668
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0007 0.0005 0.0444
Leishmania major beta tubulin 0.0027 0.0062 0.0062
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.0293 0.0293
Schistosoma mansoni hypothetical protein 0.0073 0.0192 0.0192
Giardia lamblia Kinase, CMGC MAPK 0.006 0.0156 0.0154
Mycobacterium leprae putative cytochrome p450 0.0007 0.0005 0.0507
Trichomonas vaginalis ran, putative 0.0022 0.0047 0.0047
Brugia malayi RNA, U transporter 1 0.0085 0.0227 0.3884
Brugia malayi isocitrate dehydrogenase 0.0016 0.0029 0.0501
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0027 0.0466
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0047 0.08
Brugia malayi MH1 domain containing protein 0.0008 0.0007 0.0124
Onchocerca volvulus 0.0015 0.0027 0.0219
Trichomonas vaginalis tubulin alpha chain, putative 0.0027 0.0062 0.0062
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0029 0.0029
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.009 0.009
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Brugia malayi hypothetical protein 0.0157 0.0433 0.7391
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0013 0.0013
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0007 0.0005 0.0444
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0013 0.0221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0013 0.0144
Giardia lamblia Hexose transporter 0.0015 0.0027 0.0026
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0042 0.5289
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0293 0.0293
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0047 0.0046
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0053 0.0052
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0041 0.0041
Echinococcus granulosus GPCR family 2 0.0034 0.008 0.008
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0077 0.0077
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0029 0.0029
Schistosoma mansoni Smad4 0.0008 0.0007 0.0007
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.008 0.0617
Loa Loa (eye worm) hypothetical protein 0.0033 0.0077 0.0852
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0112 0.0304 0.5201
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0144 0.1675
Giardia lamblia Rrm3p helicase 0.3514 1 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0034 0.008 0.0932
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.3514 1 1
Schistosoma mansoni smad 0.0008 0.0007 0.0007
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0053 0.5794
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0007 0.0005 0.0507
Trypanosoma brucei cytochrome P450, putative 0.0007 0.0005 0.0005
Giardia lamblia Sugar-proton symporter 0.0015 0.0027 0.0026
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0029 0.0029
Trichomonas vaginalis glucose transporter, putative 0.0034 0.008 0.008
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0027 0.0027
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0303
Loa Loa (eye worm) hypothetical protein 0.003 0.0069 0.0773
Echinococcus multilocularis importin subunit beta 1 0.003 0.0069 0.0069
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0156 0.0156
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0007 0.0005 0.0444
Brugia malayi Importin beta-1 subunit 0.003 0.0069 0.1186
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0328 0.365
Trypanosoma cruzi cytochrome P450, putative 0.0007 0.0005 0.0004
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.009 0.009
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.008 0.0617
Trichomonas vaginalis tubulin beta chain, putative 0.0027 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0027 0.0027
Leishmania major glucose transporter, lmgt1 0.0034 0.008 0.008
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0013 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0003 0.0003
Leishmania major threonyl-tRNA synthetase, putative 0.0006 0.0001 0.0001
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0053 0.0053
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0006 0.0001 0.0001
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.008 0.0617
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0013 0.0013
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0047 0.0521
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.3514 1 1
Toxoplasma gondii sugar transporter ST3 0.0015 0.0027 0.0317
Schistosoma mansoni hypothetical protein 0.0034 0.008 0.008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0013 0.0013
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.0156 0.0154
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0007 0.0005 0.0444
Echinococcus multilocularis beta tubulin 0.0027 0.0062 0.0062
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0003 0.0003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0029 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0116 0.0116
Onchocerca volvulus 0.0015 0.0027 0.0219
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0303
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Trichomonas vaginalis tubulin, putative 0.0027 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0303
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0156 0.0154
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0013 0.0013
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0038 1
Leishmania major beta tubulin 0.0027 0.0062 0.0062
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0053 1
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0006 0.0001 0.0001
Brugia malayi MH2 domain containing protein 0.0008 0.0007 0.0124
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0069 0.0069
Plasmodium vivax tubulin beta chain, putative 0.0027 0.0062 0.0476
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0013 0.0221
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0007 0.0005 0.0507
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.009 0.009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0072 0.0072
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0013 0.0013
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.0293 0.0293
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0027 0.0027
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.008 0.0617
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0003
Trypanosoma cruzi hexose transporter, putative 0.0034 0.008 0.0078
Echinococcus granulosus neuropeptide s receptor 0.0485 0.1366 0.1366
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0008 0.0008
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0006 0.0001 0.0001
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.008 0.0617
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0038 0.0423
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Leishmania major cytochrome p450-like protein 0.0007 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0303
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0027 0.0303
Leishmania major cytochrome p450-like protein 0.0007 0.0005 0.0005
Loa Loa (eye worm) sugar transporter 0.0108 0.0293 0.3261
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0144
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.1162 0.1162
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0067 0.0067
Leishmania major beta tubulin 0.0027 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0321 0.0898 0.0898
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0013 0.0013
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0062 0.0062
Schistosoma mansoni tubulin subunit beta 0.0027 0.0062 0.0062
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0079 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0108 0.0293 0.0293
Schistosoma mansoni protein kinase 0.0034 0.008 0.008
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0047 0.0361
Echinococcus granulosus cpg binding protein 0.0031 0.0071 0.0071
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0007 0.0005 0.0507
Entamoeba histolytica tubulin family protein 0.0027 0.0062 0.0062
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0033 0.0077 0.0852
Schistosoma mansoni coup transcription factor 0.001 0.0013 0.0013
Echinococcus granulosus tubulin subunit beta 0.0027 0.0062 0.0062
Brugia malayi steroid hormone receptor 0.001 0.0013 0.0221
Loa Loa (eye worm) hypothetical protein 0.0073 0.0192 0.2142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0013 0.0144
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0007 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0303
Trypanosoma brucei glucose transporter, putative 0.0034 0.008 0.008
Schistosoma mansoni ran 0.0022 0.0047 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0013 0.0221
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0013 0.0013
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0176 0.0485 0.5646
Schistosoma mansoni glucose transport protein 0.0108 0.0293 0.0293
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0013 0.0221
Loa Loa (eye worm) tubulin beta-1 chain 0.0027 0.0062 0.0687
Schistosoma mansoni hypothetical protein 0.0413 0.1162 0.1162
Trypanosoma brucei glucose transporter 2A 0.0034 0.008 0.008
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0013 0.0221
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0013 0.0013
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0092 0.0092
Brugia malayi cytochrome P450 0.0007 0.0005 0.0088
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0007 0.0005 0.0507
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0027 0.0027
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0005 0.0057
Schistosoma mansoni hypothetical protein 0.0108 0.0293 0.0293
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0017 0.2978
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0007 0.0081
Plasmodium falciparum threonine--tRNA ligase 0.0006 0.0001 0.0009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0289 0.3217
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0008 0.0008
Entamoeba histolytica hypothetical protein, conserved 0.3514 1 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0053 0.0053
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0013 0.0013
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0007 0.0081
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0007 0.0005 0.0444
Brugia malayi Tubulin beta-1 chain 0.0027 0.0062 0.1054
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0112 0.0303 0.3372
Trypanosoma brucei beta tubulin 0.0027 0.0062 0.0062
Brugia malayi Sugar transporter family protein 0.0108 0.0293 0.5003
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0027 0.0027
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0007 0.0005 0.0507
Toxoplasma gondii beta-1 tubulin, putative 0.0027 0.0062 0.0719
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0007 0.0005 0.0507
Echinococcus granulosus geminin 0.0364 0.1021 0.1021
Schistosoma mansoni lipoxygenase 0.0083 0.0221 0.0221
Brugia malayi Cam kinase protein 1 0.0034 0.008 0.1366
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0027 0.021
Echinococcus granulosus glycyl tRNA synthetase 0.0006 0.0001 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0005 0.0057
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0003
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.3514 1 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0006 0.0001 0.002
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0013 0.0013
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0006 0.0001 0.0001
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0034 0.008 0.0895
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0156 0.0156
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Schistosoma mansoni ran 0.0022 0.0047 0.0047
Plasmodium vivax CDK-related protein kinase 6, putative 0.0461 0.1297 1
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0017 0.4174
Echinococcus granulosus Smad4 0.0008 0.0007 0.0007
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.008 0.008
Trypanosoma cruzi hexose transporter, putative 0.0034 0.008 0.0078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0116 0.0116
Onchocerca volvulus Putative transporter 0.0015 0.0027 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0003
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.008 0.089
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.008 0.008
Plasmodium vivax importin-beta 2, putative 0.003 0.0069 0.0535
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.008 0.008
Trichomonas vaginalis conserved hypothetical protein 0.3514 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0013 0.0013
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0027 0.0027
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0003 0.0003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0038 0.0037
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0072 0.0798
Entamoeba histolytica Ran family GTPase 0.0022 0.0047 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0027 0.0027
Brugia malayi MAP kinase sur-1 0.006 0.0156 0.2657
Leishmania major GTP-binding protein, putative 0.0022 0.0047 0.0047
Brugia malayi MH2 domain containing protein 0.0121 0.0328 0.5601
Echinococcus granulosus snurportin 1 0.0321 0.0898 0.0898
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0013 0.0013
Schistosoma mansoni tubulin subunit beta 0.0027 0.0062 0.0062
Trypanosoma cruzi cytochrome P450, putative 0.0007 0.0005 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0007 0.0005 0.0507
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0007 0.0005 0.0507
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0027 0.0026
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0027 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0013 0.0221
Onchocerca volvulus 0.0015 0.0027 0.0219
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0027 0.0027
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0027 0.3347
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0289 0.4936
Trypanosoma brucei beta tubulin 0.0027 0.0062 0.0062
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0042 0.5289
Echinococcus multilocularis Smad4 0.0008 0.0007 0.0007
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0053 0.5794
Onchocerca volvulus 0.0015 0.0027 0.0219
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0062 0.0062
Trichomonas vaginalis sugar transporter, putative 0.0034 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0144
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0027 0.0026
Brugia malayi Sugar transporter family protein 0.0015 0.0027 0.0466
Brugia malayi MH2 domain containing protein 0.0008 0.0007 0.0124
Giardia lamblia Beta tubulin 0.0027 0.0062 0.0061
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.0156 0.0156
Schistosoma mansoni protein kinase 0.0034 0.008 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0003
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.082 0.232 0.232
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.008 0.008
Mycobacterium ulcerans sugar transporter 0.0015 0.0027 0.2927
Schistosoma mansoni rab6-interacting 0.002 0.0041 0.0041
Brugia malayi Inositol-1 0.0037 0.009 0.1542
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.009 0.009
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0038 0.0293
Trichomonas vaginalis tubulin epsilon chain, putative 0.0027 0.0062 0.0062
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0027 0.0027
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0053 0.0615
Onchocerca volvulus 0.0015 0.0027 0.0219
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0007 0.0005 0.0507
Brugia malayi MH1 domain containing protein 0.0008 0.0007 0.0124
Echinococcus multilocularis cpg binding protein 0.0031 0.0071 0.0071
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0036 0.0035
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.3514 1 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0013 0.0221
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0027 0.0027
Leishmania major beta tubulin 0.0027 0.0062 0.0062
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0007 0.0007
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0053 0.0053
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Plasmodium falciparum mitogen-activated protein kinase 2 0.0176 0.0485 0.3737
Loa Loa (eye worm) CYP4Cod1 0.0007 0.0005 0.0057
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0029 0.0501
Leishmania major beta tubulin 0.0027 0.0062 0.0062
Schistosoma mansoni sugar transporter 0.0015 0.0027 0.0027
Brugia malayi Cytochrome P450 family protein 0.0007 0.0005 0.0088
Brugia malayi hypothetical protein 0.0015 0.0027 0.0466
Toxoplasma gondii protein kinase, putative 0.0307 0.0858 1
Echinococcus multilocularis tubulin beta 1 chain 0.0027 0.0062 0.0062
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0303
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.3514 1 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Schistosoma mansoni nuclear hormone receptor 0.001 0.0013 0.0013
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0007 0.0007
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0062 0.0062
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.3514 1 1
Echinococcus granulosus dnaJ subfamily B 0.0413 0.1162 0.1162
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0027 0.2927
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.0156 0.0154
Brugia malayi nuclear receptor NHR-88 0.001 0.0013 0.0221
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0038 0.0293
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0073 0.0073
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0038 0.4133
Onchocerca volvulus 0.0015 0.0027 0.0219
Toxoplasma gondii sugar transporter ST1 0.0015 0.0027 0.0317
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0003
Echinococcus granulosus transcription factor eb 0.0112 0.0304 0.0304
Brugia malayi Cytochrome P450 family protein 0.0007 0.0005 0.0088
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0007 0.0005 0.0444
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.008 0.008
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0029 0.0226
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0156 0.0156
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.008 0.008
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.0077 0.9671
Toxoplasma gondii facilitative glucose transporter GT1 0.0108 0.0293 0.3411
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0027 0.0466
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0163 0.0163
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.008 0.0617
Plasmodium falciparum protein kinase 7 0.0307 0.0858 0.6619
Leishmania major beta tubulin 0.0027 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0112 0.0303 0.3372
Schistosoma mansoni hypothetical protein 0.002 0.0041 0.0041
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.0324 0.0324
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0053 0.0053
Onchocerca volvulus 0.0029 0.0067 0.0819
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0003
Brugia malayi major facilitator superfamily protein 0.0015 0.0027 0.0466
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0007 0.0005 0.0444
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.009 0.1051
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0303
Giardia lamblia Beta tubulin 0.0027 0.0062 0.0061
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0007 0.0005 0.0444
Schistosoma mansoni smad1 5 8 and 0.0008 0.0007 0.0007
Echinococcus multilocularis neuropeptide s receptor 0.0485 0.1366 0.1366
Leishmania major beta tubulin 0.0027 0.0062 0.0062
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0.0005 0.0004
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0072 0.0834
Onchocerca volvulus 0.024 0.0668 1
Onchocerca volvulus 0.0157 0.0433 0.6405
Echinococcus granulosus General substrate transporter 0.0093 0.0249 0.0249
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.0077 0.1307
Schistosoma mansoni thyroid hormone receptor 0.001 0.0013 0.0013
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0062 0.0062
Schistosoma mansoni thyroid hormone receptor 0.001 0.0013 0.0013
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0038 0.0038
Leishmania major beta tubulin 0.0027 0.0062 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0013 0.0221
Plasmodium vivax threonine--tRNA ligase, putative 0.0006 0.0001 0.0009
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.009 0.009
Schistosoma mansoni hypothetical protein 0.0007 0.0005 0.0005
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0012 0.0209
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0047 0.0046
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0041 0.0313
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0072 0.0072
Trichomonas vaginalis sugar transporter, putative 0.0034 0.008 0.008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0116 0.1287
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0047 0.0047
Plasmodium vivax hexose transporter 0.0108 0.0293 0.2258
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0053 0.0053
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.009 0.009
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0092 0.0708
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0303
Plasmodium vivax glycine--tRNA ligase, putative 0.0006 0.0001 0.0009
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0007 0.0005 0.0444
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0062 0.0062
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0027 0.0027
Echinococcus multilocularis geminin 0.0364 0.1021 0.1021
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0027 0.0062 0.0062
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0042 0.5289
Echinococcus multilocularis glycyl tRNA synthetase 0.0006 0.0001 0.0001
Mycobacterium leprae Conserved hypothetical protein 0.0007 0.0005 0.0507
Trypanosoma brucei glucose transporter, putative 0.0034 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0037 0.009 0.1002
Leishmania major beta tubulin 0.0027 0.0062 0.0062
Trichomonas vaginalis sugar transporter, putative 0.0034 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0144
Entamoeba histolytica hypothetical protein 0.0024 0.0053 0.0053
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0007 0.0007
Schistosoma mansoni smad1 5 8 and 0.0008 0.0007 0.0007
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.008 0.0617
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0289 0.4936
Schistosoma mansoni cytochrome P450 0.0007 0.0005 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0072 0.0072
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0027 0.3347
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.008 0.0895
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0013 0.0013
Trichomonas vaginalis glucose transporter, putative 0.0034 0.008 0.008
Schistosoma mansoni rab6-interacting 0.002 0.0041 0.0041
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0006 0.0001 0.0014
Entamoeba histolytica protein kinase, putative 0.0034 0.008 0.008
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0047 0.0361
Leishmania major beta tubulin 0.0027 0.0062 0.0062
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0008 0.0007 0.0007
Trypanosoma brucei glucose transporter, putative 0.0034 0.008 0.008
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0013 0.0013
Echinococcus multilocularis solute carrier family 22 0.0015 0.0027 0.0027
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.008 0.008
Leishmania major protein kinase, putative 0.0034 0.008 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0013 0.0144
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0047 0.0546
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0007 0.0005 0.0507
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0116 0.0116
Echinococcus granulosus solute carrier family 22 0.0015 0.0027 0.0027
Loa Loa (eye worm) tubulin beta chain 0.0027 0.0062 0.0687
Toxoplasma gondii sugar transporter ST2 0.0015 0.0027 0.0317
Schistosoma mansoni inositol monophosphatase 0.0037 0.009 0.009
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0027 0.0027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0013 0.0221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0013 0.0144
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0053 0.0052
Trichomonas vaginalis tubulin epsilon chain, putative 0.0027 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0303
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Echinococcus granulosus tubulin beta 4A class IVa 0.0027 0.0062 0.0062
Brugia malayi Pre-SET motif family protein 0.0031 0.0072 0.1224
Brugia malayi Latrophilin receptor protein 2 0.0034 0.008 0.1373
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0006 0.0001 0.002
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0013 0.0013
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0013 0.0221
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0007 0.0005 0.0507
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0027 0.0026
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0029 0.0028
Trypanosoma brucei glucose transporter, putative 0.0034 0.008 0.008
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0038 0.0649
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.3514 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0303
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0007 0.0005 0.0444
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0062 0.0062
Schistosoma mansoni polycystin 1-related 0.002 0.0041 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.008 0.008
Schistosoma mansoni tubulin subunit beta 0.0027 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0303
Schistosoma mansoni cpg binding protein 0.0031 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0144
Schistosoma mansoni lipoxygenase 0.0119 0.0324 0.0324
Trypanosoma brucei glucose transporter, putative 0.0034 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0452
Schistosoma mansoni tubulin subunit beta 0.0027 0.0062 0.0062
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0029 0.0327
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0041 0.0041
Onchocerca volvulus 0.0015 0.0027 0.0219
Echinococcus multilocularis solute carrier family 22 0.0015 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0003
Plasmodium falciparum importin beta, putative 0.003 0.0069 0.0535
Trypanosoma brucei glucose transporter, putative 0.0034 0.008 0.008
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0176 0.0485 0.3737
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0038 0.0037
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0007 0.0005 0.0507
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0003 0.0003
Toxoplasma gondii glycyl-tRNA synthetase 0.0006 0.0001 0.0014
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.0077 0.0077
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.0156 0.0156
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0006 0.0001 0.0013
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0013 0.0144
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.008 0.008
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0013 0.0013
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.008 0.008
Leishmania major beta tubulin 0.0027 0.0062 0.0062
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0034 0.008 0.0932
Echinococcus granulosus solute carrier family 22 0.0015 0.0027 0.0027
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0013 0.0013
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.0293 0.0293
Toxoplasma gondii exonuclease III APE 0.0019 0.0038 0.0443
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0029 0.0342
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0027 0.0317
Schistosoma mansoni glucose transporter 0.0015 0.0027 0.0027
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0047 0.0047
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0013 0.0013
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0053 0.0902
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0658
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0029 0.0029
Echinococcus granulosus importin subunit beta 1 0.003 0.0069 0.0069
Schistosoma mansoni tubulin subunit beta 0.0027 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0144
Echinococcus granulosus Threonyl tRNA synthetase C 0.0006 0.0001 0.0001
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0007 0.0005 0.0444
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.0585 0.6517
Loa Loa (eye worm) cytochrome P450 0.0007 0.0005 0.0057
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0006 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0303
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0003 0.0003
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0006 0.0001 0.0013
Onchocerca volvulus 0.0015 0.0027 0.0219
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0007 0.0005 0.0507
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0029 0.0029
Loa Loa (eye worm) tubulin beta-2A chain 0.0027 0.0062 0.0687
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0007 0.0005 0.0444
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0053 0.0052
Schistosoma mansoni protein kinase 0.0034 0.008 0.008
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.008 0.008
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0027 0.0027
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0029 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0013 0.0221

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 10000 nM Agonistic activity towards Melanocortin 1 receptor in the Xenopus frog skin assay ChEMBL. 12593660
EC50 (functional) > 10000 nM Agonistic activity towards Melanocortin 1 receptor in the Xenopus frog skin assay ChEMBL. 12593660
IC50 (binding) = 637 nM Antagonistic activity towards Melanocortin 1 receptor in Xenopus frog skin using competitive binding in the presence of 500 pM of alpha-melanocyte stimulating hormone ChEMBL. 12593660
IC50 (binding) = 637 nM Antagonistic activity towards Melanocortin 1 receptor in Xenopus frog skin using competitive binding in the presence of 500 pM of alpha-melanocyte stimulating hormone ChEMBL. 12593660

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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