TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 1436.05 | Formula: C70H95ClN16O15
H donors: 16 H acceptors: 15 LogP: 1.24 Rotable bonds: 36
Rule of 5 violations (Lipinski): 4
SMILES: OC[C@H](C(=O)N[C@H](C(=O)NC(C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)NC(C(=O)N)C)CCCN=C(N)N)CC(C)C)Cc1ccc2c(c1)cccc2)Cc1ccc(cc1)O)NC(=O)[C@@H]1CCCCNC(=O)[C@@H](Cc2ccc(cc2)Cl)NC(=O)C(CCC(=O)NCCC(=O)N1)NC(=O)C
InChi: 1S/C70H95ClN16O15/c1-39(2)33-52(64(97)81-51(14-9-30-77-70(73)74)69(102)87-32-10-15-57(87)68(101)78-40(3)60(72)93)82-66(99)55(37-44-16-21-45-11-5-6-12-46(45)34-44)84-65(98)54(36-43-19-24-48(90)25-20-43)85-67(100)56(38-88)86-62(95)49-13-7-8-29-76-61(94)53(35-42-17-22-47(71)23-18-42)83-63(96)50(79-41(4)89)26-27-58(91)75-31-28-59(92)80-49/h5-6,11-12,16-25,34,39-40,49-57,88,90H,7-10,13-15,26-33,35-38H2,1-4H3,(H2,72,93)(H,75,91)(H,76,94)(H,78,101)(H,79,89)(H,80,92)(H,81,97)(H,82,99)(H,83,96)(H,84,98)(H,85,100)(H,86,95)(H4,73,74,77)/t40?,49-,50?,51+,52-,53-,54+,55?,56+,57-/m1/s1
InChiKey: VISQMXVWMPKDMZ-RPGVTIHMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	g protein coupled receptor	0.0137	0.0117	0.0117
Schistosoma mansoni	opsin-like receptor	0.0137	0.0117	0.0321
Loa Loa (eye worm)	RNA binding protein	0.0074	0.0053	0.4544
Onchocerca volvulus		0.0137	0.0117	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0137	0.0117	0.0321
Brugia malayi	Cytochrome P450 family protein	0.0044	0.0022	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0137	0.0117	0.0117
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0137	0.0117	1
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.3591	0.3633	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0012	0.1027
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0137	0.0117	0.0117
Echinococcus granulosus	rhodopsin orphan GPCR	0.0137	0.0117	0.0117
Entamoeba histolytica	DNA repair and recombination protein, putative	0.3591	0.3633	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0137	0.0117	0.0117
Echinococcus granulosus	g protein coupled receptor	0.0137	0.0117	0.0117
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0137	0.0117	0.0321
Onchocerca volvulus		0.0137	0.0117	1
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0005	0.0413
Schistosoma mansoni	hypothetical protein	0.0137	0.0117	0.0321
Echinococcus multilocularis	allatostatin A receptor	0.0137	0.0117	0.0117
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.3591	0.3633	1
Onchocerca volvulus		0.0137	0.0117	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0137	0.0117	0.0117
Echinococcus granulosus	mitogen activated protein kinase 3	0.0059	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0004	0.037
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0005	0.0071
Schistosoma mansoni	lamin	0.0027	0.0005	0.0013
Echinococcus granulosus	rhodopsin orphan GPCR	0.0137	0.0117	0.0117
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0059	0.0037	0.3205
Echinococcus granulosus	neuropeptides capa receptor	0.0137	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Echinococcus granulosus	hypothetical protein	0.0137	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Brugia malayi	Probable ATP-dependent helicase DHX35	0.0038	0.0016	0.0233
Schistosoma mansoni	hypothetical protein	0.3591	0.3633	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0137	0.0117	0.0117
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0137	0.0117	0.0321
Brugia malayi	G-protein coupled receptor	0.0137	0.0117	0.1711
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0137	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.3591	0.3633	0.3633
Brugia malayi	neuropeptide F receptor	0.0137	0.0117	0.1711
Echinococcus granulosus	neuropeptide s receptor	0.0137	0.0117	0.0117
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0053	0.0146
Echinococcus granulosus	biogenic amine 5HT receptor	0.0137	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0137	0.0117	0.0117
Brugia malayi	RNA binding protein	0.0074	0.0053	0.0777
Echinococcus granulosus	g protein coupled receptor	0.0137	0.0117	0.0117
Schistosoma mansoni	biogenic amine receptor	0.0137	0.0117	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Echinococcus multilocularis	somatostatin receptor	0.0137	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0137	0.0117	0.0117
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0	0.5
Brugia malayi	Serotonin receptor	0.0137	0.0117	0.1711
Onchocerca volvulus		0.0137	0.0117	1
Brugia malayi	G-protein coupled receptor	0.0137	0.0117	0.1711
Echinococcus granulosus	microtubule associated protein 2	0.0684	0.0674	0.0674
Giardia lamblia	Rrm3p helicase	0.3591	0.3633	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0028	0.0409
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0137	0.0117	0.0321
Brugia malayi	RE15519p	0.0137	0.0117	0.1711
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0137	0.0117	0.1711
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0137	0.0117	0.0117
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0137	0.0117	0.0321
Entamoeba histolytica	hypothetical protein, conserved	0.3591	0.3633	1
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0005	0.0013
Echinococcus multilocularis	neuropeptide Y receptor	0.0137	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Brugia malayi	ORL1-like opioid receptor	0.0137	0.0117	0.1711
Echinococcus granulosus	neuropeptide receptor	0.0137	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Brugia malayi	putative neuropeptide receptor	0.0137	0.0117	0.1711
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Onchocerca volvulus		0.0137	0.0117	1
Onchocerca volvulus		0.0137	0.0117	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0137	0.0117	0.0321
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0137	0.0117	0.0321
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0137	0.0117	0.0117
Echinococcus granulosus	neuropeptide Y receptor	0.0137	0.0117	0.0117
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0037	0.0103
Brugia malayi	hypothetical protein	0.0137	0.0117	0.1711
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0137	0.0117	0.0117
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0005	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Brugia malayi	Melatonin receptor type 1A	0.0137	0.0117	0.1711
Schistosoma mansoni	histamine h1 receptor	0.0137	0.0117	0.0321
Schistosoma mansoni	neuropeptide receptor	0.0137	0.0117	0.0321
Schistosoma mansoni	amine GPCR	0.0137	0.0117	0.0321
Schistosoma mansoni	growth hormone secretagogue receptor	0.0137	0.0117	0.0321
Schistosoma mansoni	amine GPCR	0.0137	0.0117	0.0321
Schistosoma mansoni	biogenic amine receptor	0.0137	0.0117	0.0321
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0012	0.0176
Echinococcus granulosus	biogenic amine 5HT receptor	0.0137	0.0117	0.0117
Echinococcus granulosus	g-protein coupled receptor	0.0137	0.0117	0.0117
Brugia malayi	RNA recognition motif domain containing protein	0.0074	0.0053	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0137	0.0117	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0137	0.0117	0.1711
Echinococcus granulosus	orexin receptor type 2	0.0137	0.0117	0.0117
Echinococcus granulosus	lamin	0.0027	0.0005	0.0005
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0137	0.0117	0.0117
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0137	0.0117	0.0321
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0	0.5
Onchocerca volvulus		0.0137	0.0117	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0137	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Echinococcus granulosus	allatostatin A receptor	0.0137	0.0117	0.0117
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0053	0.0146
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0137	0.0117	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0137	0.0117	0.0117
Schistosoma mansoni	neuropeptide receptor	0.0137	0.0117	0.0321
Schistosoma mansoni	amine GPCR	0.0137	0.0117	0.0321
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0137	0.0117	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0074	0.0053	0.4544
Echinococcus multilocularis	neuropeptide receptor	0.0137	0.0117	0.0117
Loa Loa (eye worm)	melatonin receptor type 1A	0.0137	0.0117	1
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.3591	0.3633	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0137	0.0117	0.0117
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.3591	0.3633	1
Echinococcus multilocularis	tar DNA binding protein	0.0074	0.0053	0.0053
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.3591	0.3633	0.3633
Brugia malayi	larval opioid receptor	0.0137	0.0117	0.1711
Onchocerca volvulus		0.0137	0.0117	1
Echinococcus multilocularis	orexin receptor type 2	0.0137	0.0117	0.0117
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0059	0.0037	0.0037
Onchocerca volvulus		0.0137	0.0117	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0137	0.0117	0.0117
Onchocerca volvulus		0.0137	0.0117	1
Brugia malayi	Dopamine receptor	0.0137	0.0117	0.1711
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0137	0.0117	0.0321
Schistosoma mansoni	myosin xvIII	0.0137	0.0117	0.0321
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	0.3591	0.3633	1
Onchocerca volvulus		0.0137	0.0117	1
Brugia malayi	hypothetical protein	0.0137	0.0117	0.1711
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0137	0.0117	0.0117
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0028	0.0409
Brugia malayi	MAP kinase sur-1	0.0059	0.0037	0.0548
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0137	0.0117	0.0321
Brugia malayi	G protein-coupled receptor	0.0137	0.0117	0.1711
Echinococcus granulosus	lamin dm0	0.0027	0.0005	0.0005
Onchocerca volvulus		0.0137	0.0117	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0137	0.0117	0.1711
Echinococcus granulosus	neuropeptide FF receptor 2	0.0137	0.0117	0.0117
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0137	0.0117	0.1711
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0137	0.0117	1
Schistosoma mansoni	adenoreceptor	0.0137	0.0117	0.0321
Schistosoma mansoni	microtubule-associated protein tau	0.0684	0.0674	0.1855
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0016	0.1364
Brugia malayi	Dopamine receptor protein 1	0.0137	0.0117	0.1711
Brugia malayi	intermediate filament protein	0.0027	0.0005	0.0071
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0137	0.0117	0.0321
Loa Loa (eye worm)	G-protein coupled receptor	0.0137	0.0117	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0137	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0137	0.0117	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0059	0.0037	0.0103
Echinococcus granulosus	intermediate filament protein	0.0027	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0137	0.0117	0.1711
Brugia malayi	GnHR receptor homolog	0.0692	0.0682	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0137	0.0117	0.1711
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0037	0.0103
Onchocerca volvulus		0.0137	0.0117	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0137	0.0117	0.0117
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0137	0.0117	0.0321
Brugia malayi	AKH receptor	0.0137	0.0117	0.1711
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0137	0.0117	0.0117
Schistosoma mansoni	neuropeptide F-like receptor	0.0137	0.0117	0.0321
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0059	0.0037	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0137	0.0117	0.0321
Brugia malayi	sulfakinin receptor protein	0.0137	0.0117	0.1711
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0137	0.0117	0.0117
Onchocerca volvulus		0.0137	0.0117	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0137	0.0117	0.0117
Echinococcus granulosus	neuropeptide Y receptor	0.0137	0.0117	0.0117
Schistosoma mansoni	neuropeptide receptor	0.0137	0.0117	0.0321
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.3591	0.3633	1
Trichomonas vaginalis	conserved hypothetical protein	0.3591	0.3633	1
Schistosoma mansoni	hypothetical protein	0.0137	0.0117	0.0321
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0137	0.0117	0.1711
Echinococcus granulosus	rhodopsin orphan GPCR	0.0137	0.0117	0.0117
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0137	0.0117	0.0117
Schistosoma mansoni	neuropeptide receptor	0.0137	0.0117	0.0321
Loa Loa (eye worm)	TYRA-2 protein	0.0137	0.0117	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0137	0.0117	0.0321
Echinococcus multilocularis	neuropeptides capa receptor	0.0137	0.0117	0.0117
Loa Loa (eye worm)	neuropeptide F receptor	0.0137	0.0117	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0137	0.0117	0.0321
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0137	0.0117	0.0321
Brugia malayi	hypothetical protein	0.0137	0.0117	0.1711
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0137	0.0117	0.1711
Brugia malayi	hypothetical protein	0.0137	0.0117	0.1711
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0137	0.0117	0.0321
Echinococcus multilocularis	fmrfamide receptor	0.0137	0.0117	0.0117
Giardia lamblia	Kinase, CMGC MAPK	0.0059	0.0037	0.0103
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0059	0.0037	0.0103
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0137	0.0117	0.0117
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0137	0.0117	0.0117
Loa Loa (eye worm)	neuropeptide F receptor	0.0137	0.0117	1
Onchocerca volvulus		0.0137	0.0117	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0137	0.0117	0.0117
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0028	0.2391
Onchocerca volvulus		0.0137	0.0117	1
Loa Loa (eye worm)	TAR-binding protein	0.0074	0.0053	0.4544
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0053	0.0146
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	0.3591	0.3633	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0137	0.0117	0.0321
Echinococcus granulosus	serotonin receptor	0.0137	0.0117	0.0117
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0059	0.0037	0.0103
Echinococcus granulosus	rhodopsin orphan GPCR	0.0137	0.0117	0.0117
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.0037	0.0103
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0137	0.0117	0.0321
Brugia malayi	hypothetical protein	0.0137	0.0117	0.1711
Echinococcus multilocularis	lamin dm0	0.0027	0.0005	0.0005
Echinococcus multilocularis	g-protein coupled receptor	0.0137	0.0117	0.0117
Echinococcus multilocularis	neuropeptide receptor	0.0137	0.0117	0.0117
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0137	0.0117	0.0117
Brugia malayi	hypothetical protein	0.0137	0.0117	0.1711
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0053	0.0146
Schistosoma mansoni	hypothetical protein	0.0137	0.0117	0.0321
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0059	0.0037	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0137	0.0117	0.0117
Echinococcus granulosus	G protein coupled receptor 139	0.0137	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0028	0.2391
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.9847	1	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0137	0.0117	0.0321
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0037	0.0103
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0137	0.0117	0.0321
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0137	0.0117	1
Onchocerca volvulus		0.0137	0.0117	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0137	0.0117	0.0117
Echinococcus multilocularis	microtubule associated protein 2	0.0684	0.0674	0.0674
Echinococcus granulosus	somatostatin receptor	0.0137	0.0117	0.0117
Brugia malayi	hypothetical protein	0.0137	0.0117	0.1711
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Trypanosoma brucei	protein kinase, putative	0.0059	0.0037	0.0103
Brugia malayi	hypothetical protein	0.0137	0.0117	0.1711
Echinococcus granulosus	neuropeptides capa receptor	0.0137	0.0117	0.0117
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0137	0.0117	0.0117
Echinococcus multilocularis	g protein coupled receptor	0.0137	0.0117	0.0117
Echinococcus granulosus	rhodopsin orphan GPCR	0.0137	0.0117	0.0117
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0137	0.0117	1
Brugia malayi	follicle stimulating hormone receptor	0.0137	0.0117	0.1711
Echinococcus multilocularis	fmrfamide receptor	0.0137	0.0117	0.0117
Echinococcus multilocularis	mitogen activated protein kinase	0.0059	0.0037	0.0037
Brugia malayi	putative neuropeptide receptor NPR1	0.0137	0.0117	0.1711
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0137	0.0117	0.0117
Loa Loa (eye worm)	cytochrome P450 family protein	0.0044	0.0022	0.1913
Brugia malayi	TAR-binding protein	0.0074	0.0053	0.0777
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0137	0.0117	0.0321
Echinococcus multilocularis	neuropeptides capa receptor	0.0137	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0137	0.0117	0.0321
Echinococcus granulosus	dro:myosuppressin receptor	0.0137	0.0117	0.0117
Schistosoma mansoni	amine GPCR	0.0137	0.0117	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Schistosoma mansoni	biogenic amine receptor	0.0137	0.0117	0.0321
Echinococcus multilocularis	serotonin receptor	0.0137	0.0117	0.0117
Schistosoma mansoni	neuropeptide F-like receptor	0.0137	0.0117	0.0321
Brugia malayi	Dopamine receptor protein 2	0.0137	0.0117	0.1711
Echinococcus multilocularis	G protein coupled receptor 139	0.0137	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0012	0.0033
Echinococcus granulosus	sex peptide receptor	0.0137	0.0117	0.0117
Echinococcus granulosus	tar DNA binding protein	0.0074	0.0053	0.0053
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0059	0.0037	0.0103
Schistosoma mansoni	amine GPCR	0.0137	0.0117	0.0321
Echinococcus granulosus	neuropeptide receptor	0.0137	0.0117	0.0117
Echinococcus multilocularis	neuropeptide s receptor	0.0137	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Echinococcus multilocularis	sex peptide receptor	0.0137	0.0117	0.0117
Echinococcus granulosus	fmrfamide receptor	0.0137	0.0117	0.0117
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0037	0.0103
Schistosoma mansoni	opsin-like receptor	0.0137	0.0117	0.0321
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0059	0.0037	0.0103
Echinococcus granulosus	g protein coupled receptor	0.0137	0.0117	0.0117
Echinococcus granulosus	tm gpcr rhodopsin	0.0137	0.0117	0.0117
Echinococcus multilocularis	dro:myosuppressin receptor	0.0137	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Echinococcus multilocularis	musashi	0.0027	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0137	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0137	0.0117	0.0321
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0137	0.0117	0.0117
Brugia malayi	neuropeptide F receptor	0.0137	0.0117	0.1711
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0005	0.0413
Echinococcus granulosus	7TM GPCR rhodopsin	0.0137	0.0117	0.0117
Schistosoma mansoni	opsin-like receptor	0.0137	0.0117	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0948	0.0943	0.0943
Loa Loa (eye worm)	DEAH box polypeptide 35	0.0038	0.0016	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Schistosoma mansoni	hypothetical protein	0.0137	0.0117	0.0321
Echinococcus multilocularis	g protein coupled receptor	0.0137	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0117	1
Echinococcus granulosus	neuropeptide receptor A26	0.0137	0.0117	0.0117
Echinococcus granulosus	mitogen activated protein kinase	0.0059	0.0037	0.0037
Echinococcus multilocularis	lamin	0.0027	0.0005	0.0005
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0137	0.0117	0.0321
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0053	0.0146
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0137	0.0117	0.0117
Echinococcus multilocularis	neuropeptide Y receptor	0.0137	0.0117	0.0117
Schistosoma mansoni	lamin	0.0027	0.0005	0.0013
Echinococcus multilocularis	serotonin receptor	0.0137	0.0117	0.0117
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0137	0.0117	0.0117
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0137	0.0117	0.0117
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0137	0.0117	0.0117
Brugia malayi	hypothetical protein	0.0137	0.0117	0.1711
Brugia malayi	Serotonin receptor	0.0137	0.0117	0.1711
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0137	0.0117	1
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0059	0.0037	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	0	Evaluated for number of rats ovulating in an in vivo anti-ovulatory assay at dose(50 microg); 6/8	ChEMBL.	10715148
Activity (functional)	0	Evaluated for number of rats ovulating in an in vivo anti-ovulatory assay at dose(100 microg); 0/10	ChEMBL.	10715148
Ki (binding)	= 2.2 nM	Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293	ChEMBL.	10715148

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 377909

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 405518