Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0598 | 0.4538 | 0.5 |
Schistosoma mansoni | integrin alpha-ps | 0.0144 | 0.039 | 0.029 |
Schistosoma mansoni | integrin alpha-ps | 0.0276 | 0.1598 | 0.2607 |
Schistosoma mansoni | immunophilin | 0.0598 | 0.4538 | 0.8243 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.039 | 0.039 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0598 | 0.4538 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.0598 | 0.4538 | 0.6288 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0598 | 0.4538 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.2112 | 0.2112 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0116 | 0.014 | 0.014 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0598 | 0.4538 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0598 | 0.4538 | 0.446 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0598 | 0.4538 | 0.5 |
Loa Loa (eye worm) | integrin beta-2 | 0.1196 | 1 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0516 | 0.3786 | 0.5213 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.2179 | 0.2179 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0598 | 0.4538 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0598 | 0.4538 | 0.5 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0598 | 0.4538 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 0.3786 | 0.3786 |
Echinococcus granulosus | integrin alpha ps | 0.0132 | 0.0285 | 0.0207 |
Schistosoma mansoni | immunophilin | 0.0516 | 0.3786 | 0.6803 |
Echinococcus multilocularis | integrin alpha ps | 0.0276 | 0.1598 | 0.2084 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0598 | 0.4538 | 0.5 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0598 | 0.4538 | 0.5 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0598 | 0.4538 | 0.5 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0598 | 0.4538 | 0.8243 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0598 | 0.4538 | 0.4538 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0598 | 0.4538 | 0.5 |
Echinococcus multilocularis | integrin alpha ps | 0.0276 | 0.1598 | 0.2084 |
Schistosoma mansoni | integrin beta subunit | 0.0698 | 0.5454 | 1 |
Leishmania major | fk506-binding protein 1-like protein | 0.0598 | 0.4538 | 0.5 |
Echinococcus granulosus | integrin alpha ps | 0.0276 | 0.1598 | 0.2084 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0598 | 0.4538 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0516 | 0.3786 | 0.5213 |
Schistosoma mansoni | immunophilin | 0.0598 | 0.4538 | 0.8243 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0816 | 0.6527 | 0.6527 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0616 | 0.47 | 0.4625 |
Loa Loa (eye worm) | FKBP5 protein | 0.0598 | 0.4538 | 0.4538 |
Schistosoma mansoni | integrin alpha | 0.0616 | 0.47 | 0.8554 |
Trichomonas vaginalis | immunophilin, putative | 0.0598 | 0.4538 | 1 |
Brugia malayi | hypothetical protein | 0.0184 | 0.0757 | 0.0625 |
Echinococcus multilocularis | integrin beta 2 | 0.0882 | 0.7134 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.0132 | 0.0285 | 0.0207 |
Echinococcus multilocularis | integrin alpha 3 | 0.0472 | 0.3388 | 0.4643 |
Brugia malayi | Kelch motif family protein | 0.0184 | 0.0757 | 0.0625 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0184 | 0.0757 | 0.0757 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0598 | 0.4538 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0598 | 0.4538 | 0.5 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0598 | 0.4538 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0598 | 0.4538 | 0.6288 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0598 | 0.4538 | 0.446 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0598 | 0.4538 | 0.6288 |
Echinococcus granulosus | integrin beta 2 | 0.0882 | 0.7134 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0598 | 0.4538 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0483 | 0.3492 | 0.3492 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0598 | 0.4538 | 0.6288 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0332 | 0.2112 | 0.2 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0285 | 0.0285 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0598 | 0.4538 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.0757 | 0.0757 |
Echinococcus granulosus | integrin alpha 3 | 0.0472 | 0.3388 | 0.4643 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.0285 | 0.0091 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.15 uM | Binding affinity against integrin alpha 2b-beta 3 in enzyme linked immunosorbent assay (ELISA) | ChEMBL. | 7507165 |
IC50 (functional) | = 0.69 uM | Inhibition of 10 uM ADP induced platelet aggregation in human platelet rich citrated plasma (PRP) | ChEMBL. | 7507165 |
IC50 (binding) | = 2 uM | Binding affinity against integrin alpha V-beta5 in enzyme linked immunosorbent assay (ELISA) | ChEMBL. | 7507165 |
IC50 (binding) | = 2.3 uM | Binding affinity against integrin alpha5-beta1 in enzyme linked immunosorbent assay (ELISA) | ChEMBL. | 7507165 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.