Detailed information for compound 405613

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 988.143 | Formula: C48H69N13O10
  • H donors: 12 H acceptors: 11 LogP: -1.04 Rotable bonds: 35
    Rule of 5 violations (Lipinski): 4
  • SMILES: CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)[C@H](CC)C)Cc1ccc(cc1)O)C(C)C)CCCN=C(N)N
  • InChi: 1S/C48H69N13O10/c1-6-28(4)40(45(68)57-35(23-31-24-52-26-54-31)46(69)61-20-18-37(61)43(66)58-36(47(70)71)22-29-11-8-7-9-12-29)60-42(65)34(21-30-14-16-32(62)17-15-30)56-44(67)39(27(2)3)59-41(64)33(55-38(63)25-51-5)13-10-19-53-48(49)50/h7-9,11-12,14-17,24,26-28,33-37,39-40,51,62H,6,10,13,18-23,25H2,1-5H3,(H,52,54)(H,55,63)(H,56,67)(H,57,68)(H,58,66)(H,59,64)(H,60,65)(H,70,71)(H4,49,50,53)/t28-,33-,34-,35-,36-,37?,39-,40-/m0/s1
  • InChiKey: CLOHQSSXEHVJHA-DDWRKKPVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0057 0.0116 0.0131
Echinococcus multilocularis serotonin receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0122 0.0435 0.0492
Brugia malayi ORL1-like opioid receptor 0.0039 0.0024 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0093 0.0295 0.0318
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0039 0.0024 0.0011
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0039 0.0024 0.0027
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0128 0.0466 0.0512
Loa Loa (eye worm) hypothetical protein 0.0057 0.0116 0.0131
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0039 0.0024 0.0027
Echinococcus granulosus dro:myosuppressin receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0057 0.0116 0.0131
Onchocerca volvulus 0.0246 0.1053 0.1166
Echinococcus granulosus g protein coupled receptor 0.0039 0.0024 0.0011
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) RNA binding protein 0.0144 0.0546 0.0617
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0039 0.0024 0.0011
Brugia malayi hypothetical protein 0.0039 0.0024 0.0011
Schistosoma mansoni neuropeptide receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Brugia malayi hypothetical protein 0.0039 0.0024 0.0011
Brugia malayi AKH receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Toxoplasma gondii MAPEG family protein 0.0893 0.4272 0.4264
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0122 0.0435 0.0477
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0122 0.0435 0.0477
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0064 0.015 0.0154
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0169 0.0673 0.0746
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0144 0.0546 0.0617
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0024 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0024 0.0011
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0024 0.0011
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0093 0.0295 0.0318
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0039 0.0024 0.0011
Onchocerca volvulus 0.0041 0.0035 0.0013
Schistosoma mansoni microsomal glutathione s-transferase 0.0893 0.4272 0.482
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0122 0.0435 0.0477
Brugia malayi Dopamine receptor 0.0039 0.0024 0.0011
Brugia malayi hypothetical protein 0.0039 0.0024 0.0011
Loa Loa (eye worm) steroid hormone receptor 0.0122 0.0435 0.0492
Loa Loa (eye worm) hypothetical protein 0.0535 0.2493 0.2818
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0057 0.0116 0.0105
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0024 0.0011
Schistosoma mansoni amine GPCR 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0057 0.0116 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0122 0.0435 0.0477
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0546 0.0602
Echinococcus multilocularis ecdysone induced protein 78C 0.0122 0.0435 0.0477
Brugia malayi Pre-SET motif family protein 0.0216 0.0905 0.1008
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0169 0.0673 0.0746
Brugia malayi nuclear hormone receptor 0.0057 0.0116 0.0116
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0039 0.0024 0.0011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0024 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0024 0.0011
Loa Loa (eye worm) runx1 0.0058 0.0118 0.0133
Trypanosoma cruzi hypothetical protein, conserved 0.0128 0.0466 0.0512
Plasmodium vivax geranylgeranyltransferase, putative 0.0093 0.0295 0.0318
Schistosoma mansoni hypothetical protein 0.0366 0.1651 0.1853
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0149 0.0574 0.3386
Loa Loa (eye worm) hypothetical protein 0.0459 0.2116 0.2391
Loa Loa (eye worm) hypothetical protein 0.0169 0.0673 0.0761
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0122 0.0435 0.0477
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0057 0.0116 0.0116
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0244 0.1046 0.2378
Loa Loa (eye worm) hypothetical protein 0.0064 0.015 0.017
Loa Loa (eye worm) histone deacetylase 3 0.0052 0.0087 0.0099
Loa Loa (eye worm) hypothetical protein 0.0064 0.015 0.017
Brugia malayi nuclear receptor NHR-67 0.0057 0.0116 0.0116
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0535 0.2493 0.2807
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0057 0.0116 0.0105
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0149 0.0574 0.0634
Brugia malayi glutaminase DH11.1 0.0151 0.0584 0.0646
Schistosoma mansoni neuropeptide receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0122 0.0435 0.0492
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0128 0.0466 0.0512
Schistosoma mansoni thyroid hormone receptor 0.0122 0.0435 0.0477
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0024 0.0011
Brugia malayi G-protein coupled receptor 0.0039 0.0024 0.0011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0122 0.0435 0.0477
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0244 0.1046 0.1169
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0041 0.0035 0.0013
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0149 0.0574 0.0634
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Schistosoma mansoni neuropeptide receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1814 0.8848 1
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.004 0.0031 0.0036
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Brugia malayi Calcitonin receptor-like protein seb-1 0.0535 0.2493 0.2807
Echinococcus multilocularis Protein lozenge 0.0058 0.0118 0.0117
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0341 0.1526 0.1724
Loa Loa (eye worm) isocitrate dehydrogenase 0.0037 0.0014 0.0016
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0122 0.0435 0.0492
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0131 0.0484 0.0532
Echinococcus granulosus neuropeptide s receptor 0.0039 0.0024 0.0011
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0039 0.0024 0.0011
Schistosoma mansoni hypothetical protein 0.004 0.0031 0.002
Giardia lamblia Rab geranylgeranyltransferase 0.0128 0.0466 0.2633
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0093 0.0295 0.1441
Brugia malayi RE15519p 0.0039 0.0024 0.0011
Echinococcus multilocularis orexin receptor type 2 0.0039 0.0024 0.0011
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0128 0.0466 0.0512
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0341 0.1526 0.1711
Echinococcus multilocularis tar DNA binding protein 0.0144 0.0546 0.0602
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0093 0.0295 0.0318
Onchocerca volvulus 0.0041 0.0035 0.0013
Brugia malayi hypothetical protein 0.0459 0.2116 0.2379
Brugia malayi Tachykinin-like peptides receptor 99D 0.0039 0.0024 0.0011
Brugia malayi nuclear receptor NHR-88 0.0057 0.0116 0.0116
Echinococcus granulosus 7TM GPCR rhodopsin 0.0039 0.0024 0.0011
Brugia malayi N-terminal motif family protein 0.0189 0.0772 0.0858
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0039 0.0024 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0093 0.0295 0.0318
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0299 0.132 0.3055
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0039 0.0024 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0024 0.0011
Brugia malayi follicle stimulating hormone receptor 0.0039 0.0024 0.0011
Mycobacterium tuberculosis Hypothetical protein 0.0863 0.4121 0.4649
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0039 0.0024 0.0011
Echinococcus multilocularis serotonin receptor 0.0039 0.0024 0.0011
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0024 0.0011
Brugia malayi nuclear hormone receptor family member odr-7 0.0057 0.0116 0.0116
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0131 0.0484 0.0547
Echinococcus multilocularis FTZ F1 alpha 0.0122 0.0435 0.0477
Onchocerca volvulus 0.0041 0.0035 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0024 0.0011
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0122 0.0435 0.0477
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0024 0.0011
Schistosoma mansoni neuropeptide f receptor 76f 0.0039 0.0024 0.0011
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0024 0.0011
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0128 0.0466 0.0512
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0024 0.0011
Schistosoma mansoni amine GPCR 0.0039 0.0024 0.0011
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0024 0.0011
Echinococcus granulosus peptide allatostatin:somatostatin 0.0039 0.0024 0.0011
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0128 0.0466 0.0939
Loa Loa (eye worm) hypothetical protein 0.0064 0.015 0.017
Plasmodium falciparum histone deacetylase 1 0.0052 0.0087 0.0083
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0299 0.132 0.1478
Trypanosoma cruzi histone deacetylase 1, putative 0.0052 0.0087 0.0083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0024 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0024 0.0011
Brugia malayi histone deacetylase 3 (HD3) 0.0052 0.0087 0.0083
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0093 0.0295 0.0318
Brugia malayi Dopamine receptor protein 2 0.0039 0.0024 0.0011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0024 0.0011
Brugia malayi hypothetical protein 0.025 0.1073 0.1199
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1814 0.8848 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0057 0.0116 0.0116
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0189 0.0772 0.0848
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0122 0.0435 0.0492
Loa Loa (eye worm) hypothetical protein 0.0057 0.0116 0.0131
Brugia malayi Nuclear hormone receptor E75 0.0057 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0057 0.0116 0.0131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0024 0.0011
Brugia malayi histone deacetylase 1 (HD1) 0.0052 0.0087 0.0083
Toxoplasma gondii kringle domain-containing protein 0.004 0.0031 0.0018
Schistosoma mansoni steroid hormone receptor ad4bp 0.0122 0.0435 0.0477
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0546 0.0602
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0039 0.0024 0.0011
Brugia malayi RNA binding protein 0.0144 0.0546 0.0602
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Schistosoma mansoni zinc finger protein 0.0057 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0128 0.0466 0.0512
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Loa Loa (eye worm) hypothetical protein 0.0064 0.015 0.017
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0024 0.0011
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0341 0.1526 0.1711
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0122 0.0435 0.0466
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0039 0.0024 0.0011
Brugia malayi Dopamine receptor protein 1 0.0039 0.0024 0.0011
Echinococcus multilocularis GPCR, family 2 0.0169 0.0673 0.0746
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0149 0.0574 0.0634
Loa Loa (eye worm) hypothetical protein 0.0122 0.0435 0.0492
Echinococcus granulosus microtubule associated protein 2 0.0716 0.339 0.3822
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0122 0.0435 0.0492
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0024 0.0011
Schistosoma mansoni hypothetical protein 0.0169 0.0673 0.0746
Leishmania major histone deacetylase, putative 0.0052 0.0087 0.0083
Echinococcus granulosus alpha 1A adrenergic receptor 0.0039 0.0024 0.0011
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0128 0.0466 0.0512
Echinococcus granulosus histone deacetylase 3 0.0052 0.0087 0.0083
Brugia malayi steroid hormone receptor 0.0122 0.0435 0.0477
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0024 0.0011
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0039 0.0024 0.0011
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0299 0.132 0.1478
Schistosoma mansoni nuclear receptor 0.0057 0.0116 0.0116
Brugia malayi larval opioid receptor 0.0039 0.0024 0.0011
Onchocerca volvulus 0.0128 0.0466 0.0501
Schistosoma mansoni lipoxygenase 0.0068 0.0169 0.0176
Loa Loa (eye worm) hypothetical protein 0.0122 0.0435 0.0492
Schistosoma mansoni thyroid hormone receptor 0.0122 0.0435 0.0477
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Loa Loa (eye worm) hypothetical protein 0.0459 0.2116 0.2391
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1814 0.8848 0.8847
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0341 0.1526 1
Echinococcus granulosus FTZ F1 alpha 0.0122 0.0435 0.0477
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0128 0.0466 0.0512
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0057 0.0116 0.0131
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0024 0.0011
Plasmodium falciparum cysteine repeat modular protein 1 0.004 0.0031 0.002
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0122 0.0435 0.0477
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0093 0.0295 0.0318
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0299 0.132 0.1491
Schistosoma mansoni hypothetical protein 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0149 0.0574 0.0634
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0024 0.0027
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.015 0.0154
Echinococcus granulosus hypothetical protein 0.0039 0.0024 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0064 0.015 0.0154
Leishmania major histone deacetylase, putative 0.0052 0.0087 0.0083
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0299 0.132 0.1478
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0057 0.0116 0.0116
Trypanosoma cruzi lanosterol synthase, putative 0.0211 0.0882 0.0982
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0244 0.1046 0.1034
Loa Loa (eye worm) hypothetical protein 0.0122 0.0435 0.0492
Giardia lamblia Rab geranylgeranyltransferase 0.0341 0.1526 1
Plasmodium vivax histone deacetylase 1, putative 0.0052 0.0087 0.0083
Plasmodium falciparum geranylgeranyltransferase, putative 0.0093 0.0295 0.0318
Schistosoma mansoni nuclear hormone receptor 0.0122 0.0435 0.0477
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0068 0.0169 0.0176
Brugia malayi hypothetical protein 0.0064 0.015 0.0154
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0341 0.1526 0.3566
Toxoplasma gondii hypothetical protein 0.0213 0.0891 0.0878
Echinococcus granulosus somatostatin receptor 0.0039 0.0024 0.0011
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.1814 0.8848 1
Echinococcus granulosus histone deacetylase 1 0.0052 0.0087 0.0083
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0128 0.0466 0.0527
Trypanosoma brucei hypothetical protein, conserved 0.0128 0.0466 0.0512
Brugia malayi conserved hypotetical protein 0.0057 0.0116 0.0116
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0057 0.0116 0.0131
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0024 0.0011
Loa Loa (eye worm) DR-78 0.0057 0.0116 0.0131
Schistosoma mansoni retinoic acid receptor RXR 0.0122 0.0435 0.0477
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0024 0.0011
Echinococcus granulosus tar DNA binding protein 0.0144 0.0546 0.0602
Schistosoma mansoni hypothetical protein 0.0039 0.0024 0.0011
Brugia malayi Kringle domain containing protein 0.004 0.0031 0.002
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0546 0.0602
Brugia malayi ecdysone receptor 0.0057 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0189 0.0772 0.0872
Leishmania major geranylgeranyltransferase, putative 0.0093 0.0295 0.0318
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0039 0.0024 0.0011
Toxoplasma gondii histone deacetylase HDAC2 0.0052 0.0087 0.0073
Schistosoma mansoni biogenic amine receptor 0.0039 0.0024 0.0011
Brugia malayi GnHR receptor homolog 0.0039 0.0024 0.0011
Echinococcus granulosus neuropeptide FF receptor 2 0.0039 0.0024 0.0011
Schistosoma mansoni neuropeptide receptor 0.0039 0.0024 0.0011
Brugia malayi G protein-coupled receptor F59B2.13 0.0039 0.0024 0.0011
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0299 0.132 0.1478
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0039 0.0024 0.0011
Echinococcus multilocularis dro:myosuppressin receptor 0.0039 0.0024 0.0011
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0041 0.0035 0.0024
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0299 0.132 0.1478
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0122 0.0435 0.0477
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Brugia malayi putative neuropeptide receptor NPR1 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0122 0.0435 0.0492
Echinococcus granulosus neuropeptide receptor A26 0.0039 0.0024 0.0011
Brugia malayi Steroid receptor seven-up type 2 0.0122 0.0435 0.0477
Schistosoma mansoni amine GPCR 0.0039 0.0024 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0546 0.0602
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0122 0.0435 0.0477
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0057 0.0116 0.0116
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0057 0.0116 0.0116
Plasmodium vivax cysteine repeat modular protein 1, putative 0.004 0.0031 0.002
Onchocerca volvulus Bile acid receptor homolog 0.0122 0.0435 0.0466
Trichomonas vaginalis conserved hypothetical protein 0.0863 0.4121 1
Echinococcus granulosus g protein coupled receptor 0.0039 0.0024 0.0011
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0093 0.0295 0.0318
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0064 0.015 0.0154
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0128 0.0466 0.0512
Brugia malayi hypothetical protein 0.0057 0.0116 0.0116
Brugia malayi photoreceptor-specific nuclear receptor 0.0122 0.0435 0.0477
Echinococcus multilocularis neuropeptide s receptor 0.0039 0.0024 0.0011
Echinococcus multilocularis neuropeptide FF receptor 2 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Loa Loa (eye worm) melatonin receptor type 1A 0.0039 0.0024 0.0027
Echinococcus granulosus thyroid hormone receptor alpha 0.0057 0.0116 0.0116
Schistosoma mansoni hypothetical protein 0.0169 0.0673 0.0746
Onchocerca volvulus 0.1814 0.8848 1
Brugia malayi TAR-binding protein 0.0144 0.0546 0.0602
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0039 0.0024 0.0027
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0366 0.1651 0.1866
Brugia malayi Nuclear hormone receptor E75 0.0057 0.0116 0.0116
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0024 0.0011
Echinococcus granulosus Nuclear hormone receptor HR96 0.0057 0.0116 0.0116
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0122 0.0435 0.0477
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0068 0.0169 0.0176
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0122 0.0435 0.0492
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0039 0.0024 0.0011
Echinococcus multilocularis G protein coupled receptor 139 0.0039 0.0024 0.0011
Onchocerca volvulus 0.004 0.0031 0.0009
Giardia lamblia Rab geranylgeranyltransferase 0.0093 0.0295 0.1441
Echinococcus multilocularis microtubule associated protein 2 0.0716 0.339 0.3822
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0039 0.0024 0.0011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0169 0.0673 0.0746
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0024 0.0011
Onchocerca volvulus 0.0459 0.2116 0.2371
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0122 0.0435 0.0477
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0169 0.0673 0.0746
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0039 0.0024 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0546 0.0602
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0041 0.0035 0.0024
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0024 0.0011
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0244 0.1046 0.1169
Trichomonas vaginalis glutaminase, putative 0.0151 0.0584 0.1232
Schistosoma mansoni hypothetical protein 0.0169 0.0673 0.0746
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0535 0.2493 0.2818
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0024 0.0011
Brugia malayi putative neuropeptide receptor 0.0039 0.0024 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0116 0.0116
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0122 0.0435 0.0477
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0057 0.0116 0.0131
Echinococcus granulosus ecdysone induced protein 78C 0.0122 0.0435 0.0477
Echinococcus granulosus nuclear receptor nhr 48 0.0057 0.0116 0.0116
Loa Loa (eye worm) TAR-binding protein 0.0144 0.0546 0.0617
Loa Loa (eye worm) nuclear hormone receptor 0.0057 0.0116 0.0131
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0093 0.0295 0.0514
Brugia malayi hypothetical protein 0.0057 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0122 0.0435 0.0492
Echinococcus granulosus serotonin receptor 0.0039 0.0024 0.0011
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1814 0.8848 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.0435 0.0492
Brugia malayi Latrophilin receptor protein 2 0.0169 0.0673 0.0746
Brugia malayi G protein-coupled receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Leishmania major lanosterol synthase, putative 0.0118 0.0418 0.0457
Echinococcus granulosus Nuclear hormone receptor HR96 0.0057 0.0116 0.0116
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0863 0.4121 0.4649
Echinococcus granulosus g-protein coupled receptor 0.0039 0.0024 0.0011
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0128 0.0466 0.0512
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0039 0.0024 0.0011
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0128 0.0466 0.0512
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0244 0.1046 0.2378
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1814 0.8848 1
Echinococcus multilocularis neuropeptide receptor A26 0.0039 0.0024 0.0011
Brugia malayi thymidylate synthase 0.1814 0.8848 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0122 0.0435 0.0477
Leishmania major farnesyltransferase beta subunit 0.0244 0.1046 0.1169
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.1814 0.8848 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0122 0.0435 0.0477
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0341 0.1526 0.3566
Trypanosoma cruzi lanosterol synthase, putative 0.0211 0.0882 0.0982
Echinococcus multilocularis sex peptide receptor 0.0039 0.0024 0.0011
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0024 0.0011
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0128 0.0466 0.0512
Echinococcus granulosus G protein coupled receptor 139 0.0039 0.0024 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0122 0.0435 0.0477
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0024 0.0027
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0039 0.0024 0.0011
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0149 0.0574 0.0561
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.015 0.0154
Giardia lamblia Prenyltransferase 0.0244 0.1046 0.6668
Brugia malayi sulfakinin receptor protein 0.025 0.1073 0.1199
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0244 0.1046 0.1169
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0122 0.0435 0.0477
Loa Loa (eye worm) hypothetical protein 0.0057 0.0116 0.0131
Echinococcus granulosus neuropeptide receptor 0.0039 0.0024 0.0011
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0039 0.0024 0.0011
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0213 0.0891 0.1992
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Schistosoma mansoni opsin-like receptor 0.0039 0.0024 0.0011
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0128 0.0466 0.0512
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0116 0.0116
Schistosoma mansoni histamine h1 receptor 0.0039 0.0024 0.0011
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.1814 0.8848 1
Schistosoma mansoni coup transcription factor 0.0122 0.0435 0.0477
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0093 0.0295 0.0281
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0244 0.1046 0.1169
Trypanosoma brucei lanosterol synthase 0.0211 0.0882 0.0982
Loa Loa (eye worm) hypothetical protein 0.0093 0.0295 0.0333
Echinococcus multilocularis tissue type plasminogen activator 0.004 0.0031 0.002
Loa Loa (eye worm) hypothetical protein 0.0341 0.1526 0.1724
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0244 0.1046 0.2378
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0024 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0122 0.0435 0.0477
Schistosoma mansoni biogenic amine receptor 0.0039 0.0024 0.0011
Onchocerca volvulus Protein ultraspiracle homolog 0.0122 0.0435 0.0466
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0227 0.0959 0.107
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0116 0.0116
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0057 0.0116 0.0116
Loa Loa (eye worm) histone deacetylase 1 0.0052 0.0087 0.0099
Schistosoma mansoni amine GPCR 0.0039 0.0024 0.0011
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0149 0.0574 0.0634
Schistosoma mansoni hypothetical protein 0.0039 0.0024 0.0011
Brugia malayi hypothetical protein 0.0039 0.0024 0.0011
Schistosoma mansoni nuclear receptor nhr-48 0.0057 0.0116 0.0116
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0024 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0093 0.0295 0.0333
Schistosoma mansoni opsin-like receptor 0.0039 0.0024 0.0011
Echinococcus granulosus tachykinin peptides receptor 99D 0.0039 0.0024 0.0011
Loa Loa (eye worm) TK/ROR protein kinase 0.004 0.0031 0.0036
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0244 0.1046 0.2378
Loa Loa (eye worm) hypothetical protein 0.0064 0.015 0.017
Brugia malayi nuclear hormone receptor family member nhr-6 0.0057 0.0116 0.0116
Trichomonas vaginalis set domain proteins, putative 0.0246 0.1053 0.2394
Schistosoma mansoni adenoreceptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0211 0.0882 0.0982
Echinococcus multilocularis nuclear receptor nhr 48 0.0057 0.0116 0.0116
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Brugia malayi hypothetical protein 0.0039 0.0024 0.0011
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0122 0.0435 0.0477
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0128 0.0466 0.0512
Loa Loa (eye worm) hypothetical protein 0.0227 0.0959 0.1084
Schistosoma mansoni RAR-like nuclear receptor 0.0122 0.0435 0.0477
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0064 0.015 0.0154
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Echinococcus granulosus thymidylate synthase 0.1814 0.8848 1
Brugia malayi neuropeptide F receptor 0.0039 0.0024 0.0011
Brugia malayi nuclear receptor NHR-88 0.0122 0.0435 0.0477
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0341 0.1526 0.1711
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0128 0.0466 0.0512
Toxoplasma gondii hypothetical protein 0.0128 0.0466 0.0453
Schistosoma mansoni lozenge 0.0058 0.0118 0.0117
Onchocerca volvulus 0.0041 0.0035 0.0013
Echinococcus multilocularis somatostatin receptor 0.0039 0.0024 0.0011
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1814 0.8848 1
Onchocerca volvulus 0.0202 0.0833 0.0917
Echinococcus granulosus orexin receptor type 2 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Brugia malayi RNA recognition motif domain containing protein 0.0144 0.0546 0.0602
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0122 0.0435 0.0477
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0039 0.0024 0.0027
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.0905 0.1022
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0039 0.0024 0.0011
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0064 0.015 0.017
Onchocerca volvulus 0.0057 0.0116 0.0105
Schistosoma mansoni microtubule-associated protein tau 0.0716 0.339 0.3822
Brugia malayi Nuclear hormone receptor-like 1 0.0122 0.0435 0.0477
Loa Loa (eye worm) TYRA-2 protein 0.0039 0.0024 0.0027
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0093 0.0295 0.0318
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0341 0.1526 0.1711
Schistosoma mansoni glutaminase 0.0151 0.0584 0.0646
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0122 0.0435 0.0492
Brugia malayi hypothetical protein 0.0039 0.0024 0.0011
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0244 0.1046 0.2378
Schistosoma mansoni nuclear receptor 0.0057 0.0116 0.0116
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0039 0.0024 0.0011
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0128 0.0466 0.0512
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0024 0.0011
Echinococcus multilocularis thyroid hormone receptor alpha 0.0122 0.0435 0.0477
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0122 0.0435 0.0492
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0244 0.1046 0.1169
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0024 0.0011
Brugia malayi tailless protein 0.0057 0.0116 0.0116
Echinococcus granulosus neuropeptide receptor 0.0039 0.0024 0.0011
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0244 0.1046 0.1169
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0227 0.0959 0.107
Schistosoma mansoni hypothetical protein 0.0039 0.0024 0.0011
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0057 0.0116 0.0116
Trypanosoma brucei histone deacetylase 1 0.0052 0.0087 0.0083
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0122 0.0435 0.0477
Echinococcus granulosus GPCR family 2 0.0169 0.0673 0.0746
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0131 0.0484 0.0532
Brugia malayi Protein kinase domain containing protein 0.004 0.0031 0.002
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0122 0.0435 0.0477
Brugia malayi hypothetical protein 0.0039 0.0024 0.0011
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0039 0.0024 0.0027
Brugia malayi nuclear hormone receptor 0.0122 0.0435 0.0477
Echinococcus granulosus fmrfamide receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.025 0.1073 0.1213
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0122 0.0435 0.0477
Schistosoma mansoni growth hormone secretagogue receptor 0.0039 0.0024 0.0011
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0122 0.0435 0.0477
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0341 0.1526 0.1711
Loa Loa (eye worm) hypothetical protein 0.0057 0.0116 0.0131
Echinococcus multilocularis G-protein coupled receptor, putative 0.0039 0.0024 0.0011
Echinococcus granulosus sex peptide receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0151 0.0583 0.0644
Brugia malayi orphan nuclear receptor NR2E1 0.0057 0.0116 0.0116
Echinococcus granulosus tissue type plasminogen activator 0.004 0.0031 0.002
Loa Loa (eye worm) nuclear receptor NHR-67 0.0057 0.0116 0.0131
Echinococcus granulosus 7tm_1 domain containing protein 0.0039 0.0024 0.0011
Schistosoma mansoni histone deacetylase 0.0052 0.0087 0.0083
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.0099
Brugia malayi latrophilin 2 splice variant baaae 0.0366 0.1651 0.1853
Onchocerca volvulus 0.0122 0.0435 0.0466
Brugia malayi nuclear receptor RXR 0.0057 0.0116 0.0116
Schistosoma mansoni histone deacetylase 0.0052 0.0087 0.0083
Loa Loa (eye worm) hypothetical protein 0.0057 0.0116 0.0131
Brugia malayi Serotonin receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0227 0.0959 0.1084
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0093 0.0295 0.0514
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0093 0.0295 0.0318
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0093 0.0295 0.0281
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Trypanosoma cruzi histone deacetylase 1, putative 0.0052 0.0087 0.0083
Echinococcus granulosus g protein coupled receptor 0.0039 0.0024 0.0011
Echinococcus granulosus allatostatin A receptor 0.0039 0.0024 0.0011
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0893 0.4272 0.482
Echinococcus multilocularis thymidylate synthase 0.1814 0.8848 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0122 0.0435 0.0477
Echinococcus multilocularis histone deacetylase 1 0.0052 0.0087 0.0083
Echinococcus multilocularis g-protein coupled receptor 0.0039 0.0024 0.0011
Brugia malayi G-protein coupled receptor 0.0039 0.0024 0.0011
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0131 0.0484 0.0532
Echinococcus multilocularis allatostatin A receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0341 0.1526 0.1711
Echinococcus granulosus microsomal glutathione S transferase 3 0.0893 0.4272 0.482
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0128 0.0466 0.2633
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Loa Loa (eye worm) latrophilin receptor protein 2 0.0169 0.0673 0.0761
Brugia malayi Serotonin receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0128 0.0466 0.0512
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0024 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0122 0.0435 0.0477
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0244 0.1046 0.6668
Schistosoma mansoni amine GPCR 0.0039 0.0024 0.0011
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0244 0.1046 0.2378
Brugia malayi Histone deacetylase 1 0.0052 0.0087 0.0083
Leishmania major hypothetical protein, conserved 0.004 0.0031 0.002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0024 0.0011
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0024 0.0011
Mycobacterium ulcerans thymidylate synthase 0.1814 0.8848 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0122 0.0435 0.0477
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0024 0.0011
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0057 0.0116 0.0131
Loa Loa (eye worm) hypothetical protein 0.0122 0.0435 0.0492
Brugia malayi hypothetical protein 0.0064 0.015 0.0154
Loa Loa (eye worm) glutaminase 0.0151 0.0584 0.066
Schistosoma mansoni biogenic amine receptor 0.0039 0.0024 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0122 0.0435 0.0477
Schistosoma mansoni alpha-1 adrenergic receptor 0.0039 0.0024 0.0011
Schistosoma mansoni hypothetical protein 0.0169 0.0673 0.0746
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0024 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0122 0.0435 0.0477
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0169 0.0673 0.0746
Brugia malayi nuclear receptor RXR 0.0064 0.015 0.0154
Brugia malayi hypothetical protein 0.0039 0.0024 0.0011
Onchocerca volvulus 0.0227 0.0959 0.106
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Loa Loa (eye worm) hypothetical protein 0.0149 0.0574 0.0649
Onchocerca volvulus 0.0057 0.0116 0.0105
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0244 0.1046 0.1183
Schistosoma mansoni opsin-like receptor 0.0039 0.0024 0.0011
Brugia malayi hypothetical protein 0.0039 0.0024 0.0011
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0299 0.132 0.8568
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0122 0.0435 0.0477
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0039 0.0024 0.0011
Schistosoma mansoni lipoxygenase 0.0048 0.0067 0.0061
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0024 0.0011
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0024 0.0011
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Brugia malayi Melatonin receptor type 1A 0.0039 0.0024 0.0011
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) thymidylate synthase 0.1814 0.8848 1
Brugia malayi Trypsin family protein 0.0227 0.0959 0.107
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0122 0.0435 0.0477
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0024 0.0011
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0341 0.1526 0.3566
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0031 0.002
Trypanosoma cruzi protein farnesyltransferase, putative 0.0244 0.1046 0.1169
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0024 0.0027
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0893 0.4272 0.482
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0041 0.0035 0.0024
Echinococcus multilocularis histone deacetylase 3 0.0052 0.0087 0.0083
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0244 0.1046 0.1169
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0024 0.0011
Toxoplasma gondii histone deacetylase HDAC3 0.0052 0.0087 0.0073
Brugia malayi neuropeptide F receptor 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027
Brugia malayi ecdysteroid receptor 0.0122 0.0435 0.0477
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0039 0.0024 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0024 0.0011
Schistosoma mansoni myosin xvIII 0.0039 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0057 0.0116 0.0131
Brugia malayi hypothetical protein 0.0863 0.4121 0.4649
Loa Loa (eye worm) glutaminase 2 0.0151 0.0584 0.066
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0024 0.0011
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0122 0.0435 0.0477
Trypanosoma cruzi protein farnesyltransferase, putative 0.0244 0.1046 0.1169
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0057 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0027

Activities

Activity type Activity value Assay description Source Reference
Agonist activity (functional) = 98 Evaluated for its agonistic activity using rat uterus bioassay in Dawley rats (% of ANG II) ChEMBL. 8464045

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.