Detailed information for compound 405740

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1180.9 | Formula: C58H43Cl2N7O17
  • H donors: 13 H acceptors: 14 LogP: 2.78 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 4
  • SMILES: Oc1cc2cc(c1)C1NC(=O)C(Cc3ccc(c(c3)Cl)Oc3cc4C(NC1=O)C(=O)NC1C(=O)/N=C(\Cc5ccc(Oc(c4)c3O)c(Cl)c5)/C(=O)N[C@@H](c3c(c4cc1ccc4O)c(O)cc(c3)O)C(=O)O)NC(=O)[C@@H](c1cc(O2)c(O)cc1)N
  • InChi: 1S/C58H43Cl2N7O17/c59-33-9-22-1-7-40(33)83-43-17-27-18-44(51(43)73)84-41-8-2-23(10-34(41)60)12-36-53(75)67-50(58(80)81)32-20-29(69)21-39(72)45(32)31-15-25(4-5-37(31)70)47(55(77)63-36)65-57(79)49(27)66-56(78)48-26-13-28(68)19-30(14-26)82-42-16-24(3-6-38(42)71)46(61)54(76)62-35(11-22)52(74)64-48/h1-10,13-21,35,46-50,68-73H,11-12,61H2,(H,62,76)(H,64,74)(H,65,79)(H,66,78)(H,67,75)(H,80,81)/b63-36+/t35?,46-,47?,48?,49?,50+/m1/s1
  • InChiKey: PWUDQUICAQSQQA-IWFVSKBNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.5854 1 1
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.4191 0.7154 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0017 0.0013 0.0013
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.1017 0.1723 0.2402
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0019 0.0016
Echinococcus granulosus equilibrative nucleoside transporter 3 0.5854 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.004 0.0027
Schistosoma mansoni adenosine kinase 0.1437 0.2442 0.3413
Giardia lamblia Ribokinase 0.0164 0.0264 0.0255
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0017 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0047 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0009
Trypanosoma brucei adenosine kinase, putative 0.1437 0.2442 0.3407
Trypanosoma brucei PAB1-binding protein , putative 0.0021 0.002 0.0019
Toxoplasma gondii LsmAD domain-containing protein 0.0021 0.002 0.0079
Echinococcus multilocularis regulator of G protein signaling 7 0.0017 0.0013 0.0013
Trichomonas vaginalis S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0004
Mycobacterium ulcerans beta-lactamase 0.0032 0.004 0.1065
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0032 0.0039 0.0039
Plasmodium falciparum S-adenosylmethionine synthetase 0.0019 0.0016 0.1066
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0032 0.0039 0.0039
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.002 0.1667
Echinococcus multilocularis regulator of G protein signaling 3 0.0017 0.0013 0.0013
Echinococcus granulosus beta LACTamase domain containing family member 0.0032 0.004 0.004
Loa Loa (eye worm) PXA domain-containing protein 0.0017 0.0013 0.0013
Brugia malayi cytoplasmic intermediate filament protein 0.0026 0.0028 0.0028
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0164 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0033 0.0041 0.0041
Loa Loa (eye worm) latrophilin receptor protein 2 0.0013 0.0006 0.0006
Plasmodium vivax 6-phosphofructokinase, putative 0.0052 0.0073 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0023 0.0023 0.0023
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.5854 1 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0019 0.0016
Echinococcus multilocularis tumor protein p63 0.0304 0.0504 0.0504
Mycobacterium ulcerans fructokinase, PfkB 0.0164 0.0264 0.841
Schistosoma mansoni zinc finger protein 0.002 0.0018 0.0026
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0016 0.0011 0.019
Loa Loa (eye worm) pyruvate kinase 0.0029 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.5854 1 1
Entamoeba histolytica phosphofructokinase, putative 0.0192 0.0313 0.0301
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.0225 0.0225
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0011
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0042 0.0056 0.0056
Schistosoma mansoni regulator of G protein signaling 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0011
Leishmania major ribokinase, putative 0.0164 0.0264 0.036
Trypanosoma brucei S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0013
Giardia lamblia Histone acetyltransferase GCN5 0.0034 0.0042 0.0033
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0016 0.0011 0.0011
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.1017 0.1723 0.1713
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0021
Echinococcus granulosus axis inhibition protein axin 0.0017 0.0013 0.0013
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.004 0.0046
Trichomonas vaginalis penicillin-binding protein, putative 0.0032 0.004 0.0027
Echinococcus multilocularis pyruvate kinase 0.0029 0.0034 0.0034
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.004 0.0027
Schistosoma mansoni hypothetical protein 0.0013 0.0006 0.0008
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.002 0.0018 0.0025
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0017 0.0014 0.0014
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0032 0.0039 0.0039
Brugia malayi S-adenosylmethionine synthetase 0.0019 0.0016 0.0016
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0031 0.0037 0.0037
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.1017 0.1723 0.2402
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0052 0.0073 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0011 0.0011
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.4191 0.7154 1
Leishmania major nucleoside transporter 1, putative 0.1017 0.1723 0.2402
Echinococcus multilocularis Protein lozenge 0.0048 0.0067 0.0067
Brugia malayi MH2 domain containing protein 0.012 0.019 0.019
Loa Loa (eye worm) acetyltransferase 0.0128 0.0203 0.0203
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0011 0.0044
Schistosoma mansoni zinc finger protein 0.0013 0.0007 0.001
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.5854 1 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0011 0.0011
Plasmodium falciparum flap endonuclease 1 0.0023 0.0023 0.2091
Trypanosoma brucei ribokinase, putative 0.0164 0.0264 0.036
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0062 0.0091 0.0091
Brugia malayi hypothetical protein 0.0205 0.0335 0.0335
Brugia malayi regulator of G-protein signaling egl-10 0.0017 0.0013 0.0013
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0128 0.0203 0.0284
Wolbachia endosymbiont of Brugia malayi S-adenosylmethionine synthetase 0.0019 0.0016 0.5
Echinococcus granulosus expressed protein 0.0324 0.0539 0.0539
Echinococcus granulosus ribokinase 0.0164 0.0264 0.0264
Entamoeba histolytica DNA repair and recombination protein, putative 0.4191 0.7154 0.7151
Trypanosoma cruzi pyruvate kinase 2, putative 0.0029 0.0034 0.0038
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0016 0.0011 0.0011
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0011 0.0006
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0016 0.0011 0.0011
Echinococcus multilocularis axis inhibition protein axin 0.0017 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0013 0.0007 0.001
Entamoeba histolytica nucleoside transporter, putative 0.5854 1 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.002 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.4191 0.7154 0.7151
Trypanosoma brucei S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0013
Echinococcus granulosus lamin 0.0048 0.0066 0.0066
Entamoeba histolytica ribokinase, putative 0.0164 0.0264 0.0252
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.1017 0.1723 0.2402
Loa Loa (eye worm) cytochrome P450 0.0013 0.0007 0.0007
Leishmania major hypothetical protein, conserved 0.0032 0.004 0.0046
Onchocerca volvulus 0.0032 0.004 0.0006
Trypanosoma brucei unspecified product 0.1017 0.1723 0.2402
Mycobacterium leprae conserved hypothetical protein 0.0032 0.004 0.1065
Echinococcus granulosus S adenosylmethionine synthase type 1 0.0019 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.1017 0.1723 0.1723
Echinococcus granulosus equilibrative nucleoside transporter 0.5854 1 1
Schistosoma mansoni protein kinase 0.1017 0.1724 0.241
Trypanosoma brucei adenosine transporter 2, putative 0.1017 0.1723 0.2402
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0011 0.0006
Schistosoma mansoni methyl-cpg binding protein mbd 0.0015 0.0009 0.0013
Brugia malayi hypothetical protein 0.0017 0.0013 0.0013
Echinococcus granulosus beta-adrenergic receptor kinase 0.0017 0.0014 0.0014
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0011 0.0006
Schistosoma mansoni 6-phosphofructokinase 0.0192 0.0313 0.0437
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0011 0.0044
Trypanosoma cruzi adenosine kinase, putative 0.1437 0.2442 0.3407
Toxoplasma gondii nucleoside transporter protein 0.1017 0.1723 0.7057
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0036
Echinococcus granulosus pyruvate kinase 0.0015 0.001 0.001
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0164 0.0264 0.0264
Echinococcus multilocularis pyruvate kinase 0.0015 0.001 0.001
Loa Loa (eye worm) intermediate filament protein 0.0048 0.0066 0.0066
Giardia lamblia Rrm3p helicase 0.4191 0.7154 0.7151
Toxoplasma gondii cytochrome p450 superfamily protein 0.0013 0.0007 0.0026
Trypanosoma brucei nucleoside transporter 1, putative 0.1017 0.1723 0.2402
Onchocerca volvulus 0.0044 0.006 0.0027
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0019 0.0006
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.0095 0.0384
Entamoeba histolytica hypothetical protein 0.0032 0.0039 0.0026
Trypanosoma brucei S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0013
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0055 0.0078 0.0078
Mycobacterium tuberculosis Conserved protein 0.0032 0.004 0.0984
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.0087 0.0087
Trichomonas vaginalis esterase, putative 0.0032 0.004 0.0027
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0019 0.0016
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0087 0.0112
Trichomonas vaginalis ribokinase, putative 0.0164 0.0264 0.0252
Trypanosoma brucei unspecified product 0.1017 0.1723 0.2402
Echinococcus granulosus methyl CpG binding domain protein 2 0.0015 0.0009 0.0009
Mycobacterium leprae Probable lipase LipE 0.0032 0.004 0.1065
Entamoeba histolytica S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0004
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.4191 0.7154 0.7154
Trypanosoma cruzi nucleoside transporter-like, putative 0.1017 0.1723 0.2402
Loa Loa (eye worm) hypothetical protein 0.0032 0.004 0.004
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.4191 0.7154 0.7154
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0048 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0062 0.0091 0.0091
Schistosoma mansoni pyruvate kinase 0.0029 0.0034 0.0047
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.4838 0.8261 0.8261
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0062 0.0091 0.0091
Schistosoma mansoni S-adenosylmethionine synthetase 0.0019 0.0016 0.0023
Echinococcus granulosus fetal alzheimer antigen falz 0.002 0.0018 0.0018
Leishmania major hypothetical protein, conserved 0.0021 0.002 0.0019
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.1017 0.1723 0.2402
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0062 0.0091 0.0091
Echinococcus granulosus zinc finger protein 0.002 0.0018 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0052 0.0073 0.006
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0052 0.0073 0.0063
Loa Loa (eye worm) 6-phosphofructokinase 0.0192 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0032 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0013 0.0006 0.0008
Echinococcus granulosus regulator of G protein signaling 3 0.0017 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0044 0.0061
Trichomonas vaginalis S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0004
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.1017 0.1723 0.1713
Trypanosoma brucei cytochrome P450, putative 0.0029 0.0033 0.0037
Entamoeba histolytica hypothetical protein 0.0032 0.0039 0.0026
Onchocerca volvulus 0.0032 0.004 0.0006
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0013
Schistosoma mansoni flap endonuclease-1 0.002 0.0019 0.0027
Echinococcus multilocularis muscleblind protein 1 0.0264 0.0436 0.0436
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.1017 0.1723 0.1713
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0011 0.0041
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.004 0.0053 0.0053
Schistosoma mansoni blooms syndrome DNA helicase 0.003 0.0035 0.0049
Onchocerca volvulus 0.0032 0.004 0.0006
Echinococcus multilocularis pyruvate kinase 0.0015 0.001 0.001
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0087 0.0075
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0013
Brugia malayi Bromodomain containing protein 0.0068 0.0101 0.0101
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.5854 1 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0032 0.004 0.004
Trypanosoma cruzi ribokinase, putative 0.0164 0.0264 0.036
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0087 0.0075
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0023
Entamoeba histolytica pyruvate kinase, putative 0.002 0.0019 0.0006
Brugia malayi regulator of G-protein signaling rgs-7 0.0017 0.0013 0.0013
Schistosoma mansoni survival motor neuron protein 0.0042 0.0056 0.0078
Plasmodium vivax ataxin-2 like protein, putative 0.0021 0.002 0.1667
Plasmodium vivax S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.1066
Leishmania major adenosine kinase, putative 0.1437 0.2442 0.3407
Trichomonas vaginalis S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0004
Entamoeba histolytica hypothetical protein 0.0032 0.0039 0.0026
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0015 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0032 0.004 0.004
Echinococcus multilocularis regulator of G protein signaling 7 0.0017 0.0013 0.0013
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.004 0.0027
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.002 0.0019
Trichomonas vaginalis phosphofructokinase, putative 0.0052 0.0073 0.006
Brugia malayi beta-lactamase 0.0032 0.004 0.004
Schistosoma mansoni pyruvate kinase 0.0015 0.001 0.0013
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0011
Trypanosoma cruzi nucleobase transporter, putative 0.1017 0.1723 0.2402
Schistosoma mansoni axis inhibition protein axin 0.0017 0.0013 0.0018
Echinococcus multilocularis pyruvate kinase 0.0029 0.0034 0.0034
Brugia malayi hypothetical protein 0.0021 0.002 0.002
Trypanosoma brucei S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0013
Schistosoma mansoni hypothetical protein 0.0013 0.0006 0.0008
Echinococcus granulosus GPCR family 2 0.0013 0.0006 0.0006
Onchocerca volvulus Ribokinase homolog 0.0164 0.0264 0.0231
Onchocerca volvulus 0.0385 0.0642 0.061
Brugia malayi Ribokinase 0.0164 0.0264 0.0264
Loa Loa (eye worm) RecQ helicase 0.0038 0.0049 0.0049
Loa Loa (eye worm) STAT protein 0.0132 0.0211 0.0211
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.0164 0.0264 0.7769
Brugia malayi Adenosine kinase-like 0.1437 0.2442 0.2442
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0026 0.0028 0.2872
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0087 0.0075
Brugia malayi Regulator of G protein signaling domain containing protein 0.0017 0.0013 0.0013
Echinococcus granulosus lamin dm0 0.0048 0.0066 0.0066
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0022
Brugia malayi PXA domain containing protein 0.0017 0.0013 0.0013
Schistosoma mansoni z-protein (S1r protein) 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0011
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0052 0.0073 1
Trypanosoma brucei ribokinase, putative 0.0164 0.0264 0.036
Mycobacterium ulcerans hypothetical protein 0.0032 0.004 0.1065
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0033 0.0037
Loa Loa (eye worm) hypothetical protein 0.0044 0.006 0.006
Trypanosoma brucei adenosine transporter 2 0.1017 0.1723 0.2402
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0087 0.0122
Brugia malayi latrophilin 2 splice variant baaae 0.0027 0.0031 0.0031
Leishmania major adenosine kinase-like protein 0.0164 0.0264 0.036
Echinococcus granulosus flap endonuclease 1 0.0023 0.0023 0.0023
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0029 0.0034 0.0807
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.002 0.1667
Onchocerca volvulus 0.0048 0.0066 0.0032
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.5854 1 1
Schistosoma mansoni DNA helicase recq1 0.0016 0.0011 0.0015
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0011 0.0284
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0015 0.0009 0.0013
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0011 0.0133
Loa Loa (eye worm) DEAH box polypeptide 35 0.0039 0.005 0.005
Brugia malayi Cytochrome P450 family protein 0.0052 0.0072 0.0072
Trichomonas vaginalis S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0004
Leishmania major S-adenosylmethionine synthetase 0.0019 0.0016 0.0013
Giardia lamblia Kinase, CMGC MAPK 0.006 0.0087 0.0078
Schistosoma mansoni methyl-cpg binding protein mbd 0.0015 0.0009 0.0013
Trypanosoma cruzi S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0013
Brugia malayi 6-phosphofructokinase 0.0192 0.0313 0.0313
Brugia malayi Bloom's syndrome protein homolog 0.0038 0.0049 0.0049
Plasmodium vivax hypothetical protein, conserved 0.0032 0.004 0.4728
Schistosoma mansoni lamin 0.0048 0.0066 0.0092
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0207 0.0338 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0011 0.0016
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0017 0.0013 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0015 0.0009 0.0013
Schistosoma mansoni regulator of G protein signaling 0.0017 0.0013 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0225 0.0225
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0032 0.0039 0.0039
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0011 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0225 0.0315
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.0087 0.0087
Leishmania major putative PfkB family sugar kinase 0.0164 0.0264 0.036
Brugia malayi beta-lactamase family protein 0.0032 0.004 0.004
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0031 0.0037 0.0037
Loa Loa (eye worm) CYP4Cod1 0.0029 0.0033 0.0033
Brugia malayi hypothetical protein 0.0164 0.0264 0.0264
Trypanosoma brucei adenosine transporter, putative 0.1017 0.1723 0.2402
Echinococcus multilocularis 0.0013 0.0007 0.0007
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0055 0.0078 0.0078
Giardia lamblia Sgs1 DNA helicase, putative 0.0016 0.0011 0.0001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.0225 0.0225
Echinococcus granulosus regulator of G protein signaling 7 0.0017 0.0013 0.0013
Mycobacterium tuberculosis Conserved protein 0.0032 0.004 0.0984
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0062 0.0091 0.0127
Brugia malayi Pyruvate kinase, muscle isozyme 0.0029 0.0034 0.0034
Trypanosoma brucei S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0013
Schistosoma mansoni hypothetical protein 0.0032 0.0039 0.0054
Entamoeba histolytica phosphofructokinase, putative 0.0192 0.0313 0.0301
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0044 0.0061
Toxoplasma gondii kinase, pfkB family protein 0.0164 0.0264 0.1079
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0016 0.0011 0.0011
Trichomonas vaginalis ribokinase, putative 0.0164 0.0264 0.0252
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0011
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0032 0.004 0.0984
Loa Loa (eye worm) hypothetical protein 0.0032 0.004 0.004
Brugia malayi 6-phosphofructokinase 0.0192 0.0313 0.0313
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0192 0.0313 1
Schistosoma mansoni hypothetical protein 0.0042 0.0056 0.0078
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0011 0.0011
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.4191 0.7154 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0013 0.0006 0.0006
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0032 0.004 0.0984
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.0164 0.0264 0.0252
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0052 0.0073 0.006
Trichomonas vaginalis pyruvate kinase, putative 0.0029 0.0034 0.0021
Echinococcus multilocularis survival motor neuron protein 1 0.0205 0.0335 0.0335
Trypanosoma cruzi nucleoside transporter 1, putative 0.1017 0.1723 0.2402
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0032 0.004 0.0984
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0032 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0031
Trypanosoma cruzi adenosine kinase, putative 0.0164 0.0264 0.036
Schistosoma mansoni hypothetical protein 0.0013 0.0006 0.0008
Echinococcus multilocularis GPCR, family 2 0.0013 0.0006 0.0006
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0015 0.0009 0.0009
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0039 0.0051 0.0038
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.5854 1 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0034 0.0042 0.5145
Toxoplasma gondii phosphofructokinase PFKII 0.0052 0.0073 0.0296
Toxoplasma gondii kinase, pfkB family protein 0.1437 0.2442 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.004 0.004
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0055 0.0078 0.0078
Echinococcus multilocularis adenosine kinase 0.1437 0.2442 0.2442
Trypanosoma brucei purine nucleoside transporter 0.1017 0.1723 0.2402
Echinococcus multilocularis beta LACTamase domain containing family member 0.0032 0.004 0.004
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0039 0.0051 0.6533
Brugia malayi hypothetical protein 0.1017 0.1723 0.1723
Toxoplasma gondii pyruvate kinase PyK1 0.0029 0.0034 0.0135
Toxoplasma gondii nucleoside transporter protein 0.1017 0.1723 0.7057
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0192 0.0313 1
Entamoeba histolytica S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0004
Echinococcus multilocularis lamin dm0 0.0048 0.0066 0.0066
Echinococcus multilocularis Regulator of G protein signaling 20 0.0017 0.0013 0.0013
Schistosoma mansoni bromodomain containing protein 0.0058 0.0083 0.0117
Trypanosoma cruzi nucleobase transporter, putative 0.1017 0.1723 0.2402
Trypanosoma cruzi adenosine kinase, putative 0.1437 0.2442 0.3407
Entamoeba histolytica S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0004
Trypanosoma brucei adenosine transporter, putative 0.1017 0.1723 0.2402
Schistosoma mansoni ribokinase 0.0164 0.0264 0.0369
Echinococcus granulosus histone acetyltransferase KAT2B 0.0122 0.0193 0.0193
Brugia malayi Flap endonuclease-1 0.0023 0.0023 0.0023
Brugia malayi hypothetical protein 0.0385 0.0642 0.0642
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0225 0.0225
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0014 0.0019
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.1017 0.1723 0.2402
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0052 0.0073 0.0296
Schistosoma mansoni pyruvate kinase 0.0029 0.0034 0.0047
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0017 0.0013 0.0018
Echinococcus multilocularis pyruvate kinase 0.0023 0.0023 0.0023
Echinococcus granulosus histone lysine methyltransferase setb 0.0015 0.0009 0.0009
Trypanosoma brucei adenosine transporter 2 0.1017 0.1723 0.2402
Trypanosoma brucei adenosine transporter 2, putative 0.1017 0.1723 0.2402
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.4191 0.7154 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0033 0.0041 0.4933
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0055 0.0078 0.0078
Entamoeba histolytica recQ family helicase, putative 0.002 0.0019 0.0006
Brugia malayi PHD-finger family protein 0.0025 0.0026 0.0026
Mycobacterium tuberculosis Ribokinase RbsK 0.0164 0.0264 0.7769
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0014 0.0019
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0062 0.0091 0.0081
Trichomonas vaginalis phosphofructokinase, putative 0.0052 0.0073 0.006
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.0087 0.0354
Mycobacterium tuberculosis Conserved protein 0.0032 0.004 0.0984
Schistosoma mansoni DNA helicase recq5 0.0016 0.0011 0.0015
Schistosoma mansoni transcription factor LCR-F1 0.0032 0.0039 0.0054
Entamoeba histolytica Flap nuclease, putative 0.0023 0.0023 0.001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0039 0.0051 0.0038
Brugia malayi Cytochrome P450 family protein 0.0013 0.0007 0.0007
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0017 0.0013 0.0013
Echinococcus granulosus pyruvate kinase 0.0029 0.0034 0.0034
Toxoplasma gondii ABC1 family protein 0.0032 0.004 0.0159
Mycobacterium ulcerans S-adenosylmethionine synthetase 0.0019 0.0016 0.0306
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0052 0.0073 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.005 0.005
Schistosoma mansoni axis inhibition protein axin 0.0017 0.0013 0.0018
Trypanosoma cruzi nucleoside transporter 1, putative 0.1017 0.1723 0.2402
Trichomonas vaginalis pyruvate kinase, putative 0.0029 0.0034 0.0021
Echinococcus granulosus regulator of G protein signaling 3 0.0017 0.0013 0.0013
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0052 0.0073 0.006
Leishmania major nucleobase transporter 0.1017 0.1723 0.2402
Brugia malayi Muscleblind-like protein 0.0264 0.0436 0.0436
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0032 0.004 0.004
Echinococcus multilocularis muscleblind protein 0.0264 0.0436 0.0436
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.0264 0.0252
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0032 0.0039 0.0039
Onchocerca volvulus 0.0048 0.0066 0.0032
Trypanosoma brucei purine nucleoside transporter 0.1017 0.1723 0.2402
Schistosoma mansoni hypothetical protein 0.0027 0.0031 0.0043
Loa Loa (eye worm) hypothetical protein 0.5854 1 1
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.1017 0.1723 0.1713
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0011 0.0006
Leishmania major nucleoside transporter 1, putative 0.1017 0.1723 0.2402
Loa Loa (eye worm) hypothetical protein 0.0028 0.0032 0.0032
Echinococcus multilocularis zinc finger protein 0.002 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0205 0.0335 0.0335
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0032 0.004 0.0055
Toxoplasma gondii 6-phosphofructokinase 0.0052 0.0073 0.0296
Schistosoma mansoni intermediate filament proteins 0.0048 0.0066 0.0092
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0023 0.0023 0.0022
Entamoeba histolytica hypothetical protein, conserved 0.4191 0.7154 0.7151
Loa Loa (eye worm) methionine adenosyltransferase 0.0019 0.0016 0.0016
Echinococcus granulosus cytochrome P450 2K1 0.0013 0.0007 0.0007
Brugia malayi acetyltransferase, GNAT family protein 0.0128 0.0203 0.0203
Echinococcus multilocularis regulator of G protein signaling 0.0017 0.0013 0.0013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.004 0.0053 0.0053
Brugia malayi MAP kinase sur-1 0.006 0.0087 0.0087
Toxoplasma gondii S-adenosyl methionine synthetase 0.0019 0.0016 0.0064
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0192 0.0313 0.0428
Trypanosoma brucei adenosine transporter 2, putative 0.1017 0.1723 0.2402
Entamoeba histolytica hypothetical protein 0.0032 0.0039 0.0026
Trypanosoma brucei adenosine transporter 2, putative 0.1017 0.1723 0.2402
Trypanosoma brucei adenosine transporter 2, putative 0.1017 0.1723 0.2402
Trypanosoma cruzi nucleoside transporter 1, putative 0.1017 0.1723 0.2402
Brugia malayi hypothetical protein 0.0032 0.0039 0.0039
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0062 0.0091 0.0091
Giardia lamblia Flap structure-specific endonuclease 0.0023 0.0023 0.0013
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0055 0.0078 0.0078
Trichomonas vaginalis DNA helicase recq, putative 0.0038 0.0049 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0022
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.4191 0.7154 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0013
Echinococcus granulosus geminin 0.0667 0.1125 0.1125
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.0087 0.0112
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0225 0.0225
Onchocerca volvulus 0.0042 0.0056 0.0022
Brugia malayi Cytochrome P450 family protein 0.0029 0.0033 0.0033
Brugia malayi hypothetical protein 0.0017 0.0013 0.0013
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0016 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0014 0.0019
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0055 0.0078 0.0078
Echinococcus granulosus Regulator of G protein signaling 20 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0013
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0013 0.0006 0.0006
Schistosoma mansoni equilibrative nucleoside transporter 0.1017 0.1723 0.2409
Leishmania major ATP-dependent phosphofructokinase 0.0192 0.0313 0.0428
Schistosoma mansoni cellular tumor antigen P53 0.0044 0.006 0.0084
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.5854 1 1
Trypanosoma brucei S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0013
Trypanosoma brucei S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0013
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.5854 1 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.0087 0.0112
Schistosoma mansoni lamin 0.0048 0.0066 0.0092
Mycobacterium tuberculosis Probable hydrolase 0.0032 0.004 0.0984
Trichomonas vaginalis penicillin-binding protein, putative 0.0032 0.004 0.0027
Trichomonas vaginalis phosphofructokinase, putative 0.0192 0.0313 0.0301
Trypanosoma brucei pyruvate kinase 1, putative 0.0029 0.0034 0.0038
Trichomonas vaginalis phosphofructokinase, putative 0.0192 0.0313 0.0301
Schistosoma mansoni hypothetical protein 0.4191 0.7154 1
Mycobacterium tuberculosis Probable lipase LipE 0.0032 0.004 0.0984
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0013
Echinococcus granulosus pyruvate kinase 0.0029 0.0034 0.0034
Mycobacterium tuberculosis Probable esterase LipL 0.0032 0.004 0.0984
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.0087 0.0087
Trypanosoma brucei adenosine kinase, putative 0.1437 0.2442 0.3407
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0011 0.0011
Mycobacterium tuberculosis Adenosine kinase 0.0164 0.0264 0.7769
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0011
Brugia malayi STAT protein, DNA binding domain containing protein 0.0132 0.0211 0.0211
Onchocerca volvulus 0.0164 0.0264 0.0231
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.004 0.0046
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.1017 0.1723 0.2402
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0087 0.0112
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.0087 0.0112
Mycobacterium ulcerans esterase/lipase LipP 0.0032 0.004 0.1065
Trypanosoma cruzi adenosine kinase, putative 0.0164 0.0264 0.036
Leishmania major cytochrome p450-like protein 0.0029 0.0033 0.0037
Echinococcus multilocularis geminin 0.0667 0.1125 0.1125
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0033 0.0037
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0039 0.0051 0.0206
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0264 0.0436 0.0436
Loa Loa (eye worm) hypothetical protein 0.0032 0.004 0.004
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0026 0.0028 0.0028
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.0027 0.0109
Loa Loa (eye worm) hypothetical protein 0.0029 0.0034 0.0034
Brugia malayi hypothetical protein 0.0014 0.0007 0.0007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0032 0.004 0.0055
Entamoeba histolytica acetyltransferase, GNAT family 0.0034 0.0042 0.003
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.4191 0.7154 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0192 0.0313 1
Brugia malayi A-kinase anchor protein 10, precursor 0.0017 0.0013 0.0013
Echinococcus multilocularis beta adrenergic receptor kinase 0.0017 0.0014 0.0014
Brugia malayi Latrophilin receptor protein 2 0.0013 0.0006 0.0006
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0061 0.0089 0.0089
Loa Loa (eye worm) pyruvate kinase 0.0029 0.0034 0.0034
Brugia malayi Calcitonin receptor-like protein seb-1 0.004 0.0053 0.0053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0225 0.0225
Echinococcus granulosus mitogen activated protein kinase 0.006 0.0087 0.0087
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0011 0.0006
Schistosoma mansoni 6-phosphofructokinase 0.0192 0.0313 0.0437
Loa Loa (eye worm) hypothetical protein 0.0264 0.0436 0.0436
Trypanosoma cruzi pyruvate kinase 2, putative 0.0029 0.0034 0.0038
Mycobacterium leprae Probable adenosine kinase adk 0.0164 0.0264 0.841
Echinococcus granulosus muscleblind protein 0.0264 0.0436 0.0436
Plasmodium vivax flap endonuclease 1, putative 0.0023 0.0023 0.2091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0225 0.0315
Echinococcus granulosus pyruvate kinase 0.0015 0.001 0.001
Leishmania major tagatose-6-phosphate kinase-like protein 0.0164 0.0264 0.036
Trypanosoma brucei S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0013
Echinococcus granulosus survival motor neuron protein 1 0.0205 0.0335 0.0335
Leishmania major pyruvate kinase 0.0029 0.0034 0.0038
Echinococcus granulosus pyruvate kinase 0.0015 0.001 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.019 0.019
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0013 0.0006 0.0006
Loa Loa (eye worm) phosphofructokinase 0.0192 0.0313 0.0313
Leishmania major adenosine kinase-like protein 0.0164 0.0264 0.036
Brugia malayi Regulator of G protein signaling domain containing protein 0.0017 0.0013 0.0013
Echinococcus multilocularis bloom syndrome protein 0.0038 0.0049 0.0049
Brugia malayi intermediate filament protein 0.0048 0.0066 0.0066
Loa Loa (eye worm) pyruvate kinase-PB 0.002 0.0019 0.0019
Plasmodium vivax 6-phosphofructokinase, putative 0.0052 0.0073 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1433 0.2436 0.2436
Trichomonas vaginalis phosphofructokinase, putative 0.0052 0.0073 0.006
Loa Loa (eye worm) hypothetical protein 0.0385 0.0642 0.0642
Trichomonas vaginalis flap endonuclease-1, putative 0.0023 0.0023 0.001
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0017 0.0014 0.0014
Trypanosoma brucei S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0013
Trichomonas vaginalis ribokinase, putative 0.0164 0.0264 0.0252
Loa Loa (eye worm) hypothetical protein 0.5854 1 1
Onchocerca volvulus Putative pyridoxal kinase 0.0164 0.0264 0.0231
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.1017 0.1723 0.2402
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0087 0.0075
Echinococcus granulosus tumor protein p63 0.0304 0.0504 0.0504
Mycobacterium ulcerans lipase LipD 0.0032 0.004 0.1065
Giardia lamblia Hypothetical protein 0.5854 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.002 0.0019
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.0087 0.0112
Loa Loa (eye worm) hypothetical protein 0.0164 0.0264 0.0264
Brugia malayi beta-lactamase family protein 0.0032 0.004 0.004
Mycobacterium tuberculosis Probable lipase LipD 0.0032 0.004 0.0984
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0017 0.0013 0.0018
Echinococcus multilocularis ribokinase 0.0164 0.0264 0.0264
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0033 0.0033
Echinococcus multilocularis 6 phosphofructokinase 0.0192 0.0313 0.0313
Trichomonas vaginalis S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0004
Echinococcus granulosus axis inhibition protein axin 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.1437 0.2442 0.2442
Echinococcus granulosus regulator of G protein signaling 7 0.0017 0.0013 0.0013
Brugia malayi Cytochrome P450 family protein 0.0029 0.0033 0.0033
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.1017 0.1723 0.2402
Echinococcus multilocularis pyruvate kinase 0.0015 0.001 0.001
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0011 0.0041
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0013 0.0006 0.0006
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.003 0.0035 0.0023
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0023 0.0023 0.009
Trichomonas vaginalis DNA helicase recq1, putative 0.0038 0.0049 0.0036
Schistosoma mansoni regulator of G protein signaling 0.0017 0.0013 0.0018
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.003 0.0035 0.0023
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0017 0.0013 0.0013
Loa Loa (eye worm) flap endonuclease-1 0.0023 0.0023 0.0023
Trypanosoma brucei nucleoside transporter 1, putative 0.1017 0.1723 0.2402
Loa Loa (eye worm) hypothetical protein 0.0385 0.0642 0.0642
Trichomonas vaginalis phosphofructokinase, putative 0.0052 0.0073 0.006
Schistosoma mansoni cytochrome P450 0.0013 0.0007 0.001
Schistosoma mansoni adenosine kinase 0.1437 0.2442 0.3413
Loa Loa (eye worm) hypothetical protein 0.004 0.0053 0.0053
Echinococcus multilocularis flap endonuclease 1 0.0023 0.0023 0.0023
Entamoeba histolytica nucleoside transporter, putative 0.1017 0.1723 0.1713
Brugia malayi Bromodomain containing protein 0.0036 0.0046 0.0046
Trypanosoma cruzi nucleobase transporter, putative 0.1017 0.1723 0.2402
Plasmodium falciparum pyruvate kinase 0.0029 0.0034 0.3806
Brugia malayi Pyruvate kinase, M2 isozyme 0.0029 0.0034 0.0034
Echinococcus granulosus bloom syndrome protein 0.0038 0.0049 0.0049
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0072 0.0072
Entamoeba histolytica kinase, PfkB family 0.0164 0.0264 0.0252
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.0164 0.0264 0.0252
Echinococcus granulosus 6 phosphofructokinase 0.0192 0.0313 0.0313
Mycobacterium ulcerans carbohydrate kinase CbhK 0.0164 0.0264 0.841
Trichomonas vaginalis phosphofructokinase, putative 0.0192 0.0313 0.0301
Brugia malayi hypothetical protein 0.5854 1 1
Brugia malayi Intermediate filament tail domain containing protein 0.0048 0.0066 0.0066
Echinococcus multilocularis axis inhibition protein axin 0.0017 0.0013 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0225 0.0315
Echinococcus multilocularis expressed protein 0.0324 0.0539 0.0539
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0023 0.0023 0.0022
Echinococcus multilocularis musashi 0.0048 0.0066 0.0066
Trichomonas vaginalis phosphofructokinase, putative 0.0052 0.0073 0.006
Brugia malayi cytochrome P450 0.0013 0.0007 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.0192 0.0313 0.0301
Schistosoma mansoni regulator of G protein signaling 0.0017 0.0013 0.0018
Trichomonas vaginalis S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0004
Echinococcus multilocularis lamin 0.0048 0.0066 0.0066
Entamoeba histolytica fructokinase, putative 0.0164 0.0264 0.0252
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0023 0.0023 0.0023
Echinococcus granulosus adenosine kinase 0.1437 0.2442 0.2442
Loa Loa (eye worm) runx1 0.0048 0.0067 0.0067
Loa Loa (eye worm) RGS-3 protein 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0013
Trichomonas vaginalis S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0004
Schistosoma mansoni regulator of G protein signaling 0.0017 0.0013 0.0018
Giardia lamblia Pyruvate kinase 0.0029 0.0034 0.0024
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0032 0.004 0.1065
Trypanosoma cruzi S-adenosylmethionine synthetase, putative 0.0019 0.0016 0.0013
Loa Loa (eye worm) hypothetical protein 0.004 0.0053 0.0053
Brugia malayi PXA domain containing protein 0.0017 0.0013 0.0013
Entamoeba histolytica phosphofructokinase, putative 0.0192 0.0313 0.0301
Onchocerca volvulus 0.1273 0.2162 0.2135
Mycobacterium ulcerans pyruvate kinase 0.0029 0.0034 0.0874
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0128 0.0203 0.0203
Trypanosoma brucei pyruvate kinase 1 0.0029 0.0034 0.0038
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.4191 0.7154 1
Trypanosoma cruzi nucleoside transporter-like, putative 0.1017 0.1723 0.2402
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0029 0.0033 0.0866
Trypanosoma brucei protein kinase, putative 0.006 0.0087 0.0112
Toxoplasma gondii nucleoside transporter protein 0.1017 0.1723 0.7057
Leishmania major S-adenosylmethionine synthetase 0.0019 0.0016 0.0013
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0013 0.0006 0.0006
Leishmania major nucleobase transporter 0.1017 0.1723 0.2402
Schistosoma mansoni hypothetical protein 0.0667 0.1125 0.1572
Mycobacterium leprae Probable pyruvate kinase PykA 0.0029 0.0034 0.0874
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.1017 0.1723 0.1713
Loa Loa (eye worm) 6-phosphofructokinase 0.0192 0.0313 0.0313
Leishmania major tagatose-6-phosphate kinase-like protein 0.0164 0.0264 0.036
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.019 0.019
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0011 0.0011
Entamoeba histolytica nucleoside transporter, putative 0.1017 0.1723 0.1713
Echinococcus granulosus intermediate filament protein 0.0048 0.0066 0.0066
Echinococcus multilocularis regulator of G protein signaling 3 0.0017 0.0013 0.0013
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.0087 0.0112
Plasmodium vivax pyruvate kinase, putative 0.0029 0.0034 0.3806
Loa Loa (eye worm) beta-lactamase 0.0032 0.004 0.004
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0011 0.0284
Loa Loa (eye worm) hypothetical protein 0.0048 0.0066 0.0066
Giardia lamblia S-adenosylmethionine synthetase 0.0019 0.0016 0.0007
Echinococcus multilocularis S adenosylmethionine synthase type 1 0.0019 0.0016 0.0016
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0039 0.0051 0.0206
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.004 0.0046
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0016 0.0011 0.0011
Brugia malayi phosphofructokinase 0.0192 0.0313 0.0313
Loa Loa (eye worm) pyruvate kinase 0.0029 0.0034 0.0034
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0192 0.0313 0.0428
Toxoplasma gondii pyruvate kinase PyKII 0.0015 0.001 0.0036
Echinococcus granulosus histone acetyltransferase KAT2B 0.0039 0.0051 0.0051
Schistosoma mansoni lozenge 0.0048 0.0067 0.0093
Loa Loa (eye worm) PHD-finger family protein 0.0018 0.0015 0.0015
Leishmania major pyruvate kinase 0.0029 0.0034 0.0038
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0192 0.0313 0.9238
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0164 0.0264 0.0264
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0023 0.0023 0.0022
Brugia malayi Probable ATP-dependent helicase DHX35 0.0039 0.005 0.005
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0052 0.0073 0.1909
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0052 0.0073 1
Schistosoma mansoni hypothetical protein 0.0667 0.1125 0.1572
Schistosoma mansoni hypothetical protein 0.0013 0.0007 0.001

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 5 mg kg-1 Minmum inhibitory concentration of the compound against Streptococcus pyogenes C203 evaluated in vivo(mouse) ChEMBL. 2522992
Ka (ADMET) = 1 M-1 Association constant of compound was evaluated at pH 5 ChEMBL. 2522992
MIC (functional) = 0.125 ug ml-1 Minmum inhibitory concentration of the compound against Staphylococcus epidermis ATCC12228 evaluated in vitro ChEMBL. 2522992
MIC (functional) = 0.125 ug ml-1 Minmum inhibitory concentration of the compound against Staphylococcus epidermis L1378 evaluated in vitro ChEMBL. 2522992
MIC (functional) = 0.125 ug ml-1 Minmum inhibitory concentration of the compound against Staphylococcus simulans L785 evaluated in vitro ChEMBL. 2522992
MIC (functional) = 0.125 ug ml-1 Minmum inhibitory concentration of the compound against Staphylococcus simulans L1142 evaluated in vitro ChEMBL. 2522992
MIC (functional) = 0.125 ug ml-1 Minmum inhibitory concentration of the compound against Staphylococcus hominis L1070 evaluated in vitro ChEMBL. 2522992
MIC (functional) = 0.25 ug ml-1 Minmum inhibitory concentration of the compound against Staphylococcus aureus Tour evaluated in vitro ChEMBL. 2522992
MIC (functional) = 0.5 ug ml-1 Minmum inhibitory concentration of the compound against Staphylococcus haemolyticus L1520 evaluated in vitro ChEMBL. 2522992
MIC (functional) = 1 ug ml-1 Minmum inhibitory concentration of the compound against Streptococcus pyogenes C 203 evaluated in vitro ChEMBL. 2522992
MIC (functional) = 1 ug ml-1 Minmum inhibitory concentration of the compound against Streptococcus pneumoniae UC 41 evaluated in vitro ChEMBL. 2522992
MIC (functional) = 1 ug ml-1 Minmum inhibitory concentration of the compound administered intravenously against Streptococcus pyogenes C203 in mouse ChEMBL. 2522992
MIC (functional) = 1 ug ml-1 Minmum inhibitory concentration of the compound against Staphylococcus warneri L1375 evaluated in vitro ChEMBL. 2522992

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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