TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 1069.1 | Formula: C54H68O22
H donors: 13 H acceptors: 15 LogP: 1.94 Rotable bonds: 25
Rule of 5 violations (Lipinski): 4
SMILES: CCCCC/C=C/C=C/[C@H](C/C=C/C=C/C(=O)O[C@H]1[C@H](O[C@@H]2O[C@H](COC(=O)c3ccc(cc3)c3ccc(cc3)O)[C@@H]([C@@H]([C@H]2O[C@@H]2O[C@H](CO)[C@@H]([C@@H]([C@H]2O)O)O)O)O)[C@@H](CO)O[C@H]([C@@H]1O)c1c(O)cc(cc1CO)O)O
InChi: 1S/C54H68O22/c1-2-3-4-5-6-7-9-12-33(58)13-10-8-11-14-40(62)74-50-47(68)49(41-32(25-55)23-35(60)24-36(41)61)71-38(27-57)48(50)75-54-51(76-53-46(67)44(65)42(63)37(26-56)72-53)45(66)43(64)39(73-54)28-70-52(69)31-17-15-29(16-18-31)30-19-21-34(59)22-20-30/h6-12,14-24,33,37-39,42-51,53-61,63-68H,2-5,13,25-28H2,1H3/b7-6+,10-8+,12-9+,14-11+/t33-,37-,38-,39-,42+,43+,44+,45+,46-,47+,48-,49+,50-,51-,53+,54+/m1/s1
InChiKey: RNTWIGQXQMUZNI-JIBNUADJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	endoplasmin	0.0047	0.041	0.041
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.074	0.9983	1
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0038	0.0282	0.012
Leishmania major	fk506-binding protein 1-like protein	0.074	0.9983	1
Onchocerca volvulus		0.0102	0.1169	1
Brugia malayi	6-phosphofructokinase	0.0118	0.1399	0.1401
Leishmania major	peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative	0.0102	0.1169	0.0971
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0038	0.0282	0.0079
Brugia malayi	Endoplasmin precursor	0.005	0.0452	0.0453
Mycobacterium tuberculosis	Probable transcriptional regulatory protein (LuxR-family)	0.0184	0.2303	1
Brugia malayi	Hsp90 protein	0.0033	0.0221	0.0221
Toxoplasma gondii	heat shock protein 90, putative	0.005	0.0452	0.114
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0118	0.1399	0.1207
Loa Loa (eye worm)	hypothetical protein	0.0638	0.8577	0.8591
Leishmania major	peptidylprolyl isomerase-like protein	0.074	0.9983	1
Schistosoma mansoni	hypothetical protein	0.0185	0.2314	0.2314
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase, putative	0.0102	0.1169	0.1024
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0513	0.0514
Trypanosoma brucei	hypothetical protein, conserved	0.0102	0.1169	0.0971
Plasmodium falciparum	heat shock protein 90, putative	0.0189	0.2377	0.2254
Trypanosoma brucei	heat shock protein, putative	0.005	0.0452	0.0237
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.074	0.9983	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0053	0.0489	0.0489
Echinococcus granulosus	endoplasmin	0.0047	0.041	0.041
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0032	0.0205	0.0042
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0205	0.0042
Plasmodium falciparum	endoplasmin, putative	0.0036	0.0263	0.0101
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0033	0.0221	0.0221
Trypanosoma cruzi	heat shock protein 85, putative	0.005	0.0452	0.0404
Trichomonas vaginalis	heat shock protein, putative	0.005	0.0452	0.0294
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0205	0.0042
Mycobacterium ulcerans	hypothetical protein	0.0102	0.1169	0.0793
Mycobacterium tuberculosis	Possible two component transcriptional regulatory protein (probably LuxR-family)	0.0184	0.2303	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0043	0.0353	0.0303
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.074	0.9983	1
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13	0.0102	0.1169	0.1171
Leishmania major	eukaryotic translation initiation factor eIF-4E, putative	0.0038	0.0282	0.0062
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.074	0.9983	0.9983
Loa Loa (eye worm)	phosphofructokinase	0.0118	0.1399	0.1401
Echinococcus granulosus	6 phosphofructokinase	0.0118	0.1399	0.1399
Giardia lamblia	Heat shock protein HSP 90-alpha	0.005	0.0452	0.0253
Schistosoma mansoni	hypothetical protein	0.0102	0.1169	0.1169
Schistosoma mansoni	heat shock protein	0.005	0.0452	0.0452
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0032	0.0205	0.0042
Trypanosoma brucei	FKBP-type peptidylprolyl cis-trans isomerase, putative	0.0102	0.1169	0.0971
Brugia malayi	6-phosphofructokinase	0.0118	0.1399	0.1401
Leishmania major	heat shock protein 83-1	0.005	0.0452	0.0237
Plasmodium vivax	peptidyl-prolyl cis-trans isomerase, putative	0.0102	0.1169	0.0986
Echinococcus multilocularis		0.0102	0.1169	0.1169
Schistosoma mansoni	heat shock protein	0.005	0.0452	0.0452
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-1	0.0038	0.0282	0.0062
Mycobacterium tuberculosis	Possible nitrate/nitrite response transcriptional regulatory protein NarL	0.0184	0.2303	1
Echinococcus multilocularis	geminin	0.0185	0.2314	0.2314
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0276	0.0276
Trichomonas vaginalis	phosphofructokinase, putative	0.0118	0.1399	0.1258
Echinococcus multilocularis	heat shock protein	0.005	0.0452	0.0452
Echinococcus granulosus	heat shock protein 90	0.005	0.0452	0.0452
Echinococcus multilocularis	fk506 binding protein	0.074	0.9983	0.9983
Entamoeba histolytica	phosphofructokinase, putative	0.0118	0.1399	0.1219
Schistosoma mansoni	endoplasmin	0.005	0.0452	0.0452
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.074	0.9983	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0118	0.1399	0.1258
Schistosoma mansoni	immunophilin	0.0639	0.8593	0.8593
Trypanosoma cruzi	heat shock protein 85, putative	0.005	0.0452	0.0404
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0118	0.1399	0.1221
Trypanosoma brucei	heat shock protein, putative	0.005	0.0452	0.0237
Entamoeba histolytica	90 kDa heat shock protein, putative	0.0033	0.0221	0.0017
Echinococcus multilocularis	FK506 binding protein 8, 38 kDa	0.0103	0.1186	0.1186
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0451	0.0451
Loa Loa (eye worm)	FKBP5 protein	0.074	0.9983	1
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0102	0.1169	0.0971
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0451	0.0452
Trypanosoma cruzi	heat shock protein 85, putative	0.005	0.0452	0.0404
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0038	0.0282	0.0079
Toxoplasma gondii	eukaryotic initiation factor-4E, putative	0.0038	0.0282	0.0355
Mycobacterium ulcerans	two component transcriptional regulator	0.0184	0.2303	0.1977
Leishmania major	heat shock protein 83-1	0.005	0.0452	0.0237
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0043	0.0353	0.0151
Schistosoma mansoni	hypothetical protein	0.0185	0.2314	0.2314
Entamoeba histolytica	heat shock protein 90, putative	0.005	0.0452	0.0253
Trypanosoma brucei	heat shock protein 90, putative	0.005	0.0452	0.0237
Schistosoma mansoni	endoplasmin	0.005	0.0452	0.0452
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0102	0.1169	0.0985
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.074	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3323	0.3328
Echinococcus granulosus	eukaryotic translation initiation factor 4E	0.0038	0.0282	0.0282
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0451	0.0451
Plasmodium vivax	heat shock protein 86, putative	0.005	0.0452	0.0253
Onchocerca volvulus		0.0102	0.1169	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1169	0.1171
Brugia malayi	heat shock protein 90	0.005	0.0452	0.0453
Trypanosoma brucei	heat shock protein, putative	0.005	0.0452	0.0237
Trichomonas vaginalis	endoplasmin, putative	0.0036	0.0263	0.0101
Schistosoma mansoni	hypothetical protein	0.0053	0.0489	0.0489
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.074	0.9983	1
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0032	0.0205	0.0042
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0102	0.1169	0.1125
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.0038	0.0282	0.0232
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0741	1	1
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0038	0.0282	0.012
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0513	0.0514
Mycobacterium tuberculosis	Possible transcriptional regulatory protein	0.0184	0.2303	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0513	0.0514
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0118	0.1399	0.1357
Leishmania major	heat shock protein 83-1	0.005	0.0452	0.0237
Echinococcus granulosus	survival motor neuron protein 1	0.0258	0.3323	0.3323
Loa Loa (eye worm)	transcription factor SMAD2	0.013	0.156	0.1563
Toxoplasma gondii	heat shock protein HSP90	0.005	0.0452	0.114
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0038	0.0282	0.012
Schistosoma mansoni	hypothetical protein	0.0037	0.0276	0.0276
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0205	0.0042
Leishmania major	eukaryotic translation initiation factor-like	0.0038	0.0282	0.0062
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.074	0.9983	1
Mycobacterium ulcerans	putative regulatory protein	0.0184	0.2303	0.1977
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0102	0.1169	0.1125
Loa Loa (eye worm)	translation initiation factor 4E	0.0038	0.0282	0.0282
Trypanosoma cruzi	FKBP-type peptidylprolyl cis-trans isomerase, putative	0.0102	0.1169	0.1125
Trichomonas vaginalis	fk506-binding protein, putative	0.0102	0.1169	0.1024
Trichomonas vaginalis	phosphofructokinase, putative	0.0118	0.1399	0.1258
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0639	0.8593	0.8593
Trichomonas vaginalis	phosphofructokinase, putative	0.0118	0.1399	0.1258
Mycobacterium ulcerans	nitrate/nitrite response regulator protein NarL	0.0184	0.2303	0.1977
Schistosoma mansoni	heat shock protein	0.0033	0.0221	0.0221
Wolbachia endosymbiont of Brugia malayi	FKBP-type peptidylprolyl isomerase	0.0102	0.1169	1
Mycobacterium ulcerans	6-phosphofructokinase	0.0118	0.1399	0.1033
Leishmania major	heat shock protein 83-1	0.005	0.0452	0.0237
Trichomonas vaginalis	immunophilin, putative	0.074	0.9983	1
Trypanosoma brucei	Heat shock protein 83, putative	0.005	0.0452	0.0237
Leishmania major	ATP-dependent phosphofructokinase	0.0118	0.1399	0.1207
Loa Loa (eye worm)	6-phosphofructokinase	0.0118	0.1399	0.1401
Toxoplasma gondii	peptidyl-prolyl isomerase FKBP12, putative	0.0102	0.1169	0.444
Entamoeba histolytica	phosphofructokinase, putative	0.0118	0.1399	0.1219
Leishmania major	heat shock protein 83-1	0.005	0.0452	0.0237
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.074	0.9983	1
Mycobacterium ulcerans	hypothetical protein	0.0184	0.2303	0.1977
Plasmodium vivax	heat shock protein, putative	0.0189	0.2377	0.2222
Wolbachia endosymbiont of Brugia malayi	FKBP-type peptidylprolyl isomerase	0.0102	0.1169	1
Plasmodium vivax	heat shock protein 90, putative	0.0033	0.0221	0.0017
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.074	0.9983	1
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0033	0.0221	0.0221
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.074	0.9983	1
Trypanosoma brucei	macrophage infectivity potentiator, precursor, putative	0.0102	0.1169	0.0971
Echinococcus multilocularis	6 phosphofructokinase	0.0118	0.1399	0.1399
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0513	0.0514
Trypanosoma brucei	heat shock protein, putative	0.005	0.0452	0.0237
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0451	0.0451
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0205	0.0042
Loa Loa (eye worm)	endoplasmin	0.005	0.0452	0.0453
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0102	0.1169	0.444
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0102	0.1169	0.444
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0102	0.1169	0.444
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33	0.0102	0.1169	0.1171
Leishmania major	heat shock protein 83-1	0.005	0.0452	0.0237
Trichomonas vaginalis	heat shock protein, putative	0.0036	0.0263	0.0101
Echinococcus granulosus	geminin	0.0185	0.2314	0.2314
Leishmania major	heat shock protein 83-1	0.005	0.0452	0.0237
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0043	0.0353	0.0353
Echinococcus granulosus	heat shock protein 90	0.0043	0.0353	0.0353
Schistosoma mansoni	fk506 binding protein	0.0102	0.1169	0.1169
Echinococcus multilocularis	heat shock protein 90	0.0043	0.0353	0.0353
Echinococcus multilocularis	eukaryotic translation initiation factor 4E	0.0038	0.0282	0.0282
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0102	0.1169	0.0986
Trypanosoma brucei	heat shock protein, putative	0.005	0.0452	0.0237
Onchocerca volvulus		0.0053	0.0489	0.2825
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0205	0.0042
Loa Loa (eye worm)	heat shock protein 75	0.0033	0.0221	0.0221
Loa Loa (eye worm)	6-phosphofructokinase	0.0118	0.1399	0.1401
Mycobacterium tuberculosis	Probable transcriptional regulatory protein	0.0184	0.2303	1
Toxoplasma gondii	Hsp90 domain-containing protein	0.0189	0.2377	1
Mycobacterium leprae	PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG	0.0102	0.1169	0.401
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30	0.0102	0.1169	0.1171
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0102	0.1169	0.0985
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.074	0.9983	1
Mycobacterium ulcerans	two component transcriptional regulatory protein DevR	0.0184	0.2303	0.1977
Echinococcus multilocularis	survival motor neuron protein 1	0.0258	0.3323	0.3323
Leishmania major	heat shock protein 83-1	0.005	0.0452	0.0237
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.074	0.9983	1
Trypanosoma brucei	heat shock protein, putative	0.005	0.0452	0.0237
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.1169	0.1024
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0118	0.1399	0.5225
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0451	0.0451
Mycobacterium tuberculosis	Probable transcriptional regulatory protein (probably LuxR/UhpA-family)	0.0184	0.2303	1
Trypanosoma brucei	heat shock protein, putative	0.005	0.0452	0.0237
Schistosoma mansoni	6-phosphofructokinase	0.0118	0.1399	0.1399
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0451	0.0451
Entamoeba histolytica	phosphofructokinase, putative	0.0118	0.1399	0.1219
Leishmania major	heat shock protein 83-1	0.005	0.0452	0.0237
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0741	1	1
Trypanosoma brucei	heat shock protein, putative	0.005	0.0452	0.0237
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0451	0.0452
Schistosoma mansoni	eukaryotic translation initiation factor 4e	0.0038	0.0282	0.0282
Leishmania major	heat shock protein 83-1	0.005	0.0452	0.0237
Brugia malayi	hypothetical protein	0.0258	0.3323	0.3328
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-33	0.0102	0.1169	0.1171
Schistosoma mansoni	immunophilin	0.0741	1	1
Leishmania major	FKBP-type peptidyl-prolyl cis-trans isomerase, putative	0.0102	0.1169	0.0971
Leishmania major	peptidyl-prolyl cis-trans isomerase, putative	0.0102	0.1169	0.0971
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.074	0.9983	1
Trypanosoma cruzi	heat shock protein 90, putative	0.005	0.0452	0.0404
Trypanosoma cruzi	macrophage infectivity potentiator, precursor, putative	0.0102	0.1169	0.1125
Treponema pallidum	heat shock protein 90	0.0047	0.041	0.021
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0047	0.041	0.0194
Leishmania major	eukaryotic translation initiation factor-like protein	0.0038	0.0282	0.0062
Schistosoma mansoni	survival motor neuron protein	0.0053	0.0489	0.0489
Echinococcus granulosus	FK506 binding protein 2	0.0102	0.1169	0.1169
Echinococcus multilocularis	heat shock protein 90	0.005	0.0452	0.0452
Trichomonas vaginalis	heat shock protein, putative	0.0047	0.041	0.0251
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0451	0.0451
Trichomonas vaginalis	heat shock protein, putative	0.0047	0.041	0.0251
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.074	0.9983	1
Leishmania major	heat shock protein 83-1	0.005	0.0452	0.0237
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.074	0.9983	1
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0102	0.1169	0.0986
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.074	0.9983	1
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.074	0.9983	0.9983
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0205	0.0042
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.1169	0.1024
Brugia malayi	phosphofructokinase	0.0118	0.1399	0.1401
Brugia malayi	MH2 domain containing protein	0.013	0.156	0.1563
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0102	0.1169	0.0986
Giardia lamblia	Hypothetical protein	0.0102	0.1169	0.0986
Trypanosoma cruzi	Heat shock protein 83, putative	0.005	0.0452	0.0404
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-30	0.0102	0.1169	0.1171
Trypanosoma cruzi	FKBP-type peptidylprolyl cis-trans isomerase, putative	0.0102	0.1169	0.1125
Schistosoma mansoni	immunophilin	0.0741	1	1
Leishmania major	heat shock protein 83-1	0.005	0.0452	0.0237
Trichomonas vaginalis	fk506 binding protein, putative	0.0102	0.1169	0.1024
Leishmania major	heat shock protein 83-1	0.005	0.0452	0.0237
Loa Loa (eye worm)	heat shock protein 90	0.005	0.0452	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0276	0.0276
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0639	0.8593	0.8593
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD)	0.0102	0.1169	0.0986
Echinococcus granulosus	heat shock protein	0.005	0.0452	0.0452
Toxoplasma gondii	heat shock protein 75, putative	0.0033	0.0221	0.0074
Leishmania major	heat shock protein 83-1	0.005	0.0452	0.0237
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0741	1	1
Leishmania major	heat shock protein 83-1	0.005	0.0452	0.0237
Trypanosoma brucei	heat shock protein 90, putative	0.005	0.0452	0.0237
Chlamydia trachomatis	peptidyl-prolyl cis-trans isomerase	0.0102	0.1169	1
Leishmania major	heat shock protein 83-1	0.005	0.0452	0.0237
Brugia malayi	translation initiation factor 4E	0.0038	0.0282	0.0282
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0118	0.1399	0.5225
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0038	0.0282	0.012
Mycobacterium leprae	PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	0.0184	0.2303	1
Echinococcus granulosus	FK506 binding protein 8 38 kDa	0.0102	0.1169	0.1169
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0451	0.0451
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-13	0.0102	0.1169	0.1171
Plasmodium vivax	endoplasmin, putative	0.005	0.0452	0.0253
Trypanosoma cruzi	heat shock protein, putative	0.0033	0.0221	0.0171
Trypanosoma cruzi	heat shock protein 90, putative	0.0043	0.0353	0.0303
Trichomonas vaginalis	heat shock protein, putative	0.0043	0.0353	0.0193
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.074	0.9983	1
Trichomonas vaginalis	fk506-binding protein, putative	0.074	0.9983	1
Plasmodium falciparum	heat shock protein 90	0.005	0.0452	0.0294
Schistosoma mansoni	6-phosphofructokinase	0.0118	0.1399	0.1399
Giardia lamblia	Grp94/Hsp90	0.0047	0.041	0.021
Entamoeba histolytica	heat shock protein 90, putative	0.005	0.0452	0.0253
Loa Loa (eye worm)	MH2 domain-containing protein	0.013	0.156	0.1563
Leishmania major	heat shock protein 83-1	0.005	0.0452	0.0237
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.0038	0.0282	0.0232
Mycobacterium tuberculosis	Probable trigger factor (TF) protein Tig	0.0102	0.1169	0.401
Trichomonas vaginalis	fk506-binding protein, putative	0.0102	0.1169	0.1024

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 6.25 ug ml-1	Minimum inhibitory concentration against Candida albicans (579a) in the presence of serum	ChEMBL.	No reference
MIC (functional)	= 6.25 ug ml-1	Minimum inhibitory concentration against Candida albicans (CCH 442) in the presence of serum	ChEMBL.	No reference
MIC (functional)	= 6.25 ug ml-1	Minimum inhibitory concentration against Candida albicans (ATCC 38247) in the presence of serum	ChEMBL.	No reference
MIC (functional)	= 6.25 ug ml-1	Minimum inhibitory concentration against Candida albicans (579a) in the presence of serum	ChEMBL.	No reference
MIC (functional)	= 6.25 ug ml-1	Minimum inhibitory concentration against Candida albicans (CCH 442) in the presence of serum	ChEMBL.	No reference
MIC (functional)	= 6.25 ug ml-1	Minimum inhibitory concentration against Candida albicans (ATCC 38247) in the presence of serum	ChEMBL.	No reference
MIC (functional)	= 12.5 ug ml-1	Minimum inhibitory concentration against Candida albicans (ATCC 10231) in the presence of serum	ChEMBL.	No reference
MIC (functional)	= 12.5 ug ml-1	Minimum inhibitory concentration against Candida albicans (ATCC 62376) in the presence of serum	ChEMBL.	No reference
MIC (functional)	= 12.5 ug ml-1	Minimum inhibitory concentration against Candida albicans (ATCC 10231) in the presence of serum	ChEMBL.	No reference
MIC (functional)	= 12.5 ug ml-1	Minimum inhibitory concentration against Candida albicans (ATCC 62376) in the presence of serum	ChEMBL.	No reference
MIC (functional)	> 100 ug ml-1	Minimum inhibitory concentration against Candida albicans (ATCC 10231) in the absence of serum.	ChEMBL.	No reference
MIC (functional)	> 100 ug ml-1	Minimum inhibitory concentration against Candida albicans (579a) in the absence of serum.	ChEMBL.	No reference
MIC (functional)	> 100 ug ml-1	Minimum inhibitory concentration against Candida albicans (CCH 442) in the absence of serum.	ChEMBL.	No reference
MIC (functional)	> 100 ug ml-1	Minimum inhibitory concentration against Candida albicans (ATCC 38247) in the absence of serum.	ChEMBL.	No reference
MIC (functional)	> 100 ug ml-1	Minimum inhibitory concentration against Candida albicans (ATCC 62376) in the absence of serum.	ChEMBL.	No reference
MIC (functional)	> 100 ug ml-1	Minimum inhibitory concentration against Candida albicans (ATCC 10231) in the absence of serum.	ChEMBL.	No reference
MIC (functional)	> 100 ug ml-1	Minimum inhibitory concentration against Candida albicans (579a) in the absence of serum.	ChEMBL.	No reference
MIC (functional)	> 100 ug ml-1	Minimum inhibitory concentration against Candida albicans (CCH 442) in the absence of serum.	ChEMBL.	No reference
MIC (functional)	> 100 ug ml-1	Minimum inhibitory concentration against Candida albicans (ATCC 38247) in the absence of serum.	ChEMBL.	No reference
MIC (functional)	> 100 ug ml-1	Minimum inhibitory concentration against Candida albicans (ATCC 62376) in the absence of serum.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL262689

Bibliographic References

No literature references available for this target.

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Detailed information for compound 405943