Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neurotensin receptor 1 (high affinity) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0133 | 0.0887 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0133 | 0.0887 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.0133 | 0.0887 | 0.0888 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0133 | 0.0887 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0971 | 1 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.097 | 0.9987 | 1 |
Schistosoma mansoni | fk506 binding protein | 0.0133 | 0.0887 | 0.0887 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0135 | 0.09 | 0.09 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0971 | 1 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.097 | 0.9987 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.097 | 0.9987 | 0.9987 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.097 | 0.9987 | 1 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0133 | 0.0887 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0704 | 0.7099 | 0.7108 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0133 | 0.0887 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.097 | 0.9987 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0971 | 1 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0133 | 0.0887 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0838 | 0.8548 | 0.8548 |
Onchocerca volvulus | 0.0133 | 0.0887 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0133 | 0.0887 | 0.0887 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0133 | 0.0887 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.097 | 0.9987 | 0.9987 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0887 | 0.0888 |
Schistosoma mansoni | immunophilin | 0.0971 | 1 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.097 | 0.9987 | 0.9987 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.097 | 0.9987 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.097 | 0.9987 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.097 | 0.9987 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.097 | 0.9987 | 1 |
Schistosoma mansoni | immunophilin | 0.0838 | 0.8548 | 0.8548 |
Trichomonas vaginalis | immunophilin, putative | 0.097 | 0.9987 | 1 |
Echinococcus multilocularis | 0.0133 | 0.0887 | 0.0887 | |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.097 | 0.9987 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0728 | 0.736 | 0.7369 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.0133 | 0.0887 | 0.0887 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.0133 | 0.0887 | 0.0888 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.097 | 0.9987 | 1 |
Onchocerca volvulus | 0.0133 | 0.0887 | 1 | |
Schistosoma mansoni | immunophilin | 0.0971 | 1 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.097 | 0.9987 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.097 | 0.9987 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.097 | 0.9987 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0133 | 0.0887 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.097 | 0.9987 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.097 | 0.9987 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0133 | 0.0887 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 | 0.0133 | 0.0887 | 0.0888 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0728 | 0.736 | 0.7369 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.097 | 0.9987 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.097 | 0.9987 | 1 |
Echinococcus granulosus | FK506 binding protein 2 | 0.0133 | 0.0887 | 0.0887 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.097 | 0.9987 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 | 0.0133 | 0.0887 | 0.0888 |
Leishmania major | fk506-binding protein 1-like protein | 0.097 | 0.9987 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0836 | 0.8535 | 0.8546 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.097 | 0.9987 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0838 | 0.8548 | 0.8548 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.097 | 0.9987 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.0133 | 0.0887 | 0.0888 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 | 0.0133 | 0.0887 | 0.0888 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11.5 nM | Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide | ChEMBL. | 12852770 |
IC50 (binding) | = 11.5 nM | Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide | ChEMBL. | 12852770 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.