Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cathepsin b | 0.021 | 0.2762 | 0.2762 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0321 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0321 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0321 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0321 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.3182 | 0.058 |
Leishmania major | cathepsin L-like protease | 0.0321 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0321 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0321 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0321 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0321 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0216 | 0.3182 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0321 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0216 | 0.3182 | 0.3182 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.3182 | 0.058 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0321 | 1 | 1 |
Onchocerca volvulus | 0.0321 | 1 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0321 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.021 | 0.2762 | 0.2762 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0321 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0321 | 1 | 0.5 |
Toxoplasma gondii | cathepsin CPL | 0.0321 | 1 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0321 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0321 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0216 | 0.3182 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.0321 | 1 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0216 | 0.3182 | 0.3182 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0321 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0321 | 1 | 0.5 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0321 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0321 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0216 | 0.3182 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0321 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.021 | 0.2762 | 0.2762 |
Plasmodium vivax | vivapain-2 | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0321 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0321 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0321 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0321 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.021 | 0.2762 | 0.2762 |
Brugia malayi | Cathepsin L-like precursor | 0.0321 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0321 | 1 | 0.5 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.021 | 0.2762 | 0.2762 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0216 | 0.3182 | 0.3182 |
Plasmodium vivax | vivapain-2 | 0.0321 | 1 | 1 |
Onchocerca volvulus | 0.0321 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0321 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0216 | 0.3182 | 0.3182 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0321 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0321 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0321 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0321 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0321 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0321 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.021 | 0.2762 | 0.2762 |
Leishmania major | cathepsin L-like protease | 0.0321 | 1 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0321 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0321 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.3182 | 0.058 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0321 | 1 | 1 |
Onchocerca volvulus | 0.0321 | 1 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.0216 | 0.3182 | 0.3182 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0321 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.021 | 0.2762 | 0.2762 |
Leishmania major | cathepsin L-like protease | 0.0321 | 1 | 0.5 |
Onchocerca volvulus | 0.0321 | 1 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0321 | 1 | 1 |
Onchocerca volvulus | 0.0321 | 1 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0321 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.021 | 0.2762 | 0.2762 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0321 | 1 | 1 |
Onchocerca volvulus | 0.0321 | 1 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0321 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.021 | 0.2762 | 0.2762 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0321 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0321 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0321 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0321 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0321 | 1 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0321 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0321 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0321 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0321 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0321 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0321 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0321 | 1 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0216 | 0.3182 | 0.3182 |
Onchocerca volvulus | 0.0321 | 1 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0321 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0321 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.021 | 0.2762 | 0.2762 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0216 | 0.3182 | 0.3182 |
Onchocerca volvulus | Cathepsin L homolog | 0.0321 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0321 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0321 | 1 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0321 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1 mg l-1 | Minimum inhibitory concentration against vancomycin-sensitive Enterococcus faecalis in the presence of 30% bovine serum (n=3) (range = 0.5 | ChEMBL. | 15993054 |
MIC (functional) | = 2 mg l-1 | Minimum inhibitory concentration against methicillin-resistant Staphylococcus aureus in the presence of 30% bovine serum | ChEMBL. | 15993054 |
MIC (functional) | = 2 mg l-1 | Minimum inhibitory concentration against vancomycin-sensitive Enterococcus faecium in the presence of 30% bovine serum(n=1) | ChEMBL. | 15993054 |
MIC (functional) | = 4 mg l-1 | Minimum inhibitory concentration against methicillin-sensitive Staphylococcus aureus in the presence of 30% bovine serum | ChEMBL. | 15993054 |
MIC (functional) | = 32 mg l-1 | Minimum inhibitory concentration against vancomycin-A Enterococcus faecalis in the presence of 30% bovine serum (n=4) | ChEMBL. | 15993054 |
MIC (functional) | = 64 mg l-1 | Minimum inhibitory concentration against methicillin-sensitive Staphylococcus epidermidis in the presence of 30% bovine serum | ChEMBL. | 15993054 |
MIC (functional) | = 128 mg l-1 | Minimum inhibitory concentration against methicillin-resistant Staphylococcus epidermidis in the presence of 30% bovine serum | ChEMBL. | 15993054 |
MIC (functional) | > 128 mg l-1 | Minimum inhibitory concentration against Staphylococcus haemolyticus in the presence of 30% bovine serum | ChEMBL. | 15993054 |
MIC (functional) | > 128 mg l-1 | Minimum inhibitory concentration against vancomycin-A Enterococcus faecium in the presence of 30% bovine serum (n=1) (range = 2 | ChEMBL. | 15993054 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.