Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neurotensin receptor 1 (high affinity) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.097 | 0.9987 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0838 | 0.8548 | 0.8548 |
Leishmania major | fk506-binding protein 1-like protein | 0.097 | 0.9987 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0836 | 0.8535 | 0.8546 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.097 | 0.9987 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.0133 | 0.0887 | 0.0888 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 | 0.0133 | 0.0887 | 0.0888 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.097 | 0.9987 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 | 0.0133 | 0.0887 | 0.0888 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0133 | 0.0887 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.097 | 0.9987 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.097 | 0.9987 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.097 | 0.9987 | 1 |
Echinococcus granulosus | FK506 binding protein 2 | 0.0133 | 0.0887 | 0.0887 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.097 | 0.9987 | 1 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0728 | 0.736 | 0.7369 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.097 | 0.9987 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0133 | 0.0887 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.097 | 0.9987 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 | 0.0133 | 0.0887 | 0.0888 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.0133 | 0.0887 | 0.0888 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.097 | 0.9987 | 1 |
Onchocerca volvulus | 0.0133 | 0.0887 | 1 | |
Echinococcus multilocularis | 0.0133 | 0.0887 | 0.0887 | |
Loa Loa (eye worm) | hypothetical protein | 0.0728 | 0.736 | 0.7369 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.097 | 0.9987 | 1 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.0133 | 0.0887 | 0.0887 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.097 | 0.9987 | 1 |
Schistosoma mansoni | immunophilin | 0.0971 | 1 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.097 | 0.9987 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.097 | 0.9987 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.097 | 0.9987 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.097 | 0.9987 | 1 |
Schistosoma mansoni | immunophilin | 0.0838 | 0.8548 | 0.8548 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.097 | 0.9987 | 0.9987 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0133 | 0.0887 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0887 | 0.0888 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0838 | 0.8548 | 0.8548 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0133 | 0.0887 | 0.5 |
Onchocerca volvulus | 0.0133 | 0.0887 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0133 | 0.0887 | 0.0887 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.097 | 0.9987 | 1 |
Schistosoma mansoni | immunophilin | 0.0971 | 1 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.097 | 0.9987 | 0.9987 |
Loa Loa (eye worm) | hypothetical protein | 0.0704 | 0.7099 | 0.7108 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.097 | 0.9987 | 1 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0133 | 0.0887 | 0.5 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0133 | 0.0887 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0971 | 1 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0971 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0133 | 0.0887 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.0133 | 0.0887 | 0.0888 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0133 | 0.0887 | 0.5 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0133 | 0.0887 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0971 | 1 | 1 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0135 | 0.09 | 0.09 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.097 | 0.9987 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.097 | 0.9987 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.097 | 0.9987 | 0.9987 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.097 | 0.9987 | 1 |
Schistosoma mansoni | fk506 binding protein | 0.0133 | 0.0887 | 0.0887 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 113 nM | Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide | ChEMBL. | 12852770 |
IC50 (binding) | = 113 nM | Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide | ChEMBL. | 12852770 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.