Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0032 | 0.0007 | 0.0007 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0032 | 0.0007 | 0.0007 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0032 | 0.0007 | 0.0007 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.1667 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0008 | 0.0008 |
Leishmania major | FKBP-type peptidyl-prolyl cis-trans isomerase, putative | 0.0229 | 0.1213 | 0.1214 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0144 | 0.0691 | 0.0691 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0052 | 0.0129 | 0.0129 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0363 | 0.203 | 0.2031 |
Plasmodium vivax | peptidyl-prolyl cis-trans isomerase, putative | 0.0229 | 0.1213 | 0.1214 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0032 | 0.0007 | 0.0007 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0229 | 0.1213 | 0.1214 |
Trypanosoma cruzi | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0229 | 0.1213 | 0.1214 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0144 | 0.0691 | 0.0692 |
Onchocerca volvulus | 0.018 | 0.0909 | 0.3902 | |
Trichomonas vaginalis | set domain proteins, putative | 0.0412 | 0.233 | 0.2332 |
Onchocerca volvulus | 0.0412 | 0.233 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0909 | 0.091 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0032 | 0.0007 | 0.0007 |
Onchocerca volvulus | 0.0229 | 0.1213 | 0.5204 | |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0052 | 0.0129 | 0.1064 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0229 | 0.1213 | 1 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.1666 | 0.9992 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.1666 | 0.9992 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.0229 | 0.1213 | 0.1214 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0052 | 0.0129 | 0.0129 |
Echinococcus granulosus | smad | 0.0037 | 0.0036 | 0.0036 |
Brugia malayi | Pre-SET motif family protein | 0.0052 | 0.0129 | 0.0129 |
Schistosoma mansoni | hypothetical protein | 0.0115 | 0.0513 | 0.0513 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.005 | 0.0117 | 0.0117 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative | 0.0229 | 0.1213 | 0.1214 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | 0.0229 | 0.1213 | 0.1214 |
Echinococcus multilocularis | tumor protein p63 | 0.1227 | 0.731 | 0.731 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.1328 | 0.1329 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0229 | 0.1213 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0115 | 0.0513 | 0.0514 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1666 | 0.9992 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0052 | 0.0129 | 0.0129 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0032 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0037 | 0.0036 | 0.0036 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1666 | 0.9992 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0032 | 0.0007 | 0.0007 |
Brugia malayi | Pre-SET motif family protein | 0.0362 | 0.2024 | 0.2026 |
Brugia malayi | MH2 domain containing protein | 0.0037 | 0.0036 | 0.0036 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1438 | 0.8599 | 0.8599 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0037 | 0.0036 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.1437 | 0.8591 | 0.8598 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0.0008 | 0.0001 |
Trichomonas vaginalis | immunophilin, putative | 0.1666 | 0.9992 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0513 | 0.0514 |
Onchocerca volvulus | 0.0052 | 0.0129 | 0.0554 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0032 | 0.0008 | 0.0008 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0229 | 0.1213 | 0.1214 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0638 | 0.3711 | 0.3711 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0032 | 0.0008 | 0.0008 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0032 | 0.0007 | 0.0007 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0037 | 0.0036 | 0.0036 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.0229 | 0.1213 | 0.1214 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0229 | 0.1213 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0363 | 0.203 | 0.2031 |
Brugia malayi | MH2 domain containing protein | 0.0037 | 0.0036 | 0.0036 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0231 | 0.1221 | 0.1221 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0144 | 0.0691 | 0.0691 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0.0008 | 0.0001 |
Schistosoma mansoni | Smad4 | 0.0037 | 0.0036 | 0.0036 |
Brugia malayi | Smad1 | 0.0037 | 0.0036 | 0.0036 |
Schistosoma mansoni | hypothetical protein | 0.0229 | 0.1213 | 0.1213 |
Schistosoma mansoni | hypothetical protein | 0.0115 | 0.0513 | 0.0513 |
Schistosoma mansoni | immunophilin | 0.1438 | 0.8599 | 0.8599 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0052 | 0.0129 | 0.0129 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0229 | 0.1213 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 | 0.0229 | 0.1213 | 0.1214 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.1667 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0363 | 0.203 | 0.2031 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0129 | 0.0129 |
Brugia malayi | MH1 domain containing protein | 0.0037 | 0.0036 | 0.0036 |
Echinococcus granulosus | tumor protein p63 | 0.1227 | 0.731 | 0.731 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0229 | 0.1213 | 0.1207 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1666 | 0.9992 | 1 |
Trichomonas vaginalis | fk506 binding protein, putative | 0.0229 | 0.1213 | 0.1214 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0.0008 | 0.0001 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0032 | 0.0008 | 0.0008 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.1666 | 0.9992 | 0.9992 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0197 | 0.1015 | 0.8371 |
Schistosoma mansoni | alpha glucosidase | 0.0032 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0144 | 0.0691 | 0.0692 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0115 | 0.0513 | 0.0514 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0115 | 0.0513 | 0.0513 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0229 | 0.1213 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.0229 | 0.1213 | 0.1214 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0229 | 0.1213 | 0.1214 |
Brugia malayi | MH1 domain containing protein | 0.0037 | 0.0036 | 0.0036 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0037 | 0.0036 | 0.0036 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0144 | 0.0691 | 0.0691 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0638 | 0.3711 | 0.3711 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0229 | 0.1213 | 0.1214 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0248 | 0.1328 | 0.1329 |
Trypanosoma brucei | glucosidase, putative | 0.0032 | 0.0007 | 0.0007 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1667 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0248 | 0.1328 | 0.1328 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0115 | 0.0513 | 0.0513 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.054 | 0.3108 | 0.3111 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.1666 | 0.9992 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0229 | 0.1213 | 0.5 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.1666 | 0.9992 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0037 | 0.0036 | 0.0036 |
Schistosoma mansoni | immunophilin | 0.1667 | 1 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 | 0.0229 | 0.1213 | 0.1214 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0229 | 0.1213 | 0.1214 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.1438 | 0.8599 | 0.8599 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0229 | 0.1213 | 0.1214 |
Onchocerca volvulus | 0.0083 | 0.0321 | 0.1376 | |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0037 | 0.0036 | 0.0036 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.1666 | 0.9992 | 0.9992 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.1666 | 0.9992 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0115 | 0.0513 | 0.0513 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0115 | 0.0513 | 0.0513 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1666 | 0.9992 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0037 | 0.0036 | 0.0036 |
Schistosoma mansoni | fk506 binding protein | 0.0229 | 0.1213 | 0.1213 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0032 | 0.0007 | 0.0007 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.1666 | 0.9992 | 1 |
Brugia malayi | MH2 domain containing protein | 0.054 | 0.3108 | 0.3111 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1666 | 0.9992 | 1 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.0229 | 0.1213 | 0.1213 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0229 | 0.1213 | 0.1214 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0032 | 0.0007 | 0.0057 |
Schistosoma mansoni | hypothetical protein | 0.0115 | 0.0513 | 0.0513 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.1666 | 0.9992 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.203 | 0.2031 |
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | 0.0229 | 0.1213 | 0.1214 |
Trypanosoma brucei | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0229 | 0.1213 | 0.1214 |
Echinococcus multilocularis | 0.0229 | 0.1213 | 0.1213 | |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0032 | 0.0007 | 0.0007 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0032 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0362 | 0.2024 | 0.2026 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0052 | 0.0129 | 0.0129 |
Trypanosoma cruzi | macrophage infectivity potentiator, precursor, putative | 0.0229 | 0.1213 | 0.1214 |
Onchocerca volvulus | 0.0229 | 0.1213 | 0.5204 | |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0.0008 | 0.0001 |
Echinococcus multilocularis | Smad4 | 0.0037 | 0.0036 | 0.0036 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.054 | 0.3108 | 0.3111 |
Loa Loa (eye worm) | Smad1 | 0.0037 | 0.0036 | 0.0036 |
Schistosoma mansoni | smad1 5 8 and | 0.0037 | 0.0036 | 0.0036 |
Loa Loa (eye worm) | FKBP5 protein | 0.1666 | 0.9992 | 1 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.1666 | 0.9992 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.1666 | 0.9992 | 1 |
Schistosoma mansoni | immunophilin | 0.1667 | 1 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.1666 | 0.9992 | 1 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0229 | 0.1213 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0229 | 0.1213 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0115 | 0.0513 | 0.0513 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.1666 | 0.9992 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0124 | 0.0569 | 0.0569 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0052 | 0.0129 | 0.0129 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0032 | 0.0007 | 0.0007 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0052 | 0.0129 | 0.0129 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.018 | 0.0909 | 0.0909 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0229 | 0.1213 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0229 | 0.1213 | 0.1214 |
Echinococcus multilocularis | fk506 binding protein | 0.1666 | 0.9992 | 0.9992 |
Echinococcus granulosus | Smad4 | 0.0037 | 0.0036 | 0.0036 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0032 | 0.0007 | 0.0007 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0229 | 0.1213 | 0.1207 |
Echinococcus granulosus | FK506 binding protein 2 | 0.0229 | 0.1213 | 0.1213 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0032 | 0.0007 | 0.0007 |
Trypanosoma cruzi | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0229 | 0.1213 | 0.1214 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0037 | 0.0036 | 0.0036 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.1666 | 0.9992 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0638 | 0.3711 | 0.3711 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0115 | 0.0513 | 0.0514 |
Echinococcus multilocularis | GPCR, family 2 | 0.0115 | 0.0513 | 0.0513 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1666 | 0.9992 | 1 |
Echinococcus multilocularis | smad | 0.0037 | 0.0036 | 0.0036 |
Schistosoma mansoni | smad1 5 8 and | 0.0037 | 0.0036 | 0.0036 |
Echinococcus granulosus | GPCR family 2 | 0.0115 | 0.0513 | 0.0513 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.1213 | 0.1214 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0032 | 0.0007 | 0.0007 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 | 0.0229 | 0.1213 | 0.1214 |
Schistosoma mansoni | alpha-glucosidase | 0.0124 | 0.0569 | 0.0569 |
Schistosoma mansoni | smad | 0.0037 | 0.0036 | 0.0036 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0032 | 0.0007 | 0.0007 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0229 | 0.1213 | 0.1214 |
Leishmania major | fk506-binding protein 1-like protein | 0.1666 | 0.9992 | 1 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0008 | 0.0008 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0052 | 0.0129 | 0.0129 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1666 | 0.9992 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
K ass (binding) | = 18 10E3*1/M*1/s | Association rate constant for doxorubicin binding to endo-beta-N-acetylglucosaminidase of Mucor hiemalis by SPR biosensor | ChEMBL. | 15686902 |
K diss (binding) | = 0.34 10E-2*1/s | Dissociation rate constant for doxorubicin binding to endo-beta-N-acetylglucosaminidase of Mucor hiemalis by SPR biosensor | ChEMBL. | 15686902 |
Ka (binding) | = 5300 10E3*1/M | Association constant for doxorubicin binding to endo-beta-N-acetylglucosaminidase of Mucor hiemalis by SPR biosensor | ChEMBL. | 15686902 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.