Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | DNA excision repair protein ERCC 1 | 0.0116 | 0.3833 | 0.8647 |
Plasmodium falciparum | ERCC1 nucleotide excision repair protein, putative | 0.0116 | 0.3833 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.4134 | 0.783 |
Plasmodium vivax | DNA repair endonuclease, putative | 0.0082 | 0.2479 | 0.4111 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF6, putative | 0.0123 | 0.4134 | 1 |
Echinococcus granulosus | flap endonuclease 1 | 0.0059 | 0.1534 | 0.346 |
Echinococcus granulosus | dna repair endonuclease xpf | 0.0082 | 0.2479 | 0.5592 |
Brugia malayi | Flap endonuclease-1 | 0.0059 | 0.1534 | 0.1534 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0123 | 0.4134 | 1 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0059 | 0.1534 | 0.2905 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0123 | 0.4134 | 0.783 |
Schistosoma mansoni | excision repair cross-complementing 1 ercc1 | 0.0116 | 0.3833 | 0.7259 |
Entamoeba histolytica | DNA excision repair protein, putative | 0.0116 | 0.3833 | 0.8841 |
Schistosoma mansoni | flap endonuclease-1 | 0.0053 | 0.1305 | 0.2471 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0123 | 0.4134 | 1 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF7 | 0.0123 | 0.4134 | 1 |
Trichomonas vaginalis | nuclease Rad1 | 0.0082 | 0.2479 | 0.3634 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0123 | 0.4134 | 1 |
Loa Loa (eye worm) | ERCC4 domain-containing protein | 0.0082 | 0.2479 | 0.2582 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0123 | 0.4134 | 1 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0059 | 0.1534 | 0.1206 |
Echinococcus multilocularis | DNA excision repair protein ERCC 1 | 0.0116 | 0.3833 | 0.7259 |
Entamoeba histolytica | DNA repair endonuclease, putative | 0.0082 | 0.2479 | 0.3634 |
Toxoplasma gondii | ERCC4 domain-containing protein | 0.0082 | 0.2479 | 0.4111 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0123 | 0.4134 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0259 | 0.96 | 0.96 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0123 | 0.4134 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.0123 | 0.4134 | 0.9327 |
Loa Loa (eye worm) | helix-hairpin-helix domain-containing protein family protein | 0.0116 | 0.3833 | 0.3992 |
Giardia lamblia | Rrm3p helicase | 0.0123 | 0.4134 | 1 |
Trichomonas vaginalis | excision repair cross-complementing 1 ercc1, putative | 0.0116 | 0.3833 | 0.8841 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0059 | 0.1534 | 0.1206 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0123 | 0.4134 | 1 |
Plasmodium falciparum | DNA repair endonuclease, putative | 0.0072 | 0.2074 | 0.2352 |
Brugia malayi | Helix-hairpin-helix motif family protein | 0.0066 | 0.1808 | 0.1808 |
Plasmodium vivax | ERCC1 nucleotide excision repair protein, putative | 0.0116 | 0.3833 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0131 | 0.4432 | 0.8394 |
Toxoplasma gondii | DNA repair protein rad10 subfamily protein | 0.0116 | 0.3833 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0259 | 0.96 | 1 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF6 | 0.0123 | 0.4134 | 1 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Brugia malayi | ERCC4 domain containing protein | 0.0082 | 0.2479 | 0.2479 |
Schistosoma mansoni | DNA repair endonuclease xp-f / mei-9 / rad1 | 0.0082 | 0.2479 | 0.4695 |
Schistosoma mansoni | thyroid hormone receptor | 0.0152 | 0.528 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0259 | 0.96 | 0.96 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0059 | 0.1534 | 0.1597 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0152 | 0.528 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.4432 | 0.8394 |
Schistosoma mansoni | thyroid hormone receptor | 0.0152 | 0.528 | 1 |
Echinococcus multilocularis | dna repair endonuclease xpf | 0.0082 | 0.2479 | 0.4695 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.9552 | 0.995 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0131 | 0.4432 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.45 nM | In vitro inhibitory concentration of the compound against HMVE cell migration was determined | ChEMBL. | 15828822 |
IC50 (functional) | = 10 nM | In vitro inhibitory concentration of the compound against HMVEC endothelial tube formation was determined; 10 - 5.0 nM | ChEMBL. | 15828822 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.