Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0177 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0126 | 0.414 | 0.5 |
Onchocerca volvulus | 0.0126 | 0.414 | 1 | |
Brugia malayi | thymidylate synthase | 0.0126 | 0.414 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0177 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0126 | 0.414 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0126 | 0.414 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0126 | 0.414 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0126 | 0.414 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0177 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0126 | 0.414 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0177 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0126 | 0.414 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0177 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.03 ug ml-1 | In vitro antibacterial activity of the compound against penicillin-resistant Streptococcus pneumoniae A28272 | ChEMBL. | 15482927 |
MIC (functional) | = 0.5 ug ml-1 | In vitro antibacterial activity of the compound against methicillin-sensitive Staphylococcus aureus A15090 | ChEMBL. | 15482927 |
MIC (functional) | = 2 ug ml-1 | In vitro antibacterial activity of the compound against methicillin-sensitive Enterococcus faecalis A20688 | ChEMBL. | 15482927 |
PD50 (functional) | = 5 mg kg-1 | In vivo efficacy (PD50) against lethal S. aureus systemic infection model in mice | ChEMBL. | 15482927 |
PD50 (functional) | = 5 mg kg-1 | In vivo efficacy (PD50) against lethal S. aureus systemic infection model in mice | ChEMBL. | 15482927 |
Solubility | > 2.4 mg ml-1 | Equilibrium water solubility of the compound at pH 2.7 | ChEMBL. | 15482927 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.