Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0154 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0154 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0154 | 1 | 1 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0127 | 0.5337 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0154 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0135 | 0.683 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0154 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0154 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0154 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0127 | 0.5337 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0127 | 0.5337 | 0.5337 |
Schistosoma mansoni | nuclear hormone receptor | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0135 | 0.683 | 0.683 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0154 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.5337 | 0.5337 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0127 | 0.5337 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0154 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0135 | 0.683 | 0.683 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0154 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0154 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0127 | 0.5337 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0154 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0127 | 0.5337 | 0.5337 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0135 | 0.683 | 0.683 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0154 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0154 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0154 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0154 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0154 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0127 | 0.5337 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0154 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0127 | 0.5337 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0154 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0154 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0135 | 0.683 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0154 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0127 | 0.5337 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0135 | 0.683 | 0.683 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0127 | 0.5337 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0127 | 0.5337 | 0.5337 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0127 | 0.5337 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0154 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0127 | 0.5337 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0127 | 0.5337 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0154 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0127 | 0.5337 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0154 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0135 | 0.683 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0127 | 0.5337 | 0.5337 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0154 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0154 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0127 | 0.5337 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0154 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0154 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0154 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0154 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0127 | 0.5337 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0154 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0154 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0154 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0127 | 0.5337 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0154 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0135 | 0.683 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0154 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0154 | 1 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0127 | 0.5337 | 0.5337 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0127 | 0.5337 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0154 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0135 | 0.683 | 0.683 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0154 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 | 0.0127 | 0.5337 | 0.5337 |
Mycobacterium leprae | putative cytochrome p450 | 0.0127 | 0.5337 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0127 | 0.5337 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0154 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0154 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0154 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0154 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0154 | 1 | 1 |
Brugia malayi | cytochrome P450 | 0.0127 | 0.5337 | 0.5337 |
Schistosoma mansoni | thyroid hormone receptor | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0127 | 0.5337 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0127 | 0.5337 | 0.5 |
Echinococcus multilocularis | 0.0127 | 0.5337 | 0.5337 | |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0127 | 0.5337 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0127 | 0.5337 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0127 | 0.5337 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0154 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0154 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0154 | 1 | 1 |
Onchocerca volvulus | 0.0154 | 1 | 1 | |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0154 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0135 | 0.683 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0154 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0154 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.