Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.25 ug ml-1 | In vitro minmum inhibitory concentration against penicillin resistant Streptococcus pneumoniae A28272 | ChEMBL. | 15808470 |
MIC (functional) | = 2 ug ml-1 | In vitro minmum inhibitory concentration against methicillin sensitive Streptococcus aureus A15090 | ChEMBL. | 15808470 |
MIC (functional) | = 2 ug ml-1 | In vitro minmum inhibitory concentration against methicillin sensitive Enterococcus faecalis A20688 | ChEMBL. | 15808470 |
PD50 (functional) | = 2.5 mg kg-1 | In vivo protective dose required for mouse against systemic lethal Streptococcus aureus infection | ChEMBL. | 15808470 |
PD50 (functional) | = 2.5 mg kg-1 | In vivo protective dose required for mouse against systemic lethal Streptococcus aureus infection | ChEMBL. | 15808470 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.