Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.043 | 0.1012 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0392 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0729 | 0.8988 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.043 | 0.1012 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0729 | 0.8988 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Complex formation (functional) | = 99 % | % complex formation of cellular protein -DNA complex at a concentration of 10 microM. | ChEMBL. | 1662724 |
Complex formation (binding) | = 99 % | Percentage of intracellular covalent DNA-topoisomerase II complexes formed | ChEMBL. | 12014968 |
Complex formation (binding) | = 99 % | Percentage of intracellular covalent DNA-topoisomerase II complexes formed | ChEMBL. | 12014968 |
ID50 (functional) | = 2.3 uM | 50% reduction in KB cell number after a 3-day incubation. | ChEMBL. | 1662724 |
ID50 (binding) | = 100 uM | Inhibition of human DNA topoisomerase II | ChEMBL. | 1662724 |
ID50 (binding) | = 100 uM | Inhibition of human DNA topoisomerase II | ChEMBL. | 1662724 |
Protein-DNA complex formation (functional) | = 99 % | Compound tested for ability to form a cellular covalent topoisomerase II-DNA complex. | ChEMBL. | 8691468 |
Protein-DNA complex formation (functional) | = 99 % | Compound tested for ability to form a cellular covalent topoisomerase II-DNA complex. | ChEMBL. | 8691468 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.