Detailed information for compound 407371

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1059.27 | Formula: C55H74N14O8
  • H donors: 13 H acceptors: 8 LogP: 2.13 Rotable bonds: 37
    Rule of 5 violations (Lipinski): 3
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)C(C)C)Cc1ccccc1)NC(=O)CNC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](N)C)Cc1ccc2c(c1)cccc2)CCCN=C(N)N
  • InChi: 1S/C55H74N14O8/c1-32(2)47(48(58)71)69-54(77)43(27-34-14-5-4-6-15-34)67-51(74)41(20-11-12-24-56)64-46(70)31-63-50(73)45(29-38-30-62-40-19-10-9-18-39(38)40)68-52(75)42(21-13-25-61-55(59)60)65-53(76)44(66-49(72)33(3)57)28-35-22-23-36-16-7-8-17-37(36)26-35/h4-10,14-19,22-23,26,30,32-33,41-45,47,62H,11-13,20-21,24-25,27-29,31,56-57H2,1-3H3,(H2,58,71)(H,63,73)(H,64,70)(H,65,76)(H,66,72)(H,67,74)(H,68,75)(H,69,77)(H4,59,60,61)/t33-,41-,42-,43-,44+,45-,47-/m0/s1
  • InChiKey: JPXWTHVSOZFDDV-PLYVHYDISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tubulin beta 1 chain 0.1205 0.77 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0826 0.5168 0.6703
Echinococcus granulosus muscleblind protein 0.0161 0.0724 0.0916
Leishmania major alpha tubulin 0.0826 0.5168 0.6658
Loa Loa (eye worm) hypothetical protein 0.0151 0.0657 0.0638
Trichomonas vaginalis glutaminase, putative 0.0294 0.1615 0.0279
Trypanosoma cruzi beta tubulin, putative 0.1205 0.77 1
Brugia malayi glutaminase DH11.1 0.0294 0.1615 0.1598
Brugia malayi Tubulin alpha-2 chain 0.0826 0.5168 0.5159
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0095 0.0287 0.0347
Echinococcus granulosus tubulin alpha chain 0.0826 0.5168 0.6703
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.0677 0.0854
Trypanosoma brucei alpha tubulin 0.0826 0.5168 0.6658
Echinococcus multilocularis tubulin alpha chain 0.0826 0.5168 0.6703
Leishmania major beta tubulin 0.1205 0.77 1
Schistosoma mansoni tubulin subunit beta 0.1205 0.77 1
Echinococcus multilocularis muscleblind protein 1 0.0161 0.0724 0.0916
Trichomonas vaginalis tubulin beta chain, putative 0.0826 0.5168 0.5955
Echinococcus granulosus twitchin 0.012 0.0449 0.0559
Echinococcus granulosus tubulin gamma 1 chain 0.0618 0.3774 0.4888
Echinococcus granulosus Tubulin alpha 1 chain 0.0826 0.5168 0.6703
Schistosoma mansoni tubulin subunit epsilon 0.0618 0.3774 0.4888
Plasmodium falciparum tubulin beta chain 0.1205 0.77 1
Entamoeba histolytica tubulin gamma chain 0.0618 0.3774 0.4818
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0826 0.5168 0.5955
Loa Loa (eye worm) hypothetical protein 0.0095 0.0287 0.0267
Leishmania major beta tubulin 0.1205 0.77 1
Trypanosoma brucei zeta tubulin 0.0268 0.1441 0.1737
Schistosoma mansoni tyrosine kinase 0.0064 0.0078 0.0075
Trypanosoma cruzi tubulin delta chain 0.0268 0.1441 0.1848
Loa Loa (eye worm) hypothetical protein 0.0095 0.0287 0.0267
Toxoplasma gondii beta-tubulin, putative 0.1205 0.77 1
Echinococcus multilocularis Tubulin beta 2C chain 0.1205 0.77 1
Trichomonas vaginalis tubulin, putative 0.1205 0.77 1
Leishmania major gamma-tubulin 0.0618 0.3774 0.4818
Schistosoma mansoni alpha tubulin 0.0826 0.5168 0.6703
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0618 0.3774 0.4901
Leishmania major beta tubulin 0.1205 0.77 1
Plasmodium falciparum tubulin gamma chain 0.0618 0.3774 0.3728
Schistosoma mansoni tubulin subunit beta 0.1205 0.77 1
Leishmania major beta tubulin 0.1205 0.77 1
Loa Loa (eye worm) tubulin beta chain 0.1205 0.77 0.7696
Schistosoma mansoni tubulin subunit beta 0.1205 0.77 1
Brugia malayi Tubulin beta chain 0.0349 0.1983 0.1967
Echinococcus granulosus tubulin subunit TubB 0.0826 0.5168 0.6703
Trichomonas vaginalis tubulin epsilon chain, putative 0.1205 0.77 1
Schistosoma mansoni tubulin subunit beta 0.0268 0.1441 0.185
Echinococcus multilocularis tubulin subunit TubB 0.0826 0.5168 0.6703
Leishmania major beta tubulin 0.1205 0.77 1
Trypanosoma brucei tubulin delta chain 0.0268 0.1441 0.1737
Trypanosoma cruzi epsilon tubulin, putative 0.0618 0.3774 0.4887
Echinococcus granulosus tubulin alpha 3 chain 0.0826 0.5168 0.6703
Brugia malayi Fibronectin type III domain containing protein 0.0095 0.0287 0.0267
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0124 0.0136
Trypanosoma cruzi zeta tubulin, putative 0.0268 0.1441 0.1848
Trypanosoma brucei beta tubulin 0.1205 0.77 1
Echinococcus granulosus neuroglian 0.012 0.0449 0.0559
Trypanosoma brucei tubulin gamma chain 0.0618 0.3774 0.4818
Loa Loa (eye worm) BEN-1 protein 0.1205 0.77 0.7696
Echinococcus granulosus tubulin beta 4A class IVa 0.1205 0.77 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0826 0.5168 0.6703
Brugia malayi Tubulin alpha chain 0.0826 0.5168 0.5159
Loa Loa (eye worm) hypothetical protein 0.0095 0.0287 0.0267
Toxoplasma gondii beta tubulin 0.1205 0.77 1
Entamoeba histolytica tubulin family protein 0.1205 0.77 1
Echinococcus multilocularis tubulin alpha chain 0.0826 0.5168 0.6703
Trichomonas vaginalis tubulin alpha chain, putative 0.0349 0.1983 0.0867
Trichomonas vaginalis tubulin beta chain, putative 0.1205 0.77 1
Brugia malayi Muscleblind-like protein 0.0161 0.0724 0.0705
Brugia malayi hypothetical protein 0.0163 0.0736 0.0718
Leishmania major alpha tubulin 0.0826 0.5168 0.6658
Trichomonas vaginalis tubulin, putative 0.0349 0.1983 0.0867
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.0677 0.073
Loa Loa (eye worm) hypothetical protein 0.0095 0.0287 0.0267
Echinococcus multilocularis geminin 0.0182 0.0868 0.1104
Loa Loa (eye worm) tubulin beta chain 0.0268 0.1441 0.1423
Leishmania major alpha tubulin 0.0826 0.5168 0.6658
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0124 0.0104
Trypanosoma brucei beta tubulin 0.1205 0.77 1
Brugia malayi hypothetical protein 0.0095 0.0287 0.0267
Echinococcus granulosus beta tubulin 0.1205 0.77 1
Echinococcus granulosus tubulin alpha 1C chain 0.0826 0.5168 0.6703
Loa Loa (eye worm) tubulin gamma chain 0.0618 0.3774 0.3762
Plasmodium vivax tubulin alpha chain, putative 0.0826 0.5168 0.5955
Echinococcus granulosus defective proboscis extension response 0.0095 0.0287 0.0347
Echinococcus multilocularis tubulin gamma 1 chain 0.0618 0.3774 0.4888
Trypanosoma brucei zeta tubulin, putative 0.0268 0.1441 0.1737
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0268 0.1441 0.1871
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0124 0.0136
Schistosoma mansoni tubulin subunit alpha 0.0268 0.1441 0.185
Loa Loa (eye worm) hypothetical protein 0.0163 0.0736 0.0718
Leishmania major beta tubulin 0.1205 0.77 1
Echinococcus granulosus Tubulin beta 2C chain 0.1205 0.77 1
Echinococcus granulosus tubulin alpha chain 0.0826 0.5168 0.6703
Entamoeba histolytica tubulin alpha-1 chain 0.0826 0.5168 0.6658
Schistosoma mansoni glutaminase 0.0294 0.1615 0.2077
Schistosoma mansoni tubulin subunit beta 0.1205 0.77 1
Leishmania major beta tubulin 0.1205 0.77 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0826 0.5168 0.6703
Schistosoma mansoni tubulin subunit beta 0.1205 0.77 1
Echinococcus multilocularis beta tubulin 0.1205 0.77 1
Echinococcus multilocularis roundabout 2 0.0151 0.0657 0.0829
Loa Loa (eye worm) tubulin alpha 2 0.0209 0.1044 0.1026
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0124 0.0133
Loa Loa (eye worm) tubulin beta-1 chain 0.1205 0.77 0.7696
Plasmodium falciparum tubulin epsilon chain, putative 0.0618 0.3774 0.3728
Echinococcus multilocularis Tubulin beta 2C chain 0.1205 0.77 1
Brugia malayi alpha-tubulin 0.0826 0.5168 0.5159
Echinococcus multilocularis Immunoglobulin 0.0095 0.0287 0.0347
Loa Loa (eye worm) tubulin alpha 2 0.0558 0.3378 0.3364
Echinococcus multilocularis Tubulin beta 2C chain 0.1205 0.77 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.0657 0.0638
Echinococcus granulosus tubulin alpha chain 0.0826 0.5168 0.6703
Trypanosoma cruzi zeta tubulin, putative 0.0268 0.1441 0.1848
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0558 0.3378 0.3364
Leishmania major beta tubulin 0.1205 0.77 1
Echinococcus multilocularis neuroglian 0.012 0.0449 0.0559
Toxoplasma gondii alpha-tubulin I, putative 0.0826 0.5168 0.6712
Schistosoma mansoni tubulin subunit alpha 0.0826 0.5168 0.6703
Trichomonas vaginalis tubulin beta chain, putative 0.0826 0.5168 0.5955
Loa Loa (eye worm) tubulin beta-4 chain 0.1205 0.77 0.7696
Giardia lamblia Gamma tubulin 0.0618 0.3774 0.3728
Leishmania major delta tubulin, putative 0.0268 0.1441 0.1737
Schistosoma mansoni tubulin subunit gamma 0.0618 0.3774 0.4888
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0325 0.1821 0.2343
Trichomonas vaginalis tubulin gamma chain, putative 0.0618 0.3774 0.3728
Echinococcus multilocularis Tubulin beta 2C chain 0.1205 0.77 1
Mycobacterium leprae cell division protein FtsZ 0.0268 0.1441 0.5
Trichomonas vaginalis tubulin beta chain, putative 0.0826 0.5168 0.5955
Loa Loa (eye worm) tubulin alpha-3 chain 0.0477 0.2835 0.282
Plasmodium vivax tubulin epsilon chain, putative 0.0618 0.3774 0.3728
Schistosoma mansoni alpha tubulin 0.0826 0.5168 0.6703
Schistosoma mansoni tubulin subunit beta 0.1205 0.77 1
Echinococcus multilocularis Immunoglobulin 0.0095 0.0287 0.0347
Echinococcus granulosus tubulin beta 1 chain 0.1205 0.77 1
Echinococcus granulosus Immunoglobulin 0.0095 0.0287 0.0347
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0095 0.0287 0.0347
Entamoeba histolytica tubulin family protein 0.1205 0.77 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0826 0.5168 0.6703
Plasmodium falciparum alpha tubulin 1 0.0826 0.5168 0.5955
Loa Loa (eye worm) tubulin alpha 2 0.0558 0.3378 0.3364
Brugia malayi Cell division protein ftsZ 0.0268 0.1441 0.1423
Brugia malayi Tubulin beta chain 0.0268 0.1441 0.1423
Leishmania major alpha tubulin 0.0826 0.5168 0.6658
Loa Loa (eye worm) hypothetical protein 0.0095 0.0287 0.0267
Trypanosoma brucei alpha tubulin, putative 0.0349 0.1983 0.2454
Trichomonas vaginalis tubulin beta chain, putative 0.0826 0.5168 0.5955
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0558 0.3378 0.3094
Leishmania major beta tubulin 0.1205 0.77 1
Echinococcus multilocularis tubulin delta chain 0.0268 0.1441 0.185
Echinococcus multilocularis peroxisome assembly protein 26 0.0826 0.5168 0.6703
Onchocerca volvulus 0.0163 0.0736 0.077
Schistosoma mansoni lozenge 0.006 0.0049 0.0038
Loa Loa (eye worm) TK/KIN16 protein kinase 0.155 1 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0126 0.0494 0.0618
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0124 0.0133
Leishmania major alpha tubulin 0.0826 0.5168 0.6658
Mycobacterium tuberculosis Cell division protein FtsZ 0.0268 0.1441 1
Echinococcus multilocularis Tubulin beta 2C chain 0.1205 0.77 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.0287 0.0267
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0095 0.0287 0.0347
Onchocerca volvulus 0.0477 0.2834 0.3027
Leishmania major alpha tubulin 0.0826 0.5168 0.6658
Loa Loa (eye worm) hypothetical protein 0.0161 0.0724 0.0705
Loa Loa (eye worm) hypothetical protein 0.0126 0.0494 0.0475
Brugia malayi Tubulin alpha chain 0.0268 0.1441 0.1423
Leishmania major beta tubulin 0.1205 0.77 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0826 0.5168 0.6703
Toxoplasma gondii beta-1 tubulin, putative 0.1205 0.77 1
Entamoeba histolytica tubulin alpha chain, putative 0.0826 0.5168 0.6658
Giardia lamblia Alpha-tubulin 0.0826 0.5168 0.5955
Trichomonas vaginalis tubulin epsilon chain, putative 0.0826 0.5168 0.5955
Brugia malayi beta-tubulin, identical 0.1205 0.77 0.7696
Leishmania major beta tubulin 0.1205 0.77 1
Toxoplasma gondii alpha tubulin TUBA1 0.0826 0.5168 0.6712
Leishmania major alpha tubulin 0.0826 0.5168 0.6658
Giardia lamblia Beta tubulin 0.1205 0.77 1
Loa Loa (eye worm) hypothetical protein 0.0558 0.3378 0.3364
Echinococcus granulosus Tubulin beta 2C chain 0.1205 0.77 1
Brugia malayi Tubulin alpha-2 chain 0.0826 0.5168 0.5159
Leishmania major beta tubulin 0.1205 0.77 1
Leishmania major beta tubulin 0.1205 0.77 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0618 0.3774 0.3728
Trypanosoma brucei beta tubulin 0.1205 0.77 1
Schistosoma mansoni nephrin 0.012 0.0449 0.0559
Loa Loa (eye worm) hypothetical protein 0.0477 0.2835 0.282
Echinococcus multilocularis tubulin subunit beta 0.1205 0.77 1
Leishmania major alpha tubulin 0.0826 0.5168 0.6658
Leishmania major beta tubulin 0.1205 0.77 1
Trypanosoma brucei epsilon tubulin 0.0618 0.3774 0.4818
Trypanosoma cruzi alpha tubulin, putative 0.0826 0.5168 0.6702
Leishmania major epsilon tubulin, putative 0.0618 0.3774 0.4818
Treponema pallidum cell division protein FtsZ 0.0268 0.1441 0.5
Plasmodium vivax tubulin beta chain, putative 0.1205 0.77 1
Loa Loa (eye worm) runx1 0.006 0.0049 0.0029
Echinococcus multilocularis hypothetical protein 0.0826 0.5168 0.6703
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0124 0.0136
Echinococcus granulosus Tubulin beta 2C chain 0.1205 0.77 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0826 0.5168 0.6703
Leishmania major beta tubulin 0.1205 0.77 1
Brugia malayi Tubulin gamma chain 0.0618 0.3774 0.3762
Leishmania major alpha tubulin 0.0826 0.5168 0.6658
Echinococcus granulosus Tubulin beta 2C chain 0.1205 0.77 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1205 0.77 1
Schistosoma mansoni hypothetical protein 0.0182 0.0868 0.1104
Giardia lamblia Beta tubulin 0.1205 0.77 1
Echinococcus granulosus geminin 0.0182 0.0868 0.1104
Echinococcus multilocularis tubulin alpha 3 chain 0.0826 0.5168 0.6703
Leishmania major beta tubulin 0.1205 0.77 1
Brugia malayi tubulin alpha chain - mouse 0.0826 0.5168 0.5159
Echinococcus multilocularis tubulin alpha chain 0.0826 0.5168 0.6703
Echinococcus multilocularis tubulin epsilon chain 0.0618 0.3774 0.4888
Echinococcus granulosus peroxisome assembly protein 26 0.0826 0.5168 0.6703
Echinococcus multilocularis muscleblind protein 0.0161 0.0724 0.0916
Leishmania major alpha tubulin 0.0826 0.5168 0.6658
Trichomonas vaginalis tubulin alpha chain, putative 0.0618 0.3774 0.3728
Echinococcus multilocularis Tubulin alpha 1 chain 0.0826 0.5168 0.6703
Brugia malayi tubulin alpha-2 chain 0.0826 0.5168 0.5159
Loa Loa (eye worm) alpha-tubulin 0.0826 0.5168 0.5159
Echinococcus multilocularis tubulin alpha 0.0618 0.3774 0.4888
Echinococcus granulosus Tubulin beta 2C chain 0.1205 0.77 1
Trypanosoma cruzi tubulin delta chain 0.0268 0.1441 0.1848
Trypanosoma brucei beta tubulin 0.0618 0.3774 0.4818
Echinococcus granulosus tubulin alpha chain 0.0826 0.5168 0.6703
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0325 0.1821 0.2343
Leishmania major mitochondrial DNA polymerase beta 0.0325 0.1821 0.224
Mycobacterium ulcerans glutaminase 0.0294 0.1615 1
Loa Loa (eye worm) glutaminase 2 0.0294 0.1615 0.1598
Schistosoma mansoni tubulin subunit alpha 0.0826 0.5168 0.6703
Plasmodium falciparum alpha tubulin 2 0.0826 0.5168 0.5955
Trypanosoma brucei epsilon tubulin 0.0618 0.3774 0.4818
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0154 0.0677 0.073
Echinococcus granulosus tubulin delta chain 0.0268 0.1441 0.185
Loa Loa (eye worm) tubulin alpha chain 0.0826 0.5168 0.5159
Echinococcus granulosus tubulin subunit beta 0.1205 0.77 1
Schistosoma mansoni tubulin subunit alpha 0.0826 0.5168 0.6703
Brugia malayi Immunoglobulin I-set domain containing protein 0.0095 0.0287 0.0267
Loa Loa (eye worm) hypothetical protein 0.0477 0.2834 0.282
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0268 0.1441 0.5
Trypanosoma brucei epsilon tubulin 0.0618 0.3774 0.4818
Trichomonas vaginalis tubulin epsilon chain, putative 0.1205 0.77 1
Trypanosoma cruzi tubulin gamma chain 0.0618 0.3774 0.4887
Trichomonas vaginalis tubulin beta chain, putative 0.0826 0.5168 0.5955
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0349 0.1983 0.0867
Schistosoma mansoni tubulin subunit delta 0.0268 0.1441 0.185
Echinococcus multilocularis Protein lozenge 0.006 0.0049 0.0038
Mycobacterium ulcerans cell division protein FtsZ 0.0268 0.1441 0.7876
Echinococcus granulosus tubulin alpha 1C chain 0.0826 0.5168 0.6703
Echinococcus granulosus beta tubulin 0.1205 0.77 1
Schistosoma mansoni cell adhesion molecule 0.0126 0.0494 0.0618
Loa Loa (eye worm) hypothetical protein 0.0826 0.5168 0.5159
Trypanosoma brucei alpha tubulin 0.0826 0.5168 0.6658
Echinococcus multilocularis tubulin alpha chain 0.0826 0.5168 0.6703
Echinococcus granulosus tubulin epsilon chain 0.0618 0.3774 0.4888
Trichomonas vaginalis tubulin alpha chain, putative 0.1205 0.77 1
Loa Loa (eye worm) glutaminase 0.0294 0.1615 0.1598
Schistosoma mansoni hypothetical protein 0.0182 0.0868 0.1104
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0325 0.1821 0.224
Trypanosoma brucei beta tubulin 0.1205 0.77 1
Plasmodium vivax tubulin gamma chain, putative 0.0618 0.3774 0.3728
Trichomonas vaginalis tubulin alpha chain, putative 0.0349 0.1983 0.0867
Loa Loa (eye worm) beta-tubulin 0.1205 0.77 0.7696
Trypanosoma brucei alpha tubulin 0.0826 0.5168 0.6658
Echinococcus multilocularis beta tubulin 0.1205 0.77 1
Schistosoma mansoni vesicular amine transporter 0.0095 0.0287 0.0347
Trypanosoma brucei alpha tubulin 0.0826 0.5168 0.6658
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0268 0.1441 0.1871
Loa Loa (eye worm) tubulin alpha-2 chain 0.0826 0.5168 0.5159
Trichomonas vaginalis tubulin epsilon chain, putative 0.0826 0.5168 0.5955
Echinococcus multilocularis tubulin alpha chain 0.0826 0.5168 0.6703
Trichomonas vaginalis tubulin beta chain, putative 0.0826 0.5168 0.5955
Onchocerca volvulus Tyrosine kinase homolog 0.1448 0.9318 1
Echinococcus granulosus tubulin alpha 0.0618 0.3774 0.4888
Loa Loa (eye worm) BEN-1 protein 0.1205 0.77 0.7696
Echinococcus granulosus roundabout 2 0.0151 0.0657 0.0829
Leishmania major zeta tubulin, putative 0.0268 0.1441 0.1737
Leishmania major alpha tubulin 0.0826 0.5168 0.6658
Trichomonas vaginalis tubulin alpha chain, putative 0.0349 0.1983 0.0867
Plasmodium vivax tubulin alpha chain, putative 0.0826 0.5168 0.5955
Trichomonas vaginalis tubulin, putative 0.0349 0.1983 0.0867
Echinococcus granulosus tubulin alpha 3 chain 0.0826 0.5168 0.6703
Leishmania major alpha tubulin 0.0826 0.5168 0.6658
Onchocerca volvulus 0.0349 0.1983 0.2112
Brugia malayi hypothetical protein 0.0477 0.2834 0.282
Trichomonas vaginalis tubulin beta chain, putative 0.0349 0.1983 0.0867
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0477 0.2835 0.2227
Brugia malayi Tubulin beta-1 chain 0.1205 0.77 0.7696
Giardia lamblia Beta tubulin 0.1205 0.77 1
Loa Loa (eye worm) hypothetical protein 0.0161 0.0724 0.0705
Loa Loa (eye worm) tubulin beta-2A chain 0.1205 0.77 0.7696
Trichomonas vaginalis tubulin gamma chain, putative 0.1205 0.77 1
Schistosoma mansoni alpha tubulin 0.0826 0.5168 0.6703
Leishmania major beta tubulin 0.1205 0.77 1
Loa Loa (eye worm) tubulin alpha chain 0.0826 0.5168 0.5159
Leishmania major beta tubulin 0.1205 0.77 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0124 0.0104
Loa Loa (eye worm) alpha-tubulin 0.0826 0.5168 0.5159
Echinococcus granulosus Tubulin alpha 1 chain 0.0826 0.5168 0.6703
Trypanosoma cruzi epsilon tubulin, putative 0.0618 0.3774 0.4887
Giardia lamblia Alpha-tubulin 0.0826 0.5168 0.5955
Echinococcus granulosus alpha tubulin 0.0826 0.5168 0.6703
Loa Loa (eye worm) hypothetical protein 0.0477 0.2834 0.282
Echinococcus granulosus tubulin alpha chain 0.0826 0.5168 0.6703
Onchocerca volvulus 0.1415 0.9098 0.9763

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) < 10 % Inhibition of tumor necrosis factor alpha release by endotoxin stimulated human peripheral blood mononuclear cells at 1e-4 M ChEMBL. 15743181
Inhibition (functional) < 10 % Inhibition of tumor necrosis factor alpha release by endotoxin stimulated human peripheral blood mononuclear cells at 1e-4 M ChEMBL. 15743181
Inhibition (functional) = 62.8 % Inhibition of Candida albicans colony forming units (CFU) at 1e-4 M compound ChEMBL. 15743181
Inhibition (functional) = 62.8 % Inhibition of Candida albicans colony forming units (CFU) at 1e-4 M compound ChEMBL. 15743181

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.