Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ERCC4 domain-containing protein | 0.0082 | 0.2479 | 0.2582 |
Brugia malayi | Flap endonuclease-1 | 0.0059 | 0.1534 | 0.1534 |
Schistosoma mansoni | thyroid hormone receptor | 0.0152 | 0.528 | 1 |
Trichomonas vaginalis | excision repair cross-complementing 1 ercc1, putative | 0.0116 | 0.3833 | 0.8841 |
Toxoplasma gondii | DNA repair protein rad10 subfamily protein | 0.0116 | 0.3833 | 1 |
Schistosoma mansoni | excision repair cross-complementing 1 ercc1 | 0.0116 | 0.3833 | 0.7259 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0259 | 0.96 | 1 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0123 | 0.4134 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0259 | 0.96 | 0.96 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0123 | 0.4134 | 1 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF7 | 0.0123 | 0.4134 | 1 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0123 | 0.4134 | 1 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0059 | 0.1534 | 0.1597 |
Trichomonas vaginalis | nuclease Rad1 | 0.0082 | 0.2479 | 0.3634 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0059 | 0.1534 | 0.1206 |
Giardia lamblia | Rrm3p helicase | 0.0123 | 0.4134 | 1 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0059 | 0.1534 | 0.1206 |
Schistosoma mansoni | DNA repair endonuclease xp-f / mei-9 / rad1 | 0.0082 | 0.2479 | 0.4695 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0131 | 0.4432 | 1 |
Echinococcus granulosus | flap endonuclease 1 | 0.0059 | 0.1534 | 0.346 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0123 | 0.4134 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0059 | 0.1534 | 0.2905 |
Plasmodium vivax | ERCC1 nucleotide excision repair protein, putative | 0.0116 | 0.3833 | 1 |
Brugia malayi | Helix-hairpin-helix motif family protein | 0.0066 | 0.1808 | 0.1808 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0123 | 0.4134 | 0.783 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF6, putative | 0.0123 | 0.4134 | 1 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF6 | 0.0123 | 0.4134 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.9552 | 0.995 |
Brugia malayi | ERCC4 domain containing protein | 0.0082 | 0.2479 | 0.2479 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0123 | 0.4134 | 1 |
Loa Loa (eye worm) | helix-hairpin-helix domain-containing protein family protein | 0.0116 | 0.3833 | 0.3992 |
Toxoplasma gondii | ERCC4 domain-containing protein | 0.0082 | 0.2479 | 0.4111 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.4432 | 0.8394 |
Echinococcus multilocularis | dna repair endonuclease xpf | 0.0082 | 0.2479 | 0.4695 |
Echinococcus granulosus | DNA excision repair protein ERCC 1 | 0.0116 | 0.3833 | 0.8647 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0123 | 0.4134 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0259 | 0.96 | 0.96 |
Schistosoma mansoni | thyroid hormone receptor | 0.0152 | 0.528 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0021 | 0 | 0.5 |
Plasmodium falciparum | ERCC1 nucleotide excision repair protein, putative | 0.0116 | 0.3833 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0131 | 0.4432 | 0.8394 |
Schistosoma mansoni | flap endonuclease-1 | 0.0053 | 0.1305 | 0.2471 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0123 | 0.4134 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.0123 | 0.4134 | 0.9327 |
Echinococcus granulosus | dna repair endonuclease xpf | 0.0082 | 0.2479 | 0.5592 |
Echinococcus multilocularis | DNA excision repair protein ERCC 1 | 0.0116 | 0.3833 | 0.7259 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0152 | 0.528 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.4134 | 0.783 |
Entamoeba histolytica | DNA excision repair protein, putative | 0.0116 | 0.3833 | 0.8841 |
Plasmodium falciparum | DNA repair endonuclease, putative | 0.0072 | 0.2074 | 0.2352 |
Plasmodium vivax | DNA repair endonuclease, putative | 0.0082 | 0.2479 | 0.4111 |
Entamoeba histolytica | DNA repair endonuclease, putative | 0.0082 | 0.2479 | 0.3634 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.26 nM | In vitro inhibitory concentration of the compound against HMVE cell migration was determined | ChEMBL. | 15828822 |
IC50 (functional) | = 10 nM | In vitro inhibitory concentration of the compound against HMVEC endothelial tube formation was determined; 10 - 5.0 nM | ChEMBL. | 15828822 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.