Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cysteine peptidase, putative | 0.0098 | 0.165 | 0.165 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Plasmodium vivax | vivapain-2 | 0.0098 | 0.165 | 0.165 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Leishmania major | cathepsin L-like protease | 0.0098 | 0.165 | 0.1123 |
Onchocerca volvulus | 0.0098 | 0.165 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0063 | 0.015 | 0.015 |
Brugia malayi | Cathepsin L-like precursor | 0.0098 | 0.165 | 0.165 |
Onchocerca volvulus | 0.0098 | 0.165 | 1 | |
Echinococcus granulosus | cathepsin b | 0.0183 | 0.5269 | 0.5269 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0293 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0098 | 0.165 | 0.165 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0098 | 0.165 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0073 | 0.0593 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0098 | 0.165 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0098 | 0.165 | 0.165 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0073 | 0.0593 | 0.0593 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Brugia malayi | Cathepsin L-like precursor | 0.0063 | 0.015 | 0.015 |
Leishmania major | cathepsin L-like protease | 0.0098 | 0.165 | 0.1123 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0293 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0183 | 0.5269 | 0.5269 |
Loa Loa (eye worm) | ctsf protein | 0.0098 | 0.165 | 0.1523 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0073 | 0.0593 | 0.0593 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0293 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0098 | 0.165 | 0.1123 |
Loa Loa (eye worm) | cysteine protease | 0.0098 | 0.165 | 0.1523 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0098 | 0.165 | 0.165 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0098 | 0.165 | 0.1123 |
Echinococcus granulosus | cathepsin b | 0.0183 | 0.5269 | 0.5269 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Brugia malayi | cathepsin L-like precursor | 0.0063 | 0.015 | 0.015 |
Onchocerca volvulus | 0.0098 | 0.165 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0098 | 0.165 | 0.1523 |
Leishmania major | cathepsin L-like protease | 0.0098 | 0.165 | 0.1123 |
Echinococcus multilocularis | cysteine protease | 0.0098 | 0.165 | 0.165 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0098 | 0.165 | 0.165 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0098 | 0.165 | 0.165 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0098 | 0.165 | 0.165 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0098 | 0.165 | 0.165 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Leishmania major | cathepsin L-like protease | 0.0098 | 0.165 | 0.1123 |
Brugia malayi | Cathepsin L-like precursor | 0.0098 | 0.165 | 0.165 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0098 | 0.165 | 0.165 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0073 | 0.0593 | 0.3596 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0073 | 0.0593 | 0.045 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0063 | 0.015 | 0.015 |
Echinococcus multilocularis | cathepsin b | 0.0183 | 0.5269 | 0.5269 |
Giardia lamblia | Cathepsin B precursor | 0.0073 | 0.0593 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0098 | 0.165 | 0.165 |
Brugia malayi | Cathepsin L-like precursor | 0.0098 | 0.165 | 0.165 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.165 | 0.1523 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Onchocerca volvulus | 0.0098 | 0.165 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0183 | 0.5269 | 0.5269 |
Onchocerca volvulus | 0.0098 | 0.165 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0098 | 0.165 | 0.165 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0098 | 0.165 | 0.1523 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0293 | 1 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0293 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0183 | 0.5269 | 0.5269 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0098 | 0.165 | 0.165 |
Brugia malayi | Cathepsin L-like precursor | 0.0098 | 0.165 | 0.165 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Leishmania major | cathepsin L-like protease | 0.0098 | 0.165 | 0.1123 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0063 | 0.015 | 0.015 |
Echinococcus multilocularis | cysteine protease | 0.0098 | 0.165 | 0.165 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Leishmania major | cathepsin L-like protease | 0.0098 | 0.165 | 0.1123 |
Plasmodium vivax | vivapain-2 | 0.0098 | 0.165 | 0.165 |
Toxoplasma gondii | cathepsin CPL | 0.0098 | 0.165 | 0.1123 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Onchocerca volvulus | 0.0098 | 0.165 | 1 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0098 | 0.165 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0098 | 0.165 | 0.165 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0073 | 0.0593 | 0.5 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0098 | 0.165 | 0.165 |
Onchocerca volvulus | Cathepsin F homolog | 0.0098 | 0.165 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0073 | 0.0593 | 0.0593 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0183 | 0.5269 | 0.5269 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.5269 | 0.5197 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0098 | 0.165 | 0.165 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0293 | 1 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0293 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0098 | 0.165 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0063 | 0.015 | 0.015 |
Leishmania major | cathepsin L-like protease | 0.0098 | 0.165 | 0.1123 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0183 | 0.5269 | 0.5269 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0183 | 0.5269 | 0.5269 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0063 | 0.015 | 0.015 |
Brugia malayi | Cathepsin L-like precursor | 0.0098 | 0.165 | 0.165 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0063 | 0.015 | 0.0909 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0098 | 0.165 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0183 | 0.5269 | 0.5269 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0063 | 0.015 | 0.0909 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0293 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0098 | 0.165 | 0.165 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0098 | 0.165 | 0.165 |
Brugia malayi | Isocitrate dehydrogenase | 0.0293 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0098 | 0.165 | 0.165 |
Onchocerca volvulus | Cathepsin L homolog | 0.0098 | 0.165 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0098 | 0.165 | 0.165 |
Loa Loa (eye worm) | fibroinase | 0.0098 | 0.165 | 0.1523 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0063 | 0.015 | 0.0909 |
Onchocerca volvulus | 0.0098 | 0.165 | 1 | |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0293 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0098 | 0.165 | 0.165 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
NI (functional) | 0 | Compound was tested for inhibition of Leutenizing hormone release at 24 hours (very short duration) in castrated male rat assay; NI means no inhibition at 24 hr | ChEMBL. | 11462984 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.