Detailed information for compound 408009

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1103.2 | Formula: C53H82O24
  • H donors: 14 H acceptors: 14 LogP: -1.79 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 4
  • SMILES: COc1ccc(c(c1)[C@@H]1C[C@@H]2[C@]([C@H]1[C@@H](O[C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@@H]1O[C@H](CO)[C@@H]([C@@H]([C@H]1O)O)O)C)(C)CC[C@H]1[C@H]2CC=C2[C@]1(C)CC[C@@H](C2)O[C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@@H]1O[C@H](CO)[C@@H]([C@@H]([C@H]1O)O)O)OC
  • InChi: 1S/C53H82O24/c1-21(70-48-44(66)40(62)46(33(19-56)74-48)76-50-42(64)38(60)36(58)31(17-54)72-50)35-27(26-15-23(68-4)7-9-30(26)69-5)16-29-25-8-6-22-14-24(10-12-52(22,2)28(25)11-13-53(29,35)3)71-49-45(67)41(63)47(34(20-57)75-49)77-51-43(65)39(61)37(59)32(18-55)73-51/h6-7,9,15,21,24-25,27-29,31-51,54-67H,8,10-14,16-20H2,1-5H3/t21-,24-,25+,27-,28-,29-,31+,32+,33+,34+,35-,36-,37-,38-,39-,40+,41+,42+,43+,44+,45+,46+,47+,48-,49-,50-,51-,52-,53-/m0/s1
  • InChiKey: DXFALQYECZLSAR-CYCMHZKESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine protease, putative 0.0151 0.072 0.1633
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0076 0.0303 0.0303
Giardia lamblia Cathepsin L-like protease 0.0151 0.072 0.2013
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0088 0.0088
Plasmodium vivax unspecified product 0.0151 0.072 0.1633
Brugia malayi jmjC domain containing protein 0.0037 0.0088 0.0088
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0076 0.0303 0.0688
Echinococcus multilocularis cathepsin L cysteine protease 0.082 0.4406 0.4406
Leishmania major cathepsin L-like protease 0.082 0.4406 0.5345
Loa Loa (eye worm) cysteine protease 0.082 0.4406 0.4406
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0213 0.1061 0.1287
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0076 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0151 0.072 0.1633
Entamoeba histolytica cysteine proteinase, putative 0.082 0.4406 1
Brugia malayi Cathepsin L-like precursor 0.082 0.4406 0.4406
Giardia lamblia Cathepsin B precursor 0.0151 0.072 0.2013
Entamoeba histolytica hypothetical protein 0.0151 0.072 0.1633
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0076 0.0303 0.0688
Giardia lamblia Cathepsin B precursor 0.0151 0.072 0.2013
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0271 0.138 0.138
Trichomonas vaginalis glucosylceramidase, putative 0.0548 0.2908 0.6601
Brugia malayi Cathepsin L-like precursor 0.0549 0.2912 0.2912
Trichomonas vaginalis conserved hypothetical protein 0.0669 0.3574 0.8112
Trichomonas vaginalis glucosylceramidase, putative 0.0793 0.4257 0.9662
Brugia malayi Cathepsin L-like precursor 0.0549 0.2912 0.2912
Entamoeba histolytica cysteine protease, putative 0.0151 0.072 0.1633
Echinococcus multilocularis epidermal growth factor receptor 0.0986 0.5322 0.5322
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0422 0.2214 0.2214
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0107 0.0107
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.2754 0.625
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0586 0.312 0.312
Plasmodium vivax importin-beta 2, putative 0.0028 0.0041 0.0093
Giardia lamblia Cathepsin B precursor 0.0151 0.072 0.2013
Loa Loa (eye worm) hypothetical protein 0.0151 0.072 0.072
Entamoeba histolytica cysteine protease, putative 0.0151 0.072 0.1633
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0218 0.0218
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0157 0.0752 0.0752
Toxoplasma gondii cathepsin CPL 0.082 0.4406 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.082 0.4406 0.4406
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0076 0.0303 0.0303
Plasmodium vivax hypothetical protein, conserved 0.003 0.0053 0.0119
Loa Loa (eye worm) hypothetical protein 0.0042 0.0117 0.0117
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.2754 0.625
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.2754 0.625
Loa Loa (eye worm) TK/EGFR protein kinase 0.1834 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.082 0.4406 1
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.028 0.1428 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.082 0.4406 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0151 0.072 0.1633
Echinococcus multilocularis epidermal growth factor receptor 0.1834 1 1
Echinococcus granulosus dna polymerase eta 0.0067 0.0253 0.0253
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.028 0.1428 0.3241
Onchocerca volvulus 0.0549 0.2912 0.6598
Brugia malayi Papain family cysteine protease containing protein 0.0151 0.072 0.072
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0053 0.0053
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0151 0.072 0.0873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0549 0.2912 0.6608
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.012 0.0546 0.0662
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.082 0.4406 1
Plasmodium falciparum importin beta, putative 0.0028 0.0041 0.0093
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0107 0.0218
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0669 0.3574 0.4336
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.082 0.4406 1
Brugia malayi PHD-finger family protein 0.003 0.0053 0.0053
Onchocerca volvulus Cathepsin L homolog 0.0151 0.072 0.1607
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0013 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Onchocerca volvulus Cathepsin F homolog 0.082 0.4406 1
Giardia lamblia Rrm3p helicase 0.0669 0.3574 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Onchocerca volvulus 0.0134 0.0625 0.1391
Trichomonas vaginalis set domain proteins, putative 0.0479 0.2525 0.5731
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Brugia malayi Importin beta-1 subunit 0.0028 0.0041 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Loa Loa (eye worm) hypothetical protein 0.0151 0.072 0.072
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Echinococcus multilocularis snurportin 1 0.0302 0.1549 0.1549
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0076 0.0303 0.0368
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0151 0.072 0.2013
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0013 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0133 0.0133
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0107 0.0242
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0151 0.072 0.072
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.072 0.1633
Loa Loa (eye worm) cathepsin B 0.0151 0.072 0.072
Brugia malayi RNA, U transporter 1 0.008 0.0329 0.0329
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0717 0.3841 0.4659
Brugia malayi Protein kinase domain containing protein 0.0586 0.312 0.312
Entamoeba histolytica cysteine protease, putative 0.0151 0.072 0.1633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.072 0.1633
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0669 0.3574 0.3574
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0151 0.072 0.1633
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0076 0.0303 0.0368
Schistosoma mansoni tyrosine kinase 0.0586 0.312 0.312
Loa Loa (eye worm) hypothetical protein 0.006 0.0218 0.0218
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.026 0.1318 0.1598
Giardia lamblia DNA polymerase alpha subunit A 0.0232 0.1166 0.3263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.072 0.1633
Leishmania major cathepsin L-like protease 0.082 0.4406 0.5345
Onchocerca volvulus 0.082 0.4406 1
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0076 0.0303 0.066
Echinococcus granulosus geminin 0.0178 0.0865 0.0865
Entamoeba histolytica cysteine protease, putative 0.0151 0.072 0.1633
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0669 0.3574 0.4336
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0151 0.072 0.072
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0549 0.2912 0.2912
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0076 0.0303 0.0688
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Giardia lamblia Cathepsin L precursor 0.0151 0.072 0.2013
Loa Loa (eye worm) hypothetical protein 0.0028 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Leishmania major DNA polymerase eta, putative 0.0039 0.01 0.0122
Brugia malayi DNA polymerase delta catalytic subunit 0.0076 0.0303 0.0303
Plasmodium falciparum serine repeat antigen 9 0.0151 0.072 0.1633
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0107 0.0242
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0151 0.072 0.1633
Echinococcus multilocularis peregrin 0.003 0.0053 0.0053
Entamoeba histolytica hypothetical protein, conserved 0.0669 0.3574 0.8112
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.082 0.4406 1
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0321 0.0321
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0078 0.0314 0.0712
Echinococcus granulosus cysteine protease 0.0422 0.2214 0.2214
Brugia malayi Cathepsin L-like precursor 0.082 0.4406 0.4406
Brugia malayi Cathepsin L-like precursor 0.082 0.4406 0.4406
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0076 0.0303 0.0688
Schistosoma mansoni hypothetical protein 0.0302 0.1549 0.1549
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Leishmania major DNA polymerase kappa, putative 0.004 0.0107 0.013
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0218 0.0218
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0076 0.0303 0.0368
Trichomonas vaginalis glucosylceramidase, putative 0.0793 0.4257 0.9662
Echinococcus multilocularis cathepsin b 0.0151 0.072 0.072
Schistosoma mansoni hypothetical protein 0.0178 0.0865 0.0865
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0151 0.072 0.1633
Leishmania major cathepsin L-like protease 0.082 0.4406 0.5345
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0076 0.0303 0.0303
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0133 0.0133
Plasmodium falciparum serine repeat antigen 8 0.0151 0.072 0.1633
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0107 0.013
Giardia lamblia DINP protein human, muc B family 0.004 0.0107 0.0299
Plasmodium vivax unspecified product 0.0271 0.138 0.3132
Entamoeba histolytica DNA repair and recombination protein, putative 0.0669 0.3574 0.8112
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0151 0.072 0.1633
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.082 0.4406 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0151 0.072 0.072
Entamoeba histolytica cysteine protease, putative 0.082 0.4406 1
Onchocerca volvulus DNA polymerase homolog 0.0076 0.0303 0.066
Brugia malayi Papain family cysteine protease containing protein 0.0422 0.2214 0.2214
Giardia lamblia Cathepsin B precursor 0.0151 0.072 0.2013
Trypanosoma cruzi cruzipain precursor, putative 0.0271 0.138 0.1674
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0076 0.0303 0.0303
Leishmania major cathepsin L-like protease 0.082 0.4406 0.5345
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.01 0.0122
Onchocerca volvulus Cathepsin L homolog 0.082 0.4406 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0151 0.072 0.1633
Echinococcus granulosus cathepsin L cysteine protease 0.0422 0.2214 0.2214
Treponema pallidum hypothetical protein 0.028 0.1428 0.5
Echinococcus granulosus cathepsin b 0.0151 0.072 0.072
Echinococcus granulosus peregrin 0.003 0.0053 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Toxoplasma gondii DNA polymerase family B protein 0.0034 0.0071 0.0162
Brugia malayi Cathepsin L-like precursor 0.0271 0.138 0.138
Echinococcus multilocularis cysteine protease 0.082 0.4406 0.4406
Loa Loa (eye worm) hypothetical protein 0.082 0.4406 0.4406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0151 0.072 0.2013
Loa Loa (eye worm) hypothetical protein 0.0052 0.0172 0.0172
Trichomonas vaginalis glucosylceramidase, putative 0.0548 0.2908 0.6601
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0076 0.0303 0.0368
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0422 0.2214 0.2686
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0088 0.0088
Toxoplasma gondii cathepsin CPC2 0.0151 0.072 0.1633
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0213 0.1061 0.1287
Loa Loa (eye worm) hypothetical protein 0.0377 0.1965 0.1965
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0151 0.072 0.1633
Trypanosoma brucei unspecified product 0.0028 0.0038 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.072 0.1633
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0076 0.0303 0.066
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.072 0.072
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0433 0.0433
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Schistosoma mansoni cathepsin s 0.0271 0.138 0.138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0133 0.0133
Giardia lamblia Cathepsin L precursor 0.0151 0.072 0.2013
Loa Loa (eye worm) hypothetical protein 0.0034 0.0071 0.0071
Brugia malayi DNA polymerase family B containing protein 0.0076 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.082 0.4406 1
Giardia lamblia PHD finger protein 15 0.003 0.0053 0.0147
Echinococcus multilocularis geminin 0.0178 0.0865 0.0865
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Giardia lamblia Cathepsin B precursor 0.0151 0.072 0.2013
Mycobacterium ulcerans hypothetical protein 0.0798 0.4288 1
Leishmania major cathepsin L-like protease 0.082 0.4406 0.5345
Entamoeba histolytica cysteine proteinase, putative 0.0549 0.2912 0.6608
Toxoplasma gondii cathepsin B 0.0151 0.072 0.1633
Onchocerca volvulus 0.0151 0.072 0.1607
Onchocerca volvulus 0.082 0.4406 1
Echinococcus granulosus epidermal growth factor receptor 0.1834 1 1
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0076 0.0303 0.0688
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Loa Loa (eye worm) hypothetical protein 0.0023 0.0013 0.0013
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.012 0.0546 0.0662
Onchocerca volvulus 0.082 0.4406 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0151 0.072 0.072
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.072 0.1633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.072 0.1633
Leishmania major cathepsin L-like protease 0.082 0.4406 0.5345
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0076 0.0303 0.0303
Brugia malayi cathepsin L-like cysteine proteinase 0.0151 0.072 0.072
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0076 0.0303 0.0303
Plasmodium falciparum serine repeat antigen 7 0.0151 0.072 0.1633
Plasmodium vivax serine-repeat antigen (SERA) 0.0151 0.072 0.1633
Trypanosoma cruzi cysteine peptidase, putative 0.082 0.4406 0.5345
Loa Loa (eye worm) hypothetical protein 0.0151 0.072 0.072
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0053 0.0053
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0669 0.3574 0.4336
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Trypanosoma cruzi cysteine proteinase, putative 0.0422 0.2214 0.2686
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.072 0.1633
Trypanosoma cruzi cysteine protease, putative 0.0422 0.2214 0.2686
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0151 0.072 0.072
Echinococcus granulosus snurportin 1 0.0302 0.1549 0.1549
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0013 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0793 0.4257 0.9662
Loa Loa (eye worm) TK/INSR protein kinase 0.0586 0.312 0.312
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0103 0.0452 0.0452
Leishmania major cysteine peptidase A (CPA) 0.082 0.4406 0.5345
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0076 0.0303 0.0849
Onchocerca volvulus 0.082 0.4406 1
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.2754 0.625
Echinococcus granulosus dna polymerase kappa 0.004 0.0107 0.0107
Plasmodium falciparum serine repeat antigen 4 0.0151 0.072 0.1633
Trichomonas vaginalis glucosylceramidase, putative 0.0793 0.4257 0.9662
Loa Loa (eye worm) hypothetical protein 0.0271 0.138 0.138
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0041 0.0093
Trypanosoma cruzi DNA polymerase zeta catalytic subunit, putative 0.0034 0.0071 0.0086
Echinococcus multilocularis cathepsin L cysteine protease 0.082 0.4406 0.4406
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0151 0.072 0.1633
Echinococcus granulosus insulin receptor 0.0586 0.312 0.312
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0042 0.0117 0.0117
Schistosoma mansoni tyrosine kinase 0.0974 0.526 0.526
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0107 0.013
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1515 0.8244 1
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0377 0.1965 0.4443
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0151 0.072 0.0873
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0151 0.072 0.1633
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.072 0.072
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0717 0.3841 0.4659
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0151 0.072 0.1633
Schistosoma mansoni hypothetical protein 0.0669 0.3574 0.3574
Loa Loa (eye worm) papain family cysteine protease containing protein 0.082 0.4406 0.4406
Brugia malayi Papain family cysteine protease containing protein 0.0151 0.072 0.072
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0088 0.0088
Brugia malayi jmjC domain containing protein 0.0099 0.0433 0.0433
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0274 0.1398 0.1398
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0151 0.072 0.1633
Echinococcus granulosus cathepsin l1 0.082 0.4406 0.4406
Schistosoma mansoni cathepsin F (C01 family) 0.0549 0.2912 0.2912
Entamoeba histolytica cysteine proteinase 2 0.0422 0.2214 0.5025
Leishmania major importin beta-1 subunit, putative 0.0023 0.0012 0.0014
Onchocerca volvulus Glucosylceramidase homolog 0.052 0.2754 0.6238
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.082 0.4406 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0151 0.072 0.072
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0274 0.1398 0.1398
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0151 0.072 0.1633
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.028 0.1428 0.3241
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0053 0.0119
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0151 0.072 0.2013
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0433 0.0433
Trypanosoma brucei DNA polymerase eta, putative 0.0067 0.0253 0.0307
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0039 0.01 0.0227
Toxoplasma gondii hypothetical protein 0.0244 0.1233 0.2799
Onchocerca volvulus Alhambra homolog 0.003 0.0053 0.0089
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0151 0.072 0.1633
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0549 0.2912 0.3532
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.072 0.1633
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.012 0.0546 0.1239
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0421 0.2205 0.2205
Plasmodium vivax vivapain-2 0.082 0.4406 1
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0076 0.0303 0.0368
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0076 0.0303 0.0303
Echinococcus multilocularis cathepsin b 0.0151 0.072 0.072
Brugia malayi Pre-SET motif family protein 0.006 0.0218 0.0218
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0078 0.0314 0.0712
Schistosoma mansoni tyrosine kinase 0.1834 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0013 0.0031
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0012 0.0026
Plasmodium vivax DNA polymerase alpha, putative 0.0222 0.1113 0.2525
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.072 0.1633
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0133 0.0133
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0107 0.0107
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.1549 0.1549
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0669 0.3574 0.3574
Giardia lamblia Cathepsin L precursor 0.0151 0.072 0.2013
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0151 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.0151 0.072 0.072
Entamoeba histolytica hypothetical protein 0.0023 0.0012 0.0026
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0793 0.4257 0.4257
Entamoeba histolytica DNA polymerase zeta catalytic subunit, putative 0.0034 0.0071 0.0162
Brugia malayi Papain family cysteine protease containing protein 0.0151 0.072 0.072
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0076 0.0303 0.0849
Entamoeba histolytica cysteine proteinase 1, putative 0.0422 0.2214 0.5025
Trypanosoma cruzi cysteine peptidase, putative 0.0422 0.2214 0.2686
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0218 0.0218
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.072 0.1633
Loa Loa (eye worm) hypothetical protein 0.0067 0.0253 0.0253
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0107 0.0242
Trypanosoma cruzi cysteine peptidase, putative 0.082 0.4406 0.5345
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0107 0.013
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0151 0.072 0.072
Toxoplasma gondii cathepsin CPC1 0.0151 0.072 0.1633
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Trypanosoma cruzi DNA polymerase eta, putative 0.0067 0.0253 0.0307
Giardia lamblia Cysteine protease 0.0151 0.072 0.2013
Schistosoma mansoni cathepsin C 0.0151 0.072 0.072
Trypanosoma brucei cysteine peptidase C (CPC) 0.0151 0.072 0.0873
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0038 0.0046
Leishmania major DNA polymerase zeta catalytic subunit, putative 0.0034 0.0071 0.0086
Toxoplasma gondii DNA polymerase family B protein 0.0076 0.0303 0.0688
Schistosoma mansoni DNA polymerase eta 0.0067 0.0253 0.0253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Entamoeba histolytica cysteine proteinase, putative 0.0422 0.2214 0.5025
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0042 0.0117 0.0266
Loa Loa (eye worm) ctsf protein 0.082 0.4406 0.4406
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.2754 0.625
Loa Loa (eye worm) hypothetical protein 0.0151 0.072 0.072
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0422 0.2214 0.2214
Trypanosoma cruzi cysteine peptidase, putative 0.082 0.4406 0.5345
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0076 0.0303 0.0688
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.028 0.1428 0.3309
Giardia lamblia Cysteine protease 0.0151 0.072 0.2013
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0076 0.0303 0.0303
Echinococcus multilocularis insulin receptor 0.0586 0.312 0.312
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.072 0.1633
Brugia malayi Cathepsin L-like precursor 0.082 0.4406 0.4406
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0213 0.1061 0.1287
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0151 0.072 0.072
Schistosoma mansoni tyrosine kinase 0.0974 0.526 0.526
Giardia lamblia Cathepsin L precursor 0.0151 0.072 0.2013
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0271 0.138 0.138
Plasmodium vivax vivapain-2 0.082 0.4406 1
Onchocerca volvulus Cathepsin L homolog 0.082 0.4406 1
Plasmodium falciparum serine repeat antigen 1 0.0151 0.072 0.1633
Plasmodium falciparum serine repeat antigen 5 0.0151 0.072 0.1633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.072 0.1633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0107 0.0107
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0669 0.3574 0.4336
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0107 0.013
Loa Loa (eye worm) hypothetical protein 0.0151 0.072 0.072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Trypanosoma cruzi cysteine peptidase, putative 0.0271 0.138 0.1674
Entamoeba histolytica cysteine proteinase, putative 0.082 0.4406 1
Echinococcus granulosus cathepsin l1 0.0549 0.2912 0.2912
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0107 0.0107
Entamoeba histolytica cysteine proteinase, putative 0.0422 0.2214 0.5025
Brugia malayi Cathepsin L-like precursor 0.082 0.4406 0.4406
Plasmodium vivax vivapain-3 0.0422 0.2214 0.5025
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0076 0.0303 0.0688
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.082 0.4406 1
Plasmodium falciparum DNA polymerase zeta catalytic subunit, putative 0.0034 0.0071 0.0162
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0213 0.1061 0.1287
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0076 0.0303 0.0368
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0053 0.0119
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0076 0.0303 0.0303
Trypanosoma brucei unspecified product 0.004 0.0107 0.013
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Echinococcus granulosus cathepsin b 0.0151 0.072 0.072
Entamoeba histolytica cysteine proteinase, putative 0.0422 0.2214 0.5025
Brugia malayi Pre-SET motif family protein 0.0421 0.2205 0.2205
Echinococcus multilocularis 0.0567 0.3015 0.3015
Schistosoma mansoni cathepsin B (C01 family) 0.0151 0.072 0.072
Giardia lamblia Cathepsin L-like protease 0.0151 0.072 0.2013
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.012 0.0546 0.0662
Plasmodium vivax vivapain-1 0.0422 0.2214 0.5025
Onchocerca volvulus 0.082 0.4406 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0422 0.2214 0.2214
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0038 0.0046
Loa Loa (eye worm) hypothetical protein 0.0271 0.138 0.138
Plasmodium falciparum phd finger protein, putative 0.003 0.0053 0.0119
Brugia malayi cathepsin L precursor 0.0151 0.072 0.072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0422 0.2214 0.2686
Echinococcus multilocularis dna polymerase kappa 0.004 0.0107 0.0107
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.072 0.072
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.072 0.072
Brugia malayi cathepsin L-like precursor 0.0549 0.2912 0.2912
Giardia lamblia Hypothetical protein 0.0151 0.072 0.2013
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0669 0.3574 0.4336
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0151 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.0023 0.0013 0.0013
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0717 0.3841 0.4659
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0669 0.3574 0.4336
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0151 0.072 0.0873
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0041 0.005
Leishmania major cathepsin L-like protease 0.082 0.4406 0.5345
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0151 0.072 0.1633
Brugia malayi DNA polymerase alpha catalytic subunit 0.0222 0.1113 0.1113
Brugia malayi Cathepsin L-like cysteine proteinase 0.0549 0.2912 0.2912
Onchocerca volvulus Tyrosine kinase homolog 0.0148 0.0699 0.1561
Brugia malayi cathepsin Z-like cysteine proteinase 0.0151 0.072 0.072
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.072 0.072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.082 0.4406 1
Trichomonas vaginalis glucosylceramidase, putative 0.0793 0.4257 0.9662
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0151 0.072 0.072
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0107 0.0107
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0218 0.0218
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.072 0.072
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0107 0.0218
Echinococcus granulosus cathepsin L 0.0151 0.072 0.072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0222 0.1113 0.2525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.082 0.4406 0.4406
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Giardia lamblia Hypothetical protein 0.0151 0.072 0.2013
Entamoeba histolytica cysteine proteinase, putative 0.0422 0.2214 0.5025
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0076 0.0303 0.0688
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0013 0.0016
Trypanosoma brucei mitochondrial DNA polymerase beta 0.1515 0.8244 1
Loa Loa (eye worm) hypothetical protein 0.0549 0.2912 0.2912
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.2214 0.5025
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0071 0.0162
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0793 0.4257 0.4257
Plasmodium falciparum cysteine proteinase falcipain 2b 0.082 0.4406 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0133 0.0133
Onchocerca volvulus 0.0479 0.2525 0.5718
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0012 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0013 0.0013
Trypanosoma cruzi cysteine peptidase, putative 0.082 0.4406 0.5345
Entamoeba histolytica cysteine protease, putative 0.0151 0.072 0.1633
Trypanosoma brucei unspecified product 0.0028 0.0038 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0133 0.0133
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0986 0.5322 0.5322
Leishmania major cathepsin L-like protease 0.082 0.4406 0.5345
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0107 0.0218
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0151 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.0549 0.2912 0.2912
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Plasmodium falciparum serine repeat antigen 2 0.0151 0.072 0.1633
Brugia malayi cathepsin Z-like cysteine proteinase 0.0151 0.072 0.072
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0151 0.072 0.1633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0118 0.0118
Trypanosoma cruzi cruzipain precursor, putative 0.082 0.4406 0.5345
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0053 0.0053
Schistosoma mansoni tyrosine kinase 0.0986 0.5322 0.5322
Echinococcus multilocularis cysteine protease 0.082 0.4406 0.4406
Leishmania major mitochondrial DNA polymerase beta 0.1515 0.8244 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0218 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0549 0.2912 0.6608
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.072 0.072
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.082 0.4406 0.4406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.072 0.1633
Brugia malayi Bromodomain containing protein 0.003 0.0053 0.0053
Leishmania major DNA polymerase eta, putative 0.0067 0.0253 0.0307
Loa Loa (eye worm) fibroinase 0.082 0.4406 0.4406
Onchocerca volvulus 0.006 0.0218 0.0466
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0107 0.013
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Plasmodium vivax serine-repeat antigen (SERA) 0.0151 0.072 0.1633
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0151 0.072 0.2013
Giardia lamblia Cathepsin B precursor 0.0151 0.072 0.2013
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0042 0.0117 0.0266
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0231 0.0231
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0151 0.072 0.1633
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0034 0.0071 0.0086
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0107 0.013
Giardia lamblia Cathepsin L precursor 0.0151 0.072 0.2013
Schistosoma mansoni tyrosine kinase 0.0586 0.312 0.312
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0076 0.0303 0.0368
Plasmodium vivax SET domain protein, putative 0.006 0.0218 0.0495
Toxoplasma gondii DNA polymerase 0.0076 0.0303 0.0688
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1515 0.8244 1
Schistosoma mansoni hypothetical protein 0.0178 0.0865 0.0865
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.2754 0.625
Plasmodium falciparum cysteine proteinase falcipain 3 0.082 0.4406 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0974 0.526 0.526
Loa Loa (eye worm) hypothetical protein 0.0023 0.0013 0.0013
Trichomonas vaginalis DNA polymerase II, putative 0.012 0.0546 0.1239
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0669 0.3574 0.4336
Plasmodium vivax unspecified product 0.0422 0.2214 0.5025
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0038 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.2754 0.625
Loa Loa (eye worm) hypothetical protein 0.0034 0.0071 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0151 0.072 0.1633
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0107 0.0218
Giardia lamblia Cathepsin B precursor 0.0151 0.072 0.2013
Onchocerca volvulus 0.082 0.4406 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0013 0.0031
Schistosoma mansoni importin beta-1 0.0028 0.0041 0.0041
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0107 0.013
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0151 0.072 0.1633
Plasmodium falciparum serine repeat antigen 3 0.0151 0.072 0.1633
Trypanosoma cruzi major cysteine proteinase, putative 0.0151 0.072 0.0873
Schistosoma mansoni cathepsin F (C01 family) 0.082 0.4406 0.4406
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.082 0.4406 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.082 0.4406 0.4406
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.072 0.072
Echinococcus multilocularis cathepsin L 0.0151 0.072 0.072
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0076 0.0303 0.0303
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0422 0.2214 0.2686
Trypanosoma cruzi cysteine proteinase, putative 0.0422 0.2214 0.2686
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0844 0.4539 0.4539
Loa Loa (eye worm) hypothetical protein 0.0042 0.0117 0.0117
Echinococcus multilocularis dna polymerase eta 0.0067 0.0253 0.0253
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0133 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Brugia malayi Papain family cysteine protease containing protein 0.0422 0.2214 0.2214
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0206 0.0206
Brugia malayi Immunoglobulin I-set domain containing protein 0.0157 0.0752 0.0752
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0586 0.312 0.312
Brugia malayi cathepsin F-like cysteine proteinase 0.0271 0.138 0.138
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.072 0.072
Giardia lamblia Cathepsin L precursor 0.0151 0.072 0.2013
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0107 0.013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0041 0.0041
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0076 0.0303 0.0368
Brugia malayi fibroinase precursor 0.0151 0.072 0.072
Giardia lamblia Cysteine protease 0.0151 0.072 0.2013
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0013 0.0013
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0218 0.0218
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0088 0.0088
Mycobacterium tuberculosis Conserved hypothetical protein 0.0798 0.4288 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.082 0.4406 0.4406
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0012 0.0026
Brugia malayi ImpB/MucB/SamB family protein 0.0067 0.0253 0.0253
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0151 0.072 0.1633
Toxoplasma gondii preprocathepsin c precursor, putative 0.0151 0.072 0.1633
Plasmodium falciparum cysteine proteinase falcipain 1 0.0422 0.2214 0.5025
Trypanosoma cruzi major cysteine proteinase, putative 0.0151 0.072 0.0873
Echinococcus multilocularis cathepsin L 0.0422 0.2214 0.2214
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0034 0.0071 0.0071
Schistosoma mansoni tyrosine kinase 0.0986 0.5322 0.5322
Echinococcus granulosus epidermal growth factor receptor 0.0986 0.5322 0.5322
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.082 0.4406 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.003 0.0053 0.0053
Echinococcus granulosus importin subunit beta 1 0.0028 0.0041 0.0041
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0041 0.005
Trichomonas vaginalis glucosylceramidase, putative 0.0793 0.4257 0.9662
Brugia malayi Cathepsin L-like precursor 0.082 0.4406 0.4406
Brugia malayi Papain family cysteine protease containing protein 0.082 0.4406 0.4406
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0012 0.0026
Plasmodium falciparum serine repeat antigen 6 0.0151 0.072 0.1633
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Schistosoma mansoni cathepsin F (C01 family) 0.082 0.4406 0.4406
Giardia lamblia Cysteine protease 0.0151 0.072 0.2013
Onchocerca volvulus 0.082 0.4406 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0151 0.072 0.1633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.2214 0.5025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0133 0.0133
Giardia lamblia Encystation-specific protease 0.0151 0.072 0.2013
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0107 0.0107
Schistosoma mansoni cathepsin S (C01 family) 0.0151 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.0271 0.138 0.138
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.028 0.1428 0.3309
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0274 0.1398 0.1398
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0218 0.0495
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0151 0.072 0.1633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Echinococcus granulosus cathepsin L 0.0422 0.2214 0.2214
Giardia lamblia Cathepsin B precursor 0.0151 0.072 0.2013
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0118 0.0118

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) Toxicity in mice at 160 mg/kg, ip 28 days post dose ChEMBL. 16509595
Activity (ADMET) 0 Toxicity in mice at 160 mg/kg, ip 28 days post dose ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human Hs683 cancer cell line ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human U373 glioblastoma cell line ChEMBL. 16509595
IC50 (functional) < 10 uM Cytotoxicity against human HCT15 colon cancer cell line ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human PC3 prostate cancer cell line ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human A549 NSCLC cell line ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human MCF7 breast cancer cell line ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human Hs683 cancer cell line ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human U373 glioblastoma cell line ChEMBL. 16509595
IC50 (functional) < 10 uM Cytotoxicity against human HCT15 colon cancer cell line ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human PC3 prostate cancer cell line ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human A549 NSCLC cell line ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human MCF7 breast cancer cell line ChEMBL. 16509595
Inhibition (functional) = -26 % Antimigratory activity against human A549 NSCLC cell line at 100nM after 12h ChEMBL. 16509595
Inhibition (functional) = -26 % Antimigratory activity against human A549 NSCLC cell line at 100nM after 12h ChEMBL. 16509595
Inhibition (functional) = -13 % Antimigratory activity against human U373 glioblastoma cell line at 100nM after 22h ChEMBL. 16509595
Inhibition (functional) = -13 % Antimigratory activity against human U373 glioblastoma cell line at 100nM after 22h ChEMBL. 16509595
Inhibition (functional) = -12 % Antimigratory activity against human A549 NSCLC cell line at 100nM after 22h ChEMBL. 16509595
Inhibition (functional) = -12 % Antimigratory activity against human U373 glioblastoma cell line at 100nM after 12h ChEMBL. 16509595
Inhibition (functional) = -12 % Antimigratory activity against human A549 NSCLC cell line at 100nM after 22h ChEMBL. 16509595
Inhibition (functional) = -12 % Antimigratory activity against human U373 glioblastoma cell line at 100nM after 12h ChEMBL. 16509595
Inhibition (functional) = 14 % Antimigratory activity against human PC3 prostate cancer cell line at 100nM after 12h ChEMBL. 16509595
Inhibition (functional) = 14 % Antimigratory activity against human PC3 prostate cancer cell line at 100nM after 12h ChEMBL. 16509595
Inhibition (functional) = 15 % Antimigratory activity against human PC3 prostate cancer cell line at 100nM after 22h ChEMBL. 16509595
Inhibition (functional) = 15 % Antimigratory activity against human PC3 prostate cancer cell line at 100nM after 22h ChEMBL. 16509595

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 16509595

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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