Detailed information for compound 408168

Basic information

Technical information
  • TDR Targets ID: 408168
  • Name: (2R,3R,4S,5S,6R)-2-[(1S)-1-[(3S,8S,9S,10R,13S ,14S,16R,17S)-16-(2,5-dimethoxyphenyl)-10,13- dimethyl-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy -6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hyd roxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy- 2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H- cyclopenta[a]phenanthren-17-yl]ethoxy]-6-[[(2 S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymet hyl)oxan-2-yl]oxymethyl]oxane-3,4,5-triol
  • MW: 1103.2 | Formula: C53H82O24
  • H donors: 14 H acceptors: 14 LogP: -1.79 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 4
  • SMILES: COc1ccc(c(c1)[C@@H]1C[C@@H]2[C@]([C@H]1[C@@H](O[C@@H]1O[C@H](CO[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O)[C@H]([C@@H]([C@H]1O)O)O)C)(C)CC[C@H]1[C@H]2CC=C2[C@]1(C)CC[C@@H](C2)O[C@@H]1O[C@H](CO[C@H]2O[C@H](CO)[C@H]([C@@H]([C@H]2O)O)O)[C@H]([C@@H]([C@H]1O)O)O)OC
  • InChi: 1S/C53H82O24/c1-21(72-50-46(66)42(62)38(58)33(76-50)19-70-48-44(64)40(60)36(56)31(17-54)74-48)35-27(26-15-23(68-4)7-9-30(26)69-5)16-29-25-8-6-22-14-24(10-12-52(22,2)28(25)11-13-53(29,35)3)73-51-47(67)43(63)39(59)34(77-51)20-71-49-45(65)41(61)37(57)32(18-55)75-49/h6-7,9,15,21,24-25,27-29,31-51,54-67H,8,10-14,16-20H2,1-5H3/t21-,24-,25+,27-,28-,29-,31+,32+,33+,34+,35-,36+,37+,38+,39+,40-,41-,42-,43-,44+,45+,46+,47+,48-,49-,50+,51+,52-,53-/m0/s1
  • InChiKey: RAFRICMJKCGZTE-MTNGEYDFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,3R,4S,5S,6R)-2-[(1S)-1-[(3S,8S,9S,10R,13S,14S,16R,17S)-16-(2,5-dimethoxyphenyl)-10,13-dimethyl-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-2-yl]oxy-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethoxy]-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-3,4,5-triol
  • (2R,3R,4S,5S,6R)-2-[(1S)-1-[(3S,8S,9S,10R,13S,14S,16R,17S)-16-(2,5-dimethoxyphenyl)-10,13-dimethyl-3-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxymethyl]-2-tetrahydropyranyl]oxy]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethoxy]-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxymethyl]tetrahydropyran-3,4,5-triol
  • (2R,3R,4S,5S,6R)-2-[(1S)-1-[(3S,8S,9S,10R,13S,14S,16R,17S)-16-(2,5-dimethoxyphenyl)-10,13-dimethyl-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-2-yl]oxy-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethoxy]-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-3,4,5-triol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0133 0.0133
Schistosoma mansoni cathepsin s 0.0271 0.138 0.138
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.072 0.072
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0433 0.0433
Giardia lamblia Cathepsin L precursor 0.0151 0.072 0.2013
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0076 0.0303 0.066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.072 0.1633
Trypanosoma brucei unspecified product 0.0028 0.0038 0.0046
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0151 0.072 0.1633
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0088 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0422 0.2214 0.2686
Loa Loa (eye worm) hypothetical protein 0.0377 0.1965 0.1965
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0213 0.1061 0.1287
Toxoplasma gondii cathepsin CPC2 0.0151 0.072 0.1633
Loa Loa (eye worm) hypothetical protein 0.0052 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Loa Loa (eye worm) hypothetical protein 0.082 0.4406 0.4406
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0151 0.072 0.2013
Echinococcus multilocularis cysteine protease 0.082 0.4406 0.4406
Brugia malayi Cathepsin L-like precursor 0.0271 0.138 0.138
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0076 0.0303 0.0368
Trichomonas vaginalis glucosylceramidase, putative 0.0548 0.2908 0.6601
Onchocerca volvulus 0.082 0.4406 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0013 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Echinococcus granulosus epidermal growth factor receptor 0.1834 1 1
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0076 0.0303 0.0688
Entamoeba histolytica cysteine proteinase, putative 0.0549 0.2912 0.6608
Leishmania major cathepsin L-like protease 0.082 0.4406 0.5345
Onchocerca volvulus 0.0151 0.072 0.1607
Toxoplasma gondii cathepsin B 0.0151 0.072 0.1633
Echinococcus multilocularis geminin 0.0178 0.0865 0.0865
Giardia lamblia PHD finger protein 15 0.003 0.0053 0.0147
Mycobacterium ulcerans hypothetical protein 0.0798 0.4288 1
Giardia lamblia Cathepsin B precursor 0.0151 0.072 0.2013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Loa Loa (eye worm) hypothetical protein 0.0034 0.0071 0.0071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.082 0.4406 1
Brugia malayi DNA polymerase family B containing protein 0.0076 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0151 0.072 0.1633
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.082 0.4406 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0151 0.072 0.072
Entamoeba histolytica cysteine protease, putative 0.082 0.4406 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Entamoeba histolytica DNA repair and recombination protein, putative 0.0669 0.3574 0.8112
Plasmodium vivax unspecified product 0.0271 0.138 0.3132
Giardia lamblia DINP protein human, muc B family 0.004 0.0107 0.0299
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0133 0.0133
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0107 0.013
Plasmodium falciparum serine repeat antigen 8 0.0151 0.072 0.1633
Trichomonas vaginalis glucosylceramidase, putative 0.0793 0.4257 0.9662
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0076 0.0303 0.0368
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0218 0.0218
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0076 0.0303 0.0303
Leishmania major cathepsin L-like protease 0.082 0.4406 0.5345
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0151 0.072 0.1633
Schistosoma mansoni hypothetical protein 0.0178 0.0865 0.0865
Echinococcus multilocularis cathepsin b 0.0151 0.072 0.072
Echinococcus granulosus cathepsin b 0.0151 0.072 0.072
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Toxoplasma gondii DNA polymerase family B protein 0.0034 0.0071 0.0162
Echinococcus granulosus peregrin 0.003 0.0053 0.0053
Onchocerca volvulus Cathepsin L homolog 0.082 0.4406 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.01 0.0122
Treponema pallidum hypothetical protein 0.028 0.1428 0.5
Echinococcus granulosus cathepsin L cysteine protease 0.0422 0.2214 0.2214
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0151 0.072 0.1633
Leishmania major cathepsin L-like protease 0.082 0.4406 0.5345
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0076 0.0303 0.0303
Giardia lamblia Cathepsin B precursor 0.0151 0.072 0.2013
Trypanosoma cruzi cruzipain precursor, putative 0.0271 0.138 0.1674
Brugia malayi Papain family cysteine protease containing protein 0.0422 0.2214 0.2214
Onchocerca volvulus DNA polymerase homolog 0.0076 0.0303 0.066
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0151 0.072 0.1633
Schistosoma mansoni hypothetical protein 0.0669 0.3574 0.3574
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.072 0.072
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0717 0.3841 0.4659
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0107 0.013
Schistosoma mansoni tyrosine kinase 0.0974 0.526 0.526
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0042 0.0117 0.0117
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0151 0.072 0.0873
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0151 0.072 0.1633
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1515 0.8244 1
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0377 0.1965 0.4443
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0041 0.0093
Loa Loa (eye worm) hypothetical protein 0.0271 0.138 0.138
Echinococcus multilocularis cathepsin L cysteine protease 0.082 0.4406 0.4406
Echinococcus granulosus insulin receptor 0.0586 0.312 0.312
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0151 0.072 0.1633
Trypanosoma cruzi DNA polymerase zeta catalytic subunit, putative 0.0034 0.0071 0.0086
Onchocerca volvulus Glucosylceramidase homolog 0.052 0.2754 0.6238
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.028 0.1428 0.3241
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0151 0.072 0.1633
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.082 0.4406 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0151 0.072 0.072
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0274 0.1398 0.1398
Echinococcus granulosus cathepsin l1 0.082 0.4406 0.4406
Leishmania major importin beta-1 subunit, putative 0.0023 0.0012 0.0014
Entamoeba histolytica cysteine proteinase 2 0.0422 0.2214 0.5025
Schistosoma mansoni cathepsin F (C01 family) 0.0549 0.2912 0.2912
Brugia malayi jmjC domain containing protein 0.0099 0.0433 0.0433
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0151 0.072 0.1633
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0274 0.1398 0.1398
Loa Loa (eye worm) papain family cysteine protease containing protein 0.082 0.4406 0.4406
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0088 0.0088
Brugia malayi Papain family cysteine protease containing protein 0.0151 0.072 0.072
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0669 0.3574 0.4336
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0151 0.072 0.072
Trypanosoma cruzi cysteine peptidase, putative 0.082 0.4406 0.5345
Trypanosoma cruzi cysteine proteinase, putative 0.0422 0.2214 0.2686
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0076 0.0303 0.0303
Brugia malayi cathepsin L-like cysteine proteinase 0.0151 0.072 0.072
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0076 0.0303 0.0303
Plasmodium vivax serine-repeat antigen (SERA) 0.0151 0.072 0.1633
Plasmodium falciparum serine repeat antigen 7 0.0151 0.072 0.1633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.072 0.1633
Leishmania major cathepsin L-like protease 0.082 0.4406 0.5345
Onchocerca volvulus 0.082 0.4406 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0151 0.072 0.072
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.012 0.0546 0.0662
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.072 0.1633
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.2754 0.625
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Trichomonas vaginalis glucosylceramidase, putative 0.0793 0.4257 0.9662
Plasmodium falciparum serine repeat antigen 4 0.0151 0.072 0.1633
Echinococcus granulosus dna polymerase kappa 0.004 0.0107 0.0107
Trichomonas vaginalis glucosylceramidase, putative 0.0793 0.4257 0.9662
Onchocerca volvulus 0.082 0.4406 1
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0076 0.0303 0.0849
Leishmania major cysteine peptidase A (CPA) 0.082 0.4406 0.5345
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0103 0.0452 0.0452
Loa Loa (eye worm) TK/INSR protein kinase 0.0586 0.312 0.312
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0013 0.0016
Echinococcus granulosus snurportin 1 0.0302 0.1549 0.1549
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0151 0.072 0.072
Trypanosoma cruzi cysteine protease, putative 0.0422 0.2214 0.2686
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.072 0.1633
Plasmodium vivax hypothetical protein, conserved 0.003 0.0053 0.0119
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0076 0.0303 0.0303
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.2754 0.625
Loa Loa (eye worm) hypothetical protein 0.0042 0.0117 0.0117
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0218 0.0218
Entamoeba histolytica cysteine protease, putative 0.0151 0.072 0.1633
Loa Loa (eye worm) hypothetical protein 0.0151 0.072 0.072
Echinococcus multilocularis cathepsin l cysteine peptidase 0.082 0.4406 0.4406
Toxoplasma gondii cathepsin CPL 0.082 0.4406 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0157 0.0752 0.0752
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0586 0.312 0.312
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.2754 0.625
Giardia lamblia Cathepsin B precursor 0.0151 0.072 0.2013
Plasmodium vivax importin-beta 2, putative 0.0028 0.0041 0.0093
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0669 0.3574 0.4336
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0107 0.0218
Plasmodium falciparum importin beta, putative 0.0028 0.0041 0.0093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.082 0.4406 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0013 0.0016
Brugia malayi PHD-finger family protein 0.003 0.0053 0.0053
Onchocerca volvulus Cathepsin L homolog 0.0151 0.072 0.1607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.082 0.4406 1
Brugia malayi Papain family cysteine protease containing protein 0.0151 0.072 0.072
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0053 0.0053
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0151 0.072 0.0873
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.012 0.0546 0.0662
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0549 0.2912 0.6608
Echinococcus granulosus dna polymerase eta 0.0067 0.0253 0.0253
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.028 0.1428 0.3241
Onchocerca volvulus 0.0549 0.2912 0.6598
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.028 0.1428 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.082 0.4406 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.082 0.4406 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.1834 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.2754 0.625
Echinococcus multilocularis epidermal growth factor receptor 0.1834 1 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0151 0.072 0.1633
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0151 0.072 0.1633
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0076 0.0303 0.0303
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0213 0.1061 0.1287
Loa Loa (eye worm) cysteine protease 0.082 0.4406 0.4406
Giardia lamblia Cathepsin B precursor 0.0151 0.072 0.2013
Brugia malayi Cathepsin L-like precursor 0.082 0.4406 0.4406
Entamoeba histolytica cysteine proteinase, putative 0.082 0.4406 1
Leishmania major cathepsin L-like protease 0.082 0.4406 0.5345
Plasmodium vivax unspecified product 0.0151 0.072 0.1633
Echinococcus multilocularis cathepsin L cysteine protease 0.082 0.4406 0.4406
Brugia malayi jmjC domain containing protein 0.0037 0.0088 0.0088
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0076 0.0303 0.0688
Entamoeba histolytica cysteine protease, putative 0.0151 0.072 0.1633
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0088 0.0088
Giardia lamblia Cathepsin L-like protease 0.0151 0.072 0.2013
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0076 0.0303 0.0303
Echinococcus multilocularis epidermal growth factor receptor 0.0986 0.5322 0.5322
Entamoeba histolytica cysteine protease, putative 0.0151 0.072 0.1633
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0107 0.0107
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0422 0.2214 0.2214
Brugia malayi Cathepsin L-like precursor 0.0549 0.2912 0.2912
Trichomonas vaginalis conserved hypothetical protein 0.0669 0.3574 0.8112
Brugia malayi Cathepsin L-like precursor 0.0549 0.2912 0.2912
Trichomonas vaginalis glucosylceramidase, putative 0.0793 0.4257 0.9662
Trichomonas vaginalis glucosylceramidase, putative 0.0548 0.2908 0.6601
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0076 0.0303 0.0688
Entamoeba histolytica hypothetical protein 0.0151 0.072 0.1633
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0271 0.138 0.138
Giardia lamblia Cathepsin B precursor 0.0151 0.072 0.2013
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0076 0.0303 0.0688
Giardia lamblia Cathepsin L precursor 0.0151 0.072 0.2013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0151 0.072 0.072
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0549 0.2912 0.2912
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0669 0.3574 0.4336
Entamoeba histolytica cysteine protease, putative 0.0151 0.072 0.1633
Echinococcus granulosus geminin 0.0178 0.0865 0.0865
Onchocerca volvulus 0.082 0.4406 1
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0076 0.0303 0.066
Schistosoma mansoni hypothetical protein 0.0302 0.1549 0.1549
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0076 0.0303 0.0688
Leishmania major DNA polymerase kappa, putative 0.004 0.0107 0.013
Brugia malayi Cathepsin L-like precursor 0.082 0.4406 0.4406
Brugia malayi Cathepsin L-like precursor 0.082 0.4406 0.4406
Echinococcus granulosus cysteine protease 0.0422 0.2214 0.2214
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0078 0.0314 0.0712
Entamoeba histolytica hypothetical protein, conserved 0.0669 0.3574 0.8112
Echinococcus multilocularis peregrin 0.003 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0151 0.072 0.1633
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0321 0.0321
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.082 0.4406 1
Leishmania major DNA polymerase eta, putative 0.0039 0.01 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0028 0.0041 0.0041
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0107 0.0242
Brugia malayi DNA polymerase delta catalytic subunit 0.0076 0.0303 0.0303
Plasmodium falciparum serine repeat antigen 9 0.0151 0.072 0.1633
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0151 0.072 0.2013
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0013 0.0031
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0151 0.072 0.072
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0107 0.0242
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0151 0.072 0.072
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0076 0.0303 0.0368
Echinococcus multilocularis snurportin 1 0.0302 0.1549 0.1549
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Trichomonas vaginalis set domain proteins, putative 0.0479 0.2525 0.5731
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Brugia malayi Importin beta-1 subunit 0.0028 0.0041 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Onchocerca volvulus 0.0134 0.0625 0.1391
Giardia lamblia Rrm3p helicase 0.0669 0.3574 1
Onchocerca volvulus Cathepsin F homolog 0.082 0.4406 1
Schistosoma mansoni tyrosine kinase 0.0586 0.312 0.312
Loa Loa (eye worm) hypothetical protein 0.006 0.0218 0.0218
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0076 0.0303 0.0368
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0151 0.072 0.1633
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0669 0.3574 0.3574
Leishmania major cathepsin L-like protease 0.082 0.4406 0.5345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.072 0.1633
Giardia lamblia DNA polymerase alpha subunit A 0.0232 0.1166 0.3263
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.026 0.1318 0.1598
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.072 0.1633
Entamoeba histolytica cysteine protease, putative 0.0151 0.072 0.1633
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0717 0.3841 0.4659
Brugia malayi RNA, U transporter 1 0.008 0.0329 0.0329
Brugia malayi Protein kinase domain containing protein 0.0586 0.312 0.312
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.072 0.1633
Loa Loa (eye worm) cathepsin B 0.0151 0.072 0.072
Giardia lamblia Cathepsin B precursor 0.0151 0.072 0.2013
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0042 0.0117 0.0266
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0151 0.072 0.2013
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0231 0.0231
Onchocerca volvulus 0.006 0.0218 0.0466
Loa Loa (eye worm) fibroinase 0.082 0.4406 0.4406
Leishmania major DNA polymerase eta, putative 0.0067 0.0253 0.0307
Plasmodium vivax serine-repeat antigen (SERA) 0.0151 0.072 0.1633
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0107 0.013
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.072 0.072
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.082 0.4406 0.4406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0549 0.2912 0.6608
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0218 0.0218
Leishmania major mitochondrial DNA polymerase beta 0.1515 0.8244 1
Brugia malayi Bromodomain containing protein 0.003 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.072 0.1633
Schistosoma mansoni tyrosine kinase 0.0986 0.5322 0.5322
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0053 0.0053
Trypanosoma cruzi cruzipain precursor, putative 0.082 0.4406 0.5345
Echinococcus multilocularis cysteine protease 0.082 0.4406 0.4406
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0107 0.013
Schistosoma mansoni importin beta-1 0.0028 0.0041 0.0041
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0013 0.0031
Onchocerca volvulus 0.082 0.4406 1
Plasmodium falciparum serine repeat antigen 3 0.0151 0.072 0.1633
Trypanosoma cruzi major cysteine proteinase, putative 0.0151 0.072 0.0873
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0151 0.072 0.1633
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0151 0.072 0.1633
Loa Loa (eye worm) hypothetical protein 0.0034 0.0071 0.0071
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.2754 0.625
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0038 0.0046
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0107 0.0218
Giardia lamblia Cathepsin B precursor 0.0151 0.072 0.2013
Plasmodium falciparum cysteine proteinase falcipain 3 0.082 0.4406 1
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.2754 0.625
Loa Loa (eye worm) hypothetical protein 0.0023 0.0013 0.0013
Schistosoma mansoni tyrosine kinase 0.0974 0.526 0.526
Trichomonas vaginalis DNA polymerase II, putative 0.012 0.0546 0.1239
Plasmodium vivax unspecified product 0.0422 0.2214 0.5025
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0669 0.3574 0.4336
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0218 0.0218
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0076 0.0303 0.0368
Schistosoma mansoni tyrosine kinase 0.0586 0.312 0.312
Giardia lamblia Cathepsin L precursor 0.0151 0.072 0.2013
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0107 0.013
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0151 0.072 0.1633
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0034 0.0071 0.0086
Toxoplasma gondii DNA polymerase 0.0076 0.0303 0.0688
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1515 0.8244 1
Schistosoma mansoni hypothetical protein 0.0178 0.0865 0.0865
Plasmodium vivax SET domain protein, putative 0.006 0.0218 0.0495
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.2214 0.5025
Loa Loa (eye worm) hypothetical protein 0.0549 0.2912 0.2912
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0793 0.4257 0.4257
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0071 0.0162
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Entamoeba histolytica cysteine proteinase, putative 0.0422 0.2214 0.5025
Giardia lamblia Hypothetical protein 0.0151 0.072 0.2013
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0013 0.0016
Trypanosoma brucei mitochondrial DNA polymerase beta 0.1515 0.8244 1
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0076 0.0303 0.0688
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0222 0.1113 0.2525
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0107 0.0218
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.072 0.072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Echinococcus granulosus cathepsin L 0.0151 0.072 0.072
Echinococcus granulosus cathepsin l cysteine peptidase 0.082 0.4406 0.4406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0151 0.072 0.072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0218 0.0218
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0107 0.0107
Brugia malayi cathepsin Z-like cysteine proteinase 0.0151 0.072 0.072
Plasmodium falciparum serine repeat antigen 2 0.0151 0.072 0.1633
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0118 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0151 0.072 0.1633
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0107 0.0218
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0151 0.072 0.072
Leishmania major cathepsin L-like protease 0.082 0.4406 0.5345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Loa Loa (eye worm) hypothetical protein 0.0549 0.2912 0.2912
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Trypanosoma brucei unspecified product 0.0028 0.0038 0.0046
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0986 0.5322 0.5322
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0133 0.0133
Onchocerca volvulus 0.0479 0.2525 0.5718
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0133 0.0133
Plasmodium falciparum cysteine proteinase falcipain 2b 0.082 0.4406 1
Entamoeba histolytica cysteine protease, putative 0.0151 0.072 0.1633
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0013 0.0013
Trypanosoma cruzi cysteine peptidase, putative 0.082 0.4406 0.5345
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0012 0.0014
Plasmodium falciparum serine repeat antigen 6 0.0151 0.072 0.1633
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0012 0.0026
Brugia malayi Cathepsin L-like precursor 0.082 0.4406 0.4406
Brugia malayi Papain family cysteine protease containing protein 0.082 0.4406 0.4406
Schistosoma mansoni cathepsin F (C01 family) 0.082 0.4406 0.4406
Giardia lamblia Cysteine protease 0.0151 0.072 0.2013
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Schistosoma mansoni hypothetical protein 0.003 0.0053 0.0053
Trichomonas vaginalis glucosylceramidase, putative 0.0793 0.4257 0.9662
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0041 0.005
Echinococcus granulosus importin subunit beta 1 0.0028 0.0041 0.0041
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.082 0.4406 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0013 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Echinococcus granulosus epidermal growth factor receptor 0.0986 0.5322 0.5322
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0118 0.0118
Giardia lamblia Cathepsin B precursor 0.0151 0.072 0.2013
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0151 0.072 0.1633
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0218 0.0495
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0274 0.1398 0.1398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Echinococcus granulosus cathepsin L 0.0422 0.2214 0.2214
Loa Loa (eye worm) hypothetical protein 0.0271 0.138 0.138
Schistosoma mansoni cathepsin S (C01 family) 0.0151 0.072 0.072
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0107 0.0107
Giardia lamblia Encystation-specific protease 0.0151 0.072 0.2013
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.028 0.1428 0.3309
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0151 0.072 0.1633
Onchocerca volvulus 0.082 0.4406 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0133 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.2214 0.5025
Brugia malayi Immunoglobulin I-set domain containing protein 0.0157 0.0752 0.0752
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.072 0.072
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0586 0.312 0.312
Brugia malayi cathepsin F-like cysteine proteinase 0.0271 0.138 0.138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Brugia malayi Papain family cysteine protease containing protein 0.0422 0.2214 0.2214
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0206 0.0206
Trypanosoma cruzi cysteine proteinase, putative 0.0422 0.2214 0.2686
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0844 0.4539 0.4539
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0076 0.0303 0.0303
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0422 0.2214 0.2686
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0133 0.0133
Echinococcus multilocularis dna polymerase eta 0.0067 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0042 0.0117 0.0117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.082 0.4406 1
Schistosoma mansoni cathepsin F (C01 family) 0.082 0.4406 0.4406
Echinococcus multilocularis cathepsin L 0.0151 0.072 0.072
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.072 0.072
Echinococcus granulosus cathepsin L cysteine proteinase 0.082 0.4406 0.4406
Trypanosoma cruzi major cysteine proteinase, putative 0.0151 0.072 0.0873
Plasmodium falciparum cysteine proteinase falcipain 1 0.0422 0.2214 0.5025
Toxoplasma gondii preprocathepsin c precursor, putative 0.0151 0.072 0.1633
Schistosoma mansoni tyrosine kinase 0.0986 0.5322 0.5322
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0034 0.0071 0.0071
Echinococcus multilocularis cathepsin L 0.0422 0.2214 0.2214
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0012 0.0026
Echinococcus multilocularis cathepsin l cysteine peptidase 0.082 0.4406 0.4406
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0151 0.072 0.1633
Brugia malayi ImpB/MucB/SamB family protein 0.0067 0.0253 0.0253
Mycobacterium tuberculosis Conserved hypothetical protein 0.0798 0.4288 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0218 0.0218
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0088 0.0088
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0041 0.0041
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0107 0.013
Giardia lamblia Cathepsin L precursor 0.0151 0.072 0.2013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0013 0.0013
Giardia lamblia Cysteine protease 0.0151 0.072 0.2013
Brugia malayi fibroinase precursor 0.0151 0.072 0.072
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0076 0.0303 0.0368
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0151 0.072 0.072
Trypanosoma cruzi cysteine peptidase, putative 0.082 0.4406 0.5345
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0107 0.0242
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0107 0.013
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0067 0.0253 0.0253
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.072 0.1633
Brugia malayi Papain family cysteine protease containing protein 0.0151 0.072 0.072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0218 0.0218
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0076 0.0303 0.0849
Entamoeba histolytica cysteine proteinase 1, putative 0.0422 0.2214 0.5025
Trypanosoma cruzi cysteine peptidase, putative 0.0422 0.2214 0.2686
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Trypanosoma cruzi cysteine peptidase, putative 0.082 0.4406 0.5345
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0076 0.0303 0.0688
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.028 0.1428 0.3309
Loa Loa (eye worm) ctsf protein 0.082 0.4406 0.4406
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0042 0.0117 0.0266
Entamoeba histolytica cysteine proteinase, putative 0.0422 0.2214 0.5025
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0422 0.2214 0.2214
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.2754 0.625
Loa Loa (eye worm) hypothetical protein 0.0151 0.072 0.072
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0038 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Leishmania major DNA polymerase zeta catalytic subunit, putative 0.0034 0.0071 0.0086
Schistosoma mansoni DNA polymerase eta 0.0067 0.0253 0.0253
Toxoplasma gondii DNA polymerase family B protein 0.0076 0.0303 0.0688
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Toxoplasma gondii cathepsin CPC1 0.0151 0.072 0.1633
Trypanosoma brucei cysteine peptidase C (CPC) 0.0151 0.072 0.0873
Schistosoma mansoni cathepsin C 0.0151 0.072 0.072
Giardia lamblia Cysteine protease 0.0151 0.072 0.2013
Trypanosoma cruzi DNA polymerase eta, putative 0.0067 0.0253 0.0307
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0076 0.0303 0.0303
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0076 0.0303 0.0368
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0013 0.0031
Schistosoma mansoni tyrosine kinase 0.1834 1 1
Brugia malayi Pre-SET motif family protein 0.006 0.0218 0.0218
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0078 0.0314 0.0712
Echinococcus multilocularis cathepsin b 0.0151 0.072 0.072
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0549 0.2912 0.3532
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0151 0.072 0.1633
Onchocerca volvulus Alhambra homolog 0.003 0.0053 0.0089
Toxoplasma gondii hypothetical protein 0.0244 0.1233 0.2799
Plasmodium vivax vivapain-2 0.082 0.4406 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0421 0.2205 0.2205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.072 0.1633
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.012 0.0546 0.1239
Trypanosoma brucei DNA polymerase eta, putative 0.0067 0.0253 0.0307
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0433 0.0433
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0039 0.01 0.0227
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0053 0.0119
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0151 0.072 0.2013
Entamoeba histolytica hypothetical protein 0.0023 0.0012 0.0026
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0793 0.4257 0.4257
Loa Loa (eye worm) hypothetical protein 0.0151 0.072 0.072
Entamoeba histolytica DNA polymerase zeta catalytic subunit, putative 0.0034 0.0071 0.0162
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0669 0.3574 0.3574
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0107 0.013
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0151 0.072 0.072
Giardia lamblia Cathepsin L precursor 0.0151 0.072 0.2013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0133 0.0133
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0107 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.072 0.1633
Plasmodium vivax DNA polymerase alpha, putative 0.0222 0.1113 0.2525
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.1549 0.1549
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0012 0.0026
Onchocerca volvulus 0.082 0.4406 1
Loa Loa (eye worm) hypothetical protein 0.0271 0.138 0.138
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0038 0.0046
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0422 0.2214 0.2214
Plasmodium vivax vivapain-1 0.0422 0.2214 0.5025
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.012 0.0546 0.0662
Echinococcus multilocularis 0.0567 0.3015 0.3015
Schistosoma mansoni cathepsin B (C01 family) 0.0151 0.072 0.072
Giardia lamblia Cathepsin L-like protease 0.0151 0.072 0.2013
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Trypanosoma brucei unspecified product 0.004 0.0107 0.013
Entamoeba histolytica cysteine proteinase, putative 0.0422 0.2214 0.5025
Brugia malayi Pre-SET motif family protein 0.0421 0.2205 0.2205
Echinococcus granulosus cathepsin b 0.0151 0.072 0.072
Brugia malayi cathepsin Z-like cysteine proteinase 0.0151 0.072 0.072
Onchocerca volvulus Tyrosine kinase homolog 0.0148 0.0699 0.1561
Brugia malayi Cathepsin L-like cysteine proteinase 0.0549 0.2912 0.2912
Brugia malayi DNA polymerase alpha catalytic subunit 0.0222 0.1113 0.1113
Trichomonas vaginalis glucosylceramidase, putative 0.0793 0.4257 0.9662
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.082 0.4406 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.072 0.072
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0151 0.072 0.0873
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0717 0.3841 0.4659
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0669 0.3574 0.4336
Loa Loa (eye worm) hypothetical protein 0.0023 0.0013 0.0013
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0151 0.072 0.072
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0151 0.072 0.1633
Leishmania major cathepsin L-like protease 0.082 0.4406 0.5345
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0041 0.005
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.072 0.072
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.072 0.072
Echinococcus multilocularis dna polymerase kappa 0.004 0.0107 0.0107
Entamoeba histolytica cysteine protease, putative 0.0422 0.2214 0.5025
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0669 0.3574 0.4336
Giardia lamblia Hypothetical protein 0.0151 0.072 0.2013
Brugia malayi cathepsin L-like precursor 0.0549 0.2912 0.2912
Brugia malayi cathepsin L precursor 0.0151 0.072 0.072
Plasmodium falciparum phd finger protein, putative 0.003 0.0053 0.0119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0422 0.2214 0.2686
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.072 0.1633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Plasmodium falciparum serine repeat antigen 5 0.0151 0.072 0.1633
Plasmodium falciparum serine repeat antigen 1 0.0151 0.072 0.1633
Loa Loa (eye worm) hypothetical protein 0.0151 0.072 0.072
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0107 0.013
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0669 0.3574 0.4336
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0107 0.0107
Giardia lamblia Cathepsin L precursor 0.0151 0.072 0.2013
Schistosoma mansoni tyrosine kinase 0.0974 0.526 0.526
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0151 0.072 0.072
Brugia malayi Cathepsin L-like precursor 0.082 0.4406 0.4406
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0213 0.1061 0.1287
Plasmodium vivax vivapain-2 0.082 0.4406 1
Onchocerca volvulus Cathepsin L homolog 0.082 0.4406 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0271 0.138 0.138
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.072 0.1633
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0076 0.0303 0.0303
Giardia lamblia Cysteine protease 0.0151 0.072 0.2013
Echinococcus multilocularis insulin receptor 0.0586 0.312 0.312
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0076 0.0303 0.0368
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0213 0.1061 0.1287
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0076 0.0303 0.0303
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0053 0.0119
Plasmodium falciparum DNA polymerase zeta catalytic subunit, putative 0.0034 0.0071 0.0162
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.082 0.4406 1
Plasmodium vivax vivapain-3 0.0422 0.2214 0.5025
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0076 0.0303 0.0688
Brugia malayi Cathepsin L-like precursor 0.082 0.4406 0.4406
Entamoeba histolytica cysteine proteinase, putative 0.0422 0.2214 0.5025
Trypanosoma cruzi cysteine peptidase, putative 0.0271 0.138 0.1674
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.082 0.4406 1
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0107 0.0107
Echinococcus granulosus cathepsin l1 0.0549 0.2912 0.2912
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.082 0.4406 0.5345
Entamoeba histolytica cysteine proteinase, putative 0.082 0.4406 1

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) Toxicity in mice at 160 mg/kg, ip 28 days post dose ChEMBL. 16509595
Activity (ADMET) 0 Toxicity in mice at 160 mg/kg, ip 28 days post dose ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human Hs683 cancer cell line ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human U373 glioblastoma cell line ChEMBL. 16509595
IC50 (functional) < 10 uM Cytotoxicity against human HCT15 colon cancer cell line ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human PC3 prostate cancer cell line ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human A549 NSCLC cell line ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human MCF7 breast cancer cell line ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human Hs683 cancer cell line ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human U373 glioblastoma cell line ChEMBL. 16509595
IC50 (functional) < 10 uM Cytotoxicity against human HCT15 colon cancer cell line ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human PC3 prostate cancer cell line ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human A549 NSCLC cell line ChEMBL. 16509595
IC50 (functional) > 10 uM Cytotoxicity against human MCF7 breast cancer cell line ChEMBL. 16509595
Inhibition (functional) = -40 % Antimigratory activity against human A549 NSCLC cell line at 100nM after 22h ChEMBL. 16509595
Inhibition (functional) = -34 % Antimigratory activity against human A549 NSCLC cell line at 100nM after 12h ChEMBL. 16509595
Inhibition (functional) = -18 % Antimigratory activity against human U373 glioblastoma cell line at 100nM after 22h ChEMBL. 16509595
Inhibition (functional) = -18 % Antimigratory activity against human U373 glioblastoma cell line at 100nM after 12h ChEMBL. 16509595
Inhibition (functional) = -14 % Antimigratory activity against human U373 glioblastoma cell line at 100nM after 12h ChEMBL. 16509595
Inhibition (functional) = -14 % Antimigratory activity against human U373 glioblastoma cell line at 100nM after 12h ChEMBL. 16509595
Inhibition (functional) = -9 % Antimigratory activity against human PC3 prostate cancer cell line at 100nM after 22h ChEMBL. 16509595
Inhibition (functional) = -9 % Antimigratory activity against human U373 glioblastoma cell line at 100nM after 22h ChEMBL. 16509595
Inhibition (functional) = -9 % Antimigratory activity against human U373 glioblastoma cell line at 100nM after 22h ChEMBL. 16509595
Inhibition (functional) = -7 % Antimigratory activity against human PC3 prostate cancer cell line at 100nM after 12h ChEMBL. 16509595
Inhibition (functional) = 0 % Antimigratory activity against human A549 NSCLC cell line at 100nM after 22h ChEMBL. 16509595
Inhibition (functional) = 0 % Antimigratory activity against human A549 NSCLC cell line at 100nM after 22h ChEMBL. 16509595
Inhibition (functional) = 8 % Antimigratory activity against human PC3 prostate cancer cell line at 100nM after 12h ChEMBL. 16509595
Inhibition (functional) = 8 % Antimigratory activity against human PC3 prostate cancer cell line at 100nM after 12h ChEMBL. 16509595
Inhibition (functional) = 9 % Antimigratory activity against human A549 NSCLC cell line at 100nM after 12h ChEMBL. 16509595
Inhibition (functional) = 9 % Antimigratory activity against human A549 NSCLC cell line at 100nM after 12h ChEMBL. 16509595
Inhibition (functional) = 10 % Antimigratory activity against human PC3 prostate cancer cell line at 100nM after 22h ChEMBL. 16509595
Inhibition (functional) = 10 % Antimigratory activity against human PC3 prostate cancer cell line at 100nM after 22h ChEMBL. 16509595

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 16509595

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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