Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0619 | 0.112 | 0.3033 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1618 | 0.3573 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1618 | 0.3573 | 0.3539 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.1618 | 0.3573 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.1618 | 0.3573 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.1618 | 0.3573 | 0.3539 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0999 | 0.2053 | 0.2011 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.1618 | 0.3573 | 1 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0261 | 0.0243 | 0.0541 |
Brugia malayi | flavodoxin family protein | 0.1618 | 0.3573 | 0.3539 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0619 | 0.112 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0619 | 0.112 | 0.3033 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0347 | 0.0452 | 0.1135 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0184 | 0.0052 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.0243 | 0.0191 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0261 | 0.0243 | 0.068 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0261 | 0.0243 | 0.0191 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0184 | 0.0052 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0999 | 0.2053 | 0.5747 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0184 | 0.0052 | 0.5 |
Treponema pallidum | flavodoxin | 0.0619 | 0.112 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1618 | 0.3573 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0803 | 0.1572 | 0.4399 |
Chlamydia trachomatis | sulfite reductase | 0.0999 | 0.2053 | 1 |
Echinococcus granulosus | defective proboscis extension response | 0.0261 | 0.0243 | 0.0541 |
Echinococcus multilocularis | Immunoglobulin | 0.0261 | 0.0243 | 0.0541 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.4235 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.0243 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.0452 | 0.0402 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.1618 | 0.3573 | 1 |
Echinococcus granulosus | neuroglian | 0.0328 | 0.0407 | 0.1007 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.1618 | 0.3573 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1618 | 0.3573 | 1 |
Schistosoma mansoni | cytochrome B5 | 0.0184 | 0.0052 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.0243 | 0.0191 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.1434 | 0.3121 | 0.8159 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.1618 | 0.3573 | 1 |
Schistosoma mansoni | nephrin | 0.0328 | 0.0407 | 0.1139 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.3955 | 0.9313 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0619 | 0.112 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0413 | 0.0616 | 0.0567 |
Brugia malayi | flavodoxin family protein | 0.0619 | 0.112 | 0.1073 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0815 | 0.1602 | 0.4484 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0619 | 0.112 | 0.3033 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0619 | 0.112 | 0.3033 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0803 | 0.1572 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0261 | 0.0243 | 0.0191 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1618 | 0.3573 | 1 |
Echinococcus granulosus | twitchin | 0.0328 | 0.0407 | 0.1007 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0619 | 0.112 | 0.5 |
Echinococcus granulosus | Immunoglobulin | 0.0261 | 0.0243 | 0.0541 |
Echinococcus granulosus | methionine synthase reductase | 0.0999 | 0.2053 | 0.5684 |
Echinococcus granulosus | roundabout 2 | 0.0413 | 0.0616 | 0.1601 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0619 | 0.112 | 0.1073 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.1618 | 0.3573 | 1 |
Onchocerca volvulus | 0.3878 | 0.9123 | 0.9795 | |
Plasmodium vivax | flavodoxin domain containing protein | 0.1434 | 0.3121 | 0.8717 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0184 | 0.0052 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.1618 | 0.3573 | 0.3539 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.1618 | 0.3573 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.1618 | 0.3573 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.0243 | 0.0191 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0261 | 0.0243 | 0.068 |
Echinococcus multilocularis | neuroglian | 0.0328 | 0.0407 | 0.1007 |
Leishmania major | p450 reductase, putative | 0.1618 | 0.3573 | 1 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0184 | 0.0052 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0803 | 0.1572 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.1434 | 0.3121 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0413 | 0.0616 | 0.0567 |
Schistosoma mansoni | cell adhesion molecule | 0.0347 | 0.0452 | 0.1265 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.1618 | 0.3573 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0261 | 0.0243 | 0.0541 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0619 | 0.112 | 0.5 |
Brugia malayi | hypothetical protein | 0.0261 | 0.0243 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.0243 | 0.0191 |
Schistosoma mansoni | cytochrome P450 reductase | 0.1618 | 0.3573 | 1 |
Giardia lamblia | Hypothetical protein | 0.1434 | 0.3121 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0413 | 0.0616 | 0.1601 |
Schistosoma mansoni | vesicular amine transporter | 0.0261 | 0.0243 | 0.068 |
Leishmania major | hypothetical protein, conserved | 0.0619 | 0.112 | 0.3033 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0619 | 0.112 | 0.3033 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.1618 | 0.3573 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0999 | 0.2053 | 0.2011 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.1618 | 0.3573 | 1 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0619 | 0.112 | 0.3033 |
Leishmania major | cytochrome P450 reductase, putative | 0.1434 | 0.3121 | 0.8717 |
Echinococcus multilocularis | methionine synthase reductase | 0.0999 | 0.2053 | 0.5684 |
Trichomonas vaginalis | sulfite reductase, putative | 0.1618 | 0.3573 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.0243 | 0.0191 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0619 | 0.112 | 0.5 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0184 | 0.0052 | 0.0147 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0619 | 0.112 | 0.3033 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 76 nM | Inhibition of Enterococcus faecium AAC(6')Ii | ChEMBL. | 16913716 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.