Detailed information for compound 408390

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1575.21 | Formula: C80H100ClN17O15
  • H donors: 15 H acceptors: 17 LogP: 3.82 Rotable bonds: 51
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(=O)N)C)CCCCNC(C)C)CC(C)C)Cc1cccnc1)Cc1ccc(cc1)NC(=O)[C@H]1CC(=O)NC(=O)N1)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](Cc1ccc2c(c1)cccc2)NC(=O)C)Cc1ccc(cc1)Cl)Cc1cccnc1
  • InChi: 1S/C80H100ClN17O15/c1-45(2)34-59(71(104)89-58(18-9-10-32-85-46(3)4)79(112)98-33-13-19-67(98)78(111)86-47(5)69(82)102)90-75(108)63(39-52-14-11-30-83-42-52)92-74(107)62(37-50-23-28-57(29-24-50)88-70(103)65-41-68(101)97-80(113)96-65)94-77(110)66(44-99)95-76(109)64(40-53-15-12-31-84-43-53)93-73(106)61(36-49-21-26-56(81)27-22-49)91-72(105)60(87-48(6)100)38-51-20-25-54-16-7-8-17-55(54)35-51/h7-8,11-12,14-17,20-31,35,42-43,45-47,58-67,85,99H,9-10,13,18-19,32-34,36-41,44H2,1-6H3,(H2,82,102)(H,86,111)(H,87,100)(H,88,103)(H,89,104)(H,90,108)(H,91,105)(H,92,107)(H,93,106)(H,94,110)(H,95,109)(H2,96,97,101,113)/t47-,58+,59+,60-,61-,62+,63-,64-,65-,66+,67+/m1/s1
  • InChiKey: FFIYISLDYYMTAR-KMPPMTKRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens gonadotropin-releasing hormone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GnHR receptor homolog Get druggable targets OG5_131719 All targets in OG5_131719
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis serotonin receptor 0.0035 0.0142 0.0079
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.0142 0.0098
Brugia malayi Melatonin receptor type 1A 0.0035 0.0142 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0063 0.0489 0.1426
Schistosoma mansoni coup transcription factor 0.0426 0.5061 0.6206
Brugia malayi hypothetical protein 0.0035 0.0142 0.0199
Plasmodium vivax unspecified product 0.0031 0.0089 0.032
Trypanosoma cruzi cruzipain precursor, putative 0.0094 0.0879 1
Onchocerca volvulus 0.0035 0.0142 0.028
Onchocerca volvulus 0.0035 0.0142 0.028
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0969 0.1125
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0142 0.0079
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0482 0.052
Loa Loa (eye worm) hypothetical protein 0.0052 0.0356 0.0704
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.0142 0.0079
Echinococcus multilocularis neuropeptide FF receptor 2 0.0035 0.0142 0.0079
Onchocerca volvulus 0.0094 0.0879 0.1737
Leishmania major cathepsin L-like protease 0.0094 0.0879 1
Echinococcus granulosus hypothetical protein 0.0035 0.0142 0.0114
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0307 0.043
Loa Loa (eye worm) hypothetical protein 0.0426 0.5061 1
Brugia malayi G protein-coupled receptor 0.0035 0.0142 0.0199
Schistosoma mansoni opsin-like receptor 0.0035 0.0142 0.0098
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0201 0.2228 0.3123
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0144 0.0082
Loa Loa (eye worm) nuclear hormone receptor 0.0201 0.2228 0.4403
Echinococcus multilocularis dro:myosuppressin receptor 0.0035 0.0142 0.0079
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.0142 0.0079
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0094 0.0879 0.302
Entamoeba histolytica cysteine proteinase, putative 0.0063 0.0489 0.5151
Schistosoma mansoni neuropeptide receptor 0.0035 0.0142 0.0098
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0031 0.0089 0.0176
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.0142 0.0079
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.014 0.0942
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0142 0.0114
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0201 0.2228 0.2179
Schistosoma mansoni biogenic amine receptor 0.0035 0.0142 0.0098
Mycobacterium tuberculosis Conserved protein 0.0035 0.0144 0.0566
Onchocerca volvulus 0.0035 0.0142 0.028
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0035 0.0142 0.0199
Loa Loa (eye worm) TYRA-2 protein 0.0035 0.0142 0.028
Schistosoma mansoni neuropeptide f receptor 76f 0.0035 0.0142 0.0098
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0426 0.5061 0.6212
Echinococcus multilocularis cathepsin L cysteine protease 0.0094 0.0879 0.0822
Onchocerca volvulus 0.0201 0.2228 0.4403
Brugia malayi Cathepsin L-like precursor 0.0094 0.0879 0.1232
Loa Loa (eye worm) hypothetical protein 0.0029 0.0063 0.0124
Loa Loa (eye worm) hypothetical protein 0.0201 0.2228 0.4403
Brugia malayi Nuclear hormone receptor-like 1 0.0225 0.2532 0.3548
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0327 0.0763
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.0142 0.0114
Echinococcus multilocularis neuropeptide receptor A26 0.0035 0.0142 0.0079
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Brugia malayi Cathepsin L-like precursor 0.0063 0.0489 0.0685
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0035 0.0142 0.0098
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0327 0.3717
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.014 0.0276
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0327 0.3008
Entamoeba histolytica cysteine protease, putative 0.0094 0.0879 0.9261
Loa Loa (eye worm) hypothetical protein 0.0201 0.2228 0.4403
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0094 0.0879 0.302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0094 0.0879 0.302
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Toxoplasma gondii Erv1 / Alr family protein 0.0033 0.0117 0.0665
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0035 0.0142 0.0199
Echinococcus multilocularis cysteine protease 0.0094 0.0879 0.0822
Brugia malayi steroid hormone receptor 0.0426 0.5061 0.7093
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0035 0.0142 0.0098
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.0142 0.0098
Echinococcus multilocularis neuropeptide receptor 0.0035 0.0142 0.0079
Brugia malayi hypothetical protein 0.0035 0.0142 0.0199
Onchocerca volvulus 0.0035 0.0142 0.028
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0426 0.5061 0.6212
Loa Loa (eye worm) ctsf protein 0.0094 0.0879 0.1737
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0033 0.0117 0.0357
Echinococcus granulosus cathepsin L 0.0048 0.0307 0.0319
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0201 0.2228 0.2179
Onchocerca volvulus Cathepsin L homolog 0.0094 0.0879 0.1737
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.1686 0.3332
Entamoeba histolytica cysteine proteinase, putative 0.0094 0.0879 0.9261
Entamoeba histolytica hypothetical protein 0.0071 0.0595 0.6264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0307 0.2488
Loa Loa (eye worm) hypothetical protein 0.0426 0.5061 1
Echinococcus granulosus tar DNA binding protein 0.0062 0.0482 0.0536
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0201 0.2228 0.2179
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0142 0.0114
Brugia malayi hypothetical protein 0.0201 0.2228 0.3123
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0426 0.5061 0.7093
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0426 0.5061 1
Brugia malayi orphan nuclear receptor NR2E1 0.0201 0.2228 0.3123
Brugia malayi Nuclear hormone receptor E75 0.0201 0.2228 0.3123
Leishmania major cathepsin L-like protease 0.0094 0.0879 1
Entamoeba histolytica cysteine protease, putative 0.0048 0.0307 0.3233
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0253 0.289 0.2845
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0595 0.0676
Entamoeba histolytica cysteine protease, putative 0.0048 0.0307 0.3233
Brugia malayi hypothetical protein 0.0035 0.0142 0.0199
Schistosoma mansoni amine GPCR 0.0035 0.0142 0.0098
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0035 0.0142 0.0098
Brugia malayi Pre-SET motif family protein 0.0029 0.0063 0.0088
Schistosoma mansoni hypothetical protein 0.0041 0.0216 0.019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0426 0.5061 0.7093
Brugia malayi larval opioid receptor 0.0035 0.0142 0.0199
Brugia malayi Cathepsin L-like precursor 0.0063 0.0489 0.0685
Brugia malayi putative neuropeptide receptor NPR1 0.0035 0.0142 0.0199
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0144 0.0566
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0426 0.5061 0.6206
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0035 0.0142 0.0098
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0035 0.0142 0.028
Brugia malayi GnHR receptor homolog 0.0591 0.7136 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0142 0.0098
Onchocerca volvulus 0.0047 0.0287 0.0567
Echinococcus multilocularis g-protein coupled receptor 0.0035 0.0142 0.0079
Schistosoma mansoni neuropeptide receptor 0.0035 0.0142 0.0098
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0327 0.0344
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Loa Loa (eye worm) hypothetical protein 0.0225 0.2532 0.5002
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.0142 0.0079
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.0142 0.028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0879 1
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.0142 0.0079
Leishmania major cathepsin L-like protease 0.0094 0.0879 1
Onchocerca volvulus 0.0201 0.2228 0.4403
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0426 0.5061 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0048 0.0307 0.2488
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0426 0.5061 0.7093
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1686 0.1634
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Onchocerca volvulus 0.0035 0.0142 0.028
Echinococcus multilocularis protein patched 0.0043 0.0236 0.0174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0879 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0142 0.0079
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0144 0.0566
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0033 0.0117 0.0665
Loa Loa (eye worm) hypothetical protein 0.0099 0.095 0.1876
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.095 0.1331
Loa Loa (eye worm) hypothetical protein 0.0201 0.2228 0.4403
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.014 0.0642
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0035 0.0142 0.0199
Leishmania major hypothetical protein, conserved 0.0033 0.0117 0.1334
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.0142 0.0114
Schistosoma mansoni hypothetical protein 0.0041 0.0216 0.019
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.1486 0.1432
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0142 0.0114
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0142 0.0079
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0201 0.2228 0.2179
Trypanosoma cruzi cysteine peptidase, putative 0.0094 0.0879 1
Plasmodium vivax unspecified product 0.0048 0.0307 0.2988
Onchocerca volvulus Cathepsin F homolog 0.0094 0.0879 0.1737
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0142 0.0098
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Echinococcus granulosus 7tm_1 domain containing protein 0.0035 0.0142 0.0114
Entamoeba histolytica cysteine proteinase, putative 0.0048 0.0307 0.3233
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.014 0.0077
Echinococcus granulosus g protein coupled receptor 0.0035 0.0142 0.0114
Echinococcus multilocularis thyroid hormone receptor alpha 0.0426 0.5061 0.503
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0142 0.0079
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0035 0.0142 0.028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0426 0.5061 1
Echinococcus multilocularis neuropeptide s receptor 0.0035 0.0142 0.0079
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0236 0.0174
Echinococcus granulosus serotonin receptor 0.0035 0.0142 0.0114
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0426 0.5061 0.503
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0144 0.0202
Loa Loa (eye worm) hypothetical protein 0.0426 0.5061 1
Echinococcus granulosus G protein coupled receptor 139 0.0035 0.0142 0.0114
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0176
Brugia malayi Cathepsin L-like precursor 0.0094 0.0879 0.1232
Brugia malayi ORL1-like opioid receptor 0.0035 0.0142 0.0199
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0035 0.0142 0.0079
Schistosoma mansoni steroid hormone receptor ad4bp 0.0426 0.5061 0.6206
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0031 0.0089 0.0125
Entamoeba histolytica cysteine protease, putative 0.0048 0.0307 0.3233
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0035 0.0142 0.0098
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0142 0.0098
Trypanosoma cruzi cysteine proteinase, putative 0.0048 0.0307 0.2757
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0142 0.0114
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0035 0.0142 0.0079
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.014 0.1591
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.1686 0.2029
Onchocerca volvulus 0.0091 0.0848 0.1676
Entamoeba histolytica cysteine protease, putative 0.0048 0.0307 0.3233
Loa Loa (eye worm) hypothetical protein 0.0035 0.0144 0.0285
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0201 0.2228 0.2179
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0201 0.2228 0.4403
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0035 0.0142 0.028
Echinococcus granulosus sex peptide receptor 0.0035 0.0142 0.0114
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0327 0.0763
Schistosoma mansoni amine GPCR 0.0035 0.0142 0.0098
Entamoeba histolytica cysteine protease, putative 0.0048 0.0307 0.3233
Leishmania major cathepsin L-like protease 0.0094 0.0879 1
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0236 0.023
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0048 0.0307 0.0303
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0327 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0225 0.2532 0.3548
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0879 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0489 0.0966
Trichomonas vaginalis esterase, putative 0.0035 0.0144 0.0017
Brugia malayi putative neuropeptide receptor 0.0035 0.0142 0.0199
Echinococcus granulosus thyroid hormone receptor alpha 0.0201 0.2228 0.2701
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0094 0.0879 0.302
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0426 0.5061 0.6206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0094 0.0879 0.302
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.0142 0.0098
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0201 0.2228 0.2688
Brugia malayi Cathepsin L-like precursor 0.0094 0.0879 0.1232
Echinococcus granulosus fmrfamide receptor 0.0035 0.0142 0.0114
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0327 0.0763
Loa Loa (eye worm) hypothetical protein 0.0201 0.2228 0.4403
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.0142 0.0098
Brugia malayi neuropeptide F receptor 0.0035 0.0142 0.0199
Brugia malayi hypothetical protein 0.0035 0.0142 0.0199
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0142 0.0098
Schistosoma mansoni cathepsin s 0.0031 0.0089 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0142 0.0098
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Echinococcus multilocularis cysteine protease 0.0094 0.0879 0.0822
Onchocerca volvulus Cathepsin L homolog 0.0094 0.0879 0.1737
Schistosoma mansoni amine GPCR 0.0035 0.0142 0.0098
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0426 0.5061 0.7093
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0048 0.0307 0.0303
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.1486 0.1781
Onchocerca volvulus 0.0035 0.0142 0.028
Plasmodium falciparum cysteine proteinase falcipain 3 0.0094 0.0879 1
Brugia malayi ecdysone receptor 0.0201 0.2228 0.3123
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0035 0.0142 0.0199
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0307 0.2757
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.014 0.0112
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0035 0.0142 0.0114
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0094 0.0879 0.302
Echinococcus granulosus alpha 1A adrenergic receptor 0.0035 0.0142 0.0114
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0426 0.5061 1
Brugia malayi Nuclear hormone receptor-like 1 0.0426 0.5061 0.7093
Loa Loa (eye worm) fibroinase 0.0094 0.0879 0.1737
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0144 0.0695
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0201 0.2228 0.2701
Entamoeba histolytica cysteine proteinase, putative 0.0048 0.0307 0.3233
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0142 0.0098
Brugia malayi Serotonin receptor 0.0035 0.0142 0.0199
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0144 0.0017
Onchocerca volvulus 0.0426 0.5061 1
Entamoeba histolytica cysteine proteinase, putative 0.0048 0.0307 0.3233
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0482 0.052
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Echinococcus granulosus dro:myosuppressin receptor 0.0035 0.0142 0.0114
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0144 0.0017
Schistosoma mansoni hypothetical protein 0.0035 0.0142 0.0098
Schistosoma mansoni hypothetical protein 0.0071 0.0595 0.066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0142 0.0098
Echinococcus granulosus peptide allatostatin:somatostatin 0.0035 0.0142 0.0114
Schistosoma mansoni alpha glucosidase 0.0035 0.014 0.0095
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0595 0.066
Schistosoma mansoni retinoic acid receptor RXR 0.0426 0.5061 0.6206
Brugia malayi Cathepsin L-like precursor 0.0094 0.0879 0.1232
Brugia malayi Dopamine receptor protein 2 0.0035 0.0142 0.0199
Schistosoma mansoni myosin xvIII 0.0035 0.0142 0.0098
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0035 0.0142 0.0079
Loa Loa (eye worm) hypothetical protein 0.0201 0.2228 0.4403
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0426 0.5061 0.6212
Brugia malayi nuclear hormone receptor 0.0426 0.5061 0.7093
Loa Loa (eye worm) hypothetical protein 0.0201 0.2228 0.4403
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0142 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0094 0.0879 0.302
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.0142 0.0079
Brugia malayi RNA binding protein 0.0062 0.0482 0.0676
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0142 0.0114
Loa Loa (eye worm) hypothetical protein 0.0043 0.0236 0.0465
Echinococcus multilocularis cathepsin L cysteine protease 0.0094 0.0879 0.0822
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0482 0.052
Onchocerca volvulus 0.0094 0.0879 0.1737
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Brugia malayi Nuclear hormone receptor E75 0.0201 0.2228 0.3123
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0225 0.2532 0.5002
Brugia malayi sulfakinin receptor protein 0.0035 0.0142 0.0199
Schistosoma mansoni opsin-like receptor 0.0035 0.0142 0.0098
Plasmodium vivax vivapain-1 0.0048 0.0307 0.2988
Brugia malayi Steroid receptor seven-up type 2 0.0426 0.5061 0.7093
Brugia malayi nuclear hormone receptor family member nhr-6 0.0201 0.2228 0.3123
Loa Loa (eye worm) nuclear receptor NHR-67 0.0201 0.2228 0.4403
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0327 0.0646
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0142 0.0079
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0327 0.0328
Onchocerca volvulus Neuropeptide F receptor homolog 0.0035 0.0142 0.028
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0094 0.0879 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0595 0.0535
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0035 0.0142 0.0199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0426 0.5061 1
Loa Loa (eye worm) hypothetical protein 0.0225 0.2532 0.5002
Brugia malayi Stress-activated protein kinase jnk-1 0.0253 0.289 0.405
Entamoeba histolytica cysteine proteinase, putative 0.0094 0.0879 0.9261
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0426 0.5061 0.7093
Trypanosoma cruzi cysteine proteinase, putative 0.0048 0.0307 0.2757
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0879 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0094 0.0879 0.302
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0142 0.0114
Onchocerca volvulus 0.0035 0.0142 0.028
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0142 0.0079
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0426 0.5061 0.503
Brugia malayi G-protein coupled receptor 0.0035 0.0142 0.0199
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0144 0.0017
Leishmania major cathepsin L-like protease 0.0094 0.0879 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0144 0.0285
Entamoeba histolytica cysteine protease, putative 0.0048 0.0307 0.3233
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.0142 0.0098
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0144 0.0992
Schistosoma mansoni survival motor neuron protein 0.0047 0.0287 0.0278
Brugia malayi hypothetical protein 0.0035 0.0142 0.0199
Loa Loa (eye worm) hypothetical protein 0.0201 0.2228 0.4403
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0327 0.3232
Brugia malayi hypothetical protein 0.0225 0.2532 0.3548
Toxoplasma gondii cathepsin CPL 0.0094 0.0879 1
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0482 0.0676
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Echinococcus granulosus neuropeptide receptor 0.0035 0.0142 0.0114
Schistosoma mansoni cathepsin F (C01 family) 0.0094 0.0879 0.1014
Brugia malayi Tachykinin-like peptides receptor 99D 0.0035 0.0142 0.0199
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0094 0.0879 0.302
Onchocerca volvulus 0.0035 0.0142 0.028
Loa Loa (eye worm) hypothetical protein 0.0201 0.2228 0.4403
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0426 0.5061 0.6206
Echinococcus granulosus cathepsin L cysteine proteinase 0.0094 0.0879 0.1028
Echinococcus granulosus somatostatin receptor 0.0035 0.0142 0.0114
Onchocerca volvulus 0.0035 0.0142 0.028
Entamoeba histolytica cysteine protease, putative 0.0048 0.0307 0.3233
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Onchocerca volvulus 0.0035 0.0144 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0426 0.5061 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Brugia malayi MAP kinase sur-1 0.005 0.0327 0.0458
Schistosoma mansoni neuropeptide receptor 0.0035 0.0142 0.0098
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0482 0.0952
Trypanosoma brucei glucosidase, putative 0.0035 0.014 0.0296
Mycobacterium tuberculosis Conserved protein 0.0035 0.0144 0.0566
Loa Loa (eye worm) hypothetical protein 0.0063 0.0489 0.0966
Echinococcus granulosus orexin receptor type 2 0.0035 0.0142 0.0114
Schistosoma mansoni hypothetical protein 0.0035 0.0142 0.0098
Echinococcus granulosus nuclear receptor nhr 48 0.0201 0.2228 0.2701
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0426 0.5061 0.503
Brugia malayi nuclear receptor NHR-88 0.0201 0.2228 0.3123
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.0142 0.028
Echinococcus granulosus expressed conserved protein 0.0093 0.0874 0.1021
Brugia malayi nuclear hormone receptor 0.0201 0.2228 0.3123
Leishmania major cathepsin L-like protease 0.0094 0.0879 1
Trypanosoma brucei protein kinase, putative 0.005 0.0327 0.2749
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0094 0.0879 0.302
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0307 0.2488
Schistosoma mansoni patched 1 0.0043 0.0236 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0094 0.0879 0.302
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0426 0.5061 0.7093
Echinococcus multilocularis serotonin receptor 0.0035 0.0142 0.0079
Loa Loa (eye worm) hypothetical protein 0.0201 0.2228 0.4403
Brugia malayi G protein-coupled receptor F59B2.13 0.0035 0.0142 0.0199
Entamoeba histolytica cysteine protease, putative 0.0048 0.0307 0.3233
Schistosoma mansoni hypothetical protein 0.0041 0.0216 0.019
Schistosoma mansoni nuclear hormone receptor 0.0426 0.5061 0.6206
Brugia malayi tailless protein 0.0201 0.2228 0.3123
Schistosoma mansoni opsin-like receptor 0.0035 0.0142 0.0098
Onchocerca volvulus 0.0035 0.0142 0.028
Echinococcus granulosus 7TM GPCR rhodopsin 0.0035 0.0142 0.0114
Brugia malayi hypothetical protein 0.0035 0.0142 0.0199
Schistosoma mansoni nuclear receptor 0.0201 0.2228 0.2688
Onchocerca volvulus 0.0035 0.0142 0.028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0426 0.5061 0.7093
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.095 0.0892
Loa Loa (eye worm) cysteine protease 0.0094 0.0879 0.1737
Brugia malayi Papain family cysteine protease containing protein 0.0094 0.0879 0.1232
Onchocerca volvulus 0.0094 0.0879 0.1737
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0035 0.0142 0.0079
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0144 0.035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0879 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0426 0.5061 0.7093
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0236 0.023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0879 1
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0327 0.0265
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0035 0.0142 0.0114
Schistosoma mansoni nuclear hormone receptor 0.0201 0.2228 0.2688
Echinococcus multilocularis microtubule associated protein 2 0.0669 0.8117 0.8105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0094 0.0879 0.302
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.0142 0.028
Toxoplasma gondii ABC1 family protein 0.0035 0.0144 0.0992
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0879 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0327 0.0265
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0327 0.0763
Onchocerca volvulus 0.0094 0.0879 0.1737
Brugia malayi hypothetical protein 0.0035 0.0142 0.0199
Echinococcus granulosus cathepsin l1 0.0063 0.0489 0.0545
Loa Loa (eye worm) hypothetical protein 0.0201 0.2228 0.4403
Brugia malayi Cathepsin L-like cysteine proteinase 0.0063 0.0489 0.0685
Leishmania major cathepsin L-like protease 0.0094 0.0879 1
Brugia malayi beta-lactamase family protein 0.0035 0.0144 0.0202
Loa Loa (eye worm) beta-lactamase 0.0035 0.0144 0.0285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0879 1
Entamoeba histolytica cysteine protease, putative 0.0048 0.0307 0.3233
Schistosoma mansoni nuclear receptor nhr-48 0.0201 0.2228 0.2688
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0142 0.0114
Echinococcus granulosus Nuclear hormone receptor HR96 0.0201 0.2228 0.2701
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0426 0.5061 0.7093
Onchocerca volvulus 0.0035 0.0144 0.0285
Loa Loa (eye worm) hypothetical protein 0.0035 0.0144 0.0285
Loa Loa (eye worm) hypothetical protein 0.0063 0.0489 0.0966
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Onchocerca volvulus 0.0035 0.0142 0.028
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1686 0.1634
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Brugia malayi cathepsin F-like cysteine proteinase 0.0031 0.0089 0.0125
Loa Loa (eye worm) hypothetical protein 0.0225 0.2532 0.5002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0144 0.0285
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0033 0.0117 0.0055
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0426 0.5061 0.6212
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0094 0.0879 0.0822
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0426 0.5061 0.503
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0426 0.5061 0.7093
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0094 0.0879 0.0822
Schistosoma mansoni thyroid hormone receptor 0.0426 0.5061 0.6206
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0426 0.5061 0.7093
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0142 0.0079
Loa Loa (eye worm) hypothetical protein 0.0201 0.2228 0.4403
Mycobacterium tuberculosis Conserved protein 0.0035 0.0144 0.0566
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0033 0.0117 0.0357
Brugia malayi conserved hypotetical protein 0.0201 0.2228 0.3123
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0426 0.5061 0.503
Brugia malayi hypothetical protein 0.0035 0.0142 0.0199
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0144 0.0566
Loa Loa (eye worm) hypothetical protein 0.0426 0.5061 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0035 0.0142 0.0098
Loa Loa (eye worm) hypothetical protein 0.0035 0.0144 0.0285
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0225 0.2532 0.3065
Echinococcus multilocularis somatostatin receptor 0.0035 0.0142 0.0079
Schistosoma mansoni alpha-glucosidase 0.0136 0.141 0.1672
Echinococcus multilocularis neuropeptide receptor 0.0035 0.0142 0.0079
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0327 0.2749
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0142 0.0079
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.095 0.1115
Echinococcus granulosus microtubule associated protein 2 0.0669 0.8117 1
Onchocerca volvulus 0.0094 0.0879 0.1737
Schistosoma mansoni cathepsin F (C01 family) 0.0063 0.0489 0.0529
Echinococcus granulosus tachykinin peptides receptor 99D 0.0035 0.0142 0.0114
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0144 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0201 0.2228 0.3123
Brugia malayi AKH receptor 0.0035 0.0142 0.0199
Echinococcus multilocularis expressed conserved protein 0.0093 0.0874 0.0816
Onchocerca volvulus 0.023 0.2589 0.5114
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0426 0.5061 0.503
Trichomonas vaginalis set domain proteins, putative 0.023 0.2589 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0142 0.0114
Echinococcus granulosus cathepsin l cysteine peptidase 0.0094 0.0879 0.1028
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Schistosoma mansoni biogenic amine receptor 0.0035 0.0142 0.0098
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0035 0.0142 0.0079
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0035 0.0142 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0879 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0144 0.0101
Plasmodium vivax vivapain-3 0.0048 0.0307 0.2988
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0327 0.3008
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0142 0.0098
Schistosoma mansoni adenoreceptor 0.0035 0.0142 0.0098
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0201 0.2228 0.2701
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0327 0.3717
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0035 0.0142 0.028
Brugia malayi hypothetical protein 0.0035 0.0142 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0094 0.0879 0.302
Schistosoma mansoni histamine h1 receptor 0.0035 0.0142 0.0098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0879 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0482 0.052
Loa Loa (eye worm) hypothetical protein 0.0225 0.2532 0.5002
Trypanosoma cruzi cysteine peptidase, putative 0.0094 0.0879 1
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.2584 0.3141
Mycobacterium leprae Probable lipase LipE 0.0035 0.0144 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0225 0.2532 0.2484
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0879 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0048 0.0307 0.0303
Brugia malayi nuclear receptor NHR-88 0.0426 0.5061 0.7093
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0426 0.5061 0.6206
Brugia malayi nuclear receptor RXR 0.0201 0.2228 0.3123
Brugia malayi hypothetical protein 0.0229 0.2584 0.3621
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0094 0.0879 0.302
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0144 0.0101
Onchocerca volvulus 0.0063 0.0489 0.0966
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0225 0.2532 0.3077
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0142 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0142 0.0079
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0144 0.0285
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0094 0.0879 0.1737
Entamoeba histolytica hypothetical protein 0.0071 0.0595 0.6264
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0327 0.0344
Onchocerca volvulus Protein ultraspiracle homolog 0.0426 0.5061 1
Echinococcus multilocularis fmrfamide receptor 0.0035 0.0142 0.0079
Echinococcus granulosus neuropeptide receptor 0.0035 0.0142 0.0114
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0236 0.0465
Brugia malayi neuropeptide F receptor 0.0035 0.0142 0.0199
Echinococcus granulosus c-Jun N-terminal kinases 0.0253 0.289 0.352
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0094 0.0879 0.302
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0225 0.2532 0.3065
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0144 1
Onchocerca volvulus 0.0035 0.0142 0.028
Brugia malayi hypothetical protein 0.0071 0.0595 0.0833
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0142 0.0079
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0307 0.043
Loa Loa (eye worm) hypothetical protein 0.0225 0.2532 0.5002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0426 0.5061 0.7093
Onchocerca volvulus 0.0035 0.0144 0.0285
Schistosoma mansoni hypothetical protein 0.0035 0.0142 0.0098
Brugia malayi RE15519p 0.0035 0.0142 0.0199
Echinococcus multilocularis nuclear receptor nhr 48 0.0201 0.2228 0.2179
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0094 0.0879 0.302
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0035 0.0142 0.028
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0426 0.5061 0.6206
Brugia malayi nuclear receptor NHR-67 0.0201 0.2228 0.3123
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.1686 0.2363
Brugia malayi cathepsin L-like precursor 0.0063 0.0489 0.0685
Plasmodium vivax vivapain-2 0.0094 0.0879 1
Schistosoma mansoni amine GPCR 0.0035 0.0142 0.0098
Schistosoma mansoni alpha-1 adrenergic receptor 0.0035 0.0142 0.0098
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.014 0.0642
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0426 0.5061 0.6212
Schistosoma mansoni hypothetical protein 0.0041 0.0216 0.019
Schistosoma mansoni neuropeptide receptor 0.0035 0.0142 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0094 0.0879 0.302
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0142 0.0114
Onchocerca volvulus 0.0094 0.0879 0.1737
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0035 0.0142 0.0114
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0426 0.5061 0.6212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0142 0.0098
Loa Loa (eye worm) hypothetical protein 0.0229 0.2584 0.5105
Entamoeba histolytica cysteine proteinase 2 0.0048 0.0307 0.3233
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0035 0.0142 0.0114
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0201 0.2228 0.4403
Schistosoma mansoni amine GPCR 0.0035 0.0142 0.0098
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0094 0.0879 1
Trypanosoma cruzi cysteine peptidase, putative 0.0094 0.0879 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0426 0.5061 0.6206
Brugia malayi hypothetical protein 0.0201 0.2228 0.3123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0094 0.0879 0.302
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0144 0.0566
Trypanosoma cruzi cysteine protease, putative 0.0048 0.0307 0.2757
Brugia malayi Dopamine receptor protein 1 0.0035 0.0142 0.0199
Loa Loa (eye worm) hypothetical protein 0.0426 0.5061 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0035 0.0142 0.028
Brugia malayi Serotonin receptor 0.0035 0.0142 0.0199
Brugia malayi Cathepsin L-like precursor 0.0094 0.0879 0.1232
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0287 0.0403
Onchocerca volvulus 0.0035 0.0142 0.028
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.0142 0.0114
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0094 0.0879 0.302
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Echinococcus multilocularis FTZ F1 alpha 0.0426 0.5061 0.503
Echinococcus granulosus neuropeptide s receptor 0.0035 0.0142 0.0114
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0142 0.0079
Schistosoma mansoni cathepsin F (C01 family) 0.0094 0.0879 0.1014
Echinococcus granulosus Nuclear hormone receptor HR96 0.0201 0.2228 0.2701
Loa Loa (eye worm) hypothetical protein 0.0201 0.2228 0.4403
Brugia malayi TAR-binding protein 0.0062 0.0482 0.0676
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0144 0.0017
Onchocerca volvulus 0.0035 0.0142 0.028
Entamoeba histolytica cysteine protease, putative 0.0048 0.0307 0.3233
Echinococcus granulosus cathepsin L cysteine protease 0.0048 0.0307 0.0319
Echinococcus multilocularis G protein coupled receptor 139 0.0035 0.0142 0.0079
Echinococcus granulosus FTZ F1 alpha 0.0426 0.5061 0.6212
Brugia malayi hypothetical protein 0.0225 0.2532 0.3548
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0035 0.0142 0.0079
Loa Loa (eye worm) RNA binding protein 0.0062 0.0482 0.0952
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0035 0.0142 0.0079
Entamoeba histolytica cysteine protease, putative 0.0048 0.0307 0.3233
Entamoeba histolytica cysteine proteinase, putative 0.0048 0.0307 0.3233
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0426 0.5061 1
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0142 0.0114
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0144 1
Schistosoma mansoni nuclear hormone receptor 0.0201 0.2228 0.2688
Echinococcus multilocularis protein dispatched 1 0.0049 0.0311 0.025
Brugia malayi CHE-14 protein 0.0043 0.0236 0.033
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0327 0.3008
Echinococcus granulosus g-protein coupled receptor 0.0035 0.0142 0.0114
Echinococcus multilocularis allatostatin A receptor 0.0035 0.0142 0.0079
Onchocerca volvulus 0.0035 0.0142 0.028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0094 0.0879 0.302
Schistosoma mansoni hypothetical protein 0.0035 0.0142 0.0098
Echinococcus granulosus cathepsin l1 0.0094 0.0879 0.1028
Brugia malayi photoreceptor-specific nuclear receptor 0.0426 0.5061 0.7093
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.0142 0.0114
Entamoeba histolytica cysteine protease, putative 0.0048 0.0307 0.3233
Echinococcus multilocularis sex peptide receptor 0.0035 0.0142 0.0079
Leishmania major cysteine peptidase A (CPA) 0.0094 0.0879 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.014 0.1473
Trypanosoma cruzi cysteine peptidase, putative 0.0094 0.0879 1
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.0142 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0307 0.0682
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0144 0.0017
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0176
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0482 0.052
Onchocerca volvulus 0.0029 0.0063 0.0124
Mycobacterium ulcerans lipase LipD 0.0035 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Leishmania major cathepsin L-like protease 0.0094 0.0879 1
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.2584 0.2537
Brugia malayi follicle stimulating hormone receptor 0.0035 0.0142 0.0199
Plasmodium vivax vivapain-2 0.0094 0.0879 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0327 0.3008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0144 0.0285
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0035 0.0142 0.0079
Brugia malayi beta-lactamase family protein 0.0035 0.0144 0.0202
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2238 0.4421
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0035 0.0142 0.0098
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0201 0.2228 0.4403
Brugia malayi Cathepsin L-like precursor 0.0094 0.0879 0.1232
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0035 0.0142 0.0098
Schistosoma mansoni RAR-like nuclear receptor 0.0426 0.5061 0.6206
Mycobacterium ulcerans hypothetical protein 0.0035 0.0144 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.0142 0.0114
Loa Loa (eye worm) steroid hormone receptor 0.0426 0.5061 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Loa Loa (eye worm) hypothetical protein 0.0426 0.5061 1
Schistosoma mansoni alpha-glucosidase 0.0136 0.141 0.1672
Loa Loa (eye worm) hepatopoietin HPO2 0.0033 0.0117 0.0232
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0033 0.0117 0.0084
Onchocerca volvulus 0.0035 0.0142 0.028
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Loa Loa (eye worm) hypothetical protein 0.0201 0.2228 0.4403
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0144 0.0117
Loa Loa (eye worm) hypothetical protein 0.0426 0.5061 1
Brugia malayi ecdysteroid receptor 0.0426 0.5061 0.7093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0094 0.0879 0.302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0307 0.0682
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Brugia malayi beta-lactamase 0.0035 0.0144 0.0202
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.014 0.1473
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0063 0.0489 0.1426
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0033 0.0117 0.0357
Entamoeba histolytica hypothetical protein 0.0071 0.0595 0.6264
Onchocerca volvulus 0.0094 0.0879 0.1737
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0094 0.0879 0.302
Echinococcus multilocularis orexin receptor type 2 0.0035 0.0142 0.0079
Mycobacterium ulcerans beta-lactamase 0.0035 0.0144 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0426 0.5061 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.0142 0.0114
Echinococcus granulosus neuropeptide FF receptor 2 0.0035 0.0142 0.0114
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0426 0.5061 0.6212
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0048 0.0307 0.2757
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0236 0.0391
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Schistosoma mansoni thyroid hormone receptor 0.0426 0.5061 0.6206
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.095 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0142 0.0079
Loa Loa (eye worm) DR-78 0.0201 0.2228 0.4403
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0253 0.289 0.571
Leishmania major hypothetical protein, conserved 0.0035 0.0144 0.1638
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0489 0.5061
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0144 0.0566
Brugia malayi hypothetical protein 0.0035 0.0142 0.0199
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0201 0.2228 0.2688
Entamoeba histolytica hypothetical protein 0.0071 0.0595 0.6264
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.014 0.0196
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2543 1
Brugia malayi Cathepsin L-like precursor 0.0031 0.0089 0.0125
Schistosoma mansoni zinc finger protein 0.0201 0.2228 0.2688
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.0142 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0094 0.0879 0.302
Brugia malayi Pre-SET motif family protein 0.0202 0.2238 0.3136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0142 0.0098
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0142 0.0098
Loa Loa (eye worm) hypothetical protein 0.0094 0.0879 0.1737
Echinococcus granulosus cysteine protease 0.0048 0.0307 0.0319
Echinococcus granulosus ecdysone induced protein 78C 0.0426 0.5061 0.6212
Entamoeba histolytica cysteine proteinase 1, putative 0.0048 0.0307 0.3233
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Schistosoma mansoni serine/threonine protein kinase 0.0253 0.289 0.351
Onchocerca volvulus Bile acid receptor homolog 0.0426 0.5061 1
Schistosoma mansoni hypothetical protein 0.0047 0.0287 0.0278
Echinococcus multilocularis ecdysone induced protein 78C 0.0426 0.5061 0.503
Echinococcus granulosus allatostatin A receptor 0.0035 0.0142 0.0114
Loa Loa (eye worm) melatonin receptor type 1A 0.0035 0.0142 0.028
Schistosoma mansoni microtubule-associated protein tau 0.0669 0.8117 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0094 0.0879 0.302
Brugia malayi nuclear receptor RXR 0.0225 0.2532 0.3548
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0144 0.0566
Echinococcus multilocularis cathepsin L 0.0048 0.0307 0.0246
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0144 0.0566
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Schistosoma mansoni growth hormone secretagogue receptor 0.0035 0.0142 0.0098
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.0142 0.0098
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Toxoplasma gondii Erv1 / Alr family protein 0.0033 0.0117 0.0665
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.0142 0.028
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0426 0.5061 0.7093
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0482 0.0422
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Loa Loa (eye worm) hypothetical protein 0.0426 0.5061 1
Schistosoma mansoni nuclear receptor 0.0201 0.2228 0.2688
Brugia malayi Dopamine receptor 0.0035 0.0142 0.0199
Echinococcus multilocularis G-protein coupled receptor, putative 0.0035 0.0142 0.0079
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0094 0.0879 0.1737
Echinococcus multilocularis fmrfamide receptor 0.0035 0.0142 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0094 0.0879 0.302
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Echinococcus granulosus g protein coupled receptor 0.0035 0.0142 0.0114
Loa Loa (eye worm) hypothetical protein 0.0035 0.0142 0.028
Brugia malayi G-protein coupled receptor 0.0035 0.0142 0.0199
Schistosoma mansoni biogenic amine receptor 0.0035 0.0142 0.0098
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0482 0.0952
Echinococcus granulosus g protein coupled receptor 0.0035 0.0142 0.0114
Entamoeba histolytica cysteine protease, putative 0.0048 0.0307 0.3233
Brugia malayi Augmenter of liver regeneration 0.0033 0.0117 0.0164
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0063 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0144 0.0695
Echinococcus granulosus neuropeptide receptor A26 0.0035 0.0142 0.0114
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0142 0.0079

Activities

Activity type Activity value Assay description Source Reference
HR (functional) = 62 % Compound was tested for histamine release at a concentration of 300 ug/mL ChEMBL. 11462984
HR (functional) = 68 % Compound was tested for histamine release at a concentration of 100 ug/mL ChEMBL. 11462984
IC50 (functional) = 2.8 nM Antagonism of human GnHR receptor, determined in a reporter gene assay in HEK-293 cells ChEMBL. 11462984
IC50 (functional) = 2.8 nM Antagonism of human GnHR receptor, determined in a reporter gene assay in HEK-293 cells ChEMBL. 11462984
Inhibition (functional) > 80 % Compound was tested for inhibition of Leutenizing hormone release at 96 hours (very long duration) in castrated male rat assay ChEMBL. 11462984
Kd (functional) = 8.7 Competitive antagonism of GnRH-induced response in the reporter gene assay ChEMBL. 11462984
pA2 (functional) = 8.7 Competitive antagonism of GnRH-induced response in the reporter gene assay ChEMBL. 11462984

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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