Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0212 | 0.5625 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0101 | 0 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0212 | 0.5625 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0212 | 0.5625 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0299 | 1 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0212 | 0.5625 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0212 | 0.5625 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0212 | 0.5625 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0212 | 0.5625 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0212 | 0.5625 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0299 | 1 | 0.5 |
Onchocerca volvulus | 0.0212 | 0.5625 | 0.5 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0299 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0299 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.03 ug ml-1 | Antibacterial activity against Streptococcus pneumoniae OC9132 | ChEMBL. | 16289812 |
MIC (functional) | = 0.06 ug ml-1 | Antibacterial activity against Mef(A) efflux pump containing Streptococcus pneumoniae OC4438 | ChEMBL. | 16289812 |
MIC (functional) | = 0.25 ug ml-1 | Antibacterial activity against Staphylococcus aureus OC4172 | ChEMBL. | 16289812 |
MIC (functional) | = 2 ug ml-1 | Antibacterial activity against erm(B) ribosomal methylase gene containing Streptococcus pneumoniae OC4051 | ChEMBL. | 16289812 |
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against Haemophilus influenzae OC4882 | ChEMBL. | 16289812 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.