Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0556 | 1 | 1 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0556 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0556 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0556 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0556 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0556 | 1 | 1 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0556 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0556 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0556 | 1 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0556 | 1 | 0.5 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0556 | 1 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0556 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0441 | 0.6546 | 0.5827 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0556 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0556 | 1 | 1 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.0441 | 0.6546 | 0.5827 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.6546 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0556 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0556 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0556 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0441 | 0.6546 | 0.5827 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0556 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0556 | 1 | 1 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0556 | 1 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0556 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0556 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.24 uM | Concentration required to inhibit the VCAM-Very late antigen4 (VLA4) interaction in ELISA cell-based assay | ChEMBL. | 11755339 |
IC50 (functional) | = 0.24 uM | Concentration required to inhibit the VCAM-Very late antigen4 (VLA4) interaction in ELISA cell-based assay | ChEMBL. | 11755339 |
IC50 (functional) | = 24.4 uM | Concentration required to inhibit the VCAM-Very late antigen4 (VLA4) interaction in Ramos cell-based assay | ChEMBL. | 11755339 |
IC50 (functional) | = 24.4 uM | Concentration required to inhibit the VCAM-Very late antigen4 (VLA4) interaction in Ramos cell-based assay | ChEMBL. | 11755339 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.