Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0132 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0132 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0132 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0132 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0132 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0132 | 0.5 | 0.5 | |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0132 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0132 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0132 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0132 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0132 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0132 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0132 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0132 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0132 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0132 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0132 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0132 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0132 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0132 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0132 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0132 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0132 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0132 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0132 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0132 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0132 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0132 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0132 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0132 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0132 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0132 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0132 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0132 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0132 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0132 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0132 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0132 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0132 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0132 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0132 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0132 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0132 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0132 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0132 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0132 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0132 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0132 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Analgesic activity in mouse by formalin paw licking assay at 0-15 mins | ChEMBL. | 17181159 | |
Activity (functional) | Antiinflammatory activity in carrageenin-induced mouse paw edema | ChEMBL. | 17181159 | |
Activity (functional) | Analgesic activity in Swiss mouse by acetic acid-induced writhing test | ChEMBL. | 17181159 | |
Activity (functional) | Analgesic activity in mouse by formalin paw licking assay at 15-45 mins | ChEMBL. | 17181159 | |
Activity (binding) | 0 | Activity at COX1 assessed as inhibition of arachidonic acid-induced PGE2 production in J774 cells | ChEMBL. | 17181159 |
Activity (functional) | 0 | Antiinflammatory activity in carrageenin-induced mouse paw edema | ChEMBL. | 17181159 |
Activity (functional) | 0 | Analgesic activity in mouse by formalin paw licking assay at 0-15 mins | ChEMBL. | 17181159 |
Activity (functional) | 0 | Analgesic activity in Swiss mouse by acetic acid-induced writhing test | ChEMBL. | 17181159 |
Activity (functional) | 0 | Analgesic activity in mouse by formalin paw licking assay at 15-45 mins | ChEMBL. | 17181159 |
Activity (functional) | = 0.6 mm | Gastric damage in rat at 100 mg/kg, po by GI damage assay | ChEMBL. | 17181159 |
Inhibition (binding) | = 24 % | Activity at COX2 assessed as inhibition of arachidonic acid-induced PGE2 production in LPS-stimulated J774 cells at 100 uM | ChEMBL. | 17181159 |
Inhibition (binding) | = 24 % | Activity at COX2 assessed as inhibition of arachidonic acid-induced PGE2 production in LPS-stimulated J774 cells at 100 uM | ChEMBL. | 17181159 |
Inhibition (binding) | = 37 % | Activity at COX1 assessed as inhibition of arachidonic acid-induced PGE2 production in J774 cells at 10 uM | ChEMBL. | 17181159 |
Inhibition (binding) | = 37 % | Activity at COX1 assessed as inhibition of arachidonic acid-induced PGE2 production in J774 cells at 10 uM | ChEMBL. | 17181159 |
Inhibition (binding) | = 58 % | Activity at COX1 assessed as inhibition of arachidonic acid-induced PGE2 production in J774 cells at 100 uM | ChEMBL. | 17181159 |
Inhibition (binding) | = 58 % | Activity at COX1 assessed as inhibition of arachidonic acid-induced PGE2 production in J774 cells at 100 uM | ChEMBL. | 17181159 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.