Detailed information for compound 408704

Basic information

Technical information
  • TDR Targets ID: 408704
  • Name: 5-[(4-chlorophenyl)methyl]-2-phenylimidazo[4, 5-c]pyridine
  • MW: 319.788 | Formula: C19H14ClN3
  • H donors: 0 H acceptors: 2 LogP: 3.88 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)Cn1ccc2c(c1)nc(n2)c1ccccc1
  • InChi: 1S/C19H14ClN3/c20-16-8-6-14(7-9-16)12-23-11-10-17-18(13-23)22-19(21-17)15-4-2-1-3-5-15/h1-11,13H,12H2
  • InChiKey: AWRYDQQVGCSNME-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(4-chlorophenyl)methyl]-2-phenyl-imidazo[4,5-c]pyridine
  • 5-(4-chlorobenzyl)-2-phenyl-imidazo[4,5-c]pyridine
  • 5-[(4-chlorophenyl)methyl]-2-phenylimidazo[5,4-c]pyridine
  • 5-[(4-chlorophenyl)methyl]-2-phenyl-imidazo[5,4-c]pyridine
  • 5-(4-chlorobenzyl)-2-phenyl-imidazo[5,4-c]pyridine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni spingomyelin synthetase-related 0.0088 0.009 0.009
Schistosoma mansoni nuclear hormone receptor 0.0067 0.0056 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0142 0.0175 0.0175
Echinococcus granulosus tyrosine protein kinase Fyn 0.0065 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0088 0.009 0.009
Schistosoma mansoni nuclear hormone receptor 0.0067 0.0056 0.0056
Trypanosoma cruzi Kinesin-13 5, putative 0.0088 0.009 0.048
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.2432 0.3818 0.3817
Brugia malayi nuclear receptor NHR-88 0.0142 0.0175 0.0175
Echinococcus multilocularis liprin alpha 2 0.0088 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0067 0.0056 0.0056
Brugia malayi Immunoglobulin I-set domain containing protein 0.018 0.0235 0.0235
Echinococcus multilocularis polyhomeotic protein 2 0.0088 0.009 0.009
Schistosoma mansoni phd finger protein 0.0088 0.009 0.009
Brugia malayi protein-tyrosine kinase 0.0061 0.0046 0.0046
Echinococcus granulosus tyrosine protein kinase Fyn 0.0065 0.0052 0.0052
Schistosoma mansoni steroid hormone receptor ad4bp 0.0142 0.0175 0.0175
Schistosoma mansoni thyroid hormone receptor 0.1906 0.298 0.2987
Trichomonas vaginalis retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase, putative 0.3329 0.5243 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0142 0.0175 0.0175
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0067 0.0056 0.0056
Brugia malayi Shank2E 0.0088 0.009 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0142 0.0175 0.0175
Brugia malayi hypothetical protein 0.3329 0.5243 0.5243
Schistosoma mansoni retinoic acid receptor RXR 0.0142 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0067 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0088 0.009 0.009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0142 0.0175 0.0175
Brugia malayi nuclear hormone receptor 0.0067 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0067 0.0056 0.0056
Plasmodium vivax tyrosine kinase-like protein, putative 0.0434 0.064 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0142 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0067 0.0056 0.0056
Echinococcus granulosus sphingomyelin synthase protein 1 0.0088 0.009 0.009
Echinococcus granulosus mitogen activated protein kinase 14 0.1026 0.158 0.1584
Echinococcus granulosus tyrosine protein kinase Src42A 0.0065 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0067 0.0056 0.0056
Onchocerca volvulus 0.0088 0.009 0.4087
Brugia malayi P38 map kinase family protein 2 0.1026 0.158 0.158
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0061 0.0046 0.0046
Onchocerca volvulus Tyrosine kinase homolog 0.017 0.022 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0036 0.0006 0.0006
Brugia malayi tailless protein 0.0067 0.0056 0.0056
Schistosoma mansoni protein kinase 0.6305 0.9976 1
Schistosoma mansoni nuclear receptor nhr-48 0.0067 0.0056 0.0056
Brugia malayi ecdysteroid receptor 0.0142 0.0175 0.0175
Schistosoma mansoni protein kinase 0.0041 0.0015 0.0015
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0067 0.0056 0.0056
Echinococcus granulosus FTZ F1 alpha 0.0142 0.0175 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0142 0.0175 0.0175
Loa Loa (eye worm) SRC-1 0.0065 0.0052 0.0052
Giardia lamblia Hypothetical protein 0.0672 0.1018 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0142 0.0175 0.0175
Echinococcus multilocularis polycomb protein SCMH1 0.0088 0.009 0.009
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0142 0.0175 0.0175
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0142 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0075 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0067 0.0056 0.0056
Leishmania major hypothetical protein, conserved 0.0672 0.1018 0.6408
Loa Loa (eye worm) hypothetical protein 0.0088 0.009 0.009
Loa Loa (eye worm) nuclear receptor NHR-67 0.0067 0.0056 0.0056
Brugia malayi hypothetical protein 0.0042 0.0016 0.0015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0142 0.0175 0.0175
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1026 0.158 1
Brugia malayi nuclear receptor NHR-67 0.0067 0.0056 0.0056
Echinococcus granulosus polyhomeotic proximal chromatin protein 0.0088 0.009 0.009
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0065 0.0052 0.0052
Echinococcus granulosus nuclear receptor nhr 48 0.0067 0.0056 0.0056
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0033 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0175
Schistosoma mansoni sex comb on midleg homolog 0.0088 0.009 0.009
Schistosoma mansoni sex comb on midleg homolog 0.0088 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0088 0.009 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0142 0.0175 0.0175
Echinococcus multilocularis histone acetyltransferase myst3 0.0088 0.009 0.009
Echinococcus granulosus polycomb protein SCMH1 0.0088 0.009 0.009
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0065 0.0052 0.0052
Brugia malayi photoreceptor-specific nuclear receptor 0.0142 0.0175 0.0175
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0142 0.0175 0.0175
Brugia malayi steroid hormone receptor 0.0142 0.0175 0.0175
Schistosoma mansoni tyrosine kinase 0.0034 0.0003 0.0003
Echinococcus granulosus tyrosine protein kinase Blk 0.0061 0.0046 0.0046
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.2432 0.3818 0.3817
Echinococcus multilocularis c src tyrosine kinase 0.0036 0.0006 0.0006
Echinococcus granulosus tyrosine protein kinase Lyn 0.0077 0.0073 0.0073
Echinococcus granulosus c src tyrosine kinase 0.0036 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0175
Schistosoma mansoni retinal rod rhodopsin-sensitive cgmp 3'5'-cyclic phosphodiesterase 0.3329 0.5243 0.5256
Brugia malayi Nuclear hormone receptor E75 0.0067 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0075 0.0068 0.0068
Loa Loa (eye worm) AIDA-1b 0.0088 0.009 0.009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0142 0.0175 0.0175
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0075 0.0068 0.0068
Schistosoma mansoni Protein aveugle 0.0088 0.009 0.009
Schistosoma mansoni hypothetical protein 0.1764 0.2755 0.2761
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0067 0.0056 0.0056
Echinococcus granulosus histone acetyltransferase myst3 0.0088 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0075 0.0068 0.0068
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.1026 0.158 1
Echinococcus multilocularis activin receptor type 0.2878 0.4526 0.4537
Onchocerca volvulus Protein ultraspiracle homolog 0.0142 0.0175 0.7957
Schistosoma mansoni coup transcription factor 0.0142 0.0175 0.0175
Schistosoma mansoni Protein aveugle 0.0088 0.009 0.009
Schistosoma mansoni lip-related protein (liprin) alpha 0.0088 0.009 0.009
Echinococcus granulosus TGF beta receptor type 1 0.6305 0.9976 1
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0088 0.009 0.009
Echinococcus granulosus Sterile alpha motif SAM 0.0088 0.009 0.009
Brugia malayi hypothetical protein 0.0088 0.009 0.009
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0088 0.009 0.009
Echinococcus granulosus tyrosine kinase 0.0061 0.0046 0.0046
Trypanosoma cruzi hypothetical protein 0.0088 0.009 0.048
Brugia malayi hypothetical protein 0.0088 0.009 0.009
Echinococcus granulosus liprin alpha 2 0.0088 0.009 0.009
Echinococcus granulosus tyrosine protein kinase Src64B 0.0065 0.0052 0.0052
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0142 0.0175 0.0175
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0065 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0175
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0142 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0042 0.0016 0.0015
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.1026 0.158 1
Onchocerca volvulus 0.0088 0.009 0.4087
Schistosoma mansoni polyhomeotic 0.0088 0.009 0.009
Echinococcus granulosus mitogen activated protein kinase 11 0.1026 0.158 0.1584
Onchocerca volvulus Tankyrase homolog 0.0088 0.009 0.4087
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1026 0.158 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0142 0.0175 0.0175
Brugia malayi nuclear receptor NHR-88 0.0067 0.0056 0.0056
Loa Loa (eye worm) nuclear hormone receptor 0.0067 0.0056 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0142 0.0175 0.0175
Schistosoma mansoni tyrosine kinase 0.0065 0.0052 0.0052
Onchocerca volvulus 0.0088 0.009 0.4087
Onchocerca volvulus Cell death protein 3 homolog 0.0042 0.0016 0.0704
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0142 0.0175 0.0175
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0142 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0175
Schistosoma mansoni nuclear receptor 0.0067 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0088 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0042 0.0016 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0142 0.0175 0.0175
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.1026 0.158 0.158
Brugia malayi Sphingomyelin synthase-related 1 0.0088 0.009 0.009
Schistosoma mansoni protein kinase 0.0041 0.0015 0.0015
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0067 0.0056 0.0056
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0065 0.0052 0.0052
Brugia malayi cask-interacting protein 2 0.0088 0.009 0.009
Echinococcus multilocularis mitogen activated protein kinase 14 0.1026 0.158 0.1584
Brugia malayi coiled-coil like protein 1 0.0088 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0067 0.0056 0.0056
Echinococcus granulosus thyroid hormone receptor alpha 0.0067 0.0056 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0142 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0067 0.0056 0.0056
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.632 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0075 0.0068 0.0069
Brugia malayi hypothetical protein 0.2419 0.3797 0.3797
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0067 0.0056 0.0056
Schistosoma mansoni tyrosine kinase 0.0036 0.0006 0.0006
Onchocerca volvulus 0.0142 0.0175 0.7957
Schistosoma mansoni tyrosine kinase 0.0036 0.0006 0.0006
Trypanosoma brucei SAM domain (Sterile alpha motif), putative 0.0088 0.009 0.048
Echinococcus granulosus liprin alpha 2 0.0088 0.009 0.009
Loa Loa (eye worm) TK protein kinase 0.0061 0.0046 0.0046
Echinococcus multilocularis Sterile alpha motif type 0.0088 0.009 0.009
Entamoeba histolytica protein kinase, putative 0.0057 0.004 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0067 0.0056 0.0056
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0067 0.0056 0.0056
Brugia malayi hypothetical protein 0.0067 0.0056 0.0056
Echinococcus multilocularis tyrosine protein kinase Blk 0.0061 0.0046 0.0046
Onchocerca volvulus 0.0139 0.0171 0.7788
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0142 0.0175 0.0175
Onchocerca volvulus 0.0088 0.009 0.4087
Echinococcus multilocularis mitogen activated protein kinase 11 0.1026 0.158 0.1584
Schistosoma mansoni hypothetical protein 0.0042 0.0016 0.0016
Schistosoma mansoni thyroid hormone receptor 0.1906 0.298 0.2987
Loa Loa (eye worm) hypothetical protein 0.0075 0.0068 0.0068
Echinococcus granulosus Nuclear hormone receptor HR96 0.0067 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.2419 0.3797 0.3797
Brugia malayi Cell death protein 3 precursor 0.0042 0.0016 0.0015
Loa Loa (eye worm) steroid hormone receptor 0.0142 0.0175 0.0175
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0434 0.064 1
Echinococcus granulosus ecdysone induced protein 78C 0.0142 0.0175 0.0175
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 24 0.0088 0.009 0.048
Loa Loa (eye worm) hypothetical protein 0.0075 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0088 0.009 0.009
Schistosoma mansoni RAR-like nuclear receptor 0.0142 0.0175 0.0175
Echinococcus multilocularis TGF beta receptor type 1 0.6305 0.9976 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0067 0.0056 0.0056
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0142 0.0175 0.7957
Onchocerca volvulus 0.0067 0.0056 0.2533
Loa Loa (eye worm) hypothetical protein 0.0672 0.1018 0.1018
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0142 0.0175 0.0175
Echinococcus multilocularis caspase 2 0.0042 0.0016 0.0015
Echinococcus granulosus apoptotic protease activating factor 1 0.0042 0.0016 0.0015
Echinococcus multilocularis thyroid hormone receptor alpha 0.1906 0.298 0.2987
Echinococcus granulosus tyrosine protein kinase HCK 0.0057 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0088 0.009 0.009
Brugia malayi Nuclear hormone receptor-like 1 0.0142 0.0175 0.0175
Brugia malayi hypothetical protein 0.0075 0.0068 0.0068
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.2849 0.4481 0.4492
Echinococcus multilocularis pdz domain containing protein 0.0088 0.009 0.009
Echinococcus multilocularis Sterile alpha motif SAM 0.0088 0.009 0.009
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0065 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0067 0.0056 0.0056
Brugia malayi nuclear receptor RXR 0.0067 0.0056 0.0056
Echinococcus multilocularis nuclear receptor nhr 48 0.0067 0.0056 0.0056
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0041 0.0015 0.0015
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0067 0.0056 0.0056
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.1764 0.2755 0.2761
Trypanosoma cruzi Kinesin-13 5, putative 0.0088 0.009 0.048
Schistosoma mansoni protein kinase 0.0041 0.0015 0.0015
Loa Loa (eye worm) TK protein kinase 0.0057 0.004 0.004
Loa Loa (eye worm) tnks protein 0.0088 0.009 0.009
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0061 0.0046 0.0046
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0075 0.0068 0.0068
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0142 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.3329 0.5243 0.5243
Echinococcus multilocularis liprin alpha 2 0.0088 0.009 0.009
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0088 0.009 0.009
Brugia malayi Nuclear hormone receptor-like 1 0.0075 0.0068 0.0068
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0036 0.0006 0.0006
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0065 0.0052 0.0052
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0065 0.0052 0.0052
Echinococcus granulosus activin receptor type 0.2878 0.4526 0.4537
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0434 0.064 1
Brugia malayi nuclear hormone receptor 0.0142 0.0175 0.0175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0142 0.0175 0.0175
Brugia malayi hypothetical protein 0.0672 0.1018 0.1018
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0067 0.0056 0.2533
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0142 0.0175 0.0175
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0067 0.0056 0.0056
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0067 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0175
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0142 0.0175 0.0175
Brugia malayi AIDA-1b 0.0088 0.009 0.009
Onchocerca volvulus 0.0088 0.009 0.4087
Echinococcus multilocularis tyrosine protein kinase Srms 0.0061 0.0046 0.0046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0142 0.0175 0.0175
Brugia malayi Steroid receptor seven-up type 2 0.0142 0.0175 0.0175
Schistosoma mansoni nuclear receptor 0.0067 0.0056 0.0056
Brugia malayi SRC-1 0.0065 0.0052 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0142 0.0175 0.0175
Echinococcus granulosus Sterile alpha motif type 0.0088 0.009 0.009
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0067 0.0056 0.0056
Echinococcus multilocularis FTZ F1 alpha 0.0142 0.0175 0.0175
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0088 0.009 0.009
Echinococcus granulosus tyrosine protein kinase Src42A 0.0033 0.0002 0.0002
Brugia malayi nuclear hormone receptor family member nhr-6 0.0067 0.0056 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0142 0.0175 0.0175
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0075 0.0068 0.0068
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0075 0.0068 0.0069
Echinococcus multilocularis mitogen activated protein kinase 14 0.1026 0.158 0.1584
Loa Loa (eye worm) hypothetical protein 0.0067 0.0056 0.0056
Brugia malayi bicaudal-C 0.0088 0.009 0.009
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0065 0.0052 0.0052
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0065 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0088 0.009 0.009
Echinococcus multilocularis apoptotic protease activating factor 1 0.0042 0.0016 0.0015
Schistosoma mansoni zinc finger protein 0.0067 0.0056 0.0056
Onchocerca volvulus Bile acid receptor homolog 0.0142 0.0175 0.7957
Brugia malayi nuclear hormone receptor family member odr-7 0.0067 0.0056 0.0056
Schistosoma mansoni nuclear hormone receptor 0.0142 0.0175 0.0175
Brugia malayi Nuclear hormone receptor-like 1 0.0075 0.0068 0.0068
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.1764 0.2755 0.2761
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0142 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0067 0.0056 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0142 0.0175 0.0175
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0142 0.0175 0.0175
Schistosoma mansoni hypothetical protein 0.0088 0.009 0.009
Onchocerca volvulus 0.0042 0.0016 0.0704
Loa Loa (eye worm) hypothetical protein 0.0067 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0175
Trypanosoma cruzi UNC119 0.0672 0.1018 0.6408
Echinococcus granulosus tyrosine protein kinase Fyn 0.0065 0.0052 0.0052
Brugia malayi Protein kinase domain containing protein 0.2432 0.3818 0.3817
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0088 0.009 0.009
Schistosoma mansoni tyrosine kinase 0.0065 0.0052 0.0052
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0065 0.0052 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0142 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0088 0.009 0.009
Onchocerca volvulus 0.0088 0.009 0.4087
Echinococcus granulosus TGF-beta receptor type-1 0.6305 0.9976 1
Brugia malayi protein C17H12.11 0.2419 0.3797 0.3797
Brugia malayi nuclear receptor RXR 0.0075 0.0068 0.0068
Schistosoma mansoni protein kinase 0.2865 0.4505 0.4516
Trypanosoma cruzi UNC119 0.0672 0.1018 0.6408
Schistosoma mansoni DNAj-like protein 0.0088 0.009 0.009
Loa Loa (eye worm) DR-78 0.0067 0.0056 0.0056
Echinococcus granulosus caspase 2 0.0042 0.0016 0.0015
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0067 0.0056 0.2533
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0088 0.009 0.009
Onchocerca volvulus 0.0088 0.009 0.4087
Loa Loa (eye worm) hypothetical protein 0.0067 0.0056 0.0056
Onchocerca volvulus 0.0067 0.0056 0.2533
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0142 0.0175 0.0175
Brugia malayi Tyrosine-protein kinase abl-1 0.0036 0.0006 0.0006
Brugia malayi Nuclear hormone receptor E75 0.0067 0.0056 0.0056
Brugia malayi hypothetical protein 0.0075 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0175
Echinococcus multilocularis polyhomeotic proximal chromatin protein 0.0088 0.009 0.009
Schistosoma mansoni caspase-7 (C14 family) 0.0042 0.0016 0.0016
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0041 0.0015 0.0015
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0142 0.0175 0.0175
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0142 0.0175 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0142 0.0175 0.0175
Brugia malayi ecdysone receptor 0.0067 0.0056 0.0056
Echinococcus multilocularis tyrosine protein kinase HCK 0.0057 0.004 0.004
Echinococcus granulosus pdz domain containing protein 0.0088 0.009 0.009
Entamoeba histolytica protein kinase domain containing protein 0.0041 0.0015 0.3602
Brugia malayi orphan nuclear receptor NR2E1 0.0067 0.0056 0.0056
Echinococcus multilocularis mitogen activated protein kinase 11 0.1026 0.158 0.1584
Loa Loa (eye worm) TK/KIN16 protein kinase 0.018 0.0235 0.0235
Brugia malayi hypothetical protein 0.0067 0.0056 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0142 0.0175 0.0175
Echinococcus multilocularis ecdysone induced protein 78C 0.0142 0.0175 0.0175
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0065 0.0052 0.0052
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0036 0.0006 0.0006
Brugia malayi conserved hypotetical protein 0.0067 0.0056 0.0056
Echinococcus multilocularis tyrosine protein kinase Abl 0.0036 0.0006 0.0006
Brugia malayi Liprin-alpha 2 0.0088 0.009 0.009
Echinococcus granulosus polyhomeotic protein 2 0.0088 0.009 0.009
Trypanosoma brucei UNC119 0.0672 0.1018 0.6408

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Antiviral activity against HCV 1a ChEMBL. 16901692
CC50 (ADMET) > 100 uM Cytotoxicity against MDBK cells ChEMBL. 16901692
EC50 (functional) = 0.08 uM Antiviral activity against BVDV NADL in MDBK cells ChEMBL. 16901692
Ratio CC50/EC50 (functional) > 1250 Selectivity index, CC50 for MDBK cells/EC50 for BVDV NADL ChEMBL. 16901692

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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