TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 427.759 | Formula: C13H24B19N3+
H donors: 0 H acceptors: 0 LogP: 2.17 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: C[C]1234[B]567[B]891[B]1%103[B]3%112[B]245[B]456[C]678([B]791[B]1%10%11[B]324[B]5671)N1CCCN1[C]123[B]456[B]781[B]12[B]298[C]867([B]675[B]34[B]36[B]12[B]9873)C.C[N+](C)(C)C
InChi: 1S/C9H12B19N2.C4H12N/c1-7-14-6(10(14)12-13-11(6)15(6,7,14)19(7,11,13)20(7,12,13)18(7,10,12)14)29-4-3-5-30(29)9-16-8(2)17(9,16)22(8)23(8)21(8,16)24(9,16)26(9)25(9,17,22)28(22,23,26)27(21,23,24)26;1-5(2,3)4/h3-5H2,1-2H3;1-4H3/q;+1
InChiKey: BQSLEIIVUVIXHR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	voltage gated potassium channel	0.014	0.2234	0.2452
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0073
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0032	0.0066	0.0073
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0066	0.0066
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0032	0.0066	0.0073
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0032	0.0066	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0073
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0431	0.0473
Brugia malayi	voltage-dependent calcium channel	0.0032	0.0066	0.0073
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0032	0.0068	0.0068
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.006	0.0639	0.0702
Schistosoma mansoni	hypothetical protein	0.0032	0.0066	0.0066
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0032	0.0066	0.0066
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0032	0.0066	0.0073
Schistosoma mansoni	RAR-like nuclear receptor	0.006	0.0639	0.0639
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0396	0.7373	1
Leishmania major	protein kinase, putative	0.0064	0.0708	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0064	0.0708	1
Schistosoma mansoni	voltage-gated potassium channel	0.014	0.2234	0.2234
Brugia malayi	N-terminal motif family protein	0.0064	0.0708	0.0777
Schistosoma mansoni	voltage-gated cation channel	0.0032	0.0066	0.0066
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0066	0.0066
Echinococcus multilocularis	short transient receptor potential channel 6	0.0032	0.0066	0.0073
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0064	0.0708	0.0777
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0032	0.0066	0.0073
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0096	0.1345	0.1476
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0073
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.006	0.0639	0.0639
Echinococcus granulosus	cGMP dependent protein kinase	0.0064	0.0708	0.0777
Schistosoma mansoni	hypothetical protein	0.0034	0.0114	0.0114
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0483	0.9111	1
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0064	0.0708	0.0878
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.006	0.0639	0.0702
Onchocerca volvulus	Protein ultraspiracle homolog	0.006	0.0639	0.9037
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.006	0.0639	0.0702
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0096	0.1345	0.1345
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0064	0.0708	0.0708
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0066	0.0066
Echinococcus granulosus	potassium voltage gated channel protein	0.0032	0.0066	0.0073
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.0064	0.0708	0.0777
Echinococcus multilocularis	transient receptor potential cation channel	0.0032	0.0066	0.0073
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0396	0.7373	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0073
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0032	0.0066	0.0066
Echinococcus granulosus	voltage gated potassium channel	0.0032	0.0066	0.0073
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0044	0.0318	0.035
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0708	0.0477
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0064	0.0708	0.0878
Loa Loa (eye worm)	hypothetical protein	0.005	0.0431	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0073
Onchocerca volvulus		0.0064	0.0708	1
Trypanosoma cruzi	cAMP response protein 1, putative	0.0064	0.0708	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0064	0.0708	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0073
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0032	0.0066	0.0066
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0032	0.0066	0.0073
Leishmania major	hypothetical protein, conserved	0.0064	0.0708	1
Onchocerca volvulus		0.0064	0.0708	1
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0066	0.0066
Leishmania major	protein kinase A regulatory subunit, putative	0.0064	0.0708	1
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0064	0.0708	0.0708
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.006	0.0639	0.0702
Schistosoma mansoni	voltage-gated potassium channel	0.0076	0.0955	0.0955
Echinococcus multilocularis	sodium leak channel non selective protein	0.0032	0.0066	0.0073
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0032	0.0066	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0073
Schistosoma mansoni	hypothetical protein	0.0064	0.0708	0.0708
Echinococcus multilocularis	transient receptor potential cation channel	0.0032	0.0066	0.0073
Schistosoma mansoni	voltage-gated potassium channel	0.0096	0.1345	0.1345
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0073
Loa Loa (eye worm)	voltage-gated calcium channel	0.0032	0.0066	0.0073
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.0064	0.0708	0.5
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.0064	0.0708	0.0777
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0396	0.7373	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0096	0.1345	0.1476
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0032	0.0066	0.0066
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0032	0.0066	0.0073
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0032	0.0066	0.0073
Schistosoma mansoni	nuclear hormone receptor	0.006	0.0639	0.0639
Echinococcus granulosus	FTZ F1 alpha	0.006	0.0639	0.0702
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.006	0.0639	0.0702
Echinococcus granulosus	transient receptor potential cation channel	0.0032	0.0066	0.0073
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0064	0.0708	0.0777
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0032	0.0066	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0419	0.7832	0.8597
Loa Loa (eye worm)	hypothetical protein	0.006	0.0639	0.0702
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0032	0.0066	0.0073
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.006	0.0639	0.0702
Echinococcus multilocularis	shaker cognate	0.0032	0.0066	0.0073
Echinococcus granulosus	transient receptor potential gamma protein	0.0032	0.0066	0.0073
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.006	0.0639	0.0702
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0032	0.0066	0.0066
Echinococcus granulosus	single minded 2	0.0044	0.0318	0.035
Echinococcus multilocularis	transient receptor potential cation channel	0.0032	0.0066	0.0073
Echinococcus granulosus	potassium large conductance calcium activated	0.0032	0.0066	0.0073
Schistosoma mansoni	thyroid hormone receptor	0.006	0.0639	0.0639
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0483	0.9111	1
Echinococcus granulosus	voltage gated potassium channel	0.014	0.2234	0.2452
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0096	0.1345	0.1345
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.006	0.0639	0.0702
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.006	0.0639	0.0702
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0396	0.7373	1
Leishmania major	regulatory subunit of protein kinase a-like protein	0.0064	0.0708	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.006	0.0639	0.0702
Echinococcus multilocularis	two pore calcium channel protein 1	0.0032	0.0066	0.0073
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0064	0.0708	0.0708
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0396	0.7373	0.5
Echinococcus multilocularis	FTZ F1 alpha	0.006	0.0639	0.0702
Echinococcus multilocularis	two pore calcium channel protein 2	0.0032	0.0066	0.0073
Echinococcus multilocularis	ryanodine receptor 44f	0.0032	0.0066	0.0073
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0096	0.1345	0.1476
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0073
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0064	0.0708	0.0708
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.006	0.0639	0.0702
Echinococcus multilocularis	transient receptor potential cation channel	0.0032	0.0066	0.0073
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0032	0.0066	0.0073
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0064	0.0708	0.0777
Brugia malayi	hypothetical protein	0.0032	0.0068	0.0075
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0064	0.0708	0.0777
Echinococcus granulosus	transient receptor potential cation channel	0.0032	0.0066	0.0073
Trypanosoma cruzi	protein kinase A regulatory subunit	0.0064	0.0708	1
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0066	0.0066
Echinococcus granulosus	TRP transient receptor potential channel	0.0032	0.0066	0.0073
Schistosoma mansoni	retinoic acid receptor RXR	0.006	0.0639	0.0639
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.014	0.2234	0.2452
Trypanosoma brucei	STE group serine/threonine-protein kinase, putative	0.0044	0.0318	0.3934
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.0708	0.0708
Loa Loa (eye worm)	voltage-gated potassium channel	0.0032	0.0066	0.0073
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.0064	0.0708	0.0777
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0032	0.0066	0.0066
Echinococcus multilocularis	potassium large conductance calcium activated	0.0032	0.0066	0.0073
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.006	0.0639	0.0702
Echinococcus granulosus	ryanodine receptor 44f	0.0032	0.0066	0.0073
Schistosoma mansoni	vesicular amine transporter	0.0032	0.0066	0.0066
Echinococcus multilocularis	potassium voltage gated channel protein	0.0032	0.0066	0.0073
Loa Loa (eye worm)	hypothetical protein	0.006	0.0639	0.0702
Schistosoma mansoni	ryanodine receptor related	0.0032	0.0066	0.0066
Echinococcus granulosus	potassium voltage gated channel protein	0.0032	0.0066	0.0073
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0096	0.1345	0.1258
Schistosoma mansoni	coup transcription factor	0.006	0.0639	0.0639
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.006	0.0639	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0068	0.0075
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.006	0.0639	0.0702
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0096	0.1345	0.1345
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.006	0.0639	0.0702
Echinococcus multilocularis	short transient receptor potential channel 6	0.0032	0.0066	0.0073
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0032	0.0066	0.0073
Echinococcus multilocularis	voltage dependent calcium channel	0.0032	0.0066	0.0073
Echinococcus granulosus	two pore calcium channel protein 2	0.0032	0.0066	0.0073
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0032	0.0066	0.0073
Leishmania major	hypothetical protein, unknown function	0.0064	0.0708	1
Echinococcus granulosus	sodium leak channel non selective protein	0.0032	0.0066	0.0073
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0064	0.0708	0.0777
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0096	0.1345	0.1476
Echinococcus multilocularis	calcium activated potassium channel	0.0032	0.0066	0.0073
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0096	0.1345	0.1345
Echinococcus multilocularis	potassium voltage gated channel protein	0.0032	0.0066	0.0073
Echinococcus granulosus	transient receptor potential cation channel	0.0032	0.0066	0.0073
Schistosoma mansoni	two-pore calcium channel	0.0032	0.0066	0.0066
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0032	0.0066	0.0073
Trypanosoma cruzi	cAMP response protein 1	0.0064	0.0708	1
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0032	0.0066	0.0073
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.0064	0.0708	0.0477
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0032	0.0066	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0708	0.0777
Brugia malayi	nuclear receptor RXR	0.0032	0.0068	0.0075
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0064	0.0708	0.0777
Echinococcus granulosus	transient receptor potential cation channel	0.0032	0.0066	0.0073
Echinococcus granulosus	voltage dependent calcium channel	0.0032	0.0066	0.0073
Echinococcus granulosus	calcium activated potassium channel	0.0032	0.0066	0.0073
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0032	0.0066	0.0073
Toxoplasma gondii	cAMP-dependent protein kinase regulatory subunit	0.0064	0.0708	0.0878
Brugia malayi	steroid hormone receptor	0.006	0.0639	0.0702
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.006	0.0639	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0073
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0066	0.0066
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0032	0.0066	0.0073
Echinococcus granulosus	transient receptor potential cation channel	0.0032	0.0066	0.0073
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0064	0.0708	0.0708
Schistosoma mansoni	steroid hormone receptor ad4bp	0.006	0.0639	0.0639
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0064	0.0708	0.0708
Trypanosoma brucei	Flagellar Member 6	0.0064	0.0708	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0073
Brugia malayi	cation channel family protein	0.0032	0.0066	0.0073
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0032	0.0066	0.0934
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.1829	0.2008
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0032	0.0066	0.0073
Loa Loa (eye worm)	hypothetical protein	0.006	0.0639	0.0702
Echinococcus granulosus	voltage dependent calcium channel	0.0032	0.0066	0.0073
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.006	0.0639	0.0702
Echinococcus multilocularis	conserved hypothetical protein	0.0032	0.0066	0.0073
Brugia malayi	Transient-receptor-potential like protein	0.0032	0.0066	0.0073
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0096	0.1345	0.1476
Brugia malayi	Egg laying defective protein 4	0.0064	0.0708	0.0777
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0032	0.0068	0.0075
Schistosoma mansoni	hypothetical protein	0.0044	0.0318	0.0318
Schistosoma mansoni	60S ribosomal protein L21	0.0076	0.0955	0.0955
Echinococcus granulosus	ecdysone induced protein 78C	0.006	0.0639	0.0702
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0066	0.0066
Echinococcus granulosus	potassium voltage gated channel protein	0.0032	0.0066	0.0073
Echinococcus multilocularis	sodium channel protein	0.0032	0.0066	0.0073
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0064	0.0708	0.0777
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0064	0.0708	0.0777
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0396	0.7373	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0639	0.0702
Brugia malayi	Steroid receptor seven-up type 2	0.006	0.0639	0.0702
Echinococcus granulosus	short transient receptor potential channel 6	0.0032	0.0066	0.0073
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.0708	0.0708
Brugia malayi	hypothetical protein	0.0032	0.0068	0.0075
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.014	0.2234	0.2452
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0451	0.8474	1
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0064	0.0708	0.0708
Echinococcus multilocularis	transient receptor potential gamma protein	0.0032	0.0066	0.0073
Loa Loa (eye worm)	hypothetical protein	0.006	0.0639	0.0702
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0066	0.0066
Echinococcus granulosus	hyperpolarization activated cyclic	0.0096	0.1345	0.1476
Brugia malayi	nuclear hormone receptor	0.006	0.0639	0.0702
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.006	0.0639	0.0702
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0032	0.0068	0.0075
Leishmania major	hypothetical protein, conserved	0.0064	0.0708	1
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0396	0.7373	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.006	0.0639	0.0702
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.0064	0.0708	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0073
Brugia malayi	Nuclear hormone receptor-like 1	0.0032	0.0068	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0068	0.0075
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.006	0.0639	0.0702
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0064	0.0708	0.0777
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0066	0.0066
Schistosoma mansoni	transient receptor potential channel	0.0032	0.0066	0.0066
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.006	0.0639	0.0702
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.006	0.0639	0.0702
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0064	0.0708	0.0777
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0032	0.0066	0.0073
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.006	0.0639	0.0702
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.006	0.0639	0.0702
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.006	0.0639	0.0702
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0032	0.0066	0.0073
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.0708	0.0708
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0032	0.0066	0.0073
Loa Loa (eye worm)	hypothetical protein	0.006	0.0639	0.0702
Brugia malayi	cation channel family protein	0.0032	0.0066	0.0073
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0066	0.0066
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0096	0.1345	0.1476
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0114	0.0125
Treponema pallidum	catabolite gene activator	0.0064	0.0708	0.5
Echinococcus multilocularis	potassium voltage gated channel protein	0.0032	0.0066	0.0073
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0032	0.0066	0.0066
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0096	0.1345	0.1476
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.006	0.0639	0.0702
Schistosoma mansoni	transient receptor potential channel	0.0032	0.0066	0.0066
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.006	0.0639	0.0639
Schistosoma mansoni	voltage-dependent calcium channel	0.0032	0.0066	0.0066
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0032	0.0066	0.0073
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0064	0.0708	0.0477
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0064	0.0708	1
Onchocerca volvulus	Bile acid receptor homolog	0.006	0.0639	0.9037
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1345	0.1476
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0073
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0064	0.0708	0.0708
Treponema pallidum	cyclic nucleotide binding protein	0.0064	0.0708	0.5
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0032	0.0066	0.0066
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0032	0.0066	0.0066
Mycobacterium leprae	Conserved hypothetical protein	0.0064	0.0708	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0068	0.0075
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0032	0.0066	0.0073
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0064	0.0708	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0073
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0431	0.0473
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0483	0.9111	1
Echinococcus granulosus	hyperpolarization activated cyclic	0.0096	0.1345	0.1476
Echinococcus granulosus	short transient receptor potential channel 6	0.0032	0.0066	0.0073
Echinococcus multilocularis	transfer RNA-Gly	0.0032	0.0066	0.0073
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0064	0.0708	1
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0032	0.0066	0.0066
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0096	0.1345	0.1258
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0032	0.0066	0.0073
Echinococcus granulosus	hypothetical protein	0.0032	0.0066	0.0073
Schistosoma mansoni	transient receptor potential channel	0.0032	0.0066	0.0066
Onchocerca volvulus		0.0032	0.0066	0.0934
Echinococcus granulosus	potassium voltage gated channel protein	0.0032	0.0066	0.0073
Echinococcus granulosus	two pore calcium channel protein 1	0.0032	0.0066	0.0073
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.0064	0.0708	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0114	0.0125
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0064	0.0708	0.0878
Schistosoma mansoni	transient receptor potential channel 4	0.0032	0.0066	0.0066
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0096	0.1345	0.1476
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0064	0.0708	0.0878
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0096	0.1345	0.1476
Trypanosoma brucei	cAMP response protein 1, putative	0.0064	0.0708	1
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0064	0.0708	0.0777
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0032	0.0066	0.0073
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0096	0.1345	0.1345
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0032	0.0066	0.0073
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0066	0.0066
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0064	0.0708	0.0708
Echinococcus multilocularis	expressed conserved protein	0.0064	0.0708	0.0777
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0064	0.0708	0.0777
Schistosoma mansoni	calcium-activated potassium channel	0.0032	0.0066	0.0066
Leishmania major	protein kinase, putative	0.0064	0.0708	1
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0066	0.0066
Brugia malayi	ecdysteroid receptor	0.006	0.0639	0.0702
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.006	0.0639	0.0702
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0032	0.0066	0.0073
Loa Loa (eye worm)	steroid hormone receptor	0.006	0.0639	0.0702
Onchocerca volvulus		0.006	0.0639	0.9037
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0032	0.0066	0.0073
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0064	0.0708	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0483	0.9111	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.006	0.0639	0.0702
Loa Loa (eye worm)	hypothetical protein	0.006	0.0639	0.0702
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0064	0.0708	0.0708
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0068	0.0075
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.006	0.0639	0.0702
Treponema pallidum	cyclic nucleotide binding protein	0.0064	0.0708	0.5
Loa Loa (eye worm)	voltage-gated potassium channel	0.0032	0.0066	0.0073
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.1829	0.2008
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0396	0.7373	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.006	0.0639	0.0702
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.0064	0.0708	0.0777
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.006	0.0639	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0073
Echinococcus multilocularis	voltage gated potassium channel	0.0032	0.0066	0.0073
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.014	0.2234	0.2452
Brugia malayi	nuclear receptor NHR-88	0.006	0.0639	0.0702
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0096	0.1345	0.1476
Schistosoma mansoni	thyroid hormone receptor	0.006	0.0639	0.0639
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0451	0.8474	1
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0032	0.0066	0.0073
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0064	0.0708	0.0777
Loa Loa (eye worm)	hypothetical protein	0.006	0.0639	0.0702
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.006	0.0639	0.0702
Echinococcus multilocularis	ecdysone induced protein 78C	0.006	0.0639	0.0702
Echinococcus granulosus	potassium voltage gated channel protein	0.0032	0.0066	0.0073
Loa Loa (eye worm)	calcium channel	0.0032	0.0066	0.0073
Trichomonas vaginalis	hypothetical protein	0.0396	0.7373	0.8651
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0032	0.0066	0.0073
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0032	0.0066	0.0066
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0032	0.0066	0.0073
Treponema pallidum	catabolite gene activator (Crp)	0.0064	0.0708	0.5
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.0064	0.0708	1
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0064	0.0708	0.0777
Brugia malayi	photoreceptor-specific nuclear receptor	0.006	0.0639	0.0702
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.006	0.0639	0.0702
Echinococcus multilocularis	transient receptor potential cation channel	0.0032	0.0066	0.0073
Loa Loa (eye worm)	hypothetical protein	0.014	0.2234	0.2452
Brugia malayi	Nuclear hormone receptor-like 1	0.006	0.0639	0.0702
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0068	0.0075
Echinococcus multilocularis	potassium voltage gated channel protein	0.0032	0.0066	0.0073
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0096	0.1345	0.1476
Trypanosoma brucei	protein kinase A regulatory subunit	0.0064	0.0708	1
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0064	0.0708	0.0708
Trypanosoma cruzi	cAMP binding protein, putative	0.0064	0.0708	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0032	0.0068	0.0075
Echinococcus granulosus	shaker cognate	0.0032	0.0066	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0073
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0431	0.0473
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0032	0.0066	0.0073
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0032	0.0066	0.0073
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0064	0.0708	1
Loa Loa (eye worm)	ryanodine receptor	0.0032	0.0066	0.0073
Trypanosoma brucei	cAMP binding protein, putative	0.0064	0.0708	1
Trypanosoma cruzi	Flagellar Member 6	0.0064	0.0708	1
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0032	0.0066	0.0073
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.006	0.0639	0.9037
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0032	0.0066	0.0073
Brugia malayi	olfactory channel protein osm-9	0.0032	0.0066	0.0073
Schistosoma mansoni	voltage-gated potassium channel	0.014	0.2234	0.2234
Brugia malayi	hypothetical protein	0.0032	0.0066	0.0073
Echinococcus granulosus	transient receptor potential cation channel	0.0032	0.0066	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0073
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.006	0.0639	0.0639
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0064	0.0708	0.0878
Schistosoma mansoni	voltage-gated potassium channel	0.0528	1	1
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0032	0.0066	0.0073
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0032	0.0066	0.0934
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.006	0.0639	0.0702
Brugia malayi	MH2 domain containing protein	0.012	0.1829	0.2008
Schistosoma mansoni	voltage-gated ion channel	0.0032	0.0066	0.0066
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.006	0.0639	0.0702
Echinococcus multilocularis	voltage dependent calcium channel	0.0032	0.0066	0.0073
Echinococcus multilocularis	transient receptor potential cation channel	0.0032	0.0066	0.0073
Echinococcus granulosus	sodium channel protein	0.0032	0.0066	0.0073
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0096	0.1345	0.1476
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.006	0.0639	0.0702
Leishmania major	cyclic nucleotide-binding protein-like protein	0.0064	0.0708	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.006	0.0639	0.0702
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0032	0.0066	0.0073
Loa Loa (eye worm)	ion channel NompC	0.0032	0.0066	0.0073
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0064	0.0708	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0032	0.0068	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0708	0.0777
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0032	0.0068	0.0068
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0064	0.0708	0.0708
Brugia malayi	ion channel NompC	0.0032	0.0066	0.0073
Leishmania major	hypothetical protein, conserved	0.0064	0.0708	1

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 3.1 ug ml-1	In vitro antifungal activity against Candida albicans	ChEMBL.	7310826
MIC (functional)	= 6.2 ug ml-1	In vitro antifungal activity against Aspergillus fumigatus	ChEMBL.	7310826
MIC (functional)	= 6.2 ug ml-1	In vitro antifungal activity against Trichophyton asteroides	ChEMBL.	7310826
MIC (functional)	= 6.2 ug ml-1	In vitro antibacterial activity against Staphylococcus aureus	ChEMBL.	7310826
MIC (functional)	= 6.2 ug ml-1	In vitro antibacterial activity against Streptococcus pyogenes	ChEMBL.	7310826
MIC (functional)	> 100 ug ml-1	In vitro antibacterial activity tested against Escherichia coli	ChEMBL.	7310826
MIC (functional)	> 100 ug ml-1	In vitro antibacterial activity tested against Klebsiella pneumoniae	ChEMBL.	7310826
MIC (functional)	> 100 ug ml-1	In vitro antibacterial activity against Pseudomonas aeruginosa	ChEMBL.	7310826

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 109775

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 408776