Detailed information for compound 408792

Basic information

Technical information
  • TDR Targets ID: 408792
  • Name: (2R)-2-[[4-[4-(4-chlorophenoxy)piperidin-1-yl ]phenoxy]methyl]-2-methyl-6-nitro-3H-imidazo[ 2,1-b][1,3]oxazole
  • MW: 484.932 | Formula: C24H25ClN4O5
  • H donors: 0 H acceptors: 3 LogP: 5.08 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)OC1CCN(CC1)c1ccc(cc1)OC[C@@]1(C)Cn2c(O1)nc(c2)[N+](=O)[O-]
  • InChi: 1S/C24H25ClN4O5/c1-24(15-28-14-22(29(30)31)26-23(28)34-24)16-32-19-8-4-18(5-9-19)27-12-10-21(11-13-27)33-20-6-2-17(25)3-7-20/h2-9,14,21H,10-13,15-16H2,1H3/t24-/m1/s1
  • InChiKey: AKNCGQAEIOXCDV-XMMPIXPASA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R)-2-[[4-[4-(4-chlorophenoxy)-1-piperidyl]phenoxy]methyl]-2-methyl-6-nitro-3H-imidazo[2,1-b]oxazole
  • (2R)-2-[[4-[4-(4-chlorophenoxy)-1-piperidinyl]phenoxy]methyl]-2-methyl-6-nitro-3H-imidazo[2,1-b]oxazole
  • (2R)-2-[[4-[4-(4-chlorophenoxy)piperidino]phenoxy]methyl]-2-methyl-6-nitro-3H-imidazo[2,1-b]oxazole
  • Imidazo[2,1-b]oxazole, 2-[[4-[4-(4-chlorophenoxy)-1-piperidinyl]phenoxy]methyl]-2,3-dihydro-2-methyl-6-nitro-, (2R)-
  • AIDS-344290
  • AIDS344290

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major DNA polymerase zeta catalytic subunit, putative 0.0058 0.019 0.0152
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0027 0.0072 0.0206
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0096 0.017
Entamoeba histolytica DNA repair and recombination protein, putative 0.0912 0.346 1
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0131 0.0468 0.1257
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0278
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0131 0.0468 0.0432
Trichomonas vaginalis penicillin-binding protein, putative 0.0027 0.0069 0.0089
Trichomonas vaginalis bromodomain-containing protein, putative 0.0061 0.0201 0.0475
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0027 0.0072 0.0206
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0131 0.0468 0.1353
Mycobacterium ulcerans hypothetical protein 0.1379 0.5252 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.1239 0.4715 0.4695
Trichomonas vaginalis D-aminoacylase, putative 0.0027 0.0069 0.0089
Brugia malayi follicle stimulating hormone receptor 0.0174 0.0635 0.4409
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0278
Trichomonas vaginalis bromodomain-containing protein, putative 0.0061 0.0201 0.0475
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.2618 1 1
Mycobacterium tuberculosis Conserved protein 0.0027 0.0069 0.0059
Brugia malayi DNA polymerase delta catalytic subunit 0.0131 0.0468 0.3254
Toxoplasma gondii DNA polymerase 0.0131 0.0468 0.218
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.2618 1 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0027 0.0072 0.0098
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0131 0.0468 0.1257
Schistosoma mansoni cpg binding protein 0.0029 0.0076 0.011
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0131 0.0468 0.1257
Brugia malayi beta-lactamase 0.0027 0.0069 0.0478
Brugia malayi DNA polymerase alpha catalytic subunit 0.0384 0.144 1
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0207 0.076 0.2108
Onchocerca volvulus DNA polymerase homolog 0.0131 0.0468 0.1669
Mycobacterium leprae Probable lipase LipE 0.0027 0.0069 0.5
Mycobacterium ulcerans esterase/lipase LipP 0.0027 0.0069 0.0059
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.0289
Loa Loa (eye worm) hypothetical protein 0.0061 0.0201 0.0814
Mycobacterium ulcerans lipase LipD 0.0027 0.0069 0.0059
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0278
Trypanosoma cruzi DNA polymerase zeta catalytic subunit, putative 0.0058 0.019 0.0152
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0072 0.0497
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0027 0.0072 0.0034
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0474 0.1783 0.5152
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0071 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0071 0.0096
Loa Loa (eye worm) beta-lactamase 0.0027 0.0069 0.0278
Mycobacterium tuberculosis Conserved hypothetical protein 0.1379 0.5252 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0027 0.0069 0.0059
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0071 0.0096
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0069 0.0031
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0131 0.0468 0.3254
Onchocerca volvulus 0.0027 0.0071 0.0009
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0474 0.1783 0.5152
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0134 0.0481 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0027 0.0069 0.0478
Entamoeba histolytica hypothetical protein, conserved 0.0912 0.346 1
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0131 0.0468 0.1353
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0038 0.0153
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0912 0.346 0.3435
Leishmania major hypothetical protein, conserved 0.0027 0.0069 0.0031
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0061 0.0201 0.0475
Trichomonas vaginalis DNA polymerase II, putative 0.0207 0.076 0.2108
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0384 0.144 0.7101
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0368 0.1377 0.1344
Schistosoma mansoni hypothetical protein 0.0912 0.346 1
Echinococcus granulosus microsomal glutathione S transferase 3 0.0534 0.2012 0.5814
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0071 0.0096
Mycobacterium tuberculosis Probable lipase LipE 0.0027 0.0069 0.0059
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0038 0.5
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0912 0.346 0.3435
Mycobacterium ulcerans hypothetical protein 0.0027 0.0069 0.0059
Echinococcus granulosus ubiquitin specific protease 41 0.0027 0.0072 0.0206
Brugia malayi Bromodomain containing protein 0.0061 0.0201 0.1395
Echinococcus multilocularis survival motor neuron protein 1 0.0175 0.0638 0.1842
Giardia lamblia Kinase, putative 0.0027 0.0071 0.0096
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0131 0.0468 0.307
Loa Loa (eye worm) hypothetical protein 0.0058 0.019 0.0769
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0912 0.346 0.3435
Entamoeba histolytica bromodomain-containing protein 0.0027 0.0071 0.0096
Brugia malayi DNA polymerase family B containing protein 0.0131 0.0468 0.3254
Mycobacterium tuberculosis Probable hydrolase 0.0027 0.0069 0.0059
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0071 0.0096
Trichomonas vaginalis bromodomain-containing protein, putative 0.0038 0.0112 0.0216
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0027 0.0069 0.0059
Schistosoma mansoni cpg binding protein 0.003 0.0082 0.0128
Schistosoma mansoni survival motor neuron protein 0.0036 0.0103 0.0191
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0278
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0073 0.0245 0.4675
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0534 0.2012 0.5814
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0027 0.0069 0.0089
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0131 0.0468 0.1901
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0474 0.1783 0.5098
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0207 0.076 0.0724
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0131 0.0468 0.0432
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0534 0.2012 0.5768
Loa Loa (eye worm) hypothetical protein 0.0058 0.019 0.0769
Trypanosoma brucei mitochondrial DNA polymerase beta 0.2618 1 1
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0131 0.0468 0.1257
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0131 0.0468 0.1669
Brugia malayi hypothetical protein 0.0175 0.0638 0.4429
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0058 0.019 0.0769
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0131 0.0468 0.0432
Brugia malayi beta-lactamase family protein 0.0027 0.0069 0.0478
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0131 0.0468 0.1353
Entamoeba histolytica bromodomain-containing protein 0.0027 0.0071 0.0096
Mycobacterium tuberculosis Probable lipase LipD 0.0027 0.0069 0.0059
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0071 0.0096
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0207 0.076 0.0724
Giardia lamblia DNA polymerase alpha subunit A 0.0401 0.1504 0.4284
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0177 0.0647 0.1779
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.1239 0.4715 0.4695
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0071 0.0096
Echinococcus granulosus bromodomain containing 2 0.0061 0.0201 0.0579
Mycobacterium tuberculosis Probable esterase LipL 0.0027 0.0069 0.0059
Brugia malayi CXXC zinc finger family protein 0.0029 0.0076 0.0527
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0069 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0027 0.0069 0.0089
Toxoplasma gondii ABC1 family protein 0.0027 0.0069 0.0155
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0027 0.0072 0.0034
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0071 0.0096
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0071 0.0096
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0036 0.0103 0.0719
Mycobacterium tuberculosis Conserved protein 0.0027 0.0069 0.0059
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0207 0.076 0.0724
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0038 0.0109
Echinococcus granulosus cpg binding protein 0.003 0.0082 0.0236
Trichomonas vaginalis D-aminoacylase, putative 0.0027 0.0069 0.0089
Echinococcus granulosus beta LACTamase domain containing family member 0.0027 0.0069 0.0198
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0651 0.2463 1
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0131 0.0468 0.0432
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.019 0.0443
Trichomonas vaginalis D-aminoacylase, putative 0.0027 0.0069 0.0089
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0134 0.0481 0.1294
Mycobacterium ulcerans beta-lactamase 0.0027 0.0069 0.0059
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0131 0.0468 0.1353
Trichomonas vaginalis bromodomain containing protein, putative 0.0027 0.0071 0.0096
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0027 0.0069 0.0278
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0071 0.0096
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0131 0.0468 0.307
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0027 0.0069 0.0059
Brugia malayi beta-lactamase family protein 0.0027 0.0069 0.0478
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0131 0.0468 0.1257
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0027 0.0072 0.0206
Schistosoma mansoni microsomal glutathione s-transferase 0.0534 0.2012 0.5768
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0027 0.0069 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0112 0.0216
Schistosoma mansoni cpg binding protein 0.003 0.0082 0.0128
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0069 0.0031
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0131 0.0468 0.1257
Trichomonas vaginalis conserved hypothetical protein 0.0912 0.346 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0027 0.0072 0.0098
Plasmodium vivax DNA polymerase alpha, putative 0.0384 0.144 1
Onchocerca volvulus 0.0029 0.0076 0.003
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.1239 0.4715 0.4695
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0071 0.0096
Trichomonas vaginalis esterase, putative 0.0027 0.0069 0.0089
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0912 0.346 0.3435
Mycobacterium tuberculosis Possible penicillin-binding protein 0.017 0.0619 0.1115
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0131 0.0468 0.1257
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0027 0.0072 0.0034
Entamoeba histolytica bromodomain-containing protein 0.0027 0.0071 0.0096
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0131 0.0468 0.0432
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0027 0.0072 0.0034
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0912 0.346 0.3435
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0027 0.0072 0.0098
Brugia malayi Bromodomain containing protein 0.0061 0.0201 0.1395
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0038 0.0265
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0038 0.0109
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0071 0.0096
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0912 0.346 0.3435
Onchocerca volvulus 0.0036 0.0103 0.0145
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0069 0.0218
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0368 0.1377 0.1344
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0131 0.0468 0.1353
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0368 0.1377 0.1344
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0131 0.0468 0.1353
Toxoplasma gondii DNA polymerase family B protein 0.0058 0.019 0.0769
Echinococcus multilocularis ubiquitin specific protease 41 0.0027 0.0072 0.0206
Trichomonas vaginalis bromodomain-containing protein, putative 0.0038 0.0112 0.0216
Mycobacterium tuberculosis Conserved protein 0.0027 0.0069 0.0059
Loa Loa (eye worm) hypothetical protein 0.0175 0.0638 0.2588
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0027 0.0069 0.0089
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0071 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0069 0.0031
Echinococcus multilocularis bromodomain containing 2 0.0061 0.0201 0.0579
Plasmodium falciparum DNA polymerase zeta catalytic subunit, putative 0.0058 0.019 0.3426
Trichomonas vaginalis bromodomain-containing protein, putative 0.0038 0.0112 0.0216
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0071 0.0096
Echinococcus multilocularis beta LACTamase domain containing family member 0.0027 0.0069 0.0198
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0131 0.0468 0.0432
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0449 0.1686 0.1654
Loa Loa (eye worm) hypothetical protein 0.0073 0.0245 0.0994
Brugia malayi hypothetical protein 0.0023 0.0055 0.0385
Trichomonas vaginalis bromodomain-containing protein 4, brd4, putative 0.0027 0.0071 0.0096
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0131 0.0468 0.307
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0027 0.0072 0.0098
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0189 0.0765
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0073 0.0245 0.0994
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0912 0.346 1
Toxoplasma gondii bromodomain-containing protein 0.0027 0.0071 0.0166
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0278
Echinococcus multilocularis Bromodomain containing protein 0.0027 0.0071 0.0204
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0071 0.0096
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0278
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0071 0.0096
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0198 0.0468
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0058 0.019 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0072 0.0098
Trichomonas vaginalis bromodomain containing protein, putative 0.0038 0.0112 0.0216
Toxoplasma gondii DNA polymerase family B protein 0.0131 0.0468 0.218
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0131 0.0468 0.9717
Entamoeba histolytica DNA polymerase zeta catalytic subunit, putative 0.0058 0.019 0.0443
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0071 0.0096
Giardia lamblia Rrm3p helicase 0.0912 0.346 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0027 0.0072 0.0098
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0027 0.0072 0.0206
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0071 0.0096
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0131 0.0468 0.0432
Schistosoma mansoni hypothetical protein 0.0036 0.0103 0.0191
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0027 0.0072 0.0098
Toxoplasma gondii MAPEG family protein 0.0534 0.2012 1
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0073 0.0245 0.0605
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0131 0.0468 0.0432
Loa Loa (eye worm) hypothetical protein 0.0073 0.0245 0.0994
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0131 0.0468 0.1257
Loa Loa (eye worm) hypothetical protein 0.0651 0.2463 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0071 0.0096
Echinococcus multilocularis cpg binding protein 0.003 0.0082 0.0236
Loa Loa (eye worm) bromodomain containing protein 0.0027 0.0071 0.0287
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0174 0.0635 0.2576
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0076 0.0306
Echinococcus granulosus survival motor neuron protein 1 0.0175 0.0638 0.1842
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0912 0.346 1
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0027 0.0071 0.0096
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0368 0.1377 0.1344
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0131 0.0468 0.1669
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0071 0.0096
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0038 0.5
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0131 0.0468 0.1257
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0912 0.346 0.3435
Toxoplasma gondii hypothetical protein 0.0422 0.1585 0.7836

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 2.2 Reduction in log CFU of Mycobacterium tuberculosis Kurono infected in mouse lung at 50 mg/kg, po relative to control ChEMBL. 17181168
MIC (functional) = 0.024 ug ml-1 Antituberculosis activity against rifampicin resistant Mycobacterium tuberculosis H37Rv ChEMBL. 17181168
MIC (functional) = 0.024 ug ml-1 Antituberculosis activity against rifampicin resistant Mycobacterium tuberculosis H37Rv ChEMBL. 17181168
MIC (functional) = 0.05 ug ml-1 Antituberculosis activity against Mycobacterium tuberculosis H37Rv ChEMBL. 17181168
MIC (functional) = 0.05 ug ml-1 Antituberculosis activity against INH resistant Mycobacterium tuberculosis H37Rv ChEMBL. 17181168
MIC (functional) = 0.05 ug ml-1 Antituberculosis activity against Mycobacterium tuberculosis H37Rv ChEMBL. 17181168
MIC (functional) = 0.05 ug ml-1 Antituberculosis activity against INH resistant Mycobacterium tuberculosis H37Rv ChEMBL. 17181168

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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