TDR Targets

Basic information

Technical information

TDR Targets ID: 408942
Name: 1,2,3,4,5-pentabromo-6-[2-(2,3,4,5,6-pentabro mophenyl)ethyl]benzene
MW: 971.222 | Formula: C14H4Br10
H donors: 0 H acceptors: 0 LogP: 11.05 Rotable bonds: 3
Rule of 5 violations (Lipinski): 2
SMILES: Brc1c(CCc2c(Br)c(Br)c(c(c2Br)Br)Br)c(Br)c(c(c1Br)Br)Br
InChi: 1S/C14H4Br10/c15-5-3(6(16)10(20)13(23)9(5)19)1-2-4-7(17)11(21)14(24)12(22)8(4)18/h1-2H2
InChiKey: BZQKBFHEWDPQHD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0083	0.1111	0.4017
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0176	0.2767	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0083	0.1111	0.2762
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0093	0.1289	0.3211
Schistosoma mansoni	peptidase Clp (S14 family)	0.0082	0.1098	0.3969
Schistosoma mansoni	thyroid hormone receptor	0.0176	0.2767	1
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0041	0.0363	0.2348
Schistosoma mansoni	nuclear receptor	0.0083	0.1111	0.4017
Brugia malayi	nuclear hormone receptor	0.0176	0.2767	0.6888
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0363	0.087
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0176	0.2767	0.6951
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0176	0.2767	0.6888
Onchocerca volvulus		0.0176	0.2767	0.6639
Echinococcus multilocularis	ecdysone induced protein 78C	0.0176	0.2767	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.0512	0.185
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0082	0.1098	1
Schistosoma mansoni	nuclear hormone receptor	0.0176	0.2767	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0176	0.2767	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0192	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1098	0.2729
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0192	0.0568
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0176	0.2767	1
Echinococcus multilocularis		0.0041	0.0363	0.1314
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0363	0.087
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0363	0.087
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0176	0.2767	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1111	0.2762
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0432	0.1043
Onchocerca volvulus		0.0041	0.0363	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1111	0.2762
Echinococcus granulosus	FTZ F1 alpha	0.0176	0.2767	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0176	0.2767	0.6888
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1111	0.2762
Schistosoma mansoni	zinc finger protein	0.0083	0.1111	0.4017
Schistosoma mansoni	coup transcription factor	0.0176	0.2767	1
Brugia malayi	hypothetical protein	0.0083	0.1111	0.2613
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0049	0.0512	0.185
Schistosoma mansoni	thyroid hormone receptor	0.0176	0.2767	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0082	0.1098	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0363	0.087
Schistosoma mansoni	hypothetical protein	0.0022	0.002	0.0072
Onchocerca volvulus	Protein ultraspiracle homolog	0.0176	0.2767	0.6639
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1289	0.3211
Loa Loa (eye worm)	hypothetical protein	0.0176	0.2767	0.6951
Echinococcus multilocularis	FTZ F1 alpha	0.0176	0.2767	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0219	0.3531	0.8887
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0041	0.0363	0.1314
Loa Loa (eye worm)	hypothetical protein	0.004	0.0352	0.0841
Brugia malayi	nuclear receptor NHR-88	0.0176	0.2767	0.6888
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0542	0.927	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0082	0.1098	1
Leishmania major	UDP-galactopyranose mutase	0.0041	0.0363	0.5
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0093	0.1289	0.4658
Echinococcus granulosus	ecdysone induced protein 78C	0.0176	0.2767	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0083	0.1111	0.4017
Brugia malayi	photoreceptor-specific nuclear receptor	0.0176	0.2767	0.6888
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0083	0.1111	0.4017
Schistosoma mansoni	nuclear hormone receptor	0.0083	0.1111	0.4017
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0176	0.2767	0.6951
Loa Loa (eye worm)	hypothetical protein	0.0176	0.2767	0.6951
Loa Loa (eye worm)	hypothetical protein	0.004	0.0337	0.0804
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0083	0.1111	0.237
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1289	0.3211
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1111	0.2762
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0082	0.1098	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0176	0.2767	0.6888
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.0663	0.1455
Brugia malayi	SWIRM domain containing protein	0.0041	0.0363	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0176	0.2767	0.6951
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0363	0.087
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0083	0.1111	0.4017
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0663	0.1628
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0083	0.1111	0.4017
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0176	0.2767	0.6888
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0083	0.1111	0.4017
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0041	0.0363	0.2348
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0083	0.1111	0.2762
Schistosoma mansoni	nuclear receptor	0.0083	0.1111	0.4017
Onchocerca volvulus		0.0083	0.1111	0.237
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0082	0.1098	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1289	0.3211
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0063	0.0752	0.2716
Brugia malayi	Nuclear hormone receptor-like 1	0.0176	0.2767	0.6888
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0082	0.1098	0.5
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0082	0.1098	1
Brugia malayi	nuclear receptor RXR	0.0083	0.1111	0.2613
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0176	0.2767	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0093	0.1289	0.4658
Brugia malayi	Pre-SET motif family protein	0.0219	0.3531	0.8864
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0176	0.2767	1
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0041	0.0363	0.2348
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0512	0.1245
Brugia malayi	nuclear receptor NHR-67	0.0083	0.1111	0.2613
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0041	0.0363	0.5
Brugia malayi	steroid hormone receptor	0.0176	0.2767	0.6888
Loa Loa (eye worm)	hypothetical protein	0.0176	0.2767	0.6951
Schistosoma mansoni	hypothetical protein	0.004	0.0337	0.1219
Loa Loa (eye worm)	DR-78	0.0083	0.1111	0.2762
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1289	0.3211
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0176	0.2767	0.6888
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0176	0.2767	0.6951
Brugia malayi	Pre-SET motif family protein	0.0031	0.0192	0.0239
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0176	0.2767	0.6888
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1111	0.2762
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0056	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1289	0.3211
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0041	0.0363	0.1314
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0176	0.2767	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0176	0.2767	0.6951
Onchocerca volvulus		0.0249	0.407	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0176	0.2767	0.6951
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0396	0.0953
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0176	0.2767	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0958	0.2374
Echinococcus granulosus	peptidase Clp S14 family	0.0054	0.0593	0.2145
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0082	0.1098	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0054	0.0593	0.4744
Echinococcus granulosus	nuclear receptor nhr 48	0.0083	0.1111	0.4017
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0093	0.1289	0.4658
Loa Loa (eye worm)	hypothetical protein	0.0176	0.2767	0.6951
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0176	0.2767	0.6888
Trichomonas vaginalis	set domain proteins, putative	0.0249	0.407	0.5
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.0663	0.1628
Onchocerca volvulus		0.0083	0.1111	0.237
Brugia malayi	Probable ClpP-like protease	0.0082	0.1098	0.2578
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0176	0.2767	0.6888
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0054	0.0593	0.2145
Schistosoma mansoni	bromodomain containing protein	0.0067	0.0819	0.2959
Toxoplasma gondii	histone lysine-specific demethylase	0.0041	0.0363	0.2348
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1111	0.2762
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0056	0.0201
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0041	0.0363	0.1314
Loa Loa (eye worm)	hypothetical protein	0.0176	0.2767	0.6951
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0176	0.2767	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0244	0.3971	1
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0082	0.1098	0.0762
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0176	0.2767	1
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0041	0.0363	0.2348
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0176	0.2767	1
Loa Loa (eye worm)	hypothetical protein	0.0176	0.2767	0.6951
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1111	0.2762
Plasmodium falciparum	protoporphyrinogen oxidase	0.0041	0.0363	0.2348
Brugia malayi	hypothetical protein	0.0093	0.1289	0.307
Brugia malayi	Nuclear hormone receptor-like 1	0.0093	0.1289	0.307
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0176	0.2767	0.6888
Brugia malayi	nuclear receptor RXR	0.0093	0.1289	0.307
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0083	0.1111	0.2613
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0176	0.2767	0.6639
Echinococcus multilocularis	nuclear receptor nhr 48	0.0083	0.1111	0.4017
Brugia malayi	nuclear hormone receptor	0.0083	0.1111	0.2613
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0083	0.1111	0.4017
Brugia malayi	ecdysone receptor	0.0083	0.1111	0.2613
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0176	0.2767	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0083	0.1111	0.4017
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1111	0.2762
Brugia malayi	Nuclear hormone receptor-like 1	0.0093	0.1289	0.307
Brugia malayi	Bromodomain containing protein	0.0079	0.1038	0.2423
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0041	0.0363	0.1314
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0082	0.1098	0.3969
Schistosoma mansoni	nuclear receptor nhr-48	0.0083	0.1111	0.4017
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0041	0.0363	0.2348
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0176	0.2767	1
Brugia malayi	hypothetical protein	0.0041	0.0363	0.0681
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0176	0.2767	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0176	0.2767	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0082	0.1098	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.0306	0.1107
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0176	0.2767	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0176	0.2767	1
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0056	0.0201
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0082	0.1098	0.0762
Brugia malayi	tailless protein	0.0083	0.1111	0.2613
Brugia malayi	ecdysteroid receptor	0.0176	0.2767	0.6888
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0041	0.0363	0.5
Schistosoma mansoni	amine oxidase	0.0041	0.0363	0.1314
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0176	0.2767	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0083	0.1111	0.4017
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0176	0.2767	1
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0041	0.0363	0.1314
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0176	0.2767	0.6951
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0041	0.0363	0.2348
Onchocerca volvulus	Bile acid receptor homolog	0.0176	0.2767	0.6639
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0337	0.0613
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0093	0.1289	0.4658
Brugia malayi	follicle stimulating hormone receptor	0.0244	0.3971	1
Brugia malayi	Nuclear hormone receptor E75	0.0083	0.1111	0.2613
Schistosoma mansoni	amine oxidase	0.0041	0.0363	0.1314
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0083	0.1111	0.4017
Brugia malayi	nuclear receptor NHR-88	0.0083	0.1111	0.2613
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0176	0.2767	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1111	0.2762
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.0512	0.185
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0192	0.0696
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0083	0.1111	0.237
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1111	0.2762
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0583	1	1
Brugia malayi	hypothetical protein	0.0083	0.1111	0.2613
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0363	0.2348
Brugia malayi	conserved hypotetical protein	0.0083	0.1111	0.2613
Loa Loa (eye worm)	steroid hormone receptor	0.0176	0.2767	0.6951
Plasmodium vivax	SET domain protein, putative	0.0031	0.0192	0.0568
Brugia malayi	Steroid receptor seven-up type 2	0.0176	0.2767	0.6888
Schistosoma mansoni	nuclear hormone receptor	0.0083	0.1111	0.4017
Schistosoma mansoni	RAR-like nuclear receptor	0.0176	0.2767	1
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0082	0.1098	0.3969
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0054	0.0593	0.0258
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0176	0.2767	0.6951
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.0306	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1111	0.2762
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1111	0.2762
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0041	0.0363	0.1314
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0176	0.2767	1
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0363	0.2348
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0192	0.0696
Brugia malayi	Nuclear hormone receptor E75	0.0083	0.1111	0.2613
Brugia malayi	nuclear hormone receptor family member odr-7	0.0083	0.1111	0.2613
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0063	0.0752	0.2716
Brugia malayi	orphan nuclear receptor NR2E1	0.0083	0.1111	0.2613
Brugia malayi	amine oxidase, flavin-containing family protein	0.0041	0.0363	0.0681
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0083	0.1111	0.4017
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0083	0.1111	0.2613
Loa Loa (eye worm)	nuclear hormone receptor	0.0083	0.1111	0.2762
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0176	0.2767	0.6888
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0176	0.2767	0.6888
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0363	0.087
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0176	0.2767	0.6888
Brugia malayi	Bromodomain containing protein	0.004	0.0351	0.0648
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0176	0.2767	0.6888
Brugia malayi	hypothetical protein	0.0093	0.1289	0.307
Echinococcus granulosus	histone lysine methyltransferase setb	0.0049	0.0512	0.185
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0176	0.2767	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0083	0.1111	0.4017
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0054	0.0593	0.0258
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0172	0.0621
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1111	0.2762
Loa Loa (eye worm)	hypothetical protein	0.0176	0.2767	0.6951
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.0663	0.1455

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Displacement of androgen fluormone from androgen receptor at 100 uM	ChEMBL.	17149866
Activity (binding)		Activity against human androgen receptor expressed in HepG2 cells assessed as renilla reporter gene activation in presence of 1 nM DHT at 1 uM after 40 hrs	ChEMBL.	17149866
Activity (binding)	0	Displacement of androgen fluormone from androgen receptor at 100 uM	ChEMBL.	17149866
Activity (binding)	0	Activity against human androgen receptor expressed in HepG2 cells assessed as renilla reporter gene activation in presence of 1 nM DHT at 1 uM after 40 hrs	ChEMBL.	17149866

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL219257
PubChem: 10985889

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 408942