Detailed information for compound 408968

Basic information

Technical information
  • TDR Targets ID: 408968
  • Name: (9Z)-9-[(2-hydroxy-4-methoxyphenyl)methyliden e]benzo[f][1]benzothiol-4-one
  • MW: 334.388 | Formula: C20H14O3S
  • H donors: 1 H acceptors: 2 LogP: 4.29 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)O)/C=C\1/c2ccccc2C(=O)c2c1scc2
  • InChi: 1S/C20H14O3S/c1-23-13-7-6-12(18(21)11-13)10-17-14-4-2-3-5-15(14)19(22)16-8-9-24-20(16)17/h2-11,21H,1H3/b17-10-
  • InChiKey: OBHLGTMGSBIFCJ-YVLHZVERSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (9Z)-9-[(2-hydroxy-4-methoxy-phenyl)methylene]benzo[f]benzothiophen-4-one
  • (9Z)-9-[(2-hydroxy-4-methoxyphenyl)methylene]-4-benzo[f]benzothiophenone
  • (9Z)-9-[(2-hydroxy-4-methoxy-phenyl)methylidene]benzo[f][1]benzothiol-4-one
  • (9Z)-9-(2-hydroxy-4-methoxy-benzylidene)benzo[f]benzothiophen-4-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Tubulin Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 434 aa 39.6 %
Trichomonas vaginalis tubulin alpha chain, putative Tubulin   445 aa 428 aa 80.8 %
Plasmodium falciparum alpha tubulin 1 Tubulin   445 aa 434 aa 40.8 %
Plasmodium yoelii tubulin beta chain Tubulin   445 aa 445 aa 29.7 %
Plasmodium yoelii tubulin alpha chain Tubulin   445 aa 434 aa 40.3 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin   445 aa 434 aa 40.3 %
Echinococcus granulosus beta tubulin Tubulin   445 aa 427 aa 82.7 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 429 aa 57.8 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 446 aa 29.6 %
Onchocerca volvulus Tubulin   445 aa 433 aa 40.0 %
Trypanosoma brucei alpha tubulin Tubulin   445 aa 434 aa 40.8 %
Leishmania braziliensis gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Plasmodium falciparum alpha tubulin 2 Tubulin   445 aa 434 aa 41.2 %
Toxoplasma gondii alpha-tubulin I, putative Tubulin   445 aa 442 aa 40.0 %
Plasmodium berghei tubulin epsilon chain, putative Tubulin   445 aa 445 aa 29.4 %
Neospora caninum tubulin alpha chain Tubulin   445 aa 440 aa 40.5 %
Schistosoma japonicum Tubulin beta chain, putative Tubulin   445 aa 436 aa 96.6 %
Plasmodium vivax tubulin alpha chain, putative Tubulin   445 aa 434 aa 40.3 %
Plasmodium knowlesi alpha tubulin, putative Tubulin   445 aa 434 aa 40.3 %
Echinococcus multilocularis tubulin delta chain Tubulin   445 aa 461 aa 26.0 %
Echinococcus granulosus tubulin alpha chain Tubulin   445 aa 432 aa 35.0 %
Plasmodium falciparum tubulin gamma chain Tubulin   445 aa 438 aa 32.6 %
Cryptosporidium parvum alpha tubulin Tubulin   445 aa 438 aa 40.2 %
Plasmodium vivax tubulin epsilon chain, putative Tubulin   445 aa 444 aa 28.2 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 92.6 %
Babesia bovis tubulin alpha chain, putative Tubulin   445 aa 433 aa 40.6 %
Trypanosoma brucei tubulin gamma chain Tubulin   445 aa 436 aa 33.5 %
Loa Loa (eye worm) tubulin beta-2A chain Tubulin   445 aa 430 aa 91.9 %
Trichomonas vaginalis tubulin, putative Tubulin   445 aa 428 aa 80.8 %
Schistosoma japonicum ko:K07374 tubulin alpha, putative Tubulin   445 aa 433 aa 40.0 %
Theileria parva tubulin gamma chain, putative Tubulin   445 aa 420 aa 34.3 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.8 %
Brugia malayi beta-tubulin, identical Tubulin   445 aa 430 aa 90.9 %
Schistosoma mansoni alpha tubulin Tubulin   445 aa 436 aa 39.7 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 446 aa 29.4 %
Plasmodium knowlesi alpha-tubulin II, putative Tubulin   445 aa 434 aa 41.2 %
Cryptosporidium hominis alpha-tubulin Tubulin   445 aa 438 aa 40.2 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 82.4 %
Schistosoma japonicum Tubulin alpha chain, putative Tubulin   445 aa 457 aa 36.8 %
Dictyostelium discoideum hypothetical protein Tubulin   445 aa 438 aa 38.6 %
Echinococcus granulosus tubulin gamma 1 chain Tubulin   445 aa 436 aa 34.2 %
Leishmania infantum gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Leishmania donovani tubulin gamma chain Tubulin   445 aa 438 aa 34.2 %
Toxoplasma gondii alpha tubulin TUBA1 Tubulin   445 aa 440 aa 40.5 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin   445 aa 456 aa 30.9 %
Onchocerca volvulus Tubulin   445 aa 433 aa 39.0 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.5 %
Babesia bovis tubulin gamma chain Tubulin   445 aa 441 aa 34.2 %
Echinococcus multilocularis peroxisome assembly protein 26 Tubulin   445 aa 438 aa 29.0 %
Dictyostelium discoideum beta tubulin Tubulin   445 aa 432 aa 76.2 %
Plasmodium knowlesi tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.1 %
Leishmania braziliensis alpha tubulin Tubulin   445 aa 434 aa 40.3 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 428 aa 80.6 %
Giardia lamblia Epsilon tubulin Tubulin   445 aa 442 aa 27.6 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Toxoplasma gondii beta-tubulin, putative Tubulin   445 aa 430 aa 89.8 %
Loa Loa (eye worm) tubulin beta-1 chain Tubulin   445 aa 432 aa 88.4 %
Trypanosoma brucei gambiense gamma tubulin Tubulin   445 aa 436 aa 33.5 %
Onchocerca volvulus Tubulin   445 aa 441 aa 31.5 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 434 aa 39.6 %
Giardia lamblia Gamma tubulin Tubulin   445 aa 460 aa 32.2 %
Onchocerca volvulus Tubulin   445 aa 427 aa 49.9 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 57.1 %
Trypanosoma cruzi alpha tubulin, putative Tubulin   445 aa 434 aa 40.6 %
Echinococcus granulosus tubulin alpha 3 chain Tubulin   445 aa 434 aa 40.1 %
Echinococcus granulosus tubulin alpha chain Tubulin   445 aa 434 aa 40.1 %
Trypanosoma congolense tubulin gamma chain Tubulin   445 aa 436 aa 33.3 %
Plasmodium yoelii tubulin gamma chain Tubulin   445 aa 438 aa 32.9 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Schistosoma mansoni tubulin subunit alpha Tubulin   445 aa 439 aa 39.4 %
Onchocerca volvulus Tyrosine kinase homolog Tubulin   445 aa 434 aa 38.2 %
Toxoplasma gondii beta tubulin Tubulin   445 aa 430 aa 89.1 %
Leishmania braziliensis epsilon tubulin, putative Tubulin   445 aa 465 aa 29.9 %
Schistosoma mansoni tubulin subunit alpha Tubulin   445 aa 434 aa 38.9 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 95.8 %
Entamoeba histolytica tubulin gamma chain Tubulin   445 aa 428 aa 32.9 %
Schistosoma japonicum ko:K10389 tubulin gamma, putative Tubulin   445 aa 436 aa 33.9 %
Brugia malayi tubulin alpha chain - mouse Tubulin   445 aa 433 aa 40.0 %
Schistosoma mansoni alpha tubulin Tubulin   445 aa 434 aa 39.4 %
Onchocerca volvulus 60S ribosomal protein L13 homolog Tubulin   445 aa 430 aa 91.9 %
Leishmania donovani alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 430 aa 94.4 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Leishmania mexicana alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Entamoeba histolytica tubulin alpha chain, putative Tubulin   445 aa 439 aa 35.8 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 446 aa 29.6 %
Trypanosoma brucei alpha tubulin Tubulin   445 aa 434 aa 40.8 %
Onchocerca volvulus Putative methyltransferase KIAA1456 Tubulin   445 aa 426 aa 49.8 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 430 aa 95.1 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Onchocerca volvulus 1D304 homolog Tubulin   445 aa 433 aa 40.4 %
Onchocerca volvulus Tubulin   445 aa 434 aa 39.9 %
Trypanosoma congolense epsilon tubulin Tubulin   445 aa 464 aa 29.3 %
Echinococcus granulosus tubulin alpha 3 chain Tubulin   445 aa 439 aa 40.3 %
Echinococcus granulosus peroxisome assembly protein 26 Tubulin   445 aa 438 aa 29.2 %
Echinococcus multilocularis tubulin alpha 3 chain Tubulin   445 aa 434 aa 40.1 %
Echinococcus granulosus tubulin alpha chain Tubulin   445 aa 433 aa 33.5 %
Echinococcus multilocularis tubulin gamma 1 chain Tubulin   445 aa 436 aa 34.2 %
Neospora caninum tubulin alpha chain, putative Tubulin   445 aa 433 aa 30.9 %
Plasmodium knowlesi tubulin epsilon chain, putative Tubulin   445 aa 441 aa 29.0 %
Echinococcus multilocularis tubulin alpha Tubulin   445 aa 443 aa 30.5 %
Toxoplasma gondii beta-1 tubulin, putative Tubulin   445 aa 430 aa 89.1 %
Babesia bovis tubulin, putative Tubulin   445 aa 457 aa 21.4 %
Brugia malayi alpha-tubulin Tubulin   445 aa 434 aa 38.7 %
Plasmodium berghei alpha tubulin 1 Tubulin   445 aa 434 aa 40.3 %
Brugia malayi Tubulin beta-1 chain Tubulin   445 aa 429 aa 87.9 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 434 aa 39.6 %
Giardia lamblia Alpha-tubulin Tubulin   445 aa 434 aa 40.3 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Drosophila melanogaster gamma-Tubulin at 23C Tubulin   445 aa 439 aa 34.4 %
Schistosoma japonicum Tubulin alpha-1C chain, putative Tubulin   445 aa 438 aa 38.8 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin   445 aa 428 aa 80.8 %
Trichomonas vaginalis tubulin alpha-1 chain, putative Tubulin   445 aa 434 aa 39.6 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin   445 aa 434 aa 38.9 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.8 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Onchocerca volvulus Tubulin   445 aa 445 aa 36.2 %
Plasmodium vivax tubulin alpha chain, putative Tubulin   445 aa 434 aa 41.2 %
Brugia malayi Tubulin alpha-2 chain Tubulin   445 aa 435 aa 38.6 %
Dictyostelium discoideum gamma tubulin Tubulin   445 aa 429 aa 33.8 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Echinococcus granulosus tubulin beta 4A class IVa Tubulin   445 aa 381 aa 71.4 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Loa Loa (eye worm) tubulin alpha chain Tubulin   445 aa 432 aa 39.8 %
Trypanosoma congolense alpha tubulin Tubulin   445 aa 434 aa 40.8 %
Onchocerca volvulus Tubulin   445 aa 435 aa 39.8 %
Schistosoma japonicum ko:K07374 tubulin alpha, putative Tubulin   445 aa 433 aa 39.3 %
Plasmodium falciparum tubulin epsilon chain, putative Tubulin   445 aa 461 aa 27.8 %
Schistosoma japonicum Tubulin alpha-1 chain, putative Tubulin   445 aa 439 aa 39.4 %
Leishmania donovani epsilon tubulin, putative Tubulin   445 aa 475 aa 30.1 %
Echinococcus multilocularis tubulin alpha chain Tubulin   445 aa 438 aa 34.5 %
Echinococcus granulosus tubulin alpha 1C chain Tubulin   445 aa 434 aa 40.8 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Leishmania mexicana epsilon tubulin, putative Tubulin   445 aa 469 aa 30.5 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin   445 aa 434 aa 39.6 %
Echinococcus multilocularis tubulin, beta 4A class IVa Tubulin   445 aa 381 aa 71.4 %
Trypanosoma cruzi tubulin gamma chain Tubulin   445 aa 436 aa 33.5 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin   445 aa 434 aa 40.8 %
Cryptosporidium hominis gamma-tubulin Tubulin   445 aa 436 aa 37.4 %
Leishmania major epsilon tubulin, putative Tubulin   445 aa 465 aa 30.3 %
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Tubulin   445 aa 433 aa 30.7 %
Neospora caninum Beta-tubulin, related Tubulin   445 aa 446 aa 35.0 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 434 aa 39.6 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin   445 aa 434 aa 40.3 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.8 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 434 aa 39.6 %
Echinococcus granulosus tubulin alpha 1C chain Tubulin   445 aa 434 aa 39.6 %
Echinococcus multilocularis tubulin alpha 3 chain Tubulin   445 aa 439 aa 40.3 %
Plasmodium berghei tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.1 %
Dictyostelium discoideum alpha tubulin Tubulin   445 aa 446 aa 41.0 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Schistosoma mansoni tubulin subunit gamma Tubulin   445 aa 436 aa 33.5 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.3 %
Entamoeba histolytica tubulin alpha-1 chain Tubulin   445 aa 439 aa 36.2 %
Echinococcus multilocularis tubulin alpha chain Tubulin   445 aa 434 aa 40.1 %
Trypanosoma brucei gambiense epsilon tubulin Tubulin   445 aa 446 aa 29.4 %
Drosophila melanogaster beta-Tubulin at 60D Tubulin   445 aa 435 aa 91.3 %
Leishmania mexicana alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Cryptosporidium parvum gamma tubulin Tubulin   445 aa 436 aa 37.4 %
Giardia lamblia Alpha-tubulin Tubulin   445 aa 434 aa 40.3 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin   445 aa 456 aa 30.9 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Trypanosoma brucei gambiense alpha tubulin Tubulin   445 aa 434 aa 40.8 %
Leishmania braziliensis alpha tubulin Tubulin   445 aa 434 aa 40.3 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin   445 aa 434 aa 38.9 %
Echinococcus granulosus tubulin subunit TubB Tubulin   445 aa 441 aa 30.6 %
Trypanosoma brucei alpha tubulin Tubulin   445 aa 434 aa 40.8 %
Leishmania infantum epsilon tubulin, putative Tubulin   445 aa 475 aa 30.1 %
Leishmania mexicana beta tubulin Tubulin   445 aa 429 aa 86.2 %
Echinococcus multilocularis tubulin alpha chain Tubulin   445 aa 433 aa 33.5 %
Loa Loa (eye worm) alpha-tubulin Tubulin   445 aa 440 aa 38.2 %
Theileria parva Tubulin alpha chain, putative Tubulin   445 aa 439 aa 39.6 %
Echinococcus granulosus tubulin alpha Tubulin   445 aa 440 aa 30.2 %
Theileria parva tubulin alpha chain, putative Tubulin   445 aa 452 aa 36.7 %
Onchocerca volvulus Regulatory-associated protein of mTOR homolog Tubulin   445 aa 440 aa 38.6 %
Leishmania mexicana gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Trypanosoma brucei alpha tubulin Tubulin   445 aa 434 aa 40.8 %
Brugia malayi Tubulin gamma chain Tubulin   445 aa 440 aa 31.4 %
Onchocerca volvulus Putative cytochrome c-type heme lyase Tubulin   445 aa 429 aa 87.9 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin   445 aa 434 aa 40.8 %
Plasmodium vivax tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.1 %
Trichomonas vaginalis tubulin gamma chain, putative Tubulin   445 aa 415 aa 33.5 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Echinococcus multilocularis tubulin alpha 1C chain Tubulin   445 aa 434 aa 40.6 %
Echinococcus multilocularis tubulin alpha 1C chain Tubulin   445 aa 434 aa 39.9 %
Leishmania infantum alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Echinococcus multilocularis tubulin subunit TubB Tubulin   445 aa 441 aa 30.6 %
Echinococcus granulosus alpha tubulin Tubulin   445 aa 422 aa 29.9 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 428 aa 56.3 %
Loa Loa (eye worm) tubulin alpha-2 chain Tubulin   445 aa 440 aa 39.1 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.8 %
Brugia malayi tubulin alpha-2 chain Tubulin   445 aa 440 aa 38.4 %
Leishmania infantum alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Leishmania major gamma-tubulin Tubulin   445 aa 438 aa 34.0 %
Onchocerca volvulus Tubulin   445 aa 427 aa 82.7 %
Plasmodium berghei alpha tubulin 2 Tubulin   445 aa 434 aa 41.2 %
Echinococcus multilocularis hypothetical protein Tubulin   445 aa 422 aa 29.9 %
Schistosoma mansoni tubulin subunit epsilon Tubulin   445 aa 464 aa 31.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0197 0.0197
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0197 0.0197
Entamoeba histolytica hypothetical protein, conserved 0.0153 1 1
Schistosoma mansoni ap endonuclease 0.002 0.0197 0.0197
Schistosoma mansoni bromodomain containing protein 0.0068 0.3694 0.3694
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0139
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0197 0.0197
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0153 1 1
Toxoplasma gondii exonuclease III APE 0.002 0.0197 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.2072 0.4841
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0197 0.5
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0197 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0059 0.0059
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0197 0.0197
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0341 0.0796
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0491 0.0491
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.1544 0.1544
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0197 0.0197
Schistosoma mansoni hypothetical protein 0.0022 0.0341 0.0341
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.3413 0.3413
Brugia malayi PHD-finger family protein 0.0027 0.0677 0.1467
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0059 0.0059
Schistosoma mansoni ap endonuclease 0.002 0.0197 0.0197
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0153 1 1
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0153 1 1
Echinococcus multilocularis zinc finger protein 0.0021 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0043 0.1922 0.449
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0059 0.0059
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0197 0.5
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0491 0.0491
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0153 1 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0197 0.5
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0197 0.5
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0197 0.0461
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0197 0.0197
Brugia malayi Bromodomain containing protein 0.0041 0.173 0.3748
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0197 0.0197
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0153 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1736 0.4055
Schistosoma mansoni hypothetical protein 0.0153 1 1
Schistosoma mansoni zinc finger protein 0.0021 0.0258 0.0258
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0059 0.0059
Entamoeba histolytica DNA repair and recombination protein, putative 0.0153 1 1
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0108 0.0251
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0153 1 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.428 1
Echinococcus granulosus zinc finger protein 0.0021 0.0258 0.0258
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0491 0.0491
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0059 0.0059
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0197 0.0427
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.3413 0.3413
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0059 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0153 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0059 0.0059
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0197 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0197 0.0197
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0059 0.0059
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0153 1 1
Giardia lamblia Rrm3p helicase 0.0153 1 1
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0153 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.1544 0.1544
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0197 0.0197
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0197 0.0197
Brugia malayi Bromodomain containing protein 0.008 0.4616 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.23 uM Antiproliferative activity against human K562 cell line ChEMBL. 17181164
IC50 (functional) = 0.23 uM Antiproliferative activity against human K562 cell line ChEMBL. 17181164
IC50 (binding) = 0.77 uM Inhibition of tubulin polymerization in porcine brain ChEMBL. 17181164
IC50 (binding) = 0.77 uM Inhibition of tubulin polymerization in porcine brain ChEMBL. 17181164

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 17181164

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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