Detailed information for compound 408997

Basic information

Technical information
  • TDR Targets ID: 408997
  • Name: 3-[(7R,8R,9aR)-2-[(2-chlorophenyl)methyl]-7,8 -dimethyl-3,4,6,7,9,9a-hexahydro-1H-pyrido[1, 2-a]pyrazin-8-yl]phenol
  • MW: 384.942 | Formula: C23H29ClN2O
  • H donors: 1 H acceptors: 1 LogP: 5.13 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cccc(c1)[C@]1(C)C[C@@H]2CN(CCN2C[C@@H]1C)Cc1ccccc1Cl
  • InChi: 1S/C23H29ClN2O/c1-17-14-26-11-10-25(15-18-6-3-4-9-22(18)24)16-20(26)13-23(17,2)19-7-5-8-21(27)12-19/h3-9,12,17,20,27H,10-11,13-16H2,1-2H3/t17-,20+,23+/m0/s1
  • InChiKey: NZLFDRJFUHYJKI-XTQVGHSUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[(7R,8R,9aR)-2-(2-chlorobenzyl)-7,8-dimethyl-3,4,6,7,9,9a-hexahydro-1H-pyrido[1,2-a]pyrazin-8-yl]phenol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opioid receptor, delta 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, kappa 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, mu 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0104 0.1365 0.4673
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.0468 0.1578
Loa Loa (eye worm) hypothetical protein 0.0197 0.2882 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0928 0.3136
Schistosoma mansoni hypothetical protein 0.0023 0.0035 0.0066
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0093 0.1184 0.387
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0197 0.2882 0.287
Loa Loa (eye worm) hypothetical protein 0.0047 0.0427 0.1378
Echinococcus multilocularis ecdysone induced protein 78C 0.0197 0.2882 0.287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0304 0.556
Loa Loa (eye worm) hypothetical protein 0.0093 0.1184 0.4035
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0069 0.0053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0093 0.1184 0.1169
Loa Loa (eye worm) hypothetical protein 0.0197 0.2882 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.1184 0.4035
Brugia malayi nuclear hormone receptor family member odr-7 0.0093 0.1184 0.387
Schistosoma mansoni nuclear hormone receptor 0.0093 0.1184 0.4074
Brugia malayi nuclear receptor NHR-88 0.0093 0.1184 0.387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0263 0.444
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0197 0.2882 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0468 0.1289
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0567 0.1644
Brugia malayi Nuclear hormone receptor E75 0.0093 0.1184 0.387
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0197 0.2882 1
Loa Loa (eye worm) hypothetical protein 0.0197 0.2882 1
Loa Loa (eye worm) nuclear hormone receptor 0.0093 0.1184 0.4035
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0197 0.2882 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0308 0.0292
Brugia malayi Nuclear hormone receptor-like 1 0.0104 0.1365 0.4527
Brugia malayi conserved hypotetical protein 0.0093 0.1184 0.387
Loa Loa (eye worm) hypothetical protein 0.0104 0.1365 0.4673
Brugia malayi hypothetical protein 0.004 0.0316 0.0741
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0197 0.2882 0.287
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0197 0.2882 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0093 0.1184 0.1169
Brugia malayi tailless protein 0.0093 0.1184 0.387
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0197 0.2882 0.287
Loa Loa (eye worm) hypothetical protein 0.0042 0.0351 0.1111
Loa Loa (eye worm) hypothetical protein 0.0197 0.2882 1
Loa Loa (eye worm) hypothetical protein 0.0197 0.2882 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0197 0.2882 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0093 0.1184 0.1169
Schistosoma mansoni zinc finger protein 0.0093 0.1184 0.4074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0197 0.2882 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0197 0.2882 0.287
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0197 0.2882 0.287
Loa Loa (eye worm) hypothetical protein 0.0038 0.0282 0.0868
Schistosoma mansoni coup transcription factor 0.0197 0.2882 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0197 0.2882 1
Schistosoma mansoni nuclear receptor 0.0093 0.1184 0.4074
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0104 0.1365 0.1351
Loa Loa (eye worm) steroid hormone receptor 0.0197 0.2882 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0316 0.0301
Brugia malayi Nuclear hormone receptor-like 1 0.0104 0.1365 0.4527
Loa Loa (eye worm) hypothetical protein 0.0104 0.1365 0.4673
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.0468 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0197 0.2882 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.0468 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0263 0.444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0468 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0037 0.0263 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0197 0.2882 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0305 0.6514
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0197 0.2882 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0197 0.2882 0.287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0146 0.1267
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0468 0.1522
Echinococcus multilocularis FTZ F1 alpha 0.0197 0.2882 0.287
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0197 0.2882 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0197 0.2882 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.0468 0.0453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0263 0.444
Loa Loa (eye worm) hypothetical protein 0.0093 0.1184 0.4035
Brugia malayi nuclear receptor RXR 0.0093 0.1184 0.387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0468 1
Brugia malayi nuclear receptor NHR-88 0.0197 0.2882 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0197 0.2882 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0567 0.1644
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0282 0.0617
Echinococcus granulosus ecdysone induced protein 78C 0.0197 0.2882 0.287
Loa Loa (eye worm) hypothetical protein 0.0093 0.1184 0.4035
Brugia malayi steroid hormone receptor 0.0197 0.2882 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0197 0.2882 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0304 0.556
Echinococcus multilocularis nuclear receptor nhr 48 0.0093 0.1184 0.1169
Brugia malayi hypothetical protein 0.0093 0.1184 0.387
Schistosoma mansoni nuclear receptor nhr-48 0.0093 0.1184 0.4074
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0197 0.2882 0.287
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0197 0.2882 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.1365 0.4673
Schistosoma mansoni nuclear receptor 0.0093 0.1184 0.4074
Loa Loa (eye worm) hypothetical protein 0.0093 0.1184 0.4035
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0197 0.2882 0.287
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.0468 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.1365 0.4673
Loa Loa (eye worm) hypothetical protein 0.0197 0.2882 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0093 0.1184 0.1169
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0197 0.2882 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0567 0.1868
Echinococcus granulosus thyroid hormone receptor alpha 0.0093 0.1184 0.1169
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0197 0.2882 0.287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0141 0.1138
Brugia malayi Bromodomain containing protein 0.0082 0.1004 0.3223
Schistosoma mansoni nuclear hormone receptor 0.0093 0.1184 0.4074
Brugia malayi ecdysone receptor 0.0093 0.1184 0.387
Brugia malayi nuclear hormone receptor family member nhr-6 0.0093 0.1184 0.387
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0197 0.2882 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0197 0.2882 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0146 0.1267
Loa Loa (eye worm) hypothetical protein 0.0093 0.1184 0.4035
Loa Loa (eye worm) hypothetical protein 0.0093 0.1184 0.4035
Brugia malayi nuclear hormone receptor 0.0093 0.1184 0.387
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0634 1 1
Schistosoma mansoni hypothetical protein 0.004 0.0316 0.1048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0187 0.2387
Brugia malayi orphan nuclear receptor NR2E1 0.0093 0.1184 0.387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.01 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0197 0.2882 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0731 0.0716
Loa Loa (eye worm) hypothetical protein 0.0093 0.1184 0.4035
Schistosoma mansoni nuclear hormone receptor 0.0197 0.2882 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0197 0.2882 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0093 0.1184 0.1169
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0197 0.2882 1
Schistosoma mansoni retinoic acid receptor RXR 0.0197 0.2882 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0263 0.444
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0093 0.1184 0.4074
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.0468 0.0453
Loa Loa (eye worm) hypothetical protein 0.0197 0.2882 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0104 0.1365 0.4673
Echinococcus granulosus FTZ F1 alpha 0.0197 0.2882 0.287
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.0468 1
Schistosoma mansoni hypothetical protein 0.0038 0.0282 0.0928
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.01 0.0018
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0093 0.1184 0.1169
Schistosoma mansoni steroid hormone receptor ad4bp 0.0197 0.2882 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0146 0.1267
Loa Loa (eye worm) hypothetical protein 0.0197 0.2882 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0197 0.2882 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0567 0.1868
Brugia malayi nuclear hormone receptor 0.0197 0.2882 1
Brugia malayi Bromodomain containing protein 0.0042 0.035 0.0861
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.01 0.0018
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0069 0.0185
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0046 0.0985
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0197 0.2882 0.287
Brugia malayi Nuclear hormone receptor E75 0.0093 0.1184 0.387
Loa Loa (eye worm) hypothetical protein 0.0093 0.1184 0.4035
Schistosoma mansoni bromodomain containing protein 0.0069 0.0795 0.2719
Loa Loa (eye worm) hypothetical protein 0.0093 0.1184 0.4035
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0308 0.0292
Giardia lamblia GTOR 0.0049 0.0468 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0197 0.2882 1
Brugia malayi Nuclear hormone receptor-like 1 0.0197 0.2882 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.1184 0.4035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0263 0.444
Loa Loa (eye worm) hypothetical protein 0.0093 0.1184 0.4035
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0104 0.1365 0.4708
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0731 0.0716
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0197 0.2882 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0316 0.0301
Loa Loa (eye worm) nuclear receptor NHR-67 0.0093 0.1184 0.4035
Brugia malayi hypothetical protein 0.0104 0.1365 0.4527
Loa Loa (eye worm) DR-78 0.0093 0.1184 0.4035
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0104 0.1365 0.4708
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0468 1
Brugia malayi nuclear receptor NHR-67 0.0093 0.1184 0.387
Brugia malayi hypothetical protein 0.0104 0.1365 0.4527
Brugia malayi ecdysteroid receptor 0.0197 0.2882 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0304 0.556
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.0468 1
Schistosoma mansoni RAR-like nuclear receptor 0.0197 0.2882 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0205 0.2856
Onchocerca volvulus Bile acid receptor homolog 0.0197 0.2882 1
Brugia malayi Steroid receptor seven-up type 2 0.0197 0.2882 1
Onchocerca volvulus 0.0197 0.2882 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0263 0.444
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0069 0.0053
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0093 0.1184 0.4035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0197 0.2882 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0093 0.1184 0.1169
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0197 0.2882 0.287
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0093 0.1184 0.4074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0263 0.444
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.0468 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0197 0.2882 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0197 0.2882 0.287
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0197 0.2882 1
Brugia malayi nuclear receptor RXR 0.0104 0.1365 0.4527
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0197 0.2882 0.287
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0197 0.2882 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0093 0.1184 0.1169
Echinococcus granulosus nuclear receptor nhr 48 0.0093 0.1184 0.1169
Schistosoma mansoni thyroid hormone receptor 0.0197 0.2882 1
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0316 0.1048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.01 0.0018
Echinococcus granulosus Nuclear hormone receptor HR96 0.0093 0.1184 0.1169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0351 0.6827
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0304 0.556
Loa Loa (eye worm) hypothetical protein 0.0093 0.1184 0.4035
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0468 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0197 0.2882 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0141 0.1138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0304 0.556
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.0468 1
Brugia malayi hypothetical protein 0.0093 0.1184 0.387
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0104 0.1365 0.1351
Loa Loa (eye worm) hypothetical protein 0.0045 0.0393 0.1259
Schistosoma mansoni thyroid hormone receptor 0.0197 0.2882 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0197 0.2882 0.287

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.8 nM Antagonist activity assessed as inhibition of loperamide-stimulated [35S]GTPgammaS binding to human mu opioid receptor expressed in CHO cells ChEMBL. 17149859
IC50 (functional) = 1.8 nM Antagonist activity assessed as inhibition of loperamide-stimulated [35S]GTPgammaS binding to human mu opioid receptor expressed in CHO cells ChEMBL. 17149859
IC50 (functional) = 10 nM Antagonist activity assessed as inhibition of U50488-stimulated [35S]GTPgammaS binding to human kappa opioid receptor expressed in CHO cells ChEMBL. 17149859
IC50 (functional) = 10 nM Antagonist activity assessed as inhibition of U50488-stimulated [35S]GTPgammaS binding to human kappa opioid receptor expressed in CHO cells ChEMBL. 17149859
IC50 (functional) = 190 nM Antagonist activity assessed as inhibition of BW373U86-stimulated [35S]GTPgammaS binding to human delta opioid receptor expressed in CHO cells ChEMBL. 17149859
IC50 (functional) = 190 nM Antagonist activity assessed as inhibition of BW373U86-stimulated [35S]GTPgammaS binding to human delta opioid receptor expressed in CHO cells ChEMBL. 17149859
Ki (binding) = 0.47 nM Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cells ChEMBL. 17149859
Ki (binding) = 0.47 nM Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cells ChEMBL. 17149859
Ki (binding) = 16 nM Displacement of [3H]diprenorphine from human cloned kappa opioid receptor expressed in CHO cells ChEMBL. 17149859
Ki (binding) = 16 nM Displacement of [3H]diprenorphine from human cloned kappa opioid receptor expressed in CHO cells ChEMBL. 17149859
Ki (binding) = 57 nM Displacement of [3H]diprenorphine from human cloned delta opioid receptor expressed in CHO cells ChEMBL. 17149859
Ki (binding) = 57 nM Displacement of [3H]diprenorphine from human cloned delta opioid receptor expressed in CHO cells ChEMBL. 17149859
Ratio Ki (binding) = 34 Selectivity for human mu opioid receptor over kappa opioid receptor ChEMBL. 17149859
Ratio Ki (binding) = 120 Selectivity for human mu opioid receptor over delta opioid receptor ChEMBL. 17149859

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.