Activity (binding)
|
= 6.82
|
Inhibitory activity against dihydrofolate reductase
|
ChEMBL.
|
11495588
|
Activity (binding)
|
= 6.82
|
Activity against dihydrofolate reductase of Escherichia coli strain MB 1428
|
ChEMBL.
|
1507206
|
Activity (binding)
|
= 5.52 %
|
Binding affinity for dihydrofolate reductase from Lactobacillus casei
|
ChEMBL.
|
9379435
|
Activity (binding)
|
= 5.52 %
|
Binding affinity for dihydrofolate reductase from Lactobacillus casei
|
ChEMBL.
|
9379435
|
Cytotoxicity (functional)
|
= 0
|
Cytotoxicity was determined in uninfected macrophages (MRC-5) at 25 microM
|
ChEMBL.
|
10543874
|
IC50 (functional)
|
= 5 uM
|
Inhibition of T. brucei rhodesiense growth
|
ChEMBL.
|
10543874
|
IC50 (functional)
|
= 5 uM
|
Inhibition of T. brucei rhodesiense growth
|
ChEMBL.
|
10543874
|
Inhibition (functional)
|
= 0 %
|
Inhibition of L. infantum Amastigotes growth at the specified concentration 12.5 uM
|
ChEMBL.
|
10543874
|
Inhibition (functional)
|
= 0 %
|
Inhibition of L. infantum Amastigotes growth at the specified concentration 12.5 uM
|
ChEMBL.
|
10543874
|
Inhibition (functional)
|
= 20 %
|
Inhibition of T. cruzi Amastigotes growth at the specified concentrations: 1.56 uM
|
ChEMBL.
|
10543874
|
Inhibition (functional)
|
= 20 %
|
Inhibition of T. cruzi Amastigotes growth at the specified concentrations: 1.56 uM
|
ChEMBL.
|
10543874
|
Inhibition (functional)
|
= 65 %
|
Inhibition of T. cruzi Amastigotes growth at the specified concentrations: 3.13 uM
|
ChEMBL.
|
10543874
|
Inhibition (functional)
|
= 65 %
|
Inhibition of T. cruzi Amastigotes growth at the specified concentrations: 3.13 uM
|
ChEMBL.
|
10543874
|
Inhibition (functional)
|
= 92 %
|
Inhibition of T. cruzi Amastigotes growth at the specified concentrations: 6.25 uM
|
ChEMBL.
|
10543874
|
Inhibition (functional)
|
= 92 %
|
Inhibition of T. cruzi Amastigotes growth at the specified concentrations: 6.25 uM
|
ChEMBL.
|
10543874
|
Inhibition (functional)
|
= 99 %
|
Inhibition of T. cruzi Amastigotes growth at the specified concentrations: 12.5 uM
|
ChEMBL.
|
10543874
|
Inhibition (functional)
|
= 99 %
|
Inhibition of T. cruzi Amastigotes growth at the specified concentrations: 12.5 uM
|
ChEMBL.
|
10543874
|
Ki (binding)
|
= 5.22
|
Inhibitory activity against chicken liver dihydrofolate reductase
|
ChEMBL.
|
2502631
|
Ki (binding)
|
= 6.13
|
Inhibitory activity against Lactobacillus casei dihydrofolate reductase
|
ChEMBL.
|
2502631
|
Ki (binding)
|
= 6.82
|
Inhibitory activity against E. coli dihydrofolate reductase
|
ChEMBL.
|
1899453
|
Ki (binding)
|
= 6.82
|
Inhibition constant against binding of E. coli dihydrofolate reductase
|
ChEMBL.
|
3290487
|
Ki (binding)
|
= 3.6 nM
|
Inhibition of recombinant Dihydrofolate reductase from humans.
|
ChEMBL.
|
10543874
|
Ki (binding)
|
= 3.6 nM
|
Inhibition of recombinant Dihydrofolate reductase from humans.
|
ChEMBL.
|
10543874
|
Ki (binding)
|
= 150 nM
|
Inhibition of recombinant Dihydrofolate reductase from Leishmania major.
|
ChEMBL.
|
10543874
|
Ki (binding)
|
= 150 nM
|
Inhibition of recombinant Dihydrofolate reductase from Leishmania major.
|
ChEMBL.
|
10543874
|
Ki (binding)
|
= 220 nM
|
Inhibition of recombinant Dihydrofolate reductase from Trypanosoma cruzi.
|
ChEMBL.
|
10543874
|
Ki (binding)
|
= 220 nM
|
Inhibition of recombinant Dihydrofolate reductase from Trypanosoma cruzi.
|
ChEMBL.
|
10543874
|
Ki (binding)
|
= 930 nM
|
Inhibition of recombinant Dihydrofolate reductase from humans.
|
ChEMBL.
|
10543874
|
Ki (binding)
|
= 930 nM
|
Inhibition of recombinant Dihydrofolate reductase from humans.
|
ChEMBL.
|
10543874
|
Log (binding)
|
= 6.82 1/Ki
|
Inhibitory activity against E. coli dihydrofolate reductase
|
ChEMBL.
|
1899453
|
Log 1/C (binding)
|
= 5.22
|
Inhibition of chicken liver dihydrofolate reductase
|
ChEMBL.
|
3701780
|
Log 1/C (functional)
|
= 4.99
|
Inhibitory activity against murine tumor cells (L5178Y/R)
|
ChEMBL.
|
7086836
|
Log 1/C (binding)
|
= 5.22
|
Inhibition of chicken liver dihydrofolate reductase
|
ChEMBL.
|
3701780
|
Log 1/C (functional)
|
= 5.74
|
Inhibitory activity against murine tumor cells (L5178Y/S)
|
ChEMBL.
|
7086836
|
Log 1/Ki (binding)
|
= 5.22
|
Inhibitory activity against chicken liver dihydrofolate reductase
|
ChEMBL.
|
2502631
|
Log 1/Ki (binding)
|
= 6.13
|
Inhibitory activity against Lactobacillus casei dihydrofolate reductase
|
ChEMBL.
|
2502631
|
Log 1/Ki app (binding)
|
= 5.22
|
Inhibitory activity against chicken dihydrofolate reductase at pH 7.2.
|
ChEMBL.
|
7069722
|
Log 1/Ki app (binding)
|
= 6.13
|
Inhibitory activity against dihydrofolate reductase (DHFR) from Lactobacillus casei (expressed as log 1/Kiapp)
|
ChEMBL.
|
6809941
|
Log 1/Ki app (binding)
|
= 6.48
|
Inhibition of dihydrofolate reductase from bovine liver
|
ChEMBL.
|
7017146
|
Log 1/Ki app (binding)
|
= 6.48
|
Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2.
|
ChEMBL.
|
7069722
|
Log 1/Ki app (binding)
|
= 5.22
|
Inhibitory activity against chicken dihydrofolate reductase at pH 7.2.
|
ChEMBL.
|
7069722
|
Log 1/Ki app (binding)
|
= 6.13
|
Inhibitory activity against dihydrofolate reductase (DHFR) from Lactobacillus casei (expressed as log 1/Kiapp)
|
ChEMBL.
|
6809941
|
Log 1/Ki app (binding)
|
= 6.48
|
Inhibition of dihydrofolate reductase from bovine liver
|
ChEMBL.
|
7017146
|
Log 1/Ki app (binding)
|
= 6.48
|
Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2.
|
ChEMBL.
|
7069722
|
Log 1/Ki app (binding)
|
= 6.82
|
Compound is evaluated for the inhibition of dihydrofolate reductase from Escherichia coli
|
ChEMBL.
|
7017146
|
Log 1/Ki app (binding)
|
= 6.82
|
Apparent inhibitory (log 1/Ki) activity against Escherichia coli dihydrofolate reductase
|
ChEMBL.
|
3276891
|
Log 1/Ki app (binding)
|
= 6.82
|
Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli (expressed as log 1/Kiapp)
|
ChEMBL.
|
6809941
|
Log Ki (binding)
|
= 6.82
|
Inhibition constant against binding of E. coli dihydrofolate reductase
|
ChEMBL.
|
3290487
|
MIC (functional)
|
= 121 uM
|
Toxicity of the compound was determined against L-6 cells.
|
ChEMBL.
|
10543874
|