Detailed information for compound 409257

Basic information

Technical information
  • TDR Targets ID: 409257
  • Name: N-[4-(4-chlorophenyl)-3-phenylbutan-2-yl]-2-m ethyl-2-pyridin-4-yloxypropanamide
  • MW: 422.947 | Formula: C25H27ClN2O2
  • H donors: 1 H acceptors: 2 LogP: 5.52 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C(c1ccccc1)Cc1ccc(cc1)Cl)NC(=O)C(Oc1ccncc1)(C)C
  • InChi: 1S/C25H27ClN2O2/c1-18(28-24(29)25(2,3)30-22-13-15-27-16-14-22)23(20-7-5-4-6-8-20)17-19-9-11-21(26)12-10-19/h4-16,18,23H,17H2,1-3H3,(H,28,29)
  • InChiKey: IFMIHWYHYXZLKK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[3-(4-chlorophenyl)-1-methyl-2-phenyl-propyl]-2-methyl-2-(4-pyridyloxy)propanamide
  • N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-methyl-2-(4-pyridyloxy)propanamide
  • N-[4-(4-chlorophenyl)-3-phenyl-butan-2-yl]-2-methyl-2-pyridin-4-yloxy-propanamide
  • N-[3-(4-chlorophenyl)-1-methyl-2-phenyl-propyl]-2-methyl-2-(4-pyridyloxy)propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0064 0.0054 0.0111
Echinococcus multilocularis retinol dehydrogenase 11 0.0064 0.0054 0.7604
Entamoeba histolytica hypothetical protein, conserved 0.0064 0.0054 0.5
Brugia malayi Retinol dehydrogenase 12 0.0064 0.0054 0.0043
Echinococcus multilocularis carbonyl reductase 1 0.0064 0.0054 0.7604
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0064 0.0054 0.5
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0064 0.0054 0.7604
Loa Loa (eye worm) acetylcholinesterase 1 0.0071 0.0068 0.0068
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0064 0.0054 0.5
Schistosoma mansoni short chain dehydrogenase 0.0064 0.0054 0.7604
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.2162 0.3891 1
Leishmania major short chain dehydrogenase/reductase, putative 0.0064 0.0054 0.0111
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 1
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0064 0.0054 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0064 0.0054 0.5
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0054 0.0043
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.2162 0.3891 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 0.0043
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0064 0.0054 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0064 0.0054 0.0111
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0064 0.0054 0.5
Leishmania major short chain dehydrogenase, putative 0.0064 0.0054 0.0111
Loa Loa (eye worm) dehydrogenase 0.0064 0.0054 0.0054
Loa Loa (eye worm) carboxylesterase 0.0071 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0064 0.0054 0.0054
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0064 0.0054 0.0111
Echinococcus multilocularis conserved hypothetical protein 0.0064 0.0054 0.7604
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 0.0043
Loa Loa (eye worm) hypothetical protein 0.0064 0.0054 0.0054
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0064 0.0054 1
Leishmania major oxidoreductase-like protein 0.0064 0.0054 0.0111
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.5503 1 1
Onchocerca volvulus 0.0064 0.0054 0.5
Echinococcus multilocularis oxidoreductase 0.0064 0.0054 0.7604
Echinococcus granulosus carbonyl reductase 1 0.0064 0.0054 0.7604
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0064 0.0054 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 0.0043
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0064 0.0054 0.5
Loa Loa (eye worm) dehydrogenase 0.0064 0.0054 0.0054
Giardia lamblia Hypothetical protein 0.0064 0.0054 0.5
Schistosoma mansoni short chain dehydrogenase 0.0064 0.0054 0.7604
Leishmania major short chain dehydrogenase-like protein 0.0064 0.0054 0.0111
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0064 0.0054 0.7604
Brugia malayi Dehydrogenases, short chain protein 2 0.0064 0.0054 0.0043
Leishmania major malonyl-coa decarboxylase-like protein 0.2162 0.3891 1
Schistosoma mansoni short chain dehydrogenase 0.0064 0.0054 0.7604
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0064 0.0054 0.5
Echinococcus multilocularis histone deacetylase 6 0.0046 0.0022 0.1972
Leishmania major quinonoid dihydropteridine reductase 0.0064 0.0054 0.0111
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 0.0043
Leishmania major short chain dehydrogenase, putative 0.0064 0.0054 0.0111
Schistosoma mansoni short chain dehydrogenase 0.0064 0.0054 0.7604
Loa Loa (eye worm) oxidoreductase 0.0064 0.0054 0.0054
Echinococcus granulosus carbonyl reductase 1 0.0064 0.0054 0.7604
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0064 0.0054 0.0111
Schistosoma mansoni steroid dehydrogenase 0.0064 0.0054 0.7604
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 1
Entamoeba histolytica short chain dehydrogenase family protein 0.0064 0.0054 0.5
Brugia malayi Carboxylesterase family protein 0.0071 0.0068 0.0057
Echinococcus multilocularis carbonyl reductase 1 0.0064 0.0054 0.7604
Plasmodium vivax hypothetical protein, conserved 0.0064 0.0054 1
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0064 0.0054 0.0111
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 0.0043
Echinococcus multilocularis acetylcholinesterase 0.0071 0.0068 1
Echinococcus granulosus hypothetical protein 0.0064 0.0054 0.7604
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0054 0.0111
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0064 0.0054 0.7604
Leishmania major hypothetical protein, conserved 0.0064 0.0054 0.0111
Schistosoma mansoni steroid dehydrogenase 0.0064 0.0054 0.7604
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0064 0.0054 0.5
Onchocerca volvulus 0.0064 0.0054 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.0064 0.0054 0.7604
Schistosoma mansoni short chain dehydrogenase 0.0064 0.0054 0.7604
Echinococcus granulosus carboxylesterase 5A 0.0071 0.0068 1
Onchocerca volvulus 0.0064 0.0054 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0054 0.0111
Schistosoma mansoni short chain dehydrogenase 0.0064 0.0054 0.7604
Brugia malayi dehydrogenases, short chain protein 2 0.0064 0.0054 0.0043
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.2162 0.3891 1
Schistosoma mansoni steroid dehydrogenase 0.0064 0.0054 0.7604
Schistosoma mansoni short chain dehydrogenase 0.0064 0.0054 0.7604
Loa Loa (eye worm) hypothetical protein 0.0071 0.0068 0.0068
Echinococcus multilocularis retinol dehydrogenase 11 0.0064 0.0054 0.7604
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0064 0.0054 0.5
Echinococcus multilocularis retinol dehydrogenase 13 0.0064 0.0054 0.7604
Trypanosoma brucei short-chain dehydrogenase, putative 0.0064 0.0054 0.0111
Loa Loa (eye worm) hypothetical protein 0.0071 0.0068 0.0068
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 1
Echinococcus granulosus carbonyl reductase 1 0.0064 0.0054 0.7604
Plasmodium vivax steroid dehydrogenase, putative 0.0064 0.0054 1
Echinococcus multilocularis carbonyl reductase 1 0.0064 0.0054 0.7604
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0064 0.0054 0.5
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0064 0.0054 0.5
Schistosoma mansoni short chain dehydrogenase 0.0064 0.0054 0.7604
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0064 0.0054 0.0043
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0064 0.0054 0.0111
Leishmania major quinonoid dihydropteridine reductase 0.0064 0.0054 0.0111
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0064 0.0054 0.0111
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0054 0.7604
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0064 0.0054 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 1
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0064 0.0054 0.7604
Schistosoma mansoni short chain dehydrogenase 0.0064 0.0054 0.7604
Trypanosoma brucei short-chain dehydrogenase, putative 0.0064 0.0054 0.0111
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0054 0.7604
Leishmania major hypothetical protein, conserved 0.0064 0.0054 0.0111
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0064 0.0054 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0064 0.0054 0.5
Echinococcus granulosus carbonyl reductase 1 0.0064 0.0054 0.7604
Onchocerca volvulus 0.0064 0.0054 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.0054 0.0054
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0064 0.0054 1
Toxoplasma gondii oxidoreductase, putative 0.0064 0.0054 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0071 0.0068 1
Toxoplasma gondii carbonyl reductase 1, putative 0.0064 0.0054 1
Echinococcus granulosus retinol dehydrogenase 11 0.0064 0.0054 0.7604
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0064 0.0054 0.0111
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 0.0043
Toxoplasma gondii oxidoreductase, putative 0.0064 0.0054 1
Brugia malayi hypothetical protein 0.0064 0.0054 0.0043
Echinococcus granulosus acetylcholinesterase 0.0071 0.0068 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0064 0.0054 0.5
Leishmania major pteridine reductase 1 0.0064 0.0054 0.0111
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0064 0.0054 1
Onchocerca volvulus 0.0064 0.0054 0.5
Schistosoma mansoni steroid dehydrogenase 0.0064 0.0054 0.7604
Loa Loa (eye worm) hypothetical protein 0.0064 0.0054 0.0054
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0064 0.0054 0.0111
Loa Loa (eye worm) oxidoreductase 0.0064 0.0054 0.0054
Loa Loa (eye worm) oxidoreductase 0.0064 0.0054 0.0054
Onchocerca volvulus 0.0064 0.0054 0.5
Loa Loa (eye worm) oxidoreductase 0.0064 0.0054 0.0054
Schistosoma mansoni short chain dehydrogenase 0.0064 0.0054 0.7604
Echinococcus multilocularis acetylcholinesterase 0.0071 0.0068 1
Loa Loa (eye worm) oxidoreductase 0.0064 0.0054 0.0054
Leishmania major quinonoid dihydropteridine reductase 0.0064 0.0054 0.0111
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0064 0.0054 0.0111
Trypanosoma brucei short-chain dehydrogenase, putative 0.0064 0.0054 0.0111
Schistosoma mansoni short chain dehydrogenase 0.0064 0.0054 0.7604
Plasmodium falciparum steroid dehydrogenase, putative 0.0064 0.0054 1
Leishmania major quinonoid dihydropteridine reductase 0.0064 0.0054 0.0111
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0064 0.0054 0.0111
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0064 0.0054 0.0043
Entamoeba histolytica short chain dehydrogenase family protein 0.0064 0.0054 0.5
Onchocerca volvulus 0.0064 0.0054 0.5
Schistosoma mansoni histone deacetylase hda2 0.0046 0.0022 0.1972
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 0.0043
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0064 0.0054 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0064 0.0054 0.0111
Brugia malayi dehydrogenases, short chain protein 9 0.0064 0.0054 0.0043
Mycobacterium ulcerans short chain dehydrogenase 0.3464 0.6272 1
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0054 0.0111
Mycobacterium tuberculosis Probable oxidoreductase 0.3464 0.6272 1
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0064 0.0054 0.0054
Schistosoma mansoni short chain dehydrogenase 0.0064 0.0054 0.7604
Schistosoma mansoni retinal dehydrogenase 0.0064 0.0054 0.7604
Echinococcus granulosus oxidoreductase 0.0064 0.0054 0.7604
Leishmania major quinonoid dihydropteridine reductase 0.0064 0.0054 0.0111
Schistosoma mansoni steroid dehydrogenase 0.0064 0.0054 0.7604
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0054 0.0111
Leishmania major quinonoid dihydropteridine reductase 0.0064 0.0054 0.0111
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0054 0.0111
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0064 0.0054 0.0111
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0064 0.0054 0.5
Schistosoma mansoni short chain dehydrogenase 0.0064 0.0054 0.7604
Echinococcus granulosus steroid dehydrogenase 0.0064 0.0054 0.7604
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0064 0.0054 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0064 0.0054 0.5
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0064 0.0054 0.0111
Schistosoma mansoni carbonyl reductase 0.0064 0.0054 0.7604
Loa Loa (eye worm) histone deacetylase 0.004 0.0011 0.0011
Echinococcus multilocularis transient receptor potential cation channel 0.0064 0.0054 0.7604
Schistosoma mansoni steroid dehydrogenase 0.0064 0.0054 0.7604
Schistosoma mansoni short chain dehydrogenase 0.0064 0.0054 0.7604
Brugia malayi oxidoreductase 0.0064 0.0054 0.0043
Onchocerca volvulus 0.0064 0.0054 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 0.0043
Echinococcus multilocularis carbonyl reductase 1 0.0064 0.0054 0.7604
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0064 0.0054 0.7604
Loa Loa (eye worm) hypothetical protein 0.5503 1 1
Giardia lamblia Short-chain dehydrogenase, putative 0.0064 0.0054 0.5
Brugia malayi Dehydrogenases, short chain protein 30 0.0064 0.0054 0.0043
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0064 0.0054 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 0.0043
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0064 0.0054 0.7604
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0064 0.0054 0.0111
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 0.0043
Loa Loa (eye worm) hypothetical protein 0.0064 0.0054 0.0054
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0064 0.0054 0.0111
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0054 0.0111
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0064 0.0054 0.7604
Loa Loa (eye worm) oxidoreductase 0.0064 0.0054 0.0054
Leishmania major hypothetical protein, conserved 0.0064 0.0054 0.0111
Brugia malayi Carboxylesterase family protein 0.0071 0.0068 0.0057
Loa Loa (eye worm) oxidoreductase 0.0064 0.0054 0.0054
Schistosoma mansoni carbonyl reductase 0.0064 0.0054 0.7604
Leishmania major short chain dehydrogenase/reductase, putative 0.0064 0.0054 0.0111
Onchocerca volvulus 0.0064 0.0054 0.5
Leishmania major dehydrogenase-like protein 0.0064 0.0054 0.0111
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 0.0043
Loa Loa (eye worm) oxidoreductase 0.0064 0.0054 0.0054
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0064 0.0054 0.0111
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 0.0043
Trypanosoma brucei short-chain dehydrogenase, putative 0.0064 0.0054 0.0111
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0064 0.0054 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0064 0.0054 0.0111
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 0.0043
Loa Loa (eye worm) histone deacetylase 7A 0.004 0.0011 0.0011
Onchocerca volvulus Sepiapterin reductase homolog 0.0064 0.0054 0.5
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0064 0.0054 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0064 0.0054 0.0111
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0064 0.0054 0.7604
Loa Loa (eye worm) hypothetical protein 0.0064 0.0054 0.0054
Trypanosoma brucei oxidoreductase-like protein 0.0064 0.0054 0.0111
Loa Loa (eye worm) hypothetical protein 0.0064 0.0054 0.0054
Entamoeba histolytica hypothetical protein 0.0064 0.0054 0.5
Leishmania major hypothetical protein, conserved 0.0064 0.0054 0.0111
Echinococcus granulosus hypothetical protein 0.0064 0.0054 0.7604
Echinococcus granulosus acetylcholinesterase 0.0071 0.0068 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0064 0.0054 0.0054
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0064 0.0054 0.7604
Loa Loa (eye worm) hypothetical protein 0.0064 0.0054 0.0054
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0064 0.0054 0.0111
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 0.0043
Entamoeba histolytica hypothetical protein, conserved 0.0064 0.0054 0.5
Schistosoma mansoni steroid dehydrogenase 0.0064 0.0054 0.7604
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0064 0.0054 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0064 0.0054 0.0111
Loa Loa (eye worm) hypothetical protein 0.0064 0.0054 0.0054
Onchocerca volvulus 0.0064 0.0054 0.5
Onchocerca volvulus 0.0064 0.0054 0.5
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0064 0.0054 0.7604
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0064 0.0054 0.0111
Schistosoma mansoni steroid dehydrogenase 0.0064 0.0054 0.7604
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 0.0043
Schistosoma mansoni steroid dehydrogenase 0.0064 0.0054 0.7604
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0054 0.7604
Giardia lamblia Reductase, putative 0.0064 0.0054 0.5
Mycobacterium leprae Probable oxidoreductase 0.0064 0.0054 0.5
Echinococcus granulosus histone deacetylase 6 0.0046 0.0022 0.1972
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0064 0.0054 0.5
Echinococcus multilocularis carboxylesterase 5A 0.0071 0.0068 1
Loa Loa (eye worm) oxidoreductase 0.0064 0.0054 0.0054
Schistosoma mansoni steroid dehydrogenase 0.0064 0.0054 0.7604
Schistosoma mansoni carbonyl reductase 0.0064 0.0054 0.7604
Trichomonas vaginalis steroid dehydrogenase, putative 0.0064 0.0054 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 0.0043
Echinococcus multilocularis steroid dehydrogenase 0.0064 0.0054 0.7604
Echinococcus granulosus WW domain containing oxidoreductase 0.0064 0.0054 0.7604
Brugia malayi hypothetical protein 0.0064 0.0054 0.0043
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0064 0.0054 0.0111
Leishmania major hypothetical protein, conserved 0.0064 0.0054 0.0111
Onchocerca volvulus 0.0064 0.0054 0.5
Leishmania major 3-keto-dihydrosphingosine reductase 0.0064 0.0054 0.0111
Schistosoma mansoni short chain dehydrogenase 0.0064 0.0054 0.7604
Echinococcus multilocularis steroid dehydrogenase 0.0064 0.0054 0.7604
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0064 0.0054 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 0.0043
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0054 0.0043
Onchocerca volvulus 0.0064 0.0054 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0064 0.0054 0.0111
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0054 0.0111

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 17 nM Inhibition of [3H]CP55940 binding to human recombinant CB1 receptor in CHO cells ChEMBL. 17181138
IC50 (binding) = 1200 nM Inhibition of [3H]CP55940 binding to human recombinant CB2 receptor in CHO cells ChEMBL. 17181138

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.