TDR Targets

Basic information

Technical information

TDR Targets ID: 409290
Name: (2S,3S)-2-amino-3-[3-[2-(difluoromethyl)pheny l]-1,2,4-oxadiazol-5-yl]-1-pyrrolidin-1-ylbut an-1-one
MW: 350.363 | Formula: C17H20F2N4O2
H donors: 1 H acceptors: 3 LogP: 2.16 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C([C@H]([C@@H](c1onc(n1)c1ccccc1C(F)F)C)N)N1CCCC1
InChi: 1S/C17H20F2N4O2/c1-10(13(20)17(24)23-8-4-5-9-23)16-21-15(22-25-16)12-7-3-2-6-11(12)14(18)19/h2-3,6-7,10,13-14H,4-5,8-9,20H2,1H3/t10-,13-/m0/s1
InChiKey: ZUTXGDPQGGSLPL-GWCFXTLKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2S,3S)-2-amino-3-[3-[2-(difluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidin-1-yl-butan-1-one
(2S,3S)-2-amino-3-[3-[2-(difluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-(1-pyrrolidinyl)-1-butanone
(2S,3S)-2-azanyl-3-[3-[2-(difluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidin-1-yl-butan-1-one
(2S,3S)-2-amino-3-[3-[2-(difluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidino-butan-1-one
(2S,3S)-2-amino-3-[3-[2-(difluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-1-pyrrolidinylbutan-1-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dipeptidyl-peptidase 7	Starlite/ChEMBL	References
Homo sapiens	dipeptidyl-peptidase 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K01278 dipeptidyl-peptidase 4, putative	Get druggable targets OG5_128614	All targets in OG5_128614
Loa Loa (eye worm)	prolyl oligopeptidase	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	Get druggable targets OG5_139351	All targets in OG5_139351
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	Get druggable targets OG5_139351	All targets in OG5_139351
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	Get druggable targets OG5_139351	All targets in OG5_139351
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	Get druggable targets OG5_128614	All targets in OG5_128614
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	Get druggable targets OG5_128614	All targets in OG5_128614
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma japonicum	ko:K01276 dipeptidyl-peptidase II [EC3.4.14.2], putative	Get druggable targets OG5_139351	All targets in OG5_139351
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	serine carboxypeptidase S28, putative	dipeptidyl-peptidase 7	492 aa	471 aa	25.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tm gpcr rhodopsin	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0178	0.1468	0.1439
Onchocerca volvulus		0.0178	0.1468	0.8331
Echinococcus granulosus	g-protein coupled receptor	0.0178	0.1468	0.1439
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0209	0.175	0.1722
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0025	0.0064	1
Onchocerca volvulus		0.0178	0.1468	0.8331
Onchocerca volvulus		0.0178	0.1468	0.8331
Echinococcus granulosus	rhodopsin orphan GPCR	0.0178	0.1468	0.1439
Echinococcus granulosus	expressed protein	0.0414	0.3617	0.3595
Brugia malayi	ORL1-like opioid receptor	0.0178	0.1468	0.1439
Leishmania major		0.1113	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0178	0.1468	0.1439
Brugia malayi	larval opioid receptor	0.0178	0.1468	0.1439
Schistosoma mansoni	amine GPCR	0.055	0.4856	0.4838
Onchocerca volvulus		0.0178	0.1468	0.8331
Brugia malayi	prolyl oligopeptidase family protein	0.007	0.0482	0.045
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Schistosoma mansoni	neuropeptide receptor	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0033	0.014	0.0106
Brugia malayi	hypothetical protein	0.0178	0.1468	0.1439
Echinococcus granulosus	neuropeptides capa receptor	0.0178	0.1468	0.1439
Schistosoma mansoni	lysosomal Pro-Xaa carboxypeptidase (S28 family)	0.0025	0.0064	0.003
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0178	0.1468	0.1439
Brugia malayi	hypothetical protein	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Brugia malayi	G protein-coupled receptor	0.0178	0.1468	0.1439
Trichomonas vaginalis	lysosomal pro-X carboxypeptidase, putative	0.0025	0.0064	0.148
Echinococcus multilocularis	neuropeptide receptor	0.0178	0.1468	0.1439
Schistosoma mansoni	growth hormone secretagogue receptor	0.0178	0.1468	0.1439
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0178	0.1468	0.1439
Echinococcus granulosus	neuropeptide Y receptor	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0064	0.003
Brugia malayi	neuropeptide F receptor	0.0178	0.1468	0.1439
Brugia malayi	Dopamine receptor protein 1	0.0178	0.1468	0.1439
Brugia malayi	putative neuropeptide receptor NPR1	0.0178	0.1468	0.1439
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0025	0.0064	0.003
Loa Loa (eye worm)	melatonin receptor type 1A	0.0178	0.1468	0.1439
Loa Loa (eye worm)	prolyl oligopeptidase	0.0209	0.175	0.1722
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.007	0.0482	0.0421
Schistosoma mansoni	amine GPCR	0.0178	0.1468	0.1439
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0.0043	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0178	0.1468	0.1439
Toxoplasma gondii	sedoheptulose-1,7-bisphosphatase	0.0414	0.3618	0.3577
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0236	0.0236
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0178	0.1468	0.1439
Schistosoma mansoni	amine GPCR	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Brugia malayi	hypothetical protein	0.0178	0.1468	0.1439
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0064	0.148
Echinococcus granulosus	rhodopsin orphan GPCR	0.0178	0.1468	0.1439
Giardia lamblia	Serine peptidase, putative	0.0025	0.0064	1
Brugia malayi	putative neuropeptide receptor	0.0178	0.1468	0.1439
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.0236	0.0173
Brugia malayi	G protein-coupled receptor F59B2.13	0.0178	0.1468	0.1439
Brugia malayi	hypothetical protein	0.0178	0.1468	0.1439
Toxoplasma gondii	fructose-bisphospatase I	0.0414	0.3618	0.3577
Echinococcus multilocularis	neuropeptide receptor A26	0.0178	0.1468	0.1439
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0209	0.175	1
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Echinococcus multilocularis	orexin receptor type 2	0.0178	0.1468	0.1439
Mycobacterium ulcerans	DNA polymerase IV	0.0043	0.0236	0.5
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0064	0.148
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0178	0.1468	0.1439
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0178	0.1468	0.1439
Brugia malayi	hypothetical protein	0.0178	0.1468	0.1439
Schistosoma mansoni	hypothetical protein	0.0178	0.1468	0.1439
Schistosoma mansoni	neuropeptide F-like receptor	0.0178	0.1468	0.1439
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	0.0456	0.4006	0.3986
Onchocerca volvulus		0.0178	0.1468	0.8331
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0178	0.1468	0.1439
Onchocerca volvulus		0.0178	0.1468	0.8331
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0178	0.1468	0.1439
Onchocerca volvulus		0.0178	0.1468	0.8331
Echinococcus multilocularis	g protein coupled receptor	0.0178	0.1468	0.1439
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.007	0.0482	0.045
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0178	0.1468	0.1439
Onchocerca volvulus		0.0178	0.1468	0.8331
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0331	0.0298
Schistosoma mansoni	biogenic amine receptor	0.0178	0.1468	0.1439
Brugia malayi	neuropeptide F receptor	0.0178	0.1468	0.1439
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0236	0.0236
Echinococcus multilocularis	neuropeptide Y receptor	0.0178	0.1468	0.1439
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0064	0.148
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0025	0.0064	1
Brugia malayi	Serine protease Z688.6 precursor	0.0025	0.0064	0.003
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0064	0.003
Echinococcus granulosus	rhodopsin orphan GPCR	0.0178	0.1468	0.1439
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0064	0.003
Loa Loa (eye worm)	TYRA-2 protein	0.0178	0.1468	0.1439
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.0236	0.0173
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0064	0.148
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.1113	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0178	0.1468	0.1439
Echinococcus multilocularis	neuropeptide s receptor	0.0178	0.1468	0.1439
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0064	0.148
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Echinococcus granulosus	neuropeptide Y receptor	0.0178	0.1468	0.1439
Brugia malayi	G-protein coupled receptor	0.0178	0.1468	0.1439
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0178	0.1468	0.1439
Brugia malayi	hypothetical protein	0.0178	0.1468	0.1439
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0209	0.175	0.1722
Trypanosoma brucei	DNA polymerase IV, putative	0.0036	0.0173	0.0173
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0456	0.4006	0.3986
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0178	0.1468	0.1439
Echinococcus granulosus	G protein coupled receptor 139	0.0178	0.1468	0.1439
Echinococcus multilocularis	neuropeptide Y receptor	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0025	0.0064	1
Trypanosoma brucei	fructose-1,6-bisphosphatase	0.1113	1	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0178	0.1468	0.8331
Brugia malayi	Serine carboxypeptidase S28 family protein	0.0025	0.0064	0.003
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0178	0.1468	0.1439
Echinococcus multilocularis	neuropeptide receptor	0.0178	0.1468	0.1439
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0178	0.1468	0.1439
Schistosoma mansoni	neuropeptide f receptor 76f	0.0178	0.1468	0.1439
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.007	0.0482	0.0482
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0236	0.0236
Schistosoma mansoni	adenoreceptor	0.0178	0.1468	0.1439
Loa Loa (eye worm)	G-protein coupled receptor	0.0178	0.1468	0.1439
Echinococcus multilocularis	serotonin receptor	0.0178	0.1468	0.1439
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Brugia malayi	polk-prov protein	0.0033	0.014	0.0106
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0178	0.1468	0.1439
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0178	0.1468	0.1439
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0414	0.3618	0.3577
Onchocerca volvulus		0.0178	0.1468	0.8331
Trypanosoma brucei	DNA polymerase kappa, putative	0.0033	0.014	0.014
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.1113	1	1
Echinococcus granulosus	g protein coupled receptor	0.0178	0.1468	0.1439
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0178	0.1468	0.1439
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0178	0.1468	0.1439
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0064	0.148
Echinococcus granulosus	hypothetical protein	0.0178	0.1468	0.1439
Schistosoma mansoni	neuropeptide receptor	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Onchocerca volvulus		0.0178	0.1468	0.8331
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0178	0.1468	0.1439
Schistosoma mansoni	biogenic amine receptor	0.0178	0.1468	0.1439
Echinococcus granulosus	sex peptide receptor	0.0178	0.1468	0.1439
Brugia malayi	GnHR receptor homolog	0.0178	0.1468	0.1439
Schistosoma mansoni	neuropeptide receptor	0.0178	0.1468	0.1439
Echinococcus multilocularis	fmrfamide receptor	0.0178	0.1468	0.1439
Echinococcus granulosus	fructose 16 bisphosphatase 1	0.1113	1	1
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Echinococcus granulosus	orexin receptor type 2	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Loa Loa (eye worm)	G-protein coupled receptor	0.0178	0.1468	0.1439
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.007	0.0482	0.0482
Schistosoma mansoni	biogenic amine receptor	0.0178	0.1468	0.1439
Onchocerca volvulus		0.0178	0.1468	0.8331
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0064	0.148
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0178	0.1468	0.1439
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0178	0.1468	0.1439
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0064	0.148
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0025	0.0064	0.003
Brugia malayi	Serine protease Z688.6 precursor	0.0025	0.0064	0.003
Echinococcus granulosus	neuropeptide receptor A26	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Brugia malayi	prolyl oligopeptidase family protein	0.0209	0.175	0.1722
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0178	0.1468	0.1439
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0178	0.1468	0.1439
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0178	0.1468	0.1439
Echinococcus granulosus	Dipeptidyl peptidase 9	0.007	0.0482	0.045
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0178	0.1468	0.1439
Brugia malayi	Melatonin receptor type 1A	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0236	0.0236
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	0.1113	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0178	0.1468	0.1439
Brugia malayi	Serotonin receptor	0.0178	0.1468	0.1439
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0178	0.1468	0.1439
Trypanosoma brucei	sedoheptulose-1,7-bisphosphatase	0.0414	0.3618	0.3618
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0178	0.1468	0.1439
Brugia malayi	hypothetical protein	0.0178	0.1468	0.1439
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0178	0.1468	0.1439
Schistosoma mansoni	hypothetical protein	0.0178	0.1468	0.1439
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0178	0.1468	0.1439
Schistosoma mansoni	neuropeptide receptor	0.0178	0.1468	0.1439
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0178	0.1468	0.1439
Echinococcus granulosus	rhodopsin orphan GPCR	0.0178	0.1468	0.1439
Schistosoma mansoni	histamine h1 receptor	0.0178	0.1468	0.1439
Echinococcus multilocularis	allatostatin A receptor	0.0178	0.1468	0.1439
Trypanosoma brucei	DNA polymerase kappa, putative	0.0033	0.014	0.014
Echinococcus multilocularis	neuropeptides capa receptor	0.0178	0.1468	0.1439
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0178	0.1468	0.1439
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0178	0.1468	0.1439
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0178	0.1468	0.1439
Echinococcus granulosus	g protein coupled receptor	0.0178	0.1468	0.1439
Echinococcus multilocularis	G protein coupled receptor 139	0.0178	0.1468	0.1439
Brugia malayi	G-protein coupled receptor	0.0178	0.1468	0.1439
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0178	0.1468	0.1439
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0178	0.1468	0.1439
Onchocerca volvulus		0.0178	0.1468	0.8331
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0178	0.1468	0.1439
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0043	0.0043
Echinococcus multilocularis	expressed protein	0.0414	0.3617	0.3595
Echinococcus granulosus	g protein coupled receptor	0.0178	0.1468	0.1439
Onchocerca volvulus		0.0178	0.1468	0.8331
Echinococcus multilocularis	fmrfamide receptor	0.0178	0.1468	0.1439
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0209	0.175	0.1722
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.007	0.0482	0.0441
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.007	0.0482	0.0421
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0064	0.148
Echinococcus multilocularis	serotonin receptor	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Echinococcus multilocularis	neuropeptides capa receptor	0.0178	0.1468	0.1439
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0236	0.0236
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0178	0.1468	0.1439
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0178	0.1468	0.1439
Brugia malayi	RE15519p	0.0178	0.1468	0.1439
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0064	0.148
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0064	0.003
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Mycobacterium ulcerans	DNA polymerase IV	0.0043	0.0236	0.5
Echinococcus granulosus	7TM GPCR rhodopsin	0.0178	0.1468	0.1439
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0178	0.1468	0.1439
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0178	0.1468	0.1439
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0178	0.1468	0.1439
Echinococcus granulosus	7tm_1 domain containing protein	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0414	0.3618	0.3577
Trypanosoma brucei	unspecified product	0.0036	0.0173	0.0173
Trichomonas vaginalis	prolylcarboxypeptidase, putative	0.0025	0.0064	0.148
Brugia malayi	Dopamine receptor protein 2	0.0178	0.1468	0.1439
Brugia malayi	sulfakinin receptor protein	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0178	0.1468	0.1439
Schistosoma mansoni	hypothetical protein	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Echinococcus granulosus	dna polymerase kappa	0.0043	0.0236	0.0203
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0064	0.148
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0178	0.1468	0.1439
Echinococcus multilocularis	sex peptide receptor	0.0178	0.1468	0.1439
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0178	0.1468	0.1439
Onchocerca volvulus		0.0178	0.1468	0.8331
Echinococcus granulosus	rhodopsin orphan GPCR	0.0178	0.1468	0.1439
Loa Loa (eye worm)	neuropeptide F receptor	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Echinococcus granulosus	neuropeptide receptor	0.0178	0.1468	0.1439
Trichomonas vaginalis	DNA polymerase eta, putative	0.0043	0.0236	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0178	0.1468	0.1439
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0178	0.1468	0.1439
Echinococcus granulosus	biogenic amine 5HT receptor	0.0178	0.1468	0.1439
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0043	0.0236	1
Schistosoma mansoni	opsin-like receptor	0.0178	0.1468	0.1439
Onchocerca volvulus		0.0178	0.1468	0.8331
Schistosoma mansoni	amine GPCR	0.0178	0.1468	0.1439
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0178	0.1468	0.1439
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0178	0.1468	0.1439
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0178	0.1468	0.1439
Loa Loa (eye worm)	neuropeptide F receptor	0.0178	0.1468	0.1439
Echinococcus granulosus	rhodopsin orphan GPCR	0.0178	0.1468	0.1439
Brugia malayi	Dopamine receptor	0.0178	0.1468	0.1439
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.0236	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0178	0.1468	0.1439
Trichomonas vaginalis	prolylcarboxypeptidase, putative	0.0025	0.0064	0.148
Giardia lamblia	Thymus-specific serine protease precursor	0.0025	0.0064	1
Echinococcus granulosus	allatostatin A receptor	0.0178	0.1468	0.1439
Echinococcus granulosus	rhodopsin orphan GPCR	0.0178	0.1468	0.1439
Echinococcus granulosus	fmrfamide receptor	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Echinococcus granulosus	tm gpcr rhodopsin	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Echinococcus multilocularis	g-protein coupled receptor	0.0178	0.1468	0.1439
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.007	0.0482	0.045
Trypanosoma brucei	DNA polymerase IV, putative	0.0043	0.0236	0.0236
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0178	0.1468	0.1439
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0178	0.1468	0.1439
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Schistosoma mansoni	opsin-like receptor	0.0178	0.1468	0.1439
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0178	0.1468	0.1439
Echinococcus granulosus	neuropeptide FF receptor 2	0.0178	0.1468	0.1439
Brugia malayi	hypothetical protein	0.0178	0.1468	0.1439
Schistosoma mansoni	neuropeptide F-like receptor	0.0178	0.1468	0.1439
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0178	0.1468	0.1439
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0236	0.0236
Schistosoma mansoni	myosin xvIII	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0178	0.1468	0.1439
Brugia malayi	Serotonin receptor	0.0178	0.1468	0.1439
Echinococcus granulosus	neuropeptide receptor	0.0178	0.1468	0.1439
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0178	0.1468	0.1439
Echinococcus multilocularis	somatostatin receptor	0.0178	0.1468	0.1439
Schistosoma mansoni	fructose-16-bisphosphatase-related	0.1113	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Brugia malayi	AKH receptor	0.0178	0.1468	0.1439
Echinococcus granulosus	serotonin receptor	0.0178	0.1468	0.1439
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0064	0.148
Toxoplasma gondii	fructose-bisphospatase II	0.1113	1	1
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0178	0.1468	0.1439
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0178	0.1468	0.1439
Brugia malayi	hypothetical protein	0.0054	0.0331	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Schistosoma mansoni	amine GPCR	0.0178	0.1468	0.1439
Echinococcus granulosus	somatostatin receptor	0.0178	0.1468	0.1439
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0236	0.0236
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	0.1113	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0178	0.1468	0.1439
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0064	0.148
Echinococcus multilocularis	g protein coupled receptor	0.0178	0.1468	0.1439
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0178	0.1468	0.1439
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.007	0.0482	0.0421
Brugia malayi	hypothetical protein	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1468	0.1439
Schistosoma mansoni	opsin-like receptor	0.0178	0.1468	0.1439
Echinococcus multilocularis	dna polymerase kappa	0.0043	0.0236	0.0203
Echinococcus granulosus	dro:myosuppressin receptor	0.0178	0.1468	0.1439
Echinococcus granulosus	neuropeptides capa receptor	0.0178	0.1468	0.1439
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0456	0.4006	0.3986
Onchocerca volvulus		0.0178	0.1468	0.8331
Schistosoma mansoni	hypothetical protein	0.0178	0.1468	0.1439
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0178	0.1468	0.1439
Onchocerca volvulus		0.0178	0.1468	0.8331
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0178	0.1468	0.1439
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0236	0.0236
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0178	0.1468	0.8331
Echinococcus multilocularis	g protein coupled receptor	0.0178	0.1468	0.1439
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0064	0.148
Echinococcus granulosus	neuropeptide s receptor	0.0178	0.1468	0.1439
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.0236	0.0173
Brugia malayi	hypothetical protein	0.0178	0.1468	0.1439
Echinococcus multilocularis	dro:myosuppressin receptor	0.0178	0.1468	0.1439
Trypanosoma brucei	DNA polymerase IV, putative	0.0043	0.0236	0.0236
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0178	0.1468	0.1439

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1 uM	Inhibition of QPP	ChEMBL.	16919457
IC50 (binding)	= 1 uM	Inhibition of QPP	ChEMBL.	16919457
IC50 (binding)	= 1.82 uM	Inhibition of DPP4	ChEMBL.	16919457
IC50 (binding)	= 1.82 uM	Inhibition of DPP4	ChEMBL.	16919457
IC50 (binding)	> 100 uM	Inhibition of DPP8	ChEMBL.	16919457
IC50 (binding)	> 100 uM	Inhibition of DPP9	ChEMBL.	16919457
IC50 (binding)	> 100 uM	Inhibition of DPP8	ChEMBL.	16919457
IC50 (binding)	> 100 uM	Inhibition of DPP9	ChEMBL.	16919457

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL216774
PubChem: 23645687

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 409290