Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cathepsin L-like protease | 0.0691 | 0.3175 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0691 | 0.3175 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0691 | 0.3175 | 0.3175 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0691 | 0.3175 | 0.3175 |
Echinococcus granulosus | cathepsin b | 0.1372 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0534 | 0.1597 | 0.1597 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0475 | 0.101 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0475 | 0.101 | 0.101 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1372 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0691 | 0.3175 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1372 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0691 | 0.3175 | 0.3175 |
Plasmodium vivax | vivapain-2 | 0.0691 | 0.3175 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0691 | 0.3175 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0691 | 0.3175 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0691 | 0.3175 | 1 |
Onchocerca volvulus | 0.0691 | 0.3175 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0691 | 0.3175 | 0.3175 |
Leishmania major | cathepsin L-like protease | 0.0691 | 0.3175 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0691 | 0.3175 | 0.3175 |
Brugia malayi | Cathepsin L-like precursor | 0.0691 | 0.3175 | 0.3175 |
Brugia malayi | Cathepsin L-like precursor | 0.0691 | 0.3175 | 0.3175 |
Onchocerca volvulus | Cathepsin L homolog | 0.0691 | 0.3175 | 1 |
Leishmania major | cathepsin L-like protease | 0.0691 | 0.3175 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1372 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0475 | 0.101 | 0.101 |
Leishmania major | cathepsin L-like protease | 0.0691 | 0.3175 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0691 | 0.3175 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0691 | 0.3175 | 0.2408 |
Onchocerca volvulus | 0.0691 | 0.3175 | 1 | |
Loa Loa (eye worm) | fibroinase | 0.0691 | 0.3175 | 0.2408 |
Onchocerca volvulus | 0.0691 | 0.3175 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0534 | 0.1597 | 0.5 |
Brugia malayi | cathepsin L-like precursor | 0.0475 | 0.101 | 0.101 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0691 | 0.3175 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0691 | 0.3175 | 0.3175 |
Echinococcus granulosus | cathepsin l1 | 0.0475 | 0.101 | 0.101 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0691 | 0.3175 | 0.3175 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0475 | 0.101 | 0.3182 |
Leishmania major | cysteine peptidase A (CPA) | 0.0691 | 0.3175 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0691 | 0.3175 | 0.3175 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0475 | 0.101 | 0.101 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0534 | 0.1597 | 0.5031 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Onchocerca volvulus | 0.0691 | 0.3175 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0691 | 0.3175 | 0.3175 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0691 | 0.3175 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0691 | 0.3175 | 0.3175 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0691 | 0.3175 | 0.3175 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0691 | 0.3175 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0691 | 0.3175 | 0.3175 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0691 | 0.3175 | 0.3175 |
Giardia lamblia | Cathepsin B precursor | 0.0534 | 0.1597 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0691 | 0.3175 | 0.3175 |
Leishmania major | cathepsin L-like protease | 0.0691 | 0.3175 | 1 |
Plasmodium vivax | vivapain-2 | 0.0691 | 0.3175 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0691 | 0.3175 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0691 | 0.3175 | 0.2408 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1372 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1372 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0691 | 0.3175 | 1 |
Leishmania major | cathepsin L-like protease | 0.0691 | 0.3175 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0691 | 0.3175 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0691 | 0.3175 | 0.2408 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0691 | 0.3175 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0691 | 0.3175 | 0.2408 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0534 | 0.1597 | 0.5031 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0691 | 0.3175 | 1 |
Echinococcus granulosus | cathepsin b | 0.1372 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Onchocerca volvulus | 0.0691 | 0.3175 | 1 | |
Onchocerca volvulus | 0.0691 | 0.3175 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0691 | 0.3175 | 0.3175 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0534 | 0.1597 | 0.1597 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0691 | 0.3175 | 0.3175 |
Loa Loa (eye worm) | hypothetical protein | 0.0691 | 0.3175 | 0.2408 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0691 | 0.3175 | 0.3175 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0691 | 0.3175 | 0.3175 |
Leishmania major | cathepsin L-like protease | 0.0691 | 0.3175 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1372 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1372 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0691 | 0.3175 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0691 | 0.3175 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0475 | 0.101 | 0.101 |
Onchocerca volvulus | Cathepsin L homolog | 0.0691 | 0.3175 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0534 | 0.1597 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0691 | 0.3175 | 0.3175 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Leishmania major | cathepsin L-like protease | 0.0691 | 0.3175 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0691 | 0.3175 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0691 | 0.3175 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0691 | 0.3175 | 0.3175 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0475 | 0.101 | 0.101 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0475 | 0.101 | 0.3182 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0691 | 0.3175 | 0.3175 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1372 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Onchocerca volvulus | 0.0691 | 0.3175 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0534 | 0.1597 | 0.0653 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0691 | 0.3175 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0691 | 0.3175 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 155 nM | Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 | ChEMBL. | 16890433 |
IC50 (functional) | = 163 nM | Antimalarial activity against CQ-resistant Plasmodium falciparum W2 | ChEMBL. | 16890433 |
IC50 (functional) | = 210 nM | Antimalarial activity against CQ-sensitive Plasmodium falciparum D10 | ChEMBL. | 16890433 |
IC50 (functional) | = 467 nM | Antimalarial activity against CQ-resistant Plasmodium falciparum K1 | ChEMBL. | 16890433 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.