Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | vitamin D (1,25- dihydroxyvitamin D3) receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | steroid hormone receptor | vitamin D (1,25- dihydroxyvitamin D3) receptor | 427 aa | 416 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.111 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0 | 0.5 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0 | 0.5 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.111 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.111 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.111 | 1 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.111 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.111 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0 | 0.5 |
Toxoplasma gondii | fructose-bisphospatase II | 0.111 | 1 | 1 |
Leishmania major | 0.111 | 1 | 0.5 | |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.111 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 5 % | Calcemic activity in Sprague-Dawley rat measured as urinary calcium excretion relative to calcitriol | ChEMBL. | 17149880 |
ED50 (binding) | = 3 nM | Activity on human VDR-mediated transcription of osteocalcin VDRE fused to thymidine kinase promoter/growth hormone reporter gene in CV1 cells | ChEMBL. | 17149880 |
ED50 (binding) | = 3 nM | Activity on human VDR-mediated transcription of osteocalcin VDRE fused to thymidine kinase promoter/growth hormone reporter gene in CV1 cells | ChEMBL. | 17149880 |
ED50 (functional) | = 7 nM | Antiproliferative activity against murine keratinocytes | ChEMBL. | 17149880 |
ED50 (binding) | = 100 nM | Stabilization of human [35S]VDR against trypsin digestion by protease assay | ChEMBL. | 17149880 |
ED50 (binding) | = 100 nM | Stabilization of human [35S]VDR against trypsin digestion by protease assay | ChEMBL. | 17149880 |
IC50 (binding) | = 19.5 nM | Displacement of [3H]1,25-dihydroxyvitamin D3 from human VDR by HAP assay | ChEMBL. | 17149880 |
IC50 (binding) | = 19.5 nM | Displacement of [3H]1,25-dihydroxyvitamin D3 from human VDR by HAP assay | ChEMBL. | 17149880 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.